Published in Mol Cell Biol on October 29, 2007
The canonical Notch signaling pathway: unfolding the activation mechanism. Cell (2009) 14.72
Targeting Notch to target cancer stem cells. Clin Cancer Res (2010) 2.46
The vacuolar proton pump, V-ATPase, is required for notch signaling and endosomal trafficking in Drosophila. Dev Cell (2009) 1.90
Metalloprotease ADAM10 is required for Notch1 site 2 cleavage. J Biol Chem (2009) 1.83
Not(ch) just development: Notch signalling in the adult brain. Nat Rev Neurosci (2011) 1.69
Endocytic regulation of Notch signaling. Curr Opin Genet Dev (2009) 1.59
Notch inhibitors for cancer treatment. Pharmacol Ther (2013) 1.55
The vacuolar ATPase is required for physiological as well as pathological activation of the Notch receptor. Development (2010) 1.36
Notch signaling. Cold Spring Harb Perspect Biol (2012) 1.35
Presenilin: RIP and beyond. Semin Cell Dev Biol (2008) 1.33
Trafficking of receptor tyrosine kinases to the nucleus. Exp Cell Res (2008) 1.33
Gamma-secretase composed of PS1/Pen2/Aph1a can cleave notch and amyloid precursor protein in the absence of nicastrin. J Neurosci (2010) 1.21
The role of protease activity in ErbB biology. Exp Cell Res (2008) 1.20
Competition and collaboration: GATA-3, PU.1, and Notch signaling in early T-cell fate determination. Semin Immunol (2008) 1.14
Real-time imaging of notch activation with a luciferase complementation-based reporter. Sci Signal (2011) 1.05
Thermodynamic analysis of the CSL x Notch interaction: distribution of binding energy of the Notch RAM region to the CSL beta-trefoil domain and the mode of competition with the viral transactivator EBNA2. J Biol Chem (2009) 1.00
Histopathological and molecular heterogeneity among individuals with dementia associated with Presenilin mutations. Mol Neurodegener (2008) 0.96
γ-secretase-dependent cleavage initiates notch signaling from the plasma membrane. Traffic (2010) 0.95
Proteolytic cleavage of Notch: "HIT and RUN". Curr Mol Med (2011) 0.95
Receptor tyrosine kinases in the nucleus. Cold Spring Harb Perspect Biol (2013) 0.93
Membrane tethered delta activates notch and reveals a role for spatio-mechanical regulation of the signaling pathway. Biophys J (2013) 0.88
Molecular mechanism of the intramembrane cleavage of the β-carboxyl terminal fragment of amyloid precursor protein by γ-secretase. Front Physiol (2014) 0.87
Human CRB2 inhibits gamma-secretase cleavage of amyloid precursor protein by binding to the presenilin complex. J Biol Chem (2010) 0.87
The role of Adams in Notch signaling. Adv Exp Med Biol (2012) 0.86
The cell giveth and the cell taketh away: an overview of Notch pathway activation by endocytic trafficking of ligands and receptors. Acta Histochem (2010) 0.86
Gamma-secretase-regulated proteolysis of the Notch receptor by mitochondrial intermediate peptidase. J Biol Chem (2011) 0.83
The intracellular domains of Notch1 and Notch2 are functionally equivalent during development and carcinogenesis. Development (2015) 0.83
PKCζ regulates Notch receptor routing and activity in a Notch signaling-dependent manner. Cell Res (2014) 0.82
Second generation γ-secretase modulators exhibit different modulation of Notch β and Aβ production. J Biol Chem (2012) 0.82
Notch signaling from the endosome requires a conserved dileucine motif. Mol Biol Cell (2012) 0.81
Regulated intramembrane proteolysis and degradation of murine epithelial cell adhesion molecule mEpCAM. PLoS One (2013) 0.80
The Coxsackievirus and Adenovirus Receptor (CAR) undergoes ectodomain shedding and regulated intramembrane proteolysis (RIP). PLoS One (2013) 0.78
Differential regulation of amyloid precursor protein/presenilin 1 interaction during Aβ40/42 [corrected] production detected using fusion constructs. PLoS One (2012) 0.78
Structural and biochemical differences between the Notch and the amyloid precursor protein transmembrane domains. Sci Adv (2017) 0.75
The Notch Intracellular Domain Has an RBPj-Independent Role during Mouse Hair Follicular Development. J Invest Dermatol (2016) 0.75
