Published in Nat Struct Mol Biol on March 12, 2006
Identification of two distinct hybrid state intermediates on the ribosome. Mol Cell (2007) 4.00
Kinetically competent intermediates in the translocation step of protein synthesis. Mol Cell (2007) 2.89
Structure and dynamics of a processive Brownian motor: the translating ribosome. Annu Rev Biochem (2010) 1.84
Navigating the ribosome's metastable energy landscape. Trends Biochem Sci (2009) 1.74
A gripping tale of ribosomal frameshifting: extragenic suppressors of frameshift mutations spotlight P-site realignment. Microbiol Mol Biol Rev (2009) 1.50
Elongation in translation as a dynamic interaction among the ribosome, tRNA, and elongation factors EF-G and EF-Tu. Q Rev Biophys (2009) 1.45
Energy barriers and driving forces in tRNA translocation through the ribosome. Nat Struct Mol Biol (2013) 1.41
Role of hybrid tRNA-binding states in ribosomal translocation. Proc Natl Acad Sci U S A (2008) 1.38
Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases. J Mol Biol (2007) 1.37
A quantitative kinetic scheme for 70 S translation initiation complex formation. J Mol Biol (2007) 1.37
The role of L1 stalk-tRNA interaction in the ribosome elongation cycle. J Mol Biol (2010) 1.35
Structure of EF-G-ribosome complex in a pretranslocation state. Nat Struct Mol Biol (2013) 1.20
Synthesis and functional activity of tRNAs labeled with fluorescent hydrazides in the D-loop. RNA (2008) 1.20
A new view of protein synthesis: mapping the free energy landscape of the ribosome using single-molecule FRET. Biopolymers (2008) 1.16
Interrupted catalysis: the EF4 (LepA) effect on back-translocation. J Mol Biol (2010) 1.07
Perturbation of the tRNA tertiary core differentially affects specific steps of the elongation cycle. J Biol Chem (2008) 0.99
Fluorescent labeling of tRNAs for dynamics experiments. RNA (2007) 0.98
Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position. J Mol Biol (2013) 0.98
Crystal structure of 70S ribosome with both cognate tRNAs in the E and P sites representing an authentic elongation complex. PLoS One (2013) 0.95
Interaction of IF2 with the ribosomal GTPase-associated center during 70S initiation complex formation. Biochemistry (2009) 0.94
Contribution of intersubunit bridges to the energy barrier of ribosomal translocation. Nucleic Acids Res (2012) 0.93
Large facilities and the evolving ribosome, the cellular machine for genetic-code translation. J R Soc Interface (2009) 0.88
EF-Tu dynamics during pre-translocation complex formation: EF-Tu·GDP exits the ribosome via two different pathways. Nucleic Acids Res (2015) 0.87
Maintenance of protein synthesis reading frame by EF-P and m(1)G37-tRNA. Nat Commun (2015) 0.86
Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end. RNA (2008) 0.86
The tRNA Elbow in Structure, Recognition and Evolution. Life (Basel) (2016) 0.81
Kinetics of initiating polypeptide elongation in an IRES-dependent system. Elife (2016) 0.79
The UGG Isoacceptor of tRNAPro Is Naturally Prone to Frameshifts. Int J Mol Sci (2015) 0.78
A genetically encoded fluorescent tRNA is active in live-cell protein synthesis. Nucleic Acids Res (2016) 0.75
Kinetically competent intermediates in the translocation step of protein synthesis. Mol Cell (2007) 2.89
AlkB restores the biological function of mRNA and tRNA inactivated by chemical methylation. Mol Cell (2004) 2.26
Compound heterozygosity for loss-of-function lysyl-tRNA synthetase mutations in a patient with peripheral neuropathy. Am J Hum Genet (2010) 1.96
A comprehensive model for the allosteric regulation of mammalian ribonucleotide reductase. Functional consequences of ATP- and dATP-induced oligomerization of the large subunit. Biochemistry (2002) 1.88
Protein synthesis by single ribosomes. RNA (2003) 1.74
Single-molecule fluorescence measurements of ribosomal translocation dynamics. Mol Cell (2011) 1.65
Comprehensive model for allosteric regulation of mammalian ribonucleotide reductase: refinements and consequences. Biochemistry (2003) 1.56
Identification of distinct thiopeptide-antibiotic precursor lead compounds using translation machinery assays. Chem Biol (2009) 1.53
Distinct kinetic mechanisms of the two classes of Aminoacyl-tRNA synthetases. J Mol Biol (2006) 1.49
EF-G-dependent GTPase on the ribosome. conformational change and fusidic acid inhibition. Biochemistry (2006) 1.46
Methods for kinetic and thermodynamic analysis of aminoacyl-tRNA synthetases. Methods (2008) 1.46
