Published in Traffic on April 01, 2006
Alzheimer's disease beta-amyloid peptides are released in association with exosomes. Proc Natl Acad Sci U S A (2006) 3.98
Sorting through the cell biology of Alzheimer's disease: intracellular pathways to pathogenesis. Neuron (2006) 2.76
Trafficking and proteolytic processing of APP. Cold Spring Harb Perspect Med (2012) 2.56
Endosomal entry regulates Notch receptor activation in Drosophila melanogaster. J Cell Biol (2008) 2.32
Substrate specificity of gamma-secretase and other intramembrane proteases. Cell Mol Life Sci (2008) 2.29
The many substrates of presenilin/γ-secretase. J Alzheimers Dis (2011) 2.02
Biochemistry of amyloid β-protein and amyloid deposits in Alzheimer disease. Cold Spring Harb Perspect Med (2012) 2.01
Direct and potent regulation of gamma-secretase by its lipid microenvironment. J Biol Chem (2008) 2.00
Sorting of the Alzheimer's disease amyloid precursor protein mediated by the AP-4 complex. Dev Cell (2010) 1.98
Alzheimer's-related endosome dysfunction in Down syndrome is Abeta-independent but requires APP and is reversed by BACE-1 inhibition. Proc Natl Acad Sci U S A (2009) 1.72
Gamma-secretase-dependent and -independent effects of presenilin1 on beta-catenin.Tcf-4 transcriptional activity. PLoS One (2008) 1.49
Linking folding with aggregation in Alzheimer's beta-amyloid peptides. Proc Natl Acad Sci U S A (2007) 1.42
Rer1p competes with APH-1 for binding to nicastrin and regulates gamma-secretase complex assembly in the early secretory pathway. J Cell Biol (2007) 1.34
Regulation of Notch signaling by dynamic changes in the precision of S3 cleavage of Notch-1. Mol Cell Biol (2007) 1.28
Phosphatidylinositol-3-phosphate regulates sorting and processing of amyloid precursor protein through the endosomal system. Nat Commun (2013) 1.27
Assembly, maturation, and trafficking of the gamma-secretase complex in Alzheimer's disease. Curr Alzheimer Res (2008) 1.25
Induced dimerization of the amyloid precursor protein leads to decreased amyloid-beta protein production. J Biol Chem (2009) 1.25
Maturation of BRI2 generates a specific inhibitor that reduces APP processing at the plasma membrane and in endocytic vesicles. Neurobiol Aging (2009) 1.19
Tyr(682) in the intracellular domain of APP regulates amyloidogenic APP processing in vivo. PLoS One (2010) 1.11
ApoER2 expression increases Abeta production while decreasing Amyloid Precursor Protein (APP) endocytosis: Possible role in the partitioning of APP into lipid rafts and in the regulation of gamma-secretase activity. Mol Neurodegener (2007) 1.10
Trafficking regulation of proteins in Alzheimer's disease. Mol Neurodegener (2014) 1.08
Neuronal protein trafficking associated with Alzheimer disease: from APP and BACE1 to glutamate receptors. Cell Adh Migr (2009) 1.05
Synaptic and endosomal localization of active gamma-secretase in rat brain. PLoS One (2010) 1.02
BRI3 inhibits amyloid precursor protein processing in a mechanistically distinct manner from its homologue dementia gene BRI2. J Biol Chem (2009) 0.99
β-arrestin1 regulates γ-secretase complex assembly and modulates amyloid-β pathology. Cell Res (2012) 0.95
γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane. Traffic (2010) 0.95
Inhibition of acyl-coenzyme A: cholesterol acyl transferase modulates amyloid precursor protein trafficking in the early secretory pathway. FASEB J (2009) 0.94
Turnover of C99 is controlled by a crosstalk between ERAD and ubiquitin-independent lysosomal degradation in human neuroglioma cells. PLoS One (2013) 0.90
Mechanism for amyloid precursor-like protein 2 enhancement of major histocompatibility complex class I molecule degradation. J Biol Chem (2009) 0.90
