Published in Am J Pathol on March 01, 2006
C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression. BMC Cell Biol (2008) 0.94
Atherosclerosis, platelets and thrombosis in acute ischaemic heart disease. Eur Heart J Acute Cardiovasc Care (2012) 0.88
Gene expression differences between stroke-associated and asymptomatic carotid plaques. J Mol Med (Berl) (2011) 0.88
GPCR kinase 2 interacting protein 1 (GIT1) regulates osteoclast function and bone mass. J Cell Physiol (2010) 0.87
Secreted proteins from carotid endarterectomy: an untargeted approach to disclose molecular clues of plaque progression. J Transl Med (2013) 0.85
Proteomic Biomarkers of Atherosclerosis. Biomark Insights (2008) 0.81
Transcription and translation of human F11R gene are required for an initial step of atherogenesis induced by inflammatory cytokines. J Transl Med (2011) 0.81
BRCA2 variants and cardiovascular disease in a multi-ethnic study. BMC Med Genet (2012) 0.75
Angiogenesis in cancer, vascular, rheumatoid and other disease. Nat Med (1995) 26.60
Requirement of JNK2 for scavenger receptor A-mediated foam cell formation in atherogenesis. Science (2004) 2.38
Expression of interleukin-18 in human atherosclerotic plaques and relation to plaque instability. Circulation (2001) 2.13
Western array analysis of human atherosclerotic plaques: downregulation of apoptosis-linked gene 2. Cardiovasc Res (2003) 2.09
Neovascular expression of E-selectin, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 in human atherosclerosis and their relation to intimal leukocyte content. Circulation (1996) 2.05
Tumor necrosis factor receptor levels are associated with carotid atherosclerosis. Stroke (2002) 1.94
Endothelial cell apoptosis: biochemical characteristics and potential implications for atherosclerosis. J Mol Cell Cardiol (2001) 1.91
Initiator caspases in apoptosis signaling pathways. Apoptosis (2002) 1.86
Essential role of junctional adhesion molecule-1 in basic fibroblast growth factor-induced endothelial cell migration. Arterioscler Thromb Vasc Biol (2003) 1.71
Leukocyte recruitment in the cerebrospinal fluid of mice with experimental meningitis is inhibited by an antibody to junctional adhesion molecule (JAM). J Exp Med (1999) 1.68
Free cholesterol loading of macrophages is associated with widespread mitochondrial dysfunction and activation of the mitochondrial apoptosis pathway. J Biol Chem (2001) 1.67
High-level expression of Egr-1 and Egr-1-inducible genes in mouse and human atherosclerosis. J Clin Invest (2000) 1.67
Interendothelial junctions and their role in the control of angiogenesis, vascular permeability and leukocyte transmigration. Thromb Haemost (2001) 1.61
Increased matrix metalloproteinase-9 activity in unstable carotid plaques. A potential role in acute plaque disruption. Stroke (2000) 1.59
Chronic physiological shear stress inhibits tumor necrosis factor-induced proinflammatory responses in rabbit aorta perfused ex vivo. Circulation (2003) 1.53
S1P induces FA remodeling in human pulmonary endothelial cells: role of Rac, GIT1, FAK, and paxillin. J Appl Physiol (1985) (2002) 1.52
GIT1 functions as a scaffold for MEK1-extracellular signal-regulated kinase 1 and 2 activation by angiotensin II and epidermal growth factor. Mol Cell Biol (2004) 1.42
Structural basis for SH3 domain-mediated high-affinity binding between Mona/Gads and SLP-76. EMBO J (2003) 1.38
Apoptosis induced by topoisomerase inhibitors. Curr Med Chem Anticancer Agents (2003) 1.31
Association between plaque instability, angiogenesis and symptomatic carotid occlusive disease. Br J Surg (2001) 1.29
Signaling through JAM-1 and alphavbeta3 is required for the angiogenic action of bFGF: dissociation of the JAM-1 and alphavbeta3 complex. Blood (2003) 1.27
Overexpression of eotaxin and the CCR3 receptor in human atherosclerosis: using genomic technology to identify a potential novel pathway of vascular inflammation. Circulation (2000) 1.24
