Published in Drug Metab Dispos on March 15, 2006
Metabolism and disposition of dasatinib after oral administration to humans. Drug Metab Dispos (2008) 1.74
Prevalence of HBV and HBV vaccination coverage in health care workers of tertiary hospitals of Peshawar, Pakistan. Virol J (2011) 1.44
Retracted Aurora kinase-C-T191D is constitutively active mutant. BMC Cell Biol (2012) 1.40
Hepatitis C virus genotypes in Pakistan: a systemic review. Virol J (2011) 1.27
2011 White paper on recent issues in bioanalysis and regulatory findings from audits and inspections. Bioanalysis (2011) 1.12
Analytical ultracentrifugation combined with X-ray and neutron scattering: Experiment and modelling. Methods (2011) 1.09
2012 white paper on recent issues in bioanalysis and alignment of multiple guidelines. Bioanalysis (2012) 1.09
LC-FAIMS-MS/MS for quantification of a peptide in plasma and evaluation of FAIMS global selectivity from plasma components. Anal Chem (2008) 1.08
Trend of transfusion transmitted infections frequency in blood donors: provide a road map for its prevention and control. J Transl Med (2012) 1.06
Phospholipids in liquid chromatography/mass spectrometry bioanalysis: comparison of three tandem mass spectrometric techniques for monitoring plasma phospholipids, the effect of mobile phase composition on phospholipids elution and the association of phospholipids with matrix effects. Rapid Commun Mass Spectrom (2009) 1.04
Complement factor H-ligand interactions: self-association, multivalency and dissociation constants. Immunobiology (2011) 1.01
Common genotypes of hepatitis B virus. J Coll Physicians Surg Pak (2004) 1.01
Comparative metabolism of 14C-labeled apixaban in mice, rats, rabbits, dogs, and humans. Drug Metab Dispos (2009) 0.95
Overcoming bioanalytical challenges in an Onglyza(®) intravenous [(14)C]microdose absolute bioavailability study with accelerator MS. Bioanalysis (2012) 0.91
Quantification of 4-beta-hydroxycholesterol in human plasma using automated sample preparation and LC-ESI-MS/MS analysis. Chem Res Toxicol (2011) 0.90
Cytochrome P450 3A-mediated metabolism of buspirone in human liver microsomes. Drug Metab Dispos (2005) 0.90
Approach to evaluating dried blood spot sample stability during drying process and discovery of a treated card to maintain analyte stability by rapid on-card pH modification. Anal Chem (2011) 0.90
Multiple interactions of complement Factor H with its ligands in solution: a progress report. Adv Exp Med Biol (2010) 0.89
Lacteal secretion, fetal and maternal tissue distribution of dasatinib in rats. Drug Metab Dispos (2008) 0.88
Rabies molecular virology, diagnosis, prevention and treatment. Virol J (2012) 0.87
Characterization of the in vitro and in vivo metabolism and disposition and cytochrome P450 inhibition/induction profile of saxagliptin in human. Drug Metab Dispos (2012) 0.86
A universal surrogate peptide to enable LC-MS/MS bioanalysis of a diversity of human monoclonal antibody and human Fc-fusion protein drug candidates in pre-clinical animal studies. Biomed Chromatogr (2012) 0.85
The effects of endosulfan on the testes of bluegill fish, Lepomis macrochirus: a histopathological study. Arch Environ Contam Toxicol (2006) 0.84
Biotransformation of [14C]dasatinib: in vitro studies in rat, monkey, and human and disposition after administration to rats and monkeys. Drug Metab Dispos (2008) 0.84
Prevalence of hepatitis B virus genotypes in HBsAg positive individuals of Afghanistan. Virol J (2011) 0.84
A novel high-throughput automated chip-based nanoelectrospray tandem mass spectrometric method for PAMPA sample analysis. J Pharm Biomed Anal (2005) 0.84