Enhanced β-secretase processing alters APP axonal transport and leads to axonal defects. Hum Mol Genet (2012) 0.89
Cysteine 27 variant of the delta-opioid receptor affects amyloid precursor protein processing through altered endocytic trafficking. Mol Cell Biol (2011) 0.89
A paired RNAi and RabGAP overexpression screen identifies Rab11 as a regulator of β-amyloid production. Cell Rep (2013) 0.89
Amyloid precursor protein-mediated endocytic pathway disruption induces axonal dysfunction and neurodegeneration. J Clin Invest (2016) 0.87
Ubiquitinations in the notch signaling pathway. Int J Mol Sci (2013) 0.86
Secretion stimulates intramembrane proteolysis of a secretory granule membrane enzyme. J Biol Chem (2010) 0.85
Structural and Functional Determinants of gamma-Secretase, an Intramembrane Protease Implicated in Alzheimer's Disease. Curr Genomics (2007) 0.84
A γ-secretase inhibitor, but not a γ-secretase modulator, induced defects in BDNF axonal trafficking and signaling: evidence for a role for APP. PLoS One (2015) 0.84
Function of Integrin-Linked Kinase in Modulating the Stemness of IL-6-Abundant Breast Cancer Cells by Regulating γ-Secretase-Mediated Notch1 Activation in Caveolae. Neoplasia (2015) 0.83
Advances on the understanding of the origins of synaptic pathology in AD. Curr Genomics (2007) 0.83
The role of APP and BACE1 trafficking in APP processing and amyloid-β generation. Alzheimers Res Ther (2013) 0.83
The very many faces of presenilins and the γ-secretase complex. Protoplasma (2013) 0.82
Signaling from the secretory granule to the nucleus. Crit Rev Biochem Mol Biol (2012) 0.82
Notch signaling from the endosome requires a conserved dileucine motif. Mol Biol Cell (2012) 0.81
Probing the efficacy of peptide-based inhibitors against acid- and zinc-promoted oligomerization of amyloid-β peptide via single-oligomer spectroscopy. Biophys Chem (2011) 0.80
Polar transmembrane-based amino acids in presenilin 1 are involved in endoplasmic reticulum localization, Pen2 protein binding, and γ-secretase complex stabilization. J Biol Chem (2011) 0.80
Axonal amyloid precursor protein and its fragments undergo somatodendritic endocytosis and processing. Mol Biol Cell (2014) 0.79
Alphabeta hinders nuclear targeting of AICD and Fe65 in primary neuronal cultures. J Mol Neurosci (2009) 0.79
Cellular basis of Alzheimer's disease. Ann Indian Acad Neurol (2010) 0.77
Partial BACE1 reduction in a Down syndrome mouse model blocks Alzheimer-related endosomal anomalies and cholinergic neurodegeneration: role of APP-CTF. Neurobiol Aging (2015) 0.76
Presenilin 1 and Presenilin 2 Target γ-Secretase Complexes to Distinct Cellular Compartments. J Biol Chem (2016) 0.75
MT5-MMP Promotes Alzheimer's Pathogenesis in the Frontal Cortex of 5xFAD Mice and APP Trafficking in vitro. Front Mol Neurosci (2017) 0.75
Modifications and Trafficking of APP in the Pathogenesis of Alzheimer's Disease. Front Mol Neurosci (2017) 0.75
The C9orf72 GGGGCC repeat is translated into aggregating dipeptide-repeat proteins in FTLD/ALS. Science (2013) 6.34
Loss-of-function of human PINK1 results in mitochondrial pathology and can be rescued by parkin. J Neurosci (2007) 5.68
Amyloidogenic processing of the Alzheimer beta-amyloid precursor protein depends on lipid rafts. J Cell Biol (2003) 4.71
Reconstitution of gamma-secretase activity. Nat Cell Biol (2003) 4.66
Control of peripheral nerve myelination by the beta-secretase BACE1. Science (2006) 4.55
Abeta42-driven cerebral amyloidosis in transgenic mice reveals early and robust pathology. EMBO Rep (2006) 4.06