Notch signaling: cell fate control and signal integration in development. Science (1999) 28.83
Alzheimer's disease: genes, proteins, and therapy. Physiol Rev (2001) 19.19
Activating mutations of NOTCH1 in human T cell acute lymphoblastic leukemia. Science (2004) 18.84
In vivo half-life of a protein is a function of its amino-terminal residue. Science (1986) 13.44
Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells. Nature (2005) 11.49
Signalling downstream of activated mammalian Notch. Nature (1995) 11.08
Notch-1 signalling requires ligand-induced proteolytic release of intracellular domain. Nature (1998) 10.58
A presenilin-1-dependent gamma-secretase-like protease mediates release of Notch intracellular domain. Nature (1999) 10.36
Two transmembrane aspartates in presenilin-1 required for presenilin endoproteolysis and gamma-secretase activity. Nature (1999) 8.28
A subset of NSAIDs lower amyloidogenic Abeta42 independently of cyclooxygenase activity. Nature (2001) 7.35
A transcriptionally [correction of transcriptively] active complex of APP with Fe65 and histone acetyltransferase Tip60. Science (2001) 7.03
Notch signals control the fate of immature progenitor cells in the intestine. Nature (2005) 6.13
Notch signaling: from the outside in. Dev Biol (2000) 6.06
A ligand-induced extracellular cleavage regulates gamma-secretase-like proteolytic activation of Notch1. Mol Cell (2000) 5.56
The role of Notch in tumorigenesis: oncogene or tumour suppressor? Nat Rev Cancer (2003) 4.75
Diverse compounds mimic Alzheimer disease-causing mutations by augmenting Abeta42 production. Nat Med (2005) 4.00
Universality and structure of the N-end rule. J Biol Chem (1989) 3.97
Regulation of notch signaling activity. Curr Biol (2004) 3.88
Notch and Presenilin: regulated intramembrane proteolysis links development and degeneration. Annu Rev Neurosci (2003) 3.79
The endocytic protein alpha-Adaptin is required for numb-mediated asymmetric cell division in Drosophila. Dev Cell (2002) 3.16
Ligand endocytosis drives receptor dissociation and activation in the Notch pathway. Development (2000) 2.94
Embryonic lethality in mice homozygous for a processing-deficient allele of Notch1. Nature (2000) 2.85
Notch activity influences the alphabeta versus gammadelta T cell lineage decision. Cell (1997) 2.66
GxxxG motifs within the amyloid precursor protein transmembrane sequence are critical for the etiology of Abeta42. EMBO J (2007) 2.61
Longer forms of amyloid beta protein: implications for the mechanism of intramembrane cleavage by gamma-secretase. J Neurosci (2005) 2.48
Constitutive phosphorylation of the Parkinson's disease associated alpha-synuclein. J Biol Chem (2000) 2.27
Requirement for dynamin during Notch signaling in Drosophila neurogenesis. Dev Biol (1997) 2.26
Complex cellular and subcellular regulation of notch expression during embryonic and imaginal development of Drosophila: implications for notch function. J Cell Biol (1991) 2.05
The Mesp2 transcription factor establishes segmental borders by suppressing Notch activity. Nature (2005) 1.94
RBP-L, a transcription factor related to RBP-Jkappa. Mol Cell Biol (1997) 1.89
Glycine 384 is required for presenilin-1 function and is conserved in bacterial polytopic aspartyl proteases. Nat Cell Biol (2000) 1.87
Monoubiquitination and endocytosis direct gamma-secretase cleavage of activated Notch receptor. J Cell Biol (2004) 1.79
gamma-Cleavage is dependent on zeta-cleavage during the proteolytic processing of amyloid precursor protein within its transmembrane domain. J Biol Chem (2005) 1.61
Potential role of presenilin-regulated signaling pathways in sporadic neurodegeneration. Nat Med (2004) 1.60
Amyloid precursor protein and Notch intracellular domains are generated after transport of their precursors to the cell surface. Traffic (2006) 1.57
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J (2002) 1.57
Potential link between amyloid beta-protein 42 and C-terminal fragment gamma 49-99 of beta-amyloid precursor protein. J Biol Chem (2003) 1.49
Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem (2006) 1.44