The role of MAP kinases in endothelial activation. Vascul Pharmacol (2002) 1.22
Oxidized low-density lipoprotein (oxLDL) triggers hypoxia-inducible factor-1alpha (HIF-1alpha) accumulation via redox-dependent mechanisms. Blood (2003) 1.15
Increased expression and activation of stress-activated protein kinases/c-Jun NH(2)-terminal protein kinases in atherosclerotic lesions coincide with p53. Am J Pathol (2000) 1.14
Synergistic effect of urotensin II with mildly oxidized LDL on DNA synthesis in vascular smooth muscle cells. Circulation (2001) 1.12
Translational regulation of x-linked inhibitor of apoptosis protein by interleukin-6: a novel mechanism of tumor cell survival. Cancer Res (2004) 1.09
Serum tumour necrosis factor-alpha, interleukin-2 and interleukin-10 activation in stable angina and acute coronary syndromes. Coron Artery Dis (2003) 1.06
Gene expression profiling of apoptosis-related genes in human atherosclerosis: upregulation of death-associated protein kinase. Arterioscler Thromb Vasc Biol (2002) 1.05
Involvement of TRAF4 in oxidative activation of c-Jun N-terminal kinase. J Biol Chem (2002) 1.00
Carotid intraplaque hemorrhage: the significance of neovascularity. J Vasc Surg (1987) 0.98
Identification and characterization of the cytoplasmic protein TRAF4 as a p53-regulated proapoptotic gene. J Biol Chem (2003) 0.96
Protein expression changes in spinal muscular atrophy revealed with a novel antibody array technology. Brain (2003) 0.93
The unstable plaque. Cerebrovasc Dis (2004) 0.93
Expression of platelet-activating factor receptor in human carotid atherosclerotic plaques: relevance to progression of atherosclerosis. Circulation (2000) 0.90
Expression of Bcl-x, Bcl-2, Bax, and Bak in endarterectomy and atherectomy specimens. J Pathol (2002) 0.90
Ebselen inhibits tumor necrosis factor-alpha-induced c-Jun N-terminal kinase activation and adhesion molecule expression in endothelial cells. Exp Cell Res (2004) 0.89
Induced expression and association of the Mona/Gads adapter and Gab3 scaffolding protein during monocyte/macrophage differentiation. Mol Cell Biol (2002) 0.89
Increased endothelial expression of intercellular adhesion molecule-1 in symptomatic versus asymptomatic human carotid atherosclerotic plaque. Stroke (1998) 0.86
The association of platelet-derived growth factor receptor expression, plaque morphology and histological features with symptoms in carotid atherosclerosis. Cardiovasc Surg (2000) 0.80
Unique cell membrane expression of topoisomerase-II alpha as a useful diagnostic marker of liposarcoma. Pathol Int (2004) 0.80
Plaque angiogenesis: its functions and regulation. Cold Spring Harb Symp Quant Biol (2002) 0.80
C-reactive protein and rapidly progressive coronary artery disease--is there any relation? Clin Cardiol (2003) 0.79
Differential gene expression in primary and recurrent carotid stenosis. Biochem Biophys Res Commun (2003) 0.78
Increased expression of HDJ-2 (hsp40) in carotid artery atherosclerosis: a novel heat shock protein associated with luminal stenosis and plaque ulceration. J Vasc Surg (2001) 0.77
Prevention of human smooth muscle cell proliferation without induction of apoptosis by the topoisomerase I inhibitor topotecan. Biochem Pharmacol (2001) 0.77
Changes in Ca2+ signaling and contractile protein isoforms in smooth muscle cells from guinea pig ileum during culture. J Smooth Muscle Res (2001) 0.77
A DNA methylation fingerprint of 1628 human samples. Genome Res (2011) 2.16
Hyaluronan-mediated angiogenesis in vascular disease: uncovering RHAMM and CD44 receptor signaling pathways. Matrix Biol (2006) 1.79
Circulating and platelet-derived microparticles in human blood enhance thrombosis on atherosclerotic plaques. Thromb Haemost (2012) 1.63
Molecular and cellular mechanisms involved in cardiac remodeling after acute myocardial infarction. J Mol Cell Cardiol (2011) 1.61
