Published in Cell Stem Cell on June 07, 2007
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Lkb1 regulates cell cycle and energy metabolism in haematopoietic stem cells. Nature (2010) 3.93
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FOXO1 couples metabolic activity and growth state in the vascular endothelium. Nature (2016) 1.66
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HOXB4's road map to stem cell expansion. Proc Natl Acad Sci U S A (2007) 1.43
Integrating physiological regulation with stem cell and tissue homeostasis. Neuron (2011) 1.41
GABP controls a critical transcription regulatory module that is essential for maintenance and differentiation of hematopoietic stem/progenitor cells. Blood (2010) 1.40
mTORC1 signaling governs hematopoietic stem cell quiescence. Cell Cycle (2009) 1.39
Induction of autophagy supports the bioenergetic demands of quiescent muscle stem cell activation. EMBO J (2014) 1.37
Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner. Blood (2014) 1.32
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A "FOXO" in sight: targeting Foxo proteins from conception to cancer. Med Res Rev (2009) 1.31
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The BH3-only protein Puma plays an essential role in cytokine deprivation induced apoptosis of mast cells. Blood (2007) 1.18
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Mn(III) meso-tetrakis-(N-ethylpyridinium-2-yl) porphyrin mitigates total body irradiation-induced long-term bone marrow suppression. Free Radic Biol Med (2011) 1.17
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FoxO is a critical regulator of stem cell maintenance in immortal Hydra. Proc Natl Acad Sci U S A (2012) 1.17
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GATA-3 regulates hematopoietic stem cell maintenance and cell-cycle entry. Blood (2012) 1.14
Critical role of FoxO3a in alcohol-induced autophagy and hepatotoxicity. Am J Pathol (2013) 1.13
The antiproliferative activity of kinase inhibitors in chronic myeloid leukemia cells is mediated by FOXO transcription factors. Stem Cells (2014) 1.13
"Sly as a FOXO": new paths with Forkhead signaling in the brain. Curr Neurovasc Res (2007) 1.12
Energy metabolism and energy-sensing pathways in mammalian embryonic and adult stem cell fate. J Cell Sci (2012) 1.12
FOXO3 signalling links ATM to the p53 apoptotic pathway following DNA damage. Nat Commun (2012) 1.12
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Resveratrol ameliorates ionizing irradiation-induced long-term hematopoietic stem cell injury in mice. Free Radic Biol Med (2012) 1.11
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Antagonism between FOXO and MYC Regulates Cellular Powerhouse. Front Oncol (2013) 1.10
Stem cells and the impact of ROS signaling. Development (2014) 1.10
Inhibition of p38 mitogen-activated protein kinase promotes ex vivo hematopoietic stem cell expansion. Stem Cells Dev (2011) 1.09
FoxO3A promotes metabolic adaptation to hypoxia by antagonizing Myc function. EMBO J (2011) 1.09
Effects of iron overload on the bone marrow microenvironment in mice. PLoS One (2015) 1.09
Prolyl hydroxylation by EglN2 destabilizes FOXO3a by blocking its interaction with the USP9x deubiquitinase. Genes Dev (2014) 1.09
Hematopoietic stem cell injury induced by ionizing radiation. Antioxid Redox Signal (2014) 1.09
Sustained PU.1 levels balance cell-cycle regulators to prevent exhaustion of adult hematopoietic stem cells. Mol Cell (2013) 1.09
The redox-sensitive transcription factor Nrf2 regulates murine hematopoietic stem cell survival independently of ROS levels. Blood (2011) 1.08
Nutrient-sensing pathways and metabolic regulation in stem cells. J Cell Biol (2013) 1.08
Rapamycin increases oxidative stress response gene expression in adult stem cells. Aging (Albany NY) (2012) 1.08
Tie2/angiopoietin-1 signaling regulates hematopoietic stem cell quiescence in the bone marrow niche. Cell (2004) 12.67
Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44
The Genomes of Oryza sativa: a history of duplications. PLoS Biol (2005) 7.67
Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells. Nat Med (2006) 7.62
Regulation of oxidative stress by ATM is required for self-renewal of haematopoietic stem cells. Nature (2004) 7.21
Ubiquitin ligases: cell-cycle control and cancer. Nat Rev Cancer (2006) 6.76
Development of functional human blood and immune systems in NOD/SCID/IL2 receptor {gamma} chain(null) mice. Blood (2005) 6.16
DNA damage-induced G2-M checkpoint activation by histone H2AX and 53BP1. Nat Cell Biol (2002) 5.85
A genetic variation map for chicken with 2.8 million single-nucleotide polymorphisms. Nature (2004) 5.24
Chemotherapy-resistant human AML stem cells home to and engraft within the bone-marrow endosteal region. Nat Biotechnol (2007) 5.21
Phosphorylation-dependent degradation of c-Myc is mediated by the F-box protein Fbw7. EMBO J (2004) 4.95
Regulation of the HIF-1alpha level is essential for hematopoietic stem cells. Cell Stem Cell (2010) 4.90
Side population purified from hepatocellular carcinoma cells harbors cancer stem cell-like properties. Hepatology (2006) 4.61
Cdkn1a deletion improves stem cell function and lifespan of mice with dysfunctional telomeres without accelerating cancer formation. Nat Genet (2006) 4.43