Effect of mobile phase pH, aqueous-organic ratio, and buffer concentration on electrospray ionization tandem mass spectrometric fragmentation patterns: implications in liquid chromatography/tandem mass spectrometric bioanalysis. Rapid Commun Mass Spectrom (2010) 0.84
2010 white paper on recent issues in regulated bioanalysis & global harmonization of bioanalytical guidance. Bioanalysis (2010) 0.83
It is time for a paradigm shift in drug discovery bioanalysis: from SRM to HRMS. J Mass Spectrom (2011) 0.82
Active hepatitis C infection and HCV genotypes prevalent among the IDUs of Khyber Pakhtunkhwa. Virol J (2011) 0.82
Disposition of [1'-(14)C]stavudine after oral administration to humans. Drug Metab Dispos (2010) 0.82
Bioavailability enhancement of a poorly water-soluble drug by solid dispersion in polyethylene glycol-polysorbate 80 mixture. Int J Pharm (2004) 0.82
High-field asymmetric waveform ion mobility spectrometry coupled with liquid chromatography/electrospray ionization tandem mass spectrometry (LC/ESI-FAIMS-MS/MS) multi-component bioanalytical method development, performance evaluation and demonstration of the constancy of the compensation voltage with change of mobile phase composition or flow rate. Rapid Commun Mass Spectrom (2007) 0.82
Fit-for-purpose bioanalytical cross-validation for LC-MS/MS assays in clinical studies. Bioanalysis (2013) 0.81
Quantitative analysis of polyethylene glycol (PEG) and PEGylated proteins in animal tissues by LC-MS/MS coupled with in-source CID. Anal Chem (2014) 0.81
The use of a dual dye photometric calibration method to identify possible sample dilution from an automated multichannel liquid-handling system. Clin Lab Med (2007) 0.81
Attribution of the discrepancy between ELISA and LC-MS/MS assay results of a PEGylated scaffold protein in post-dose monkey plasma samples due to the presence of anti-drug antibodies. Anal Bioanal Chem (2011) 0.81
High-resolution MS in regulated bioanalysis: where are we now and where do we go from here? Bioanalysis (2013) 0.80
Plasma phospholipids implicated in the matrix effect observed in liquid chromatography/tandem mass spectrometry bioanalysis: evaluation of the use of colloidal silica in combination with divalent or trivalent cations for the selective removal of phospholipids from plasma. Rapid Commun Mass Spectrom (2008) 0.80
Validation of 4β-hydroxycholesterol and evaluation of other endogenous biomarkers for the assessment of CYP3A activity in healthy subjects. Br J Clin Pharmacol (2014) 0.79
Targeted quantitative bioanalysis in plasma using liquid chromatography/high-resolution accurate mass spectrometry: an evaluation of global selectivity as a function of mass resolving power and extraction window, with comparison of centroid and profile modes. Rapid Commun Mass Spectrom (2011) 0.79
Full-scan high resolution accurate mass spectrometry (HRMS) in regulated bioanalysis: LC-HRMS for the quantitation of prednisone and prednisolone in human plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.79
Pharmacokinetics and pharmacodynamics of the vasopeptidase inhibitor, omapatrilat in healthy subjects. Br J Clin Pharmacol (2003) 0.79
In vitro and in vivo metabolism and pharmacokinetics of BMS-562086, a potent and orally bioavailable corticotropin-releasing factor-1 receptor antagonist. Drug Metab Dispos (2012) 0.79
Prevalence of active HCV infection among the blood donors of Khyber Pakhtunkwa and FATA region of Pakistan and evaluation of the screening tests for anti-HCV. Virol J (2011) 0.78
Subchronic urinary bladder effects of muraglitazar in male rats. Toxicol Sci (2006) 0.78
Pellet digestion: a simple and efficient sample preparation technique for LC-MS/MS quantification of large therapeutic proteins in plasma. Bioanalysis (2012) 0.78