CD40: an upstream master switch for endothelial cell activation uncovered by RNAi-coupled transcriptional profiling. Blood (2008) 1.56
Angiogenic oligosaccharides of hyaluronan induce multiple signaling pathways affecting vascular endothelial cell mitogenic and wound healing responses. J Biol Chem (2002) 1.50
Rapid change in plaque size, composition, and molecular footprint after recombinant apolipoprotein A-I Milano (ETC-216) administration: magnetic resonance imaging study in an experimental model of atherosclerosis. J Am Coll Cardiol (2008) 1.50
Low density lipoproteins downregulate lysyl oxidase in vascular endothelial cells and the arterial wall. Arterioscler Thromb Vasc Biol (2002) 1.50
Ischaemic heart disease in women: are there sex differences in pathophysiology and risk factors? Position paper from the working group on coronary pathophysiology and microcirculation of the European Society of Cardiology. Cardiovasc Res (2010) 1.45
[Neovascularization in human coronary arteries with lesions of different severity]. Rev Esp Cardiol (2003) 1.45
The NR4A subfamily of nuclear receptors: new early genes regulated by growth factors in vascular cells. Cardiovasc Res (2005) 1.43
Endothelial and smooth muscle cells dysfunction distal to recanalized chronic total coronary occlusions and the relationship with the collateral connection grade. JACC Cardiovasc Interv (2012) 1.41
A novel anti-ischemic nitric oxide donor inhibits thrombosis without modifying haemodynamic parameters. Thromb Haemost (2004) 1.41
Pax genes in embryogenesis and oncogenesis. J Cell Mol Med (2008) 1.37
Can angiogenesis be exploited to improve stroke outcome? Mechanisms and therapeutic potential. Clin Sci (Lond) (2006) 1.36
Bleeding in acute coronary syndromes and percutaneous coronary interventions: position paper by the Working Group on Thrombosis of the European Society of Cardiology. Eur Heart J (2011) 1.34
Changes in hyaluronan production and metabolism following ischaemic stroke in man. Brain (2006) 1.30
Angiogenesis, neurogenesis and neuroplasticity in ischemic stroke. Curr Cardiol Rev (2010) 1.26
Thrombin and protease-activated receptors (PARs) in atherothrombosis. Thromb Haemost (2008) 1.26
Antiplatelet agents for the treatment and prevention of atherothrombosis. Eur Heart J (2011) 1.23
Regulation of lysyl oxidase in vascular cells: lysyl oxidase as a new player in cardiovascular diseases. Cardiovasc Res (2008) 1.21
Neuron-derived orphan receptor-1 (NOR-1) modulates vascular smooth muscle cell proliferation. Circ Res (2003) 1.19
Atherosclerosis and thrombosis: insights from large animal models. J Biomed Biotechnol (2011) 1.15
Sphingosine-1-phosphate: A bioactive lipid that confers high-density lipoprotein with vasculoprotection mediated by nitric oxide and prostacyclin. Thromb Haemost (2009) 1.13
Mechanisms of chronic state of inflammation as mediators that link obese adipose tissue and metabolic syndrome. Mediators Inflamm (2013) 1.11
C-reactive protein isoforms differ in their effects on thrombus growth. Arterioscler Thromb Vasc Biol (2008) 1.09
Intraplaque MMP-8 levels are increased in asymptomatic patients with carotid plaque progression on ultrasound. Atherosclerosis (2005) 1.09
The subcutaneous adipose tissue reservoir of functionally active stem cells is reduced in obese patients. FASEB J (2012) 1.05
Involvement of neuron-derived orphan receptor-1 (NOR-1) in LDL-induced mitogenic stimulus in vascular smooth muscle cells: role of CREB. Arterioscler Thromb Vasc Biol (2004) 1.01
Influence of statin use on endothelial function: from bench to clinics. Curr Pharm Des (2007) 0.99
NOR-1 is involved in VEGF-induced endothelial cell growth. Atherosclerosis (2005) 0.98
Sterol regulatory element binding proteins downregulate LDL receptor-related protein (LRP1) expression and LRP1-mediated aggregated LDL uptake by human macrophages. Cardiovasc Res (2007) 0.97
