Published in Cancer Chemother Pharmacol on March 11, 2006
Mutations in the phosphatidylinositol-3-kinase pathway predict for antitumor activity of the inhibitor PX-866 whereas oncogenic Ras is a dominant predictor for resistance. Cancer Res (2009) 3.59
EGFR and MET receptor tyrosine kinase-altered microRNA expression induces tumorigenesis and gefitinib resistance in lung cancers. Nat Med (2011) 2.46
Comprehensive genomic analysis reveals clinically relevant molecular distinctions between thymic carcinomas and thymomas. Clin Cancer Res (2009) 1.42
Lapatinib resistance in HCT116 cells is mediated by elevated MCL-1 expression and decreased BAK activation and not by ERBB receptor kinase mutation. Mol Pharmacol (2008) 1.34
Src-Induced cisplatin resistance mediated by cell-to-cell communication. Cancer Res (2009) 0.93
Protein phosphatase PHLPP induces cell apoptosis and exerts anticancer activity by inhibiting Survivin phosphorylation and nuclear export in gallbladder cancer. Oncotarget (2015) 0.87
MicroRNA and MET in lung cancer. Ann Transl Med (2015) 0.84
Gap junction enhancer increases efficacy of cisplatin to attenuate mammary tumor growth. PLoS One (2012) 0.83
Chemoprevention of murine lung cancer by gefitinib in combination with prostacyclin synthase overexpression. Lung Cancer (2010) 0.81
Efficient blockade of Akt signaling is a determinant factor to overcome resistance to matuzumab. Mol Cancer (2011) 0.78
Antitumor activity of a novel EGFR tyrosine kinase inhibitor against human lung carcinoma in vitro and in vivo. Invest New Drugs (2008) 0.77
B5, a novel pyrrole-substituted indolinone, exerts potent antitumor efficacy through G2/M cell cycle arrest. Invest New Drugs (2009) 0.76
MiR-31 regulates the cisplatin resistance by targeting Src in gallbladder cancer. Oncotarget (2016) 0.75
Targeting the K-Ras/PDEδ protein-protein interaction: the solution for Ras-driven cancers or just another therapeutic mirage? ChemMedChem (2013) 0.75
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood (2005) 6.16
Foxo3a is essential for maintenance of the hematopoietic stem cell pool. Cell Stem Cell (2007) 5.94
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol (2007) 5.21
Humanized anti-interleukin-6 receptor antibody treatment of multicentric Castleman disease. Blood (2005) 4.29
Plasmacytoid dendritic cells prime alloreactive T cells to mediate graft-versus-host disease as antigen-presenting cells. Blood (2009) 2.39
Mechanisms for cytotoxic effects of anti-tumor necrosis factor agents on transmembrane tumor necrosis factor alpha-expressing cells: comparison among infliximab, etanercept, and adalimumab. Arthritis Rheum (2008) 1.97
Fanconi anemia FANCG protein in mitigating radiation- and enzyme-induced DNA double-strand breaks by homologous recombination in vertebrate cells. Mol Cell Biol (2003) 1.84
B cell activation regulates exosomal HLA production. Eur J Immunol (2008) 1.78
Infliximab induces potent anti-inflammatory responses by outside-to-inside signals through transmembrane TNF-alpha. Gastroenterology (2005) 1.66
Non-B, non-T neoplasms with lymphoblast morphology: further clarification and classification. Am J Surg Pathol (2003) 1.63
Successful treatment of primary cardiac lymphoma by rituximab-CHOP and high-dose chemotherapy with autologous peripheral blood stem cell transplantation. Int J Hematol (2007) 1.63
Cyclophosphamide-induced cardiomyopathy in a patient with seminoma and a history of mediastinal irradiation. Intern Med (2005) 1.49
Antimicrobial susceptibility and molecular epidemiological analysis of clinical strains of Pseudomonas aeruginosa. J Infect Chemother (2008) 1.48
