Published in J Biol Chem on August 31, 2001
Integrating the mechanisms of apoptosis induced by endoplasmic reticulum stress. Nat Cell Biol (2011) 8.75
Consequences of cellular cholesterol accumulation: basic concepts and physiological implications. J Clin Invest (2002) 3.52
Cholesterol-induced macrophage apoptosis requires ER stress pathways and engagement of the type A scavenger receptor. J Cell Biol (2005) 3.14
Calcium/calmodulin-dependent protein kinase II links ER stress with Fas and mitochondrial apoptosis pathways. J Clin Invest (2009) 2.82
Role of ERO1-alpha-mediated stimulation of inositol 1,4,5-triphosphate receptor activity in endoplasmic reticulum stress-induced apoptosis. J Cell Biol (2009) 2.66
The role of endoplasmic reticulum stress in the progression of atherosclerosis. Circ Res (2010) 2.44
Niemann-Pick C heterozygosity confers resistance to lesional necrosis and macrophage apoptosis in murine atherosclerosis. Proc Natl Acad Sci U S A (2003) 1.87
Reduced macrophage apoptosis is associated with accelerated atherosclerosis in low-density lipoprotein receptor-null mice. Arterioscler Thromb Vasc Biol (2004) 1.86
NADPH oxidase links endoplasmic reticulum stress, oxidative stress, and PKR activation to induce apoptosis. J Cell Biol (2010) 1.74
MicroRNA-33 deficiency reduces the progression of atherosclerotic plaque in ApoE-/- mice. J Am Heart Assoc (2012) 1.63
Macrophage apoptosis in atherosclerosis: consequences on plaque progression and the role of endoplasmic reticulum stress. Antioxid Redox Signal (2009) 1.34
Cholesterol in islet dysfunction and type 2 diabetes. J Clin Invest (2008) 1.32
The impact of macrophage insulin resistance on advanced atherosclerotic plaque progression. Circ Res (2010) 1.29
Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis. Cell Metab (2008) 1.25
Macrophage apoptosis in advanced atherosclerosis. Ann N Y Acad Sci (2009) 1.12
Attenuated free cholesterol loading-induced apoptosis but preserved phospholipid composition of peritoneal macrophages from mice that do not express group VIA phospholipase A2. J Biol Chem (2007) 1.10
ATP-binding membrane cassette transporter A1 (ABCA1): a possible link between inflammation and reverse cholesterol transport. Mol Med (2010) 1.10
Cholesterol induces pancreatic β cell apoptosis through oxidative stress pathway. Cell Stress Chaperones (2011) 1.06
Understanding postprandial inflammation and its relationship to lifestyle behaviour and metabolic diseases. Int J Vasc Med (2011) 1.03
The role of tobacco smoke induced mitochondrial damage in vascular dysfunction and atherosclerosis. Mutat Res (2007) 1.00
Nutraceutical agents with anti-inflammatory properties prevent dietary saturated-fat induced disturbances in blood-brain barrier function in wild-type mice. J Neuroinflammation (2013) 1.00
Acyl-coenzyme A:cholesterol acyltransferase promotes oxidized LDL/oxysterol-induced apoptosis in macrophages. J Lipid Res (2005) 0.98
The emerging role of cardiovascular risk factor-induced mitochondrial dysfunction in atherogenesis. J Biomed Sci (2009) 0.97
Triacylglycerol accumulation activates the mitochondrial apoptosis pathway in macrophages. J Biol Chem (2011) 0.93
C16 ceramide is crucial for triacylglycerol-induced apoptosis in macrophages. Cell Death Dis (2012) 0.90
Identification of differential protein expression associated with development of unstable human carotid plaques. Am J Pathol (2006) 0.90
Lipoprotein subclass metabolism in nonalcoholic steatohepatitis. J Lipid Res (2014) 0.88
Mitochondria: a pathogenic paradigm in hypertensive renal disease. Hypertension (2014) 0.88
Decreased lipid efflux and increased susceptibility to cholesterol-induced apoptosis in macrophages lacking phosphatidylcholine transfer protein. Biochem J (2005) 0.86
Involvement of oxygen-regulated protein 150 in AMP-activated protein kinase-mediated alleviation of lipid-induced endoplasmic reticulum stress. J Biol Chem (2011) 0.85