Numb inhibits membrane localization of Sanpodo, a four-pass transmembrane protein, to promote asymmetric divisions in Drosophila. Dev Cell (2003) 1.42
Sulindac sulfide is a noncompetitive gamma-secretase inhibitor that preferentially reduces Abeta 42 generation. J Biol Chem (2003) 1.37
Drosophila nicastrin is essential for the intramembranous cleavage of notch. Dev Cell (2002) 1.34
Alzheimer disease gamma-secretase: a complex story of GxGD-type presenilin proteases. Trends Cell Biol (2002) 1.26
Processing of Notch and amyloid precursor protein by gamma-secretase is spatially distinct. Proc Natl Acad Sci U S A (2004) 1.21
AML1/Runx1 rescues Notch1-null mutation-induced deficiency of para-aortic splanchnopleural hematopoiesis. Blood (2006) 1.13
Presenilin-dependent gamma-secretase on plasma membrane and endosomes is functionally distinct. Biochemistry (2006) 1.04
Analysis of transmembrane domain mutants is consistent with sequential cleavage of Notch by gamma-secretase. J Neurochem (2005) 1.02
Intramembrane proteolysis by presenilin and presenilin-like proteases. J Cell Sci (2003) 1.01
Random mutagenesis of presenilin-1 identifies novel mutants exclusively generating long amyloid beta-peptides. J Biol Chem (2005) 0.96
A loss of function mutant of the presenilin homologue SEL-12 undergoes aberrant endoproteolysis in Caenorhabditis elegans and increases abeta 42 generation in human cells. J Biol Chem (2000) 0.91
Mutations at the P1' position of Notch1 decrease intracellular domain stability rather than cleavage by gamma-secretase. Biochem Biophys Res Commun (2002) 0.88
Proteolytic processing of presenilin-1 (PS-1) is not associated with Alzheimer's disease with or without PS-1 mutations. FEBS Lett (1997) 0.84
Efficient expression of a transfected foreign gene by Cos1 cells in serum-free medium. Biosci Biotechnol Biochem (1994) 0.77
Frequent pathway mutations of splicing machinery in myelodysplasia. Nature (2011) 11.44
A robust algorithm for copy number detection using high-density oligonucleotide single nucleotide polymorphism genotyping arrays. Cancer Res (2005) 11.02
Highly sensitive method for genomewide detection of allelic composition in nonpaired, primary tumor specimens by use of affymetrix single-nucleotide-polymorphism genotyping microarrays. Am J Hum Genet (2007) 4.52
Frequent inactivation of A20 in B-cell lymphomas. Nature (2009) 4.22
AML-1 is required for megakaryocytic maturation and lymphocytic differentiation, but not for maintenance of hematopoietic stem cells in adult hematopoiesis. Nat Med (2004) 4.00
Involvement of caspase-4 in endoplasmic reticulum stress-induced apoptosis and Abeta-induced cell death. J Cell Biol (2004) 3.85
Gain-of-function of mutated C-CBL tumour suppressor in myeloid neoplasms. Nature (2009) 3.80
Notch2 is preferentially expressed in mature B cells and indispensable for marginal zone B lineage development. Immunity (2003) 3.73
Docosahexaenoic acid protects from dendritic pathology in an Alzheimer's disease mouse model. Neuron (2004) 3.21
Notch1 but not Notch2 is essential for generating hematopoietic stem cells from endothelial cells. Immunity (2003) 2.94
MafA is a key regulator of glucose-stimulated insulin secretion. Mol Cell Biol (2005) 2.85
Neuregulin 1 transcripts are differentially expressed in schizophrenia and regulated by 5' SNPs associated with the disease. Proc Natl Acad Sci U S A (2006) 2.71
Genome-wide expression analysis of mouse liver reveals CLOCK-regulated circadian output genes. J Biol Chem (2003) 2.66
CSF hypocretin-1 (orexin-A) concentrations in narcolepsy with and without cataplexy and idiopathic hypersomnia. J Sleep Res (2002) 2.60
Prospective 10-year surveillance of human prion diseases in Japan. Brain (2010) 2.41
A diet enriched with the omega-3 fatty acid docosahexaenoic acid reduces amyloid burden in an aged Alzheimer mouse model. J Neurosci (2005) 2.36
Delta1-Notch3 interactions bias the functional differentiation of activated CD4+ T cells. Immunity (2003) 2.34