Pretreatment prediction of interferon-alfa efficacy in chronic hepatitis C patients. Clin Gastroenterol Hepatol (2005) 1.47
The impact of cytogenetic abnormalities on the prognosis of primary myelofibrosis: a prospective survey of 202 cases in Japan. Eur J Haematol (2009) 1.44
The iron-binding protein Dps confers hydrogen peroxide stress resistance to Campylobacter jejuni. J Bacteriol (2003) 1.41
Retrospective nationwide survey of Japanese patients with transfusion-dependent MDS and aplastic anemia highlights the negative impact of iron overload on morbidity/mortality. Eur J Haematol (2007) 1.41
Systemic vasculitis associated with alphal-antitrypsin deficiency. Intern Med (2003) 1.39
Expression of FoxP3, a key molecule in CD4CD25 regulatory T cells, in adult T-cell leukaemia/lymphoma cells. Br J Haematol (2004) 1.38
Protection against autoimmune nephritis in MyD88-deficient MRL/lpr mice. Arthritis Rheum (2007) 1.37
SOCS3 is a physiological negative regulator for granulopoiesis and granulocyte colony-stimulating factor receptor signaling. J Biol Chem (2003) 1.33
Characterization and distribution of bone marrow-derived cells in mouse cornea. Invest Ophthalmol Vis Sci (2005) 1.33
Defective fetal liver erythropoiesis and T lymphopoiesis in mice lacking the phosphatidylserine receptor. Blood (2004) 1.32
Human Flt3 is expressed at the hematopoietic stem cell and the granulocyte/macrophage progenitor stages to maintain cell survival. J Immunol (2008) 1.32
Identification of the human eosinophil lineage-committed progenitor: revision of phenotypic definition of the human common myeloid progenitor. J Exp Med (2008) 1.31
Effect of promoter methylation on the regulation of IFN-gamma gene during in vitro differentiation of human peripheral blood T cells into a Th2 population. J Immunol (2003) 1.29
Donor-derived thymic-dependent T cells cause chronic graft-versus-host disease. Blood (2006) 1.28
Spred-1 negatively regulates interleukin-3-mediated ERK/mitogen-activated protein (MAP) kinase activation in hematopoietic cells. J Biol Chem (2004) 1.28
Fractalkine and CX3CR1 are involved in the recruitment of intraepithelial lymphocytes of intrahepatic bile ducts. Hepatology (2005) 1.28
Gastric perforation due to metastasis from adenocarcinoma of the lung. Anticancer Res (2002) 1.23
Perforin gene mutations in adult-onset hemophagocytic lymphohistiocytosis. Haematologica (2007) 1.21
Purified human hematopoietic stem cells contribute to the generation of cardiomyocytes through cell fusion. FASEB J (2006) 1.20
Success with infliximab in treating refractory hemophagocytic lymphohistiocytosis. Am J Hematol (2006) 1.19
Membranous glomerulonephritis development with Th2-type immune deviations in MRL/lpr mice deficient for IL-27 receptor (WSX-1). J Immunol (2005) 1.18
Influence of interleukin-12 receptor beta1 polymorphisms on tuberculosis. Hum Genet (2002) 1.18
Efficient generation of antigen-specific cytotoxic T cells using retrovirally transduced CD40-activated B cells. J Immunol (2002) 1.17
Expression of AIRE gene in peripheral monocyte/dendritic cell lineage. Immunol Lett (2002) 1.16
Allogeneic stem-cell transplantation with reduced conditioning intensity as a novel immunotherapy and antiviral therapy for adult T-cell leukemia/lymphoma. Blood (2005) 1.09
Detection of human herpesvirus-8 in peripheral blood mononuclear cells from adult Japanese patients with multicentric Castleman's disease. Br J Haematol (2003) 1.08
Biliary epithelial cells regulate autoreactive T cells: implications for biliary-specific diseases. Hepatology (2005) 1.08