Modulation of endosomal cholesteryl ester metabolism by membrane cholesterol. J Biol Chem (2005) 0.83
Metabolism, energetics, and lipid biology in the podocyte - cellular cholesterol-mediated glomerular injury. Front Endocrinol (Lausanne) (2014) 0.81
A diet enriched in docosahexanoic Acid exacerbates brain parenchymal extravasation of apo B lipoproteins induced by chronic ingestion of saturated fats. Int J Vasc Med (2011) 0.80
PON3 knockout mice are susceptible to obesity, gallstone formation, and atherosclerosis. FASEB J (2014) 0.80
The impact of insulin resistance on macrophage death pathways in advanced atherosclerosis. Novartis Found Symp (2007) 0.78
Chlamydia pneumoniae augments the oxidized low-density lipoprotein-induced death of mouse macrophages by a caspase-independent pathway. Infect Immun (2005) 0.78
Effect of oxysterol-induced apoptosis of vascular smooth muscle cells on experimental hypercholesterolemia. J Biomed Biotechnol (2009) 0.78
Interaction of functional NPC1 gene polymorphism with smoking on coronary heart disease. BMC Med Genet (2010) 0.78
Liposomal cholesterol delivery activates the macrophage innate immune arm to facilitate intracellular Leishmania donovani killing. Infect Immun (2013) 0.78
Challenging the rodent hegemony: a new rabbit model of nonalcoholic steatohepatitis. Am J Pathol (2010) 0.77
Concentration-Dependent Diversifcation Effects of Free Cholesterol Loading on Macrophage Viability and Polarization. Cell Physiol Biochem (2015) 0.77
Consumption of a high β-glucan barley flour improves glucose control and fatty liver and increases muscle acylcarnitines in the Zucker diabetic fatty rat. Eur J Nutr (2012) 0.77
Protein Thiol Redox Signaling in Monocytes and Macrophages. Antioxid Redox Signal (2016) 0.76
Excess cholesterol induces mouse egg activation and may cause female infertility. Proc Natl Acad Sci U S A (2014) 0.76
Fish oil supplementation reverses the effect of cholesterol on apoptotic gene expression in smooth muscle cells. Lipids Health Dis (2010) 0.76
The effect of cholesteryl ester transfer protein on pancreatic beta cell dysfunction in mice. Nutr Metab (Lond) (2016) 0.75
Overexpression of Sirt3 inhibits lipid accumulation in macrophages through mitochondrial IDH2 deacetylation. Int J Clin Exp Pathol (2015) 0.75
Evaluation of in vitro anti-inflammatory effects of crude ginger and rosemary extracts obtained through supercritical CO2 extraction on macrophage and tumor cell line: the influence of vehicle type. BMC Complement Altern Med (2015) 0.75
Correlation between Mitochondrial Reactive Oxygen and Severity of Atherosclerosis. Oxid Med Cell Longev (2015) 0.75
Mouse models of atherosclerosis: a historical perspective and recent advances. Lipids Health Dis (2017) 0.75
High-sucrose-induced maternal obesity disrupts ovarian function and decreases fertility in Drosophila melanogaster. Biochim Biophys Acta (2017) 0.75
The response-to-retention hypothesis of early atherogenesis. Arterioscler Thromb Vasc Biol (1995) 4.60
The synthesis of complex-type oligosaccharides. II. Characterization of the processing intermediates in the synthesis of the complex oligosaccharide units of the vesicular stomatitis virus G protein. J Biol Chem (1978) 3.43
Purification and characterization of a rat liver Golgi alpha-mannosidase capable of processing asparagine-linked oligosaccharides. J Biol Chem (1979) 3.43
Processing of high mannose oligosaccharides to form complex type oligosaccharides on the newly synthesized polypeptides of the vesicular stomatitis virus G protein and the IgG heavy chain. J Biol Chem (1978) 2.83
The synthesis of complex-type oligosaccharides. I. Structure of the lipid-linked oligosaccharide precursor of the complex-type oligosaccharides of the vesicular stomatitis virus G protein. J Biol Chem (1978) 2.48
Cholesterol distribution in living cells: fluorescence imaging using dehydroergosterol as a fluorescent cholesterol analog. Biophys J (1998) 2.30
