Published in Circulation on March 21, 2006
A randomized, double-blind, placebo-controlled, dose-escalation study of intravenous adult human mesenchymal stem cells (prochymal) after acute myocardial infarction. J Am Coll Cardiol (2009) 8.13
Mechanisms underlying acute protection from cardiac ischemia-reperfusion injury. Physiol Rev (2008) 5.52
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res (2010) 5.47
Monocytes: protagonists of infarct inflammation and repair after myocardial infarction. Circulation (2010) 3.37
Cardiomyogenesis in the adult human heart. Circ Res (2010) 2.79
c-kit+ precursors support postinfarction myogenesis in the neonatal, but not adult, heart. Proc Natl Acad Sci U S A (2012) 2.35
Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med (2009) 2.15
A distinct type of cell in myocardium: interstitial Cajal-like cells (ICLCs). J Cell Mol Med (2009) 1.84
Ageing, menopause, and ischaemic heart disease mortality in England, Wales, and the United States: modelling study of national mortality data. BMJ (2011) 1.73
Stem cell factor gene transfer promotes cardiac repair after myocardial infarction via in situ recruitment and expansion of c-kit+ cells. Circ Res (2012) 1.68
The intersection between aging and cardiovascular disease. Circ Res (2012) 1.61
c-kit is required for cardiomyocyte terminal differentiation. Circ Res (2008) 1.58
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
Progenitor cells isolated from the human heart: a potential cell source for regenerative therapy. Neth Heart J (2008) 1.51
The roles of senescence and telomere shortening in cardiovascular disease. Nat Rev Cardiol (2013) 1.48
Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells. Circ Res (2012) 1.37
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33
Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ Res (2009) 1.32
Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31
Cardiac hypertrophy involves both myocyte hypertrophy and hyperplasia in anemic zebrafish. PLoS One (2009) 1.27
Epicardium: interstitial Cajal-like cells (ICLC) highlighted by immunofluorescence. J Cell Mol Med (2009) 1.27
Endoscopic time-lapse imaging of immune cells in infarcted mouse hearts. Circ Res (2013) 1.26
Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16
Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One (2011) 1.14
Relative roles of CD90 and c-kit to the regenerative efficacy of cardiosphere-derived cells in humans and in a mouse model of myocardial infarction. J Am Heart Assoc (2014) 1.13
Pharmacologic and genetic strategies to enhance cell therapy for cardiac regeneration. J Mol Cell Cardiol (2011) 1.04
Endothelial cells contribute to generation of adult ventricular myocytes during cardiac homeostasis. Cell Rep (2014) 1.02
Recent insights into the molecular mechanisms involved in aging and the malignant transformation of adult stem/progenitor cells and their therapeutic implications. Ageing Res Rev (2008) 1.02
Stem cell transplant into preimplantation embryo yields myocardial infarction-resistant adult phenotype. Stem Cells (2009) 1.01
Atherosclerosis as a disease of failed endogenous repair. Front Biosci (2008) 1.00
Stem cell-based therapies in ischemic heart diseases: a focus on aspects of microcirculation and inflammation. Basic Res Cardiol (2011) 1.00
Protein O-GlcNAcylation is a novel cytoprotective signal in cardiac stem cells. Stem Cells (2013) 0.99
Asymmetric chromatid segregation in cardiac progenitor cells is enhanced by Pim-1 kinase. Circ Res (2012) 0.98
Cardiac stem cell therapy for cardiac repair. Curr Treat Options Cardiovasc Med (2014) 0.96
Potential of cardiac stem/progenitor cells and induced pluripotent stem cells for cardiac repair in ischaemic heart disease. Clin Sci (Lond) (2013) 0.95
Skeletal myoblasts for cardiac repair. Regen Med (2010) 0.95
Resident vascular progenitor cells: an emerging role for non-terminally differentiated vessel-resident cells in vascular biology. Stem Cell Res (2008) 0.94
Embryonic and foetal Islet-1 positive cells in human hearts are also positive to c-Kit. Eur J Histochem (2011) 0.93
ATP-sensitive K(+) channel-deficient dilated cardiomyopathy proteome remodeled by embryonic stem cell therapy. Stem Cells (2010) 0.93
Increased apoptosis and myocyte enlargement with decreased cardiac mass; distinctive features of the aging male, but not female, monkey heart. J Mol Cell Cardiol (2007) 0.92
Building a new heart from old parts: stem cell turnover in the aging heart. Circ Res (2010) 0.92
Considerations in designing systems for large scale production of human cardiomyocytes from pluripotent stem cells. Stem Cell Res Ther (2014) 0.92
Characterization of a novel cardiac isoform of the cell cycle-related kinase that is regulated during heart failure. J Biol Chem (2008) 0.90
Myocardial uptake of 99mTc-annexin-V and 111In-antimyosin-antibodies after ischemia-reperfusion in rats. Eur J Nucl Med Mol Imaging (2007) 0.90
Innate regeneration in the aging heart: healing from within. Mayo Clin Proc (2013) 0.89
Stem cell factor expression after renal ischemia promotes tubular epithelial survival. PLoS One (2010) 0.89