Transgenic mice overexpressing murine thrombopoietin develop myelofibrosis and osteosclerosis. Leuk Res (2005) 1.08
Efficacy of trastuzumab in Japanese patients with HER2-positive advanced gastric or gastroesophageal junction cancer: a subgroup analysis of the Trastuzumab for Gastric Cancer (ToGA) study. Gastric Cancer (2011) 1.08
Autoreactive T-cell responses in primary biliary cirrhosis are proinflammatory whereas those of controls are regulatory. Gastroenterology (2006) 1.07
T cell leukemia/lymphoma 1 and galectin-1 regulate survival/cell death pathways in human naive and IgM+ memory B cells through altering balances in Bcl-2 family proteins. J Immunol (2009) 1.06
Rituximab for the treatment of corticosteroid-refractory chronic graft-versus-host disease. Int J Hematol (2009) 1.05
The developmental program of human dendritic cells is operated independently of conventional myeloid and lymphoid pathways. Blood (2007) 1.05
Mice that express human interleukin-8 have increased mobilization of immature myeloid cells, which exacerbates inflammation and accelerates colon carcinogenesis. Gastroenterology (2012) 1.05
Roles of Stat3 and ERK in G-CSF signaling. Stem Cells (2005) 1.04
Immunohistochemical alpha- and beta-catenin and E-cadherin expression and their clinicopathological significance in human lung adenocarcinoma. Pathol Res Pract (2006) 1.04
Transplanted human cord blood cells give rise to hepatocytes in engrafted mice. Ann N Y Acad Sci (2003) 1.04
Amelioration of autoimmune nephritis by imatinib in MRL/lpr mice. Arthritis Rheum (2005) 1.03
Distinct costimulation dependent and independent autoreactive T-cell clones in primary biliary cirrhosis. Gastroenterology (2003) 1.02
Signal transducers and activators of transcription 3 augments the transcriptional activity of CCAAT/enhancer-binding protein alpha in granulocyte colony-stimulating factor signaling pathway. J Biol Chem (2005) 1.01
Decreased expression of interleukin-21 receptor on peripheral B lymphocytes in systemic lupus erythematosus. Int J Mol Med (2005) 1.00
Prevalent hyper-methylation of the CDH13 gene promoter in malignant B cell lymphomas. Int J Oncol (2004) 1.00
Advances in therapies for acute promyelocytic leukemia. Cancer Sci (2011) 1.00
Enhanced expression of type I interferon and toll-like receptor-3 in primary biliary cirrhosis. Lab Invest (2005) 1.00
Comparison of chemosensitivity tests: clonogenic assay versus MTT assay. Acta Med Okayama (2002) 0.99
Waist circumference is the main determinant of elevated C-reactive protein in metabolic syndrome. Diabetes Res Clin Pract (2007) 0.99
The role of Tyk2, Stat1 and Stat4 in LPS-induced endotoxin signals. Int Immunol (2004) 0.98
Impact of cytogenetics on outcome of stem cell transplantation for acute myeloid leukemia in first remission: a large-scale retrospective analysis of data from the Japan Society for Hematopoietic Cell Transplantation. Int J Hematol (2004) 0.98
Stromal cell-derived factor-1 overexpression induces gastric dysplasia through expansion of stromal myofibroblasts and epithelial progenitors. Gut (2012) 0.98
Myeloablative allogeneic hematopoietic stem cell transplantation for non-Hodgkin lymphoma: a nationwide survey in Japan. Blood (2006) 0.98
Characterization of caspase-8L: a novel isoform of caspase-8 that behaves as an inhibitor of the caspase cascade. Blood (2002) 0.96
Impact of human leucocyte antigen mismatch on graft-versus-host disease and graft failure after reduced intensity conditioning allogeneic haematopoietic stem cell transplantation from related donors. Br J Haematol (2005) 0.95
Ocular manifestation of acute graft-versus-host disease after allogeneic peripheral blood stem cell transplantation. Int J Hematol (2002) 0.94