Novel MS solutions inspired by MIST. Bioanalysis (2010) 0.78
Systematic evaluation of the root cause of non-linearity in liquid chromatography/tandem mass spectrometry bioanalytical assays and strategy to predict and extend the linear standard curve range. Rapid Commun Mass Spectrom (2012) 0.78
High-field asymmetric waveform ion mobility spectrometry for determining the location of in-source collision-induced dissociation in electrospray ionization mass spectrometry. Anal Chem (2009) 0.78
LC-MS/MS method using unbonded silica column and aqueous/methanol mobile phase for the simultaneous quantification of a drug candidate and co-administered metformin in rat plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2010) 0.78
Cynomolgus monkey as a potential model to assess drug interactions involving hepatic organic anion transporting polypeptides: in vitro, in vivo, and in vitro-to-in vivo extrapolation. J Pharmacol Exp Ther (2013) 0.77
Comparative biotransformation of radiolabeled [(14)C]omapatrilat and stable-labeled [(13)C(2)]omapatrilat after oral administration to rats, dogs, and humans. Drug Metab Dispos (2003) 0.77
A strategy for liquid chromatography/tandem mass spectrometry based quantitation of pegylated protein drugs in plasma using plasma protein precipitation with water-miscible organic solvents and subsequent trypsin digestion to generate surrogate peptides for detection. Rapid Commun Mass Spectrom (2011) 0.77
A user-friendly robotic sample preparation program for fully automated biological sample pipetting and dilution to benefit the regulated bioanalysis. J Lab Autom (2012) 0.77
Response to combination therapy of HCV 3a infected Pakistani patients and the role of NS5A protein. Virol J (2011) 0.77
PCR/RFLP-based analysis of genetically distinct Plasmodium vivax population of Pvmsp-3α and Pvmsp-3β genes in Pakistan. Malar J (2014) 0.77
Cis-regulatory elements affecting the Nanos gene promoter in the germline stem cells. J Biotechnol (2009) 0.77
Protein covalent binding of maxipost through a cytochrome P450-mediated ortho-quinone methide intermediate in rats. Drug Metab Dispos (2003) 0.76
Mechanistic studies on a P450-mediated rearrangement of BMS-690514: conversion of a pyrrolotriazine to a hydroxypyridotriazine. Chem Res Toxicol (2010) 0.76
Biotransformation profiling of [(14)C]ixabepilone in human plasma, urine and feces samples using accelerator mass spectrometry (AMS). Drug Metab Pharmacokinet (2009) 0.76
Metabolism and disposition of [14C]BMS-690514 after oral administration to rats, rabbits, and dogs. Drug Metab Dispos (2010) 0.76
Metabolism, pharmacokinetics, and protein covalent binding of radiolabeled MaxiPost (BMS-204352) in humans. Drug Metab Dispos (2004) 0.76
In vitro characterization of the metabolic pathways and cytochrome P450 inhibition and induction potential of BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor. Drug Metab Dispos (2011) 0.75
Application of DNA comet assay for detection of radiation treatment of grams and pulses. J Food Sci Technol (2010) 0.75
Utility of porous graphitic carbon stationary phase in quantitative liquid chromatography/tandem mass spectrometry bioanalysis: quantitation of diastereomers in plasma. Rapid Commun Mass Spectrom (2006) 0.75
Dual universal peptide approach to bioanalysis of human monoclonal antibody protein drug candidates in animal studies. Bioanalysis (2013) 0.75
The synthesis of (14)C-labeled, (13)CD2-labeled saxagliptin, and its (13)CD2-labeled 5-hydroxy metabolite. J Labelled Comp Radiopharm (2014) 0.75
Synthesis of [3α-(3) H] 17α-hydroxy pregnenolone and [3α-(3) H] pregnenolone. J Labelled Comp Radiopharm (2013) 0.75
