Published in Mol Metab on May 20, 2014
Plasma levels of homocysteine and cysteine increased in pediatric NAFLD and strongly correlated with severity of liver damage. Int J Mol Sci (2014) 0.82
Herbal medicines and nonalcoholic fatty liver disease. World J Gastroenterol (2016) 0.79
Dietary Betaine Supplementation Increases Fgf21 Levels to Improve Glucose Homeostasis and Reduce Hepatic Lipid Accumulation in Mice. Diabetes (2016) 0.78
Protective Effect of Tyrosol and S-Adenosylmethionine against Ethanol-Induced Oxidative Stress of Hepg2 Cells Involves Sirtuin 1, P53 and Erk1/2 Signaling. Int J Mol Sci (2016) 0.76
Folic acid supplementation during high-fat diet feeding restores AMPK activation via an AMP-LKB1-dependent mechanism. Am J Physiol Regul Integr Comp Physiol (2015) 0.76
Tetradecylthiopropionic acid induces hepatic mitochondrial dysfunction and steatosis, accompanied by increased plasma homocysteine in mice. Lipids Health Dis (2016) 0.75
Nuciferine downregulates Per-Arnt-Sim kinase expression during its alleviation of lipogenesis and inflammation on oleic acid-induced hepatic steatosis in HepG2 cells. Front Pharmacol (2015) 0.75
Maternal Betaine Supplementation throughout Gestation and Lactation Modifies Hepatic Cholesterol Metabolic Genes in Weaning Piglets via AMPK/LXR-Mediated Pathway and Histone Modification. Nutrients (2016) 0.75
Proteomics-Based Identification of the Molecular Signatures of Liver Tissues from Aged Rats following Eight Weeks of Medium-Intensity Exercise. Oxid Med Cell Longev (2016) 0.75
Identification of candidate diagnostic biomarkers for adolescent idiopathic scoliosis using UPLC/QTOF-MS analysis: a first report of lipid metabolism profiles. Sci Rep (2016) 0.75
Hepatocyte specific TIMP3 expression prevents diet dependent fatty liver disease and hepatocellular carcinoma. Sci Rep (2017) 0.75
Analysis of relative gene expression data using real-time quantitative PCR and the 2(-Delta Delta C(T)) Method. Methods (2001) 414.27
Nonalcoholic fatty liver disease. N Engl J Med (2002) 22.41
Determination of stable housekeeping genes, differentially regulated target genes and sample integrity: BestKeeper--Excel-based tool using pair-wise correlations. Biotechnol Lett (2004) 18.55
Adiponectin stimulates glucose utilization and fatty-acid oxidation by activating AMP-activated protein kinase. Nat Med (2002) 14.15
AMPK: a nutrient and energy sensor that maintains energy homeostasis. Nat Rev Mol Cell Biol (2012) 10.42
Molecular mediators of hepatic steatosis and liver injury. J Clin Invest (2004) 9.40
AMP-activated protein kinase (AMPK) action in skeletal muscle via direct phosphorylation of PGC-1alpha. Proc Natl Acad Sci U S A (2007) 8.23
Characterization of the AMP-activated protein kinase kinase from rat liver and identification of threonine 172 as the major site at which it phosphorylates AMP-activated protein kinase. J Biol Chem (1996) 7.23
Mechanisms of disease:Molecular and metabolic mechanisms of insulin resistance and beta-cell failure in type 2 diabetes. Nat Rev Mol Cell Biol (2008) 6.23
Nonalcoholic fatty liver disease and hepatocellular carcinoma: a weighty connection. Hepatology (2010) 5.44
Maternal epigenetics and methyl supplements affect agouti gene expression in Avy/a mice. FASEB J (1998) 4.62
The epidemiology of nonalcoholic fatty liver disease: a global perspective. Semin Liver Dis (2008) 3.69
Betaine decreases hyperhomocysteinemia, endoplasmic reticulum stress, and liver injury in alcohol-fed mice. Gastroenterology (2003) 3.18
Methionine metabolism in mammals. J Nutr Biochem (1990) 3.06
The enzymatic synthesis of S-adenosyl-L-homocysteine from adenosine and homocysteine. J Biol Chem (1959) 3.05
Methionine adenosyltransferase 1A knockout mice are predisposed to liver injury and exhibit increased expression of genes involved in proliferation. Proc Natl Acad Sci U S A (2001) 2.93
Loss of the glycine N-methyltransferase gene leads to steatosis and hepatocellular carcinoma in mice. Hepatology (2008) 2.91
Recent insights into hepatic lipid metabolism in non-alcoholic fatty liver disease (NAFLD). Prog Lipid Res (2008) 2.77
Role of long-chain fatty acyl-CoA esters in the regulation of metabolism and in cell signalling. Biochem J (1997) 2.59
AMP kinase and malonyl-CoA: targets for therapy of the metabolic syndrome. Nat Rev Drug Discov (2004) 2.46
Molecular therapy for obesity and diabetes based on a long-term increase in hepatic fatty-acid oxidation. Hepatology (2011) 2.39
From the metabolic syndrome to NAFLD or vice versa? Dig Liver Dis (2010) 2.24
Increased levels of plasma acylcarnitines in obesity and type 2 diabetes and identification of a marker of glucolipotoxicity. Obesity (Silver Spring) (2010) 2.23
Mechanisms of hepatic steatosis in mice fed a lipogenic methionine choline-deficient diet. J Lipid Res (2008) 2.21
Carnitine biosynthesis in mammals. Biochem J (2002) 2.13
Methionine metabolism and liver disease. Annu Rev Nutr (2008) 1.98
Obesity affects the liver - the link between adipocytes and hepatocytes. Digestion (2010) 1.96