Clusters of hyperactive neurons near amyloid plaques in a mouse model of Alzheimer's disease. Science (2008) 3.59
ALS-associated fused in sarcoma (FUS) mutations disrupt Transportin-mediated nuclear import. EMBO J (2010) 3.58
A gamma-secretase inhibitor blocks Notch signaling in vivo and causes a severe neurogenic phenotype in zebrafish. EMBO Rep (2002) 3.53
Phosphorylation of the translation initiation factor eIF2alpha increases BACE1 levels and promotes amyloidogenesis. Neuron (2008) 2.99
Microglial Cx3cr1 knockout prevents neuron loss in a mouse model of Alzheimer's disease. Nat Neurosci (2010) 2.79
Loss of parkin or PINK1 function increases Drp1-dependent mitochondrial fragmentation. J Biol Chem (2009) 2.64
Misfolded proteinase K-resistant hyperphosphorylated alpha-synuclein in aged transgenic mice with locomotor deterioration and in human alpha-synucleinopathies. J Clin Invest (2002) 2.47
The two faces of protein misfolding: gain- and loss-of-function in neurodegenerative diseases. EMBO J (2008) 2.43
Mitochondrial dysfunction in Parkinson's disease: molecular mechanisms and pathophysiological consequences. EMBO J (2012) 2.36
Presenilin-1 mutations of leucine 166 equally affect the generation of the Notch and APP intracellular domains independent of their effect on Abeta 42 production. Proc Natl Acad Sci U S A (2002) 2.29
hnRNP A3 binds to GGGGCC repeats and is a constituent of p62-positive/TDP43-negative inclusions in the hippocampus of patients with C9orf72 mutations. Acta Neuropathol (2013) 2.27
Efficient CRISPR/Cas9 genome editing with low off-target effects in zebrafish. Development (2013) 2.22
Inhibition of mitochondrial fusion by α-synuclein is rescued by PINK1, Parkin and DJ-1. EMBO J (2010) 2.12
A critical function of the pial basement membrane in cortical histogenesis. J Neurosci (2002) 2.00
The cell adhesion protein P-selectin glycoprotein ligand-1 is a substrate for the aspartyl protease BACE1. J Biol Chem (2003) 1.99
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem (2002) 1.97
Hyperphosphorylation and insolubility of alpha-synuclein in transgenic mouse oligodendrocytes. EMBO Rep (2002) 1.91
Missense mutations in the progranulin gene linked to frontotemporal lobar degeneration with ubiquitin-immunoreactive inclusions reduce progranulin production and secretion. J Biol Chem (2007) 1.87
Bidirectional transcripts of the expanded C9orf72 hexanucleotide repeat are translated into aggregating dipeptide repeat proteins. Acta Neuropathol (2013) 1.82
Regulated intramembrane proteolysis--lessons from amyloid precursor protein processing. J Neurochem (2011) 1.79
Mitochondrial dysfunction in Parkinson's disease. Biochim Biophys Acta (2009) 1.77
Reactive glia in the injured brain acquire stem cell properties in response to sonic hedgehog. [corrected]. Cell Stem Cell (2013) 1.77
Proteolytic processing of TAR DNA binding protein-43 by caspases produces C-terminal fragments with disease defining properties independent of progranulin. J Neurochem (2009) 1.76
FET proteins TAF15 and EWS are selective markers that distinguish FTLD with FUS pathology from amyotrophic lateral sclerosis with FUS mutations. Brain (2011) 1.76
Intramembrane proteolysis by gamma-secretase. J Biol Chem (2008) 1.74
Alpha-synuclein has a high affinity for packing defects in a bilayer membrane: a thermodynamics study. J Biol Chem (2004) 1.73
PEN-2 is an integral component of the gamma-secretase complex required for coordinated expression of presenilin and nicastrin. J Biol Chem (2002) 1.71
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem (2007) 1.71
Active gamma-secretase complexes contain only one of each component. J Biol Chem (2007) 1.69