Improved outcome of allogeneic bone marrow transplantation due to breastfeeding-induced tolerance to maternal antigens. Blood (2009) 0.94
Immunogenicity of influenza vaccine in children with pediatric rheumatic diseases receiving immunosuppressive agents. Pediatr Infect Dis J (2011) 0.94
The Sprouty-related protein, Spred-1, localizes in a lipid raft/caveola and inhibits ERK activation in collaboration with caveolin-1. Genes Cells (2005) 0.94
Repeated relapses of acute myelogenous leukemia in the isolated extramedullary sites following allogeneic bone marrow transplantations. Intern Med (2007) 0.93
Polymerase chain reaction detection of bacterial 16S rRNA gene in human blood. Microbiol Immunol (2008) 0.93
A functional M196R polymorphism of tumour necrosis factor receptor type 2 is associated with systemic lupus erythematosus: a case-control study and a meta-analysis. Ann Rheum Dis (2006) 0.93
Matrix metalloproteinase-2 in pancreatic juice for diagnosis of pancreatic cancer. Pancreas (2002) 0.92
Adult T-cell leukemia development from a human T-cell leukemia virus type I carrier after a living-donor liver transplantation. Transplantation (2006) 0.92
Molecular mimicry of mitochondrial and nuclear autoantigens in primary biliary cirrhosis. Gastroenterology (2003) 0.92
Parathyroid hormone-related protein measured at the time of first visit is an indicator of bone metastases and survival in lung carcinoma patients with hypercalcemia. Cancer (2002) 0.92
Distinct clinical phenotype and immunoreactivity in Japanese siblings with autoimmune polyglandular syndrome type 1 (APS-1) associated with compound heterozygous novel AIRE gene mutations. Clin Immunol (2002) 0.92
Efficacy and safety of capecitabine plus cisplatin in Japanese patients with advanced or metastatic gastric cancer: subset analyses of the AVAGAST study and the ToGA study. Gastric Cancer (2012) 0.92
Critical role of the Fc receptor gamma-chain on APCs in the development of allergen-induced airway hyperresponsiveness and inflammation. J Immunol (2007) 0.91
Successful treatment of pituitary abscess with oral administration of sparfloxacin. Intern Med (2008) 0.91
Effects of ultrasound energy application on cardiac performance in open-chest Guinea pigs. Circ J (2006) 0.91
Cholesterol embolization treated with corticosteroids--two case reports. Angiology (2005) 0.90
Recurrence of cervical carcinoma manifesting as cardiac metastasis three years after curative resection. Am J Med Sci (2004) 0.90
Metastatic basaloid-squamous cell carcinoma of the esophagus treated by 5-fluorouracil and cisplatin. World J Gastroenterol (2007) 0.90
Human cord blood- and bone marrow-derived CD34+ cells regenerate gastrointestinal epithelial cells. FASEB J (2004) 0.90
Legionella dumoffii DjlA, a member of the DnaJ family, is required for intracellular growth. Infect Immun (2004) 0.90
Enhanced expression of PCAF endows apoptosis resistance in cisplatin-resistant cells. Mol Cancer Res (2010) 0.90
Analysis of immune reconstitution after autologous CD34+ stem/progenitor cell transplantation for systemic sclerosis: predominant reconstitution of Th1 CD4+ T cells. Rheumatology (Oxford) (2010) 0.90
Fluorescence in situ hybridization (FISH) analysis of primary ocular adnexal MALT lymphoma. BMC Cancer (2006) 0.89
Cyclosporin-A enhances docetaxel-induced apoptosis through inhibition of nuclear factor-kappaB activation in human gastric carcinoma cells. Clin Cancer Res (2003) 0.89
Oxaliplatin-induced allergic reaction in patients with colorectal cancer in Japan. Int J Clin Oncol (2009) 0.89