High levels of homocysteine inhibit lysyl oxidase (LOX) and downregulate LOX expression in vascular endothelial cells. Atherosclerosis (2004) 0.97
Cellular prion protein is increased in the plasma and peri-infarcted brain tissue after acute stroke. J Neurosci Res (2007) 0.96
Effect of Mediterranean diet on the expression of pro-atherogenic genes in a population at high cardiovascular risk. Atherosclerosis (2009) 0.95
Modified C-reactive protein is expressed by stroke neovessels and is a potent activator of angiogenesis in vitro. Brain Pathol (2009) 0.95
The hypoxia-inducible factor 1/NOR-1 axis regulates the survival response of endothelial cells to hypoxia. Mol Cell Biol (2009) 0.95
Endogenous expression of C-reactive protein is increased in active (ulcerated noncomplicated) human carotid artery plaques. Stroke (2006) 0.95
A generic operational strategy to qualify translational safety biomarkers. Drug Discov Today (2011) 0.94
C-reactive protein exerts angiogenic effects on vascular endothelial cells and modulates associated signalling pathways and gene expression. BMC Cell Biol (2008) 0.94
LDL receptor-related protein and the vascular wall: implications for atherothrombosis. Arterioscler Thromb Vasc Biol (2005) 0.94
A microarray study of gene and protein regulation in human and rat brain following middle cerebral artery occlusion. BMC Neurosci (2007) 0.94
Association study between polymorphims in GAS6-TAM genes and carotid atherosclerosis. Thromb Haemost (2010) 0.94
Trends in qualifying biomarkers in drug safety. Consensus of the 2011 meeting of the spanish society of clinical pharmacology. Front Pharmacol (2012) 0.93
Prostacyclin induction by high-density lipoprotein (HDL) in vascular smooth muscle cells depends on sphingosine 1-phosphate receptors: effect of simvastatin. Thromb Haemost (2008) 0.93
Hyaluronan expression following middle cerebral artery occlusion in the rat. Neuroreport (2006) 0.93
Expression of cyclin-dependent kinase 5 mRNA and protein in the human brain following acute ischemic stroke. Brain Pathol (2007) 0.92
Efficacy of long-term continuous subcutaneous apomorphine infusion in advanced Parkinson's disease with motor fluctuations: a multicenter study. Mov Disord (2008) 0.92
Antiplatelet properties of natural products. Vascul Pharmacol (2013) 0.92
Presentation, management, and outcomes of ischaemic heart disease in women. Nat Rev Cardiol (2013) 0.92
Angiotensin II upregulates LDL receptor-related protein (LRP1) expression in the vascular wall: a new pro-atherogenic mechanism of hypertension. Cardiovasc Res (2008) 0.91
Recombinant HDL(Milano) exerts greater anti-inflammatory and plaque stabilizing properties than HDL(wild-type). Atherosclerosis (2011) 0.91
Hypoxia stimulates low-density lipoprotein receptor-related protein-1 expression through hypoxia-inducible factor-1α in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2011) 0.90
Mechanisms underlying the cardiovascular effects of COX-inhibition: benefits and risks. Curr Pharm Des (2007) 0.90
Imaging of early inflammation in low-to-moderate carotid stenosis by 18-FDG-PET. Front Biosci (Landmark Ed) (2009) 0.90
Human coronary smooth muscle cells internalize versican-modified LDL through LDL receptor-related protein and LDL receptors. Arterioscler Thromb Vasc Biol (2002) 0.90
Lipid-lowering therapy with statins reduces microparticle shedding from endothelium, platelets and inflammatory cells. Thromb Haemost (2013) 0.89
Transcription factor SOX18 is expressed in human coronary atherosclerotic lesions and regulates DNA synthesis and vascular cell growth. Arterioscler Thromb Vasc Biol (2005) 0.89
Cholesteryl esters of aggregated LDL are internalized by selective uptake in human vascular smooth muscle cells. Arterioscler Thromb Vasc Biol (2005) 0.89