Distinct origins of tRNA(m1G37) methyltransferase. J Mol Biol (2004) 1.38
Role of hybrid tRNA-binding states in ribosomal translocation. Proc Natl Acad Sci U S A (2008) 1.38
Distinct determinants of tRNA recognition by the TrmD and Trm5 methyl transferases. J Mol Biol (2007) 1.37
A quantitative kinetic scheme for 70 S translation initiation complex formation. J Mol Biol (2007) 1.37
Aminoacylation of tRNA with phosphoserine for synthesis of cysteinyl-tRNA(Cys). Nat Struct Mol Biol (2008) 1.33
Aminoacyl-tRNA synthetases: versatile players in the changing theater of translation. RNA (2002) 1.29
Single-molecule structural dynamics of EF-G--ribosome interaction during translocation. Biochemistry (2007) 1.27
Shape-selective RNA recognition by cysteinyl-tRNA synthetase. Nat Struct Mol Biol (2004) 1.25
Structural origins of amino acid selection without editing by cysteinyl-tRNA synthetase. EMBO J (2002) 1.20
Synthesis and functional activity of tRNAs labeled with fluorescent hydrazides in the D-loop. RNA (2008) 1.20
The archetype gamma-class carbonic anhydrase (Cam) contains iron when synthesized in vivo. Biochemistry (2009) 1.20
Mitochondrial dysfunction is induced by high levels of glucose and free fatty acids in 3T3-L1 adipocytes. Mol Cell Endocrinol (2010) 1.19
Genes adopt non-optimal codon usage to generate cell cycle-dependent oscillations in protein levels. Mol Syst Biol (2012) 1.19
The translational fidelity function of IF3 during transition from the 30 S initiation complex to the 70 S initiation complex. J Mol Biol (2007) 1.19
MiR-155 promotes proliferation of human breast cancer MCF-7 cells through targeting tumor protein 53-induced nuclear protein 1. J Biomed Sci (2013) 1.18
Allosteric vs. spontaneous exit-site (E-site) tRNA dissociation early in protein synthesis. Proc Natl Acad Sci U S A (2011) 1.18
Mechanical studies of single ribosome/mRNA complexes. Biophys J (2005) 1.16
A recurrent loss-of-function alanyl-tRNA synthetase (AARS) mutation in patients with Charcot-Marie-Tooth disease type 2N (CMT2N). Hum Mutat (2011) 1.14
Dynamics of translation by single ribosomes through mRNA secondary structures. Nat Struct Mol Biol (2013) 1.13
Catalysis by the second class of tRNA(m1G37) methyl transferase requires a conserved proline. Biochemistry (2006) 1.09
Interrupted catalysis: the EF4 (LepA) effect on back-translocation. J Mol Biol (2010) 1.07
Control of catalytic cycle by a pair of analogous tRNA modification enzymes. J Mol Biol (2010) 1.06
Zinc-mediated amino acid discrimination in cysteinyl-tRNA synthetase. J Mol Biol (2003) 1.05
Quantitative single cell monitoring of protein synthesis at subcellular resolution using fluorescently labeled tRNA. Nucleic Acids Res (2011) 1.01
The homotetrameric phosphoseryl-tRNA synthetase from Methanosarcina mazei exhibits half-of-the-sites activity. J Biol Chem (2008) 1.01
Indirect readout of tRNA for aminoacylation. Biochemistry (2007) 1.01
Kinetic characterization and molecular docking of a novel, potent, and selective slow-binding inhibitor of human cathepsin L. Mol Pharmacol (2008) 1.00
Field and long-term demonstration of a wide area quantum key distribution network. Opt Express (2014) 0.99
Kinetics and thermodynamics of RRF, EF-G, and thiostrepton interaction on the Escherichia coli ribosome. Biochemistry (2004) 0.99
Mechanism of N-methylation by the tRNA m1G37 methyltransferase Trm5. RNA (2010) 0.99
Perturbation of the tRNA tertiary core differentially affects specific steps of the elongation cycle. J Biol Chem (2008) 0.99
Metabolic profiles characterizing different phenotypes of polycystic ovary syndrome: plasma metabolomics analysis. BMC Med (2012) 0.98
Fluorescent labeling of tRNAs for dynamics experiments. RNA (2007) 0.98
Structural and mechanistic basis for enhanced translational efficiency by 2-thiouridine at the tRNA anticodon wobble position. J Mol Biol (2013) 0.98
Alpha 1-antitrypsin polymerization: a fluorescence correlation spectroscopic study. Biochemistry (2005) 0.97
Differentiating analogous tRNA methyltransferases by fragments of the methyl donor. RNA (2011) 0.97
Differential effects of thiopeptide and orthosomycin antibiotics on translational GTPases. Chem Biol (2011) 0.96
Recognition of guanosine by dissimilar tRNA methyltransferases. RNA (2012) 0.96
Fluorescent labeling of tRNA dihydrouridine residues: Mechanism and distribution. RNA (2011) 0.95
Poly(C) synthesis by class I and class II CCA-adding enzymes. Biochemistry (2002) 0.95