Fbxw7/Cdc4 is a p53-dependent, haploinsufficient tumour suppressor gene. Nature (2004) 4.35
Bidirectional ephrinB2-EphB4 signaling controls bone homeostasis. Cell Metab (2006) 4.33
Thrombopoietin/MPL signaling regulates hematopoietic stem cell quiescence and interaction with the osteoblastic niche. Cell Stem Cell (2007) 4.31
Generation of rat pancreas in mouse by interspecific blastocyst injection of pluripotent stem cells. Cell (2010) 4.24
Nonmyelinating Schwann cells maintain hematopoietic stem cell hibernation in the bone marrow niche. Cell (2011) 4.04
A memory retrieval-extinction procedure to prevent drug craving and relapse. Science (2012) 4.04
Prospective identification, isolation, and systemic transplantation of multipotent mesenchymal stem cells in murine bone marrow. J Exp Med (2009) 4.03
DC-STAMP is essential for cell-cell fusion in osteoclasts and foreign body giant cells. J Exp Med (2005) 4.02
The F-box protein Skp2 participates in c-Myc proteosomal degradation and acts as a cofactor for c-Myc-regulated transcription. Mol Cell (2003) 3.87
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Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
v-ATPase V0 subunit d2-deficient mice exhibit impaired osteoclast fusion and increased bone formation. Nat Med (2006) 3.78
PML targeting eradicates quiescent leukaemia-initiating cells. Nature (2008) 3.75
SCF(FBW7) regulates cellular apoptosis by targeting MCL1 for ubiquitylation and destruction. Nature (2011) 3.69
Role of the SCFSkp2 ubiquitin ligase in the degradation of p21Cip1 in S phase. J Biol Chem (2003) 3.68
Mitogenic signalling and the p16INK4a-Rb pathway cooperate to enforce irreversible cellular senescence. Nat Cell Biol (2006) 3.63
Two E3 ubiquitin ligases, SCF-Skp2 and DDB1-Cul4, target human Cdt1 for proteolysis. EMBO J (2006) 3.53
Targeting a complex transcriptome: the construction of the mouse full-length cDNA encyclopedia. Genome Res (2003) 3.50
Chk2-deficient mice exhibit radioresistance and defective p53-mediated transcription. EMBO J (2002) 3.45
A PML–PPAR-δ pathway for fatty acid oxidation regulates hematopoietic stem cell maintenance. Nat Med (2012) 3.33
Skp2-mediated degradation of p27 regulates progression into mitosis. Dev Cell (2004) 3.27
Enhanced self-renewal of hematopoietic stem cells mediated by the polycomb gene product Bmi-1. Immunity (2004) 3.25
PML regulates apoptosis at endoplasmic reticulum by modulating calcium release. Science (2010) 3.21
A differentiation checkpoint limits hematopoietic stem cell self-renewal in response to DNA damage. Cell (2012) 3.21
A diacylglycerol-dependent signaling pathway contributes to regulation of antibacterial autophagy. Cell Host Microbe (2010) 3.18
Cytoplasmic ubiquitin ligase KPC regulates proteolysis of p27(Kip1) at G1 phase. Nat Cell Biol (2004) 3.14
TGF-beta-FOXO signalling maintains leukaemia-initiating cells in chronic myeloid leukaemia. Nature (2010) 3.12
Skp2 targeting suppresses tumorigenesis by Arf-p53-independent cellular senescence. Nature (2010) 3.09
Chk2 is a tumor suppressor that regulates apoptosis in both an ataxia telangiectasia mutated (ATM)-dependent and an ATM-independent manner. Mol Cell Biol (2002) 3.08
Regulation of the cell cycle by SCF-type ubiquitin ligases. Semin Cell Dev Biol (2005) 3.08
Arteriolar niches maintain haematopoietic stem cell quiescence. Nature (2013) 3.07
Metabolic regulation of hematopoietic stem cells in the hypoxic niche. Cell Stem Cell (2011) 3.05
Heterogeneity and hierarchy within the most primitive hematopoietic stem cell compartment. J Exp Med (2010) 2.98
Phosphorylation-dependent regulation of cytosolic localization and oncogenic function of Skp2 by Akt/PKB. Nat Cell Biol (2009) 2.91
Different anti-HCV profiles of statins and their potential for combination therapy with interferon. Hepatology (2006) 2.87
Dissecting the cell entry pathway of dengue virus by single-particle tracking in living cells. PLoS Pathog (2008) 2.77
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Ontogeny and multipotency of neural crest-derived stem cells in mouse bone marrow, dorsal root ganglia, and whisker pad. Cell Stem Cell (2008) 2.69
Increased proliferation of B cells and auto-immunity in mice lacking protein kinase Cdelta. Nature (2002) 2.68
Interferon regulatory factor-2 protects quiescent hematopoietic stem cells from type I interferon-dependent exhaustion. Nat Med (2009) 2.66
TGF-beta as a candidate bone marrow niche signal to induce hematopoietic stem cell hibernation. Blood (2008) 2.64
Inherent calcineurin inhibitor FKBP38 targets Bcl-2 to mitochondria and inhibits apoptosis. Nat Cell Biol (2003) 2.64
Phosphorylation of beta-catenin by cyclic AMP-dependent protein kinase stabilizes beta-catenin through inhibition of its ubiquitination. Mol Cell Biol (2005) 2.62
New ISSCR guidelines underscore major principles for responsible translational stem cell research. Cell Stem Cell (2008) 2.61
Mouse Fbw7/Sel-10/Cdc4 is required for notch degradation during vascular development. J Biol Chem (2003) 2.59
p57(Kip2) and p27(Kip1) cooperate to maintain hematopoietic stem cell quiescence through interactions with Hsc70. Cell Stem Cell (2011) 2.58