Games played by rogue proteins in prion disorders and Alzheimer's disease. Science (2003) 1.61
Secretome protein enrichment identifies physiological BACE1 protease substrates in neurons. EMBO J (2012) 1.61
Dipeptide repeat protein pathology in C9ORF72 mutation cases: clinico-pathological correlations. Acta Neuropathol (2013) 1.59
Boxing-acute complications and late sequelae: from concussion to dementia. Dtsch Arztebl Int (2010) 1.59
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J (2002) 1.57
How does parkin ligate ubiquitin to Parkinson's disease? EMBO Rep (2004) 1.54
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
GGA proteins regulate retrograde transport of BACE1 from endosomes to the trans-Golgi network. Mol Cell Neurosci (2005) 1.47
Regulated intramembrane proteolysis of Bri2 (Itm2b) by ADAM10 and SPPL2a/SPPL2b. J Biol Chem (2007) 1.46
Insulin-degrading enzyme rapidly removes the beta-amyloid precursor protein intracellular domain (AICD). J Biol Chem (2002) 1.45
Arginine methylation next to the PY-NLS modulates Transportin binding and nuclear import of FUS. EMBO J (2012) 1.45
Differential effects of Parkinson's disease-associated mutations on stability and folding of DJ-1. J Biol Chem (2003) 1.45
Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem (2006) 1.44
Presenilin and nicastrin regulate each other and determine amyloid beta-peptide production via complex formation. Proc Natl Acad Sci U S A (2002) 1.44
Requirements for stress granule recruitment of fused in sarcoma (FUS) and TAR DNA-binding protein of 43 kDa (TDP-43). J Biol Chem (2012) 1.43
Presenilin-1 affects trafficking and processing of betaAPP and is targeted in a complex with nicastrin to the plasma membrane. J Cell Biol (2002) 1.42
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem (2013) 1.40
Identification of distinct gamma-secretase complexes with different APH-1 variants. J Biol Chem (2004) 1.40
The N-terminus of the intrinsically disordered protein α-synuclein triggers membrane binding and helix folding. Biophys J (2010) 1.39
Function, therapeutic potential and cell biology of BACE proteases: current status and future prospects. J Neurochem (2014) 1.37
Membrane orientation and subcellular localization of transmembrane protein 106B (TMEM106B), a major risk factor for frontotemporal lobar degeneration. J Biol Chem (2012) 1.37
Oxidative stress in transgenic mice with oligodendroglial alpha-synuclein overexpression replicates the characteristic neuropathology of multiple system atrophy. Am J Pathol (2005) 1.36
A gamma-secretase-like intramembrane cleavage of TNFalpha by the GxGD aspartyl protease SPPL2b. Nat Cell Biol (2006) 1.36
Gamma-secretase inhibition reduces spine density in vivo via an amyloid precursor protein-dependent pathway. J Neurosci (2009) 1.35
TDP-43 and FUS: a nuclear affair. Trends Neurosci (2011) 1.35
A zebrafish model of tauopathy allows in vivo imaging of neuronal cell death and drug evaluation. J Clin Invest (2009) 1.32
Furin-, ADAM 10-, and gamma-secretase-mediated cleavage of a receptor tyrosine phosphatase and regulation of beta-catenin's transcriptional activity. Mol Cell Biol (2006) 1.32
Absence of alpha 7 integrin in dystrophin-deficient mice causes a myopathy similar to Duchenne muscular dystrophy. Hum Mol Genet (2006) 1.30
Amyloid beta-induced changes in nitric oxide production and mitochondrial activity lead to apoptosis. J Biol Chem (2004) 1.28
Expression of the Alzheimer protease BACE1 is suppressed via its 5'-untranslated region. EMBO Rep (2004) 1.27
Regulated intramembrane proteolysis of the interleukin-1 receptor II by alpha-, beta-, and gamma-secretase. J Biol Chem (2007) 1.27