Activation of nuclear receptor coactivator PGC-1alpha by arginine methylation. Genes Dev (2005) 1.92
Increased hepatocyte CYP2E1 expression in a rat nutritional model of hepatic steatosis with inflammation. Gastroenterology (1996) 1.83
Elevation of serum cystathionine levels in patients with cobalamin and folate deficiency. Blood (1993) 1.80
Neonatal hepatic steatosis by disruption of the adenosine kinase gene. Proc Natl Acad Sci U S A (2002) 1.70
Methyl donor deficiency induces cardiomyopathy through altered methylation/acetylation of PGC-1α by PRMT1 and SIRT1. J Pathol (2011) 1.61
Medium-chain acyl-CoA dehydrogenase (MCAD) deficiency: diagnosis by acylcarnitine analysis in blood. Am J Hum Genet (1993) 1.52
Non-alcoholic steatohepatitis and animal models: understanding the human disease. Int J Biochem Cell Biol (2008) 1.49
S-adenosylmethionine regulates cytoplasmic HuR via AMP-activated kinase. Gastroenterology (2006) 1.44
Deletion of betaine-homocysteine S-methyltransferase in mice perturbs choline and 1-carbon metabolism, resulting in fatty liver and hepatocellular carcinomas. J Biol Chem (2011) 1.40
Betaine attenuates alcoholic steatosis by restoring phosphatidylcholine generation via the phosphatidylethanolamine methyltransferase pathway. J Hepatol (2006) 1.39
AMP-activated protein kinase: a cellular energy sensor with a key role in metabolic disorders and in cancer. Biochem Soc Trans (2011) 1.39
Biochemical and evolutionary significance of phospholipid methylation. J Biol Chem (1998) 1.37
Reversible modulation of the activities of both liver microsomal hydroxymethylglutaryl coenzyme A reductase and its inactivating enzyme. Evidence for regulation by phosphorylation-dephosphorylation. Biochem Biophys Res Commun (1978) 1.29
A gender-specific role for phosphatidylethanolamine N-methyltransferase-derived phosphatidylcholine in the regulation of plasma high density and very low density lipoproteins in mice. J Biol Chem (2003) 1.27
Metabolic regulatory properties of S-adenosylmethionine and S-adenosylhomocysteine. Clin Chem Lab Med (2007) 1.21
Interaction between dietary methionine and methyl donor intake on rat liver betaine-homocysteine methyltransferase gene expression and organization of the human gene. J Biol Chem (1999) 1.15
Involvement of AMP-activated protein kinase in beneficial effects of betaine on high-sucrose diet-induced hepatic steatosis. Am J Physiol Gastrointest Liver Physiol (2007) 1.12
Impaired sulfur-amino acid metabolism and oxidative stress in nonalcoholic fatty liver are alleviated by betaine supplementation in rats. J Nutr (2008) 1.08
Betaine improves nonalcoholic fatty liver and associated hepatic insulin resistance: a potential mechanism for hepatoprotection by betaine. Am J Physiol Gastrointest Liver Physiol (2010) 1.08
Binding of S-methyl-5'-thioadenosine and S-adenosyl-L-methionine to protein MJ0100 triggers an open-to-closed conformational change in its CBS motif pair. J Mol Biol (2009) 1.07
Alterations in hepatic one-carbon metabolism and related pathways following a high-fat dietary intervention. Physiol Genomics (2011) 1.04
Betaine improved adipose tissue function in mice fed a high-fat diet: a mechanism for hepatoprotective effect of betaine in nonalcoholic fatty liver disease. Am J Physiol Gastrointest Liver Physiol (2010) 1.03
Mechanism for prevention of alcohol-induced liver injury by dietary methyl donors. Toxicol Sci (2010) 1.00
Casitas b-lineage lymphoma-deficient mice are protected against high-fat diet-induced obesity and insulin resistance. Diabetes (2006) 0.96
Homocysteine metabolism and its relation to health and disease. Biofactors (2010) 0.95
Regulation of hepatic betaine-homocysteine methyltransferase by dietary betaine. J Nutr (1983) 0.94
Methyl donor deficiency impairs fatty acid oxidation through PGC-1α hypomethylation and decreased ER-α, ERR-α, and HNF-4α in the rat liver. J Hepatol (2012) 0.93
C57Bl/6 N mice on a western diet display reduced intestinal and hepatic cholesterol levels despite a plasma hypercholesterolemia. BMC Genomics (2012) 0.93
Lack of phosphatidylethanolamine N-methyltransferase alters plasma VLDL phospholipids and attenuates atherosclerosis in mice. Arterioscler Thromb Vasc Biol (2009) 0.88
Simultaneous quantification of S-adenosyl methionine and S-adenosyl homocysteine in human plasma by stable-isotope dilution ultra performance liquid chromatography tandem mass spectrometry. J Chromatogr B Analyt Technol Biomed Life Sci (2009) 0.87
Corresponding increase in long-chain acyl-CoA and acylcarnitine after exercise in muscle from VLCAD mice. J Lipid Res (2008) 0.86
ACTIONS OF BETAINE, CARNITINE AND CHOLINE ON THE PATTERN OF HEPATIC LIPOSIS IN MICE FED A HIGH-FAT, LOW-PROTEIN DIET. Anat Rec (1964) 0.81
Regulation of homocysteine homeostasis through the transcriptional coactivator PGC-1alpha. Am J Physiol Endocrinol Metab (2009) 0.77
Dietary betaine modifies hepatic metabolism but not renal injury in rat polycystic kidney disease. Am J Physiol Gastrointest Liver Physiol (2000) 0.77