Prospective comparison of the diagnostic potential of real-time PCR, double-sandwich enzyme-linked immunosorbent assay for galactomannan, and a (1-->3)-beta-D-glucan test in weekly screening for invasive aspergillosis in patients with hematological disorders. J Clin Microbiol (2004) 2.28
Ubiquitin carboxy-terminal hydrolase L1 binds to and stabilizes monoubiquitin in neuron. Hum Mol Genet (2003) 2.24
Recurrent mutations in multiple components of the cohesin complex in myeloid neoplasms. Nat Genet (2013) 2.14
Fbxw7 acts as a critical fail-safe against premature loss of hematopoietic stem cells and development of T-ALL. Genes Dev (2008) 2.12
Role of p21-activated kinase pathway defects in the cognitive deficits of Alzheimer disease. Nat Neurosci (2006) 2.09
Evi-1 is a critical regulator for hematopoietic stem cells and transformed leukemic cells. Cell Stem Cell (2008) 2.05
F3/contactin acts as a functional ligand for Notch during oligodendrocyte maturation. Cell (2003) 2.05
Presenilin-dependent intramembrane proteolysis of CD44 leads to the liberation of its intracellular domain and the secretion of an Abeta-like peptide. J Biol Chem (2002) 1.97
Evidence of novel neuronal functions of dysbindin, a susceptibility gene for schizophrenia. Hum Mol Genet (2004) 1.95
Gain-of-function mutations and copy number increases of Notch2 in diffuse large B-cell lymphoma. Cancer Sci (2009) 1.95
Genome-wide association study of schizophrenia in a Japanese population. Biol Psychiatry (2010) 1.89
Curcumin structure-function, bioavailability, and efficacy in models of neuroinflammation and Alzheimer's disease. J Pharmacol Exp Ther (2008) 1.86
Human dysbindin (DTNBP1) gene expression in normal brain and in schizophrenic prefrontal cortex and midbrain. Arch Gen Psychiatry (2004) 1.82
Hes1 immortalizes committed progenitors and plays a role in blast crisis transition in chronic myelogenous leukemia. Blood (2009) 1.78
Generation of Abeta38 and Abeta42 is independently and differentially affected by familial Alzheimer disease-associated presenilin mutations and gamma-secretase modulation. J Biol Chem (2007) 1.71
Insulin-degrading enzyme as a downstream target of insulin receptor signaling cascade: implications for Alzheimer's disease intervention. J Neurosci (2004) 1.62
Allogeneic hematopoietic stem cell transplantation from family members other than HLA-identical siblings over the last decade (1991-2000). Blood (2003) 1.60
Clinical significance of pulse rate rise during sleep as a screening marker for the assessment of sleep fragmentation in sleep-disordered breathing. Sleep Med (2003) 1.59
Meta-analysis of the association between variants in SORL1 and Alzheimer disease. Arch Neurol (2011) 1.59
Functional images reflect aggressiveness of endometrial carcinoma: estrogen receptor expression combined with 18F-FDG PET. J Nucl Med (2009) 1.57
Presenilins mediate a dual intramembranous gamma-secretase cleavage of Notch-1. EMBO J (2002) 1.57
Notch2 integrates signaling by the transcription factors RBP-J and CREB1 to promote T cell cytotoxicity. Nat Immunol (2008) 1.57
Differential regulation of osteoclastogenesis by Notch2/Delta-like 1 and Notch1/Jagged1 axes. Arthritis Res Ther (2012) 1.55
MYC rearrangements are useful for predicting outcomes following rituximab and chemotherapy: multicenter analysis of Japanese patients with diffuse large B-cell lymphoma. Leuk Lymphoma (2013) 1.55
Feasibility of 62Cu-ATSM PET for evaluation of brain ischaemia and misery perfusion in patients with cerebrovascular disease. Eur J Nucl Med Mol Imaging (2011) 1.53
A two-stage case-control association study of the dihydropyrimidinase-like 2 gene (DPYSL2) with schizophrenia in Japanese subjects. J Hum Genet (2010) 1.52
Tol2 transposon-mediated transgenesis in Xenopus tropicalis. Genesis (2006) 1.51
c-Maf plays a crucial role for the definitive erythropoiesis that accompanies erythroblastic island formation in the fetal liver. Blood (2011) 1.51
HES-1 preserves purified hematopoietic stem cells ex vivo and accumulates side population cells in vivo. Blood (2002) 1.51