The presenilin C-terminus is required for ER-retention, nicastrin-binding and gamma-secretase activity. EMBO J (2004) 1.26
Requirement of PEN-2 for stabilization of the presenilin N-/C-terminal fragment heterodimer within the gamma-secretase complex. J Biol Chem (2004) 1.26
Age-dependent cognitive decline and amygdala pathology in alpha-synuclein transgenic mice. Neurobiol Aging (2006) 1.26
Rescue of progranulin deficiency associated with frontotemporal lobar degeneration by alkalizing reagents and inhibition of vacuolar ATPase. J Neurosci (2011) 1.26
Pathological activity of familial Alzheimer's disease-associated mutant presenilin can be executed by six different gamma-secretase complexes. Neurobiol Dis (2007) 1.25
Novel γ-secretase enzyme modulators directly target presenilin protein. J Biol Chem (2011) 1.24
Assembly, trafficking and function of gamma-secretase. Neurodegener Dis (2006) 1.22
Stress granules in neurodegeneration--lessons learnt from TAR DNA binding protein of 43 kDa and fused in sarcoma. FEBS J (2013) 1.21
Intramembrane proteolysis by signal peptide peptidases: a comparative discussion of GXGD-type aspartyl proteases. J Biol Chem (2009) 1.20
Parkin phosphorylation and modulation of its E3 ubiquitin ligase activity. J Biol Chem (2004) 1.20
The 28-amino acid form of an APLP1-derived Abeta-like peptide is a surrogate marker for Abeta42 production in the central nervous system. EMBO Mol Med (2009) 1.20
Pathological properties of the Parkinson's disease-associated protein DJ-1 in alpha-synucleinopathies and tauopathies: relevance for multiple system atrophy and Pick's disease. Acta Neuropathol (2004) 1.19
Structural determinants of the C-terminal helix-kink-helix motif essential for protein stability and survival promoting activity of DJ-1. J Biol Chem (2007) 1.18
Dual cleavage of neuregulin 1 type III by BACE1 and ADAM17 liberates its EGF-like domain and allows paracrine signaling. J Neurosci (2013) 1.18
Three-amino acid spacing of presenilin endoproteolysis suggests a general stepwise cleavage of gamma-secretase-mediated intramembrane proteolysis. J Neurosci (2010) 1.18
Loss of fused in sarcoma (FUS) promotes pathological Tau splicing. EMBO Rep (2012) 1.17
A novel sorting nexin modulates endocytic trafficking and alpha-secretase cleavage of the amyloid precursor protein. J Biol Chem (2008) 1.17
Differential localization and identification of a critical aspartate suggest non-redundant proteolytic functions of the presenilin homologues SPPL2b and SPPL3. J Biol Chem (2005) 1.17
Gamma-secretase complex assembly within the early secretory pathway. J Biol Chem (2004) 1.16
Gamma-secretase activity is associated with a conformational change of nicastrin. J Biol Chem (2003) 1.14
The GxGD motif of presenilin contributes to catalytic function and substrate identification of gamma-secretase. J Neurosci (2006) 1.13
Beta-amyloid precursor protein mutants respond to gamma-secretase modulators. J Biol Chem (2010) 1.12
Inhibition of APP trafficking by tau protein does not increase the generation of amyloid-beta peptides. Traffic (2006) 1.12
Mitochondrion-derived reactive oxygen species lead to enhanced amyloid beta formation. Antioxid Redox Signal (2012) 1.12
Highly efficient targeted mutagenesis in mice using TALENs. Genetics (2013) 1.12
In vivo imaging of disease-related mitochondrial dynamics in a vertebrate model system. J Neurosci (2012) 1.11
Purification, pharmacological modulation, and biochemical characterization of interactors of endogenous human gamma-secretase. Biochemistry (2009) 1.11
Basement membrane-dependent survival of retinal ganglion cells. Invest Ophthalmol Vis Sci (2005) 1.10