The synthesis of complex-type oligosaccharides. III. Identification of an alpha-D-mannosidase activity involved in a late stage of processing of complex-type oligosaccharides. J Biol Chem (1978) 2.16
Biosynthetic intermediates of beta-glucuronidase contain high mannose oligosaccharides with blocked phosphate residues. J Biol Chem (1980) 2.08
Free cholesterol loading of macrophages induces apoptosis involving the fas pathway. J Biol Chem (2000) 1.85
Zn2+-stimulated sphingomyelinase is secreted by many cell types and is a product of the acid sphingomyelinase gene. J Biol Chem (1996) 1.78
Sphingomyelinase treatment induces ATP-independent endocytosis. J Cell Biol (1998) 1.72
Secretory sphingomyelinase, a product of the acid sphingomyelinase gene, can hydrolyze atherogenic lipoproteins at neutral pH. Implications for atherosclerotic lesion development. J Biol Chem (1998) 1.68
Preferential ATP-binding cassette transporter A1-mediated cholesterol efflux from late endosomes/lysosomes. J Biol Chem (2001) 1.68
The response-to-retention hypothesis of atherogenesis reinforced. Curr Opin Lipidol (1998) 1.62
Human vascular endothelial cells are a rich and regulatable source of secretory sphingomyelinase. Implications for early atherogenesis and ceramide-mediated cell signaling. J Biol Chem (1998) 1.60
The cellular trafficking and zinc dependence of secretory and lysosomal sphingomyelinase, two products of the acid sphingomyelinase gene. J Biol Chem (1998) 1.57
Sphingomyelinase converts lipoproteins from apolipoprotein E knockout mice into potent inducers of macrophage foam cell formation. Arterioscler Thromb Vasc Biol (2000) 1.51
Acid sphingomyelinase-deficient macrophages have defective cholesterol trafficking and efflux. J Biol Chem (2001) 1.44
Rabbit aorta and human atherosclerotic lesions hydrolyze the sphingomyelin of retained low-density lipoprotein. Proposed role for arterial-wall sphingomyelinase in subendothelial retention and aggregation of atherogenic lipoproteins. J Clin Invest (1996) 1.38
Interleukin 8 is induced by cholesterol loading of macrophages and expressed by macrophage foam cells in human atheroma. J Biol Chem (1996) 1.37
Acute systemic inflammation up-regulates secretory sphingomyelinase in vivo: a possible link between inflammatory cytokines and atherogenesis. Proc Natl Acad Sci U S A (2000) 1.34
Sphingomyelinase, an enzyme implicated in atherogenesis, is present in atherosclerotic lesions and binds to specific components of the subendothelial extracellular matrix. Arterioscler Thromb Vasc Biol (1999) 1.33
Increased sphingomyelin content of plasma lipoproteins in apolipoprotein E knockout mice reflects combined production and catabolic defects and enhances reactivity with mammalian sphingomyelinase. J Clin Invest (1998) 1.23
Accelerated transfer of cholesteryl esters in dyslipidemic plasma. Role of cholesteryl ester transfer protein. J Clin Invest (1987) 1.19
Sphingomyelinase enhances low density lipoprotein uptake and ability to induce cholesteryl ester accumulation in macrophages. J Biol Chem (1991) 1.13
Clearance of chylomicron remnants by the low density lipoprotein receptor-related protein/alpha 2-macroglobulin receptor. J Biol Chem (1991) 1.11
Unmodified low density lipoprotein causes cholesteryl ester accumulation in J774 macrophages. Proc Natl Acad Sci U S A (1985) 1.11
Free cholesterol loading of macrophages stimulates phosphatidylcholine biosynthesis and up-regulation of CTP: phosphocholine cytidylyltransferase. J Biol Chem (1994) 1.08
Beta-very low density lipoprotein is sequestered in surface-connected tubules in mouse peritoneal macrophages. J Cell Biol (1993) 1.06
The uptake and degradation of matrix-bound lipoproteins by macrophages require an intact actin Cytoskeleton, Rho family GTPases, and myosin ATPase activity. J Biol Chem (2001) 1.03
The distal pathway of lipoprotein-induced cholesterol esterification, but not sphingomyelinase-induced cholesterol esterification, is energy-dependent. J Biol Chem (1996) 1.01