The DYRK1A gene, encoded in chromosome 21 Down syndrome critical region, bridges between beta-amyloid production and tau phosphorylation in Alzheimer disease. Hum Mol Genet (2006) 1.50
A focused microarray approach to functional glycomics: transcriptional regulation of the glycome. Glycobiology (2005) 1.49
MafB is essential for renal development and F4/80 expression in macrophages. Mol Cell Biol (2006) 1.48
Peripheral ethanolamine plasmalogen deficiency: a logical causative factor in Alzheimer's disease and dementia. J Lipid Res (2007) 1.48
Effects of voriconazole co-administration on oxycodone-induced adverse events: a case in the retrospective survey. Eur J Clin Pharmacol (2011) 1.44
Secretion of the Notch-1 Abeta-like peptide during Notch signaling. J Biol Chem (2006) 1.44
Antineoplastic effect of a single oral dose of the novel Flt3 inhibitor KRN383 on xenografted human leukemic cells harboring Flt3-activating mutations. Leuk Res (2006) 1.42
Induction of neuronal death by ER stress in Alzheimer's disease. J Chem Neuroanat (2004) 1.42
Atlas stumbled: kinesin light chain-1 variant E triggers a vicious cycle of axonal transport disruption and amyloid-β generation in Alzheimer's disease. Bioessays (2014) 1.41
Stem cell leukemia protein directs hematopoietic stem cell fate. Blood (2004) 1.41
Neuroprotective effects of lithium in cultured cells and animal models of diseases. Bipolar Disord (2002) 1.41
Important functional role of residue x of the presenilin GxGD protease active site motif for APP substrate cleavage specificity and substrate selectivity of γ-secretase. J Neurochem (2013) 1.40
Progressive changes of white matter integrity in schizophrenia revealed by diffusion tensor imaging. Psychiatry Res (2007) 1.39
Radioactive iodine (131I) therapy for differentiated thyroid cancer in Japan: current issues with historical review and future perspective. Ann Nucl Med (2011) 1.39
Mutations in UVSSA cause UV-sensitive syndrome and impair RNA polymerase IIo processing in transcription-coupled nucleotide-excision repair. Nat Genet (2012) 1.38
Age-related decline in circadian output. J Neurosci (2011) 1.38
Validation of grading scale for evaluating symptoms of idiopathic normal-pressure hydrocephalus. Dement Geriatr Cogn Disord (2007) 1.36
Impaired long-term memory retention and working memory in sdy mutant mice with a deletion in Dtnbp1, a susceptibility gene for schizophrenia. Mol Brain (2008) 1.35
Highly efficient ex vivo expansion of human hematopoietic stem cells using Delta1-Fc chimeric protein. Stem Cells (2006) 1.35
Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 1.35
Dietary n-3 polyunsaturated fatty acid depletion activates caspases and decreases NMDA receptors in the brain of a transgenic mouse model of Alzheimer's disease. Eur J Neurosci (2005) 1.30
Neuropsychiatric symptoms in patients with idiopathic normal pressure hydrocephalus. Behav Neurol (2009) 1.29
The dorsomedial hypothalamic nucleus is not necessary for food-anticipatory circadian rhythms of behavior, temperature or clock gene expression in mice. Eur J Neurosci (2009) 1.28
Rotation mechanism of Enterococcus hirae V1-ATPase based on asymmetric crystal structures. Nature (2013) 1.26
Expression of the circadian clock gene Period2 in the hippocampus: possible implications for synaptic plasticity and learned behaviour. ASN Neuro (2009) 1.26
Evaluation of genome-wide power of genetic association studies based on empirical data from the HapMap project. Hum Mol Genet (2007) 1.25
Novel γ-secretase enzyme modulators directly target presenilin protein. J Biol Chem (2011) 1.24
AML1/Runx1 negatively regulates quiescent hematopoietic stem cells in adult hematopoiesis. J Immunol (2008) 1.24
Is misery perfusion still a predictor of stroke in symptomatic major cerebral artery disease? Brain (2012) 1.23
Intramembrane processing by signal peptide peptidase regulates the membrane localization of hepatitis C virus core protein and viral propagation. J Virol (2008) 1.23
JAGGED1 and delta1 differentially regulate the outcome of experimental autoimmune encephalomyelitis. J Immunol (2007) 1.23