A simplified and completely automated workflow for regulated LC-MS/MS bioanalysis using cap-piercing direct sampling and evaporation-free solid phase extraction. J Chromatogr B Analyt Technol Biomed Life Sci (2013) 0.75
Integrated quantitative and qualitative workflow for in vivo bioanalytical support in drug discovery using hybrid Q-TOF-MS. Bioanalysis (2012) 0.75
Reductive isoxazole ring opening of the anticoagulant razaxaban is the major metabolic clearance pathway in rats and dogs. Drug Metab Dispos (2007) 0.75
Distinguishing a phosphate ester prodrug from its isobaric sulfate metabolite by mass spectrometry without the metabolite standard. Rapid Commun Mass Spectrom (2009) 0.75
Metabolism of [2-14C]p-hydroxyphenyl acetic acid in rat, monkey and human hepatocytes and in bile-duct cannulated rats. Xenobiotica (2010) 0.75
Identification of the oxidative and conjugative enzymes involved in the biotransformation of brivanib. Drug Metab Dispos (2011) 0.75
Synthesis of carbon-14 and stable isotope labeled Avagacestat: a novel gamma secretase inhibitor for the treatment of Alzheimer's disease. J Labelled Comp Radiopharm (2014) 0.75
An exploratory universal LC-MS/MS assay for bioanalysis of hinge region-stabilized human IgG4 mAbs in clinical studies. Bioanalysis (2014) 0.75
Metabolism and disposition of [14C]brivanib alaninate after oral administration to rats, monkeys, and humans. Drug Metab Dispos (2011) 0.75
Novelity in GB virus C/hepatitis G virus and its controversy. J Ayub Med Coll Abbottabad (2002) 0.75
Acivicin-induced alterations in renal and hepatic glutathione concentrations and in gamma-glutamyltransferase activities. Biochem Pharmacol (2004) 0.75
Increased productivity in quantitative bioanalysis using a monolithic column coupled with high-flow direct-injection liquid chromatography/tandem mass spectrometry. Rapid Commun Mass Spectrom (2006) 0.75
In vitro and in vivo metabolism of a gamma-secretase inhibitor BMS-299897 and generation of active metabolites in milligram quantities with a microbial bioreactor. Curr Drug Metab (2006) 0.75
Comparative metabolism of radiolabeled muraglitazar in animals and humans by quantitative and qualitative metabolite profiling. Drug Metab Dispos (2006) 0.75
Metabolism and disposition of [14C]BMS-690514, an ErbB/vascular endothelial growth factor receptor inhibitor, after oral administration to humans. Drug Metab Dispos (2010) 0.75
A rugged and accurate liquid chromatography-tandem mass spectrometry method for quantitative determination of BMS-790052 in plasma. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.75
Synthesis of a stable isotopically labeled universal surrogate peptide for use as an internal standard in LC-MS/MS bioanalysis of human IgG and Fc-fusion protein drug candidates. J Labelled Comp Radiopharm (2014) 0.75
Metabolic chiral inversion of brivanib and its relevance to safety and pharmacology. Drug Metab Dispos (2012) 0.75
Theory-guided efficient strategy to maximize speed and resolution in rapid gradient LC-MS/MS bioanalysis. J Chromatogr B Analyt Technol Biomed Life Sci (2011) 0.75
High-throughput quantitation of nefazodone and its metabolites in human plasma by high flow direct-injection LC-MS/MS. J Pharm Biomed Anal (2007) 0.75
An alternative and robust synthesis of [(13) C4 ]Baraclude® (entecavir). J Labelled Comp Radiopharm (2013) 0.75
The synthesis of 14C-labeled N-succinimidyl-3-maleimidopropionate, a linker molecule for PEGylated biologics. J Labelled Comp Radiopharm (2014) 0.75
Molecular detection of Toxoplasma gondii in water sources of district Nowshehra, Khyber Pakhtunkhwa, Pakistan. J Toxicol Environ Health A (2013) 0.75