Wnt pathway activation, cell migration, and lipid uptake is regulated by low-density lipoprotein receptor-related protein 5 in human macrophages. Eur Heart J (2011) 0.89
Controlling the angiogenic switch in developing atherosclerotic plaques: possible targets for therapeutic intervention. J Angiogenes Res (2009) 0.88
Low-density lipoprotein receptor-related protein 1 mediates hypoxia-induced very low density lipoprotein-cholesteryl ester uptake and accumulation in cardiomyocytes. Cardiovasc Res (2012) 0.88
Induction of RISK by HMG-CoA reductase inhibition affords cardioprotection after myocardial infarction. Atherosclerosis (2009) 0.88
Expression of basic fibroblast growth factor mRNA and protein in the human brain following ischaemic stroke. Angiogenesis (2005) 0.87
Stem cells isolated from adipose tissue of obese patients show changes in their transcriptomic profile that indicate loss in stemcellness and increased commitment to an adipocyte-like phenotype. BMC Genomics (2013) 0.87
Antithrombotic medication for cardioembolic stroke prevention. Stroke Res Treat (2011) 0.87
Cyclin-dependent kinase-5 targeting for ischaemic stroke. Curr Opin Pharmacol (2008) 0.87
Tissue factor regulates microvessel formation and stabilization by induction of chemokine (C-C motif) ligand 2 expression. Arterioscler Thromb Vasc Biol (2011) 0.87
Proteomic signature of Apolipoprotein J in the early phase of new-onset myocardial infarction. J Proteome Res (2010) 0.87
Platelets and atherogenesis: Platelet anti-aggregation activity and endothelial protection from tomatoes (Solanum lycopersicum L.). Exp Ther Med (2012) 0.87
Monomeric C-reactive protein is prothrombotic and dissociates from circulating pentameric C-reactive protein on adhered activated platelets under flow. Cardiovasc Res (2011) 0.87
Low-density lipoproteins impair migration of human coronary vascular smooth muscle cells and induce changes in the proteomic profile of myosin light chain. Cardiovasc Res (2007) 0.86
Hypoxia exacerbates Ca(2+)-handling disturbances induced by very low density lipoproteins (VLDL) in neonatal rat cardiomyocytes. J Mol Cell Cardiol (2011) 0.86
Oleanolic acid induces prostacyclin release in human vascular smooth muscle cells through a cyclooxygenase-2-dependent mechanism. J Nutr (2008) 0.86
Detection of subclinical atherosclerosis in familial hypercholesterolemia using non-invasive imaging modalities. Atherosclerosis (2012) 0.86
Hypoxia induces metalloproteinase-9 activation and human vascular smooth muscle cell migration through low-density lipoprotein receptor-related protein 1-mediated Pyk2 phosphorylation. Arterioscler Thromb Vasc Biol (2013) 0.86
Evolution of lipid profiles after bariatric surgery. Obes Surg (2012) 0.85
Unique vascular protective properties of natural products: supplements or future main-line drugs with significant anti-atherosclerotic potential? Vasc Cell (2012) 0.85
Aggregated low-density lipoprotein uptake induces membrane tissue factor procoagulant activity and microparticle release in human vascular smooth muscle cells. Circulation (2004) 0.85
Overexpression of hypoxia/inflammatory markers in atherosclerotic carotid plaques. Front Biosci (2008) 0.85
LRP1 gene polymorphisms are associated with premature risk of cardiovascular disease in patients with familial hypercholesterolemia. Rev Esp Cardiol (Engl Ed) (2012) 0.85
Modulation of endothelium and endothelial progenitor cell function by low-density lipoproteins: implication for vascular repair, angiogenesis and vasculogenesis. Pathobiology (2009) 0.85
Angina, "normal" coronary angiography, and vascular dysfunction: risk assessment strategies. PLoS Med (2007) 0.85
Simvastatin potenciates PGI(2) release induced by HDL in human VSMC: effect on Cox-2 up-regulation and MAPK signalling pathways activated by HDL. Atherosclerosis (2004) 0.84
Expression of signaling molecules associated with apoptosis in human ischemic stroke tissue. Cell Biochem Biophys (2007) 0.84