Association of an aminoacyl-tRNA synthetase with a putative metabolic protein in archaea. Biochemistry (2003) 0.94
Interaction of IF2 with the ribosomal GTPase-associated center during 70S initiation complex formation. Biochemistry (2009) 0.94
tRNA integrity is a prerequisite for rapid CCA addition: implication for quality control. J Mol Biol (2008) 0.94
Domain-domain communication for tRNA aminoacylation: the importance of covalent connectivity. Biochemistry (2005) 0.93
Impaired function is a common feature of neuropathy-associated glycyl-tRNA synthetase mutations. Hum Mutat (2014) 0.92
Allosteric communication in cysteinyl tRNA synthetase: a network of direct and indirect readout. J Biol Chem (2011) 0.92
A role for SUMO in nucleotide excision repair. DNA Repair (Amst) (2011) 0.92
Enhancement of single-molecule fluorescence signals by colloidal silver nanoparticles in studies of protein translation. ACS Nano (2010) 0.91
Probing translation with small-molecule inhibitors. Chem Biol (2010) 0.91
Amino acid discrimination by a highly differentiated metal center of an aminoacyl-tRNA synthetase. Biochemistry (2003) 0.91
Monitoring translation with modified mRNAs strategically labeled with isomorphic fluorescent guanosine mimetics. ACS Chem Biol (2013) 0.91
Molecular docking of cathepsin L inhibitors in the binding site of papain. J Chem Inf Model (2008) 0.91
Potential for interdependent development of tRNA determinants for aminoacylation and ribosome decoding. Nat Commun (2011) 0.90
Real-time assay for testing components of protein synthesis. Nucleic Acids Res (2012) 0.90
The conserved protein EF4 (LepA) modulates the elongation cycle of protein synthesis. Proc Natl Acad Sci U S A (2011) 0.90
Quantifying elongation rhythm during full-length protein synthesis. J Am Chem Soc (2013) 0.89
Conservation of structure and mechanism by Trm5 enzymes. RNA (2013) 0.89
Kinetic quality control of anticodon recognition by a eukaryotic aminoacyl-tRNA synthetase. J Mol Biol (2007) 0.89
Pyrophosphorolysis of CCA addition: implication for fidelity. J Mol Biol (2011) 0.88
Single-turnover kinetics of Saccharomyces cerevisiae inorganic pyrophosphatase. Biochemistry (2002) 0.88
Breaking the stereo barrier of amino acid attachment to tRNA by a single nucleotide. J Mol Biol (2005) 0.88
The structural basis for peptidomimetic inhibition of eukaryotic ribonucleotide reductase: a conformationally flexible pharmacophore. J Med Chem (2008) 0.86
Apoptotic regulation and tRNA. Protein Cell (2010) 0.86
Pyrrolo-C as a molecular probe for monitoring conformations of the tRNA 3' end. RNA (2008) 0.86
The catalytic domain of topological knot tRNA methyltransferase (TrmH) discriminates between substrate tRNA and nonsubstrate tRNA via an induced-fit process. J Biol Chem (2013) 0.86
Fluorescence correlation spectroscopic study of serpin depolymerization by computationally designed peptides. J Mol Biol (2007) 0.85
The temperature sensitivity of a mutation in the essential tRNA modification enzyme tRNA methyltransferase D (TrmD). J Biol Chem (2013) 0.85
Modified bases in RNA reduce secondary structure and enhance hybridization. Biochemistry (2004) 0.83
Unrestricted accessibility of short oligonucleotides to RNA. RNA (2005) 0.82
Overexpression of PGC-1β improves insulin sensitivity and mitochondrial function in 3T3-L1 adipocytes. Mol Cell Biochem (2011) 0.82
Synthesis of cysteinyl-tRNACys by a prolyl-tRNA synthetase. RNA Biol (2004) 0.82
Properties of Escherichia coli EF-Tu mutants designed for fluorescence resonance energy transfer from tRNA molecules. Protein Eng Des Sel (2010) 0.82
LYRM1, a novel gene promotes proliferation and inhibits apoptosis of preadipocytes. Eur J Endocrinol (2008) 0.82
Knockdown of NYGGF4 increases glucose transport in C2C12 mice skeletal myocytes by activation IRS-1/PI3K/AKT insulin pathway. J Bioenerg Biomembr (2012) 0.82
Distinct kinetic determinants for the stepwise CCA addition to tRNA. RNA (2009) 0.81
Ultrasound-mediated microbubble destruction facilitates gene transfection in rat C6 glioma cells. Mol Biol Rep (2008) 0.81
Affinity-driven selection of tripeptide inhibitors of ribonucleotide reductase. Bioorg Med Chem Lett (2002) 0.81
Overexpression of LYRM1 induces mitochondrial impairment in 3T3-L1 adipocytes. Mol Genet Metab (2010) 0.81
Amino acid activation of a dual-specificity tRNA synthetase is independent of tRNA. J Mol Biol (2002) 0.81
Large-scale motions within ribosomal 50S subunits as demonstrated using photolabile oligonucleotides. Bioorg Chem (2002) 0.81