Lipoproteins activate acyl-coenzyme A:cholesterol acyltransferase in macrophages only after cellular cholesterol pools are expanded to a critical threshold level. J Biol Chem (1991) 1.01
Mechanism of the association of HDL3 with endothelial cells, smooth muscle cells, and fibroblasts. Evidence against the role of specific ligand and receptor proteins. J Biol Chem (1984) 0.99
Regulation of the threshold for lipoprotein-induced acyl-CoA:cholesterol O-acyltransferase stimulation in macrophages by cellular sphingomyelin content. J Lipid Res (1994) 0.98
Human plasma cholesteryl ester transfer protein enhances the transfer of cholesteryl ester from high density lipoproteins into cultured HepG2 cells. J Biol Chem (1987) 0.98
Transforming growth factor-beta 1 inhibits scavenger receptor activity in THP-1 human macrophages. J Biol Chem (1991) 0.97
Immunolocalization of acyl-coenzyme A:cholesterol O-acyltransferase in macrophages. J Biol Chem (1998) 0.93
Enrichment of acyl coenzyme A:cholesterol O-acyltransferase near trans-golgi network and endocytic recycling compartment. Arterioscler Thromb Vasc Biol (2000) 0.92
Transcriptional activation of the murine CTP:phosphocholine cytidylyltransferase gene (Ctpct): combined action of upstream stimulatory and inhibitory cis-acting elements. Biochim Biophys Acta (1999) 0.86
Cholesterol loading of macrophages leads to marked enhancement of native lipoprotein(a) and apoprotein(a) internalization and degradation. J Biol Chem (1993) 0.85
Cholesteryl ester loading of mouse peritoneal macrophages is associated with changes in the expression or modification of specific cellular proteins, including increase in an alpha-enolase isoform. Arterioscler Thromb (1993) 0.84
Atherosclerosis--an inflammatory disease. N Engl J Med (1999) 0.83
Effects of particle size on cell uptake of model triglyceride-rich particles with and without apoprotein E. Biochemistry (1994) 0.82
Macrophage-targeted CTP:phosphocholine cytidylyltransferase (1-314) transgenic mice. Biochim Biophys Acta (1999) 0.81
p53 and atherosclerosis. Circ Res (2001) 0.81
The binding activity of the macrophage lipoprotein(a)/apolipoprotein(a) receptor is induced by cholesterol via a post-translational mechanism and recognizes distinct kringle domains on apolipoprotein(a). J Biol Chem (1996) 0.80
Stimulation of CTP:phosphocholine cytidylyltransferase by free cholesterol loading of macrophages involves signaling through protein dephosphorylation. J Biol Chem (1995) 0.80
N-asparagine-linked oligosaccharides: processing. Methods Enzymol (1982) 0.79
Macrophage foam cell lipoprotein(a)/apoprotein(a) receptor. Cell-surface localization, dependence of induction on new protein synthesis, and ligand specificity. Arterioscler Thromb (1994) 0.78
Recognition of vesicular lipoproteins by the apolipoprotein B,E receptor of cultured fibroblasts. J Lipid Res (1986) 0.78
Evidence for prolonged cell-surface contact of acetyl-LDL before entry into macrophages. Arterioscler Thromb Vasc Biol (1997) 0.77
Lipoprotein-liposome interactions. Methods Enzymol (1986) 0.76
In search of an endpoint. Curr Opin Lipidol (2000) 0.76
Interferon-gamma down-regulates the lipoprotein(a)/apoprotein(a) receptor activity on macrophage foam cells. Evidence for disruption of ligand-induced receptor recycling by interferon-gamma. J Biol Chem (1994) 0.75
Human chondroitin 6-sulfotransferase: cloning, gene structure, and chromosomal localization. Biochim Biophys Acta (1998) 0.75
In search of a starting point. Curr Opin Lipidol (2001) 0.75
Effect and cellular site of action of cysteine protease inhibitors on the cholesterol esterification pathway in macrophages and Chinese hamster ovary cells. Biochemistry (1995) 0.75
Atherosclerosis: cell biology and lipoproteins. Curr Opin Lipidol (1997) 0.75
Cholesterol esterification as a limiting factor in accumulation of cell cholesterol: a comparison of two J774 macrophage cell lines. Biochim Biophys Acta (1989) 0.75