Revertant fibers in the mdx murine model of Duchenne muscular dystrophy: an age- and muscle-related reappraisal. PLoS One (2013) 0.88
Metabolic modulation and cellular therapy of cardiac dysfunction and failure. J Cell Mol Med (2009) 0.87
K(ATP) channel-dependent metaboproteome decoded: systems approaches to heart failure prediction, diagnosis, and therapy. Cardiovasc Res (2011) 0.86
Stem cells for heart failure in the aging heart. Heart Fail Rev (2010) 0.86
Mesenchymal stem cells: emerging therapy for Duchenne muscular dystrophy. PM R (2009) 0.86
Exercise for the heart: signaling pathways. Oncotarget (2015) 0.85
Stem cell therapy for heart failure. Methodist Debakey Cardiovasc J (2013) 0.85
Cell transplantation for cardiac regeneration: where do we stand? Neth Heart J (2008) 0.84
Mouse strain determines cardiac growth potential. PLoS One (2013) 0.84
Abi3bp regulates cardiac progenitor cell proliferation and differentiation. Circ Res (2014) 0.83
The Role of MicroRNAs in Cardiac Stem Cells. Stem Cells Int (2015) 0.83
Expression profile of microRNAs regulating proliferation and differentiation in mouse adult cardiac stem cells. PLoS One (2013) 0.83
Cardiac progenitors and the embryonic cell cycle. Cell Cycle (2007) 0.83
Stem cell stimulation of endogenous myocyte regeneration. Clin Sci (Lond) (2013) 0.83
Cell therapy in congestive heart failure. J Zhejiang Univ Sci B (2007) 0.83
Intervention for apoptosis in cardiomyopathy. Heart Fail Rev (2008) 0.83
The existence of myocardial repair: mechanistic insights and enhancements. Cardiol Rev (2013) 0.82
Reactive Oxygen Species in Mesenchymal Stem Cell Aging: Implication to Lung Diseases. Oxid Med Cell Longev (2015) 0.82
Injectable hydrogel as stem cell scaffolds from the thermosensitive terpolymer of NIPAAm/AAc/HEMAPCL. Int J Nanomedicine (2012) 0.82
Stem cells from in- or outside of the heart: isolation, characterization, and potential for myocardial tissue regeneration. Pediatr Cardiol (2009) 0.81
In vitro epigenetic reprogramming of human cardiac mesenchymal stromal cells into functionally competent cardiovascular precursors. PLoS One (2012) 0.81
Cardiac Hegemony of Senescence. Curr Transl Geriatr Exp Gerontol Rep (2013) 0.81
Cardiac stem cells: A promising treatment option for heart failure. Exp Ther Med (2012) 0.81
Cardiomyocyte regeneration. Cells (2013) 0.80
Growth factors induce the improved cardiac remodeling in autologous mesenchymal stem cell-implanted failing rat hearts. J Zhejiang Univ Sci B (2010) 0.80
Nox2 and Nox4 influence neonatal c-kit(+) cardiac precursor cell status and differentiation. Am J Physiol Heart Circ Physiol (2013) 0.80
Cell therapy for heart disease: where are we in 2011? J Am Coll Cardiol (2011) 0.80
The Potential of GMP-Compliant Platelet Lysate to Induce a Permissive State for Cardiovascular Transdifferentiation in Human Mediastinal Adipose Tissue-Derived Mesenchymal Stem Cells. Biomed Res Int (2015) 0.79
SDF-1-enhanced cardiogenesis requires CXCR4 induction in pluripotent stem cells. J Cardiovasc Transl Res (2010) 0.79
Stochastic control of proliferation and differentiation in stem cell dynamics. J Math Biol (2014) 0.79
In vivo magnetic resonance imaging tracking of transplanted superparamagnetic iron oxide-labeled bone marrow mesenchymal stem cells in rats with myocardial infarction. Mol Med Rep (2014) 0.79
Characterization of contracting cardiomyocyte colonies in the primary culture of neonatal rat myocardial cells: a model of in vitro cardiomyogenesis. Cell Cycle (2014) 0.79
Myostatin regulates tissue potency and cardiac calcium-handling proteins. Endocrinology (2014) 0.78
Trophic actions of bone marrow-derived mesenchymal stromal cells for muscle repair/regeneration. Cells (2012) 0.78
Telomere length and the risk of atrial fibrillation: insights into the role of biological versus chronological aging. Circ Arrhythm Electrophysiol (2014) 0.78
Developmental origin and lineage plasticity of endogenous cardiac stem cells. Development (2016) 0.77
p21(WAF1/Cip1/Sdi1) knockout mice respond to doxorubicin with reduced cardiotoxicity. Toxicol Appl Pharmacol (2011) 0.77
Differentiation induction of mouse cardiac stem cells into sinus node-like cells by co-culturing with sinus node. Int J Clin Exp Pathol (2014) 0.76
Postmyocardial infarct remodeling and heart failure: potential contributions from pro- and antiaging factors. Cardiol Res Pract (2011) 0.76
Cardiac regeneration in children. Pediatr Cardiol (2015) 0.76
Genesis of myocardial repair with cardiac progenitor cells and tissue engineering. Heart Asia (2010) 0.75
Cardiac stem cells in patients with heart disease. Exp Ther Med (2013) 0.75
Interactions between the regulatory subunit of type I protein kinase A and p90 ribosomal S6 kinase1 regulate cardiomyocyte apoptosis. Mol Pharmacol (2013) 0.75
Reversal of ischemic cardiomyopathy with Sca-1+ stem cells modified with multiple growth factors. PLoS One (2014) 0.75
Stem cell therapies for heart disease: why do we need bioengineers? IEEE Eng Med Biol Mag (2007) 0.75
Transcription factor-induced activation of cardiac gene expression in human c-kit+ cardiac progenitor cells. PLoS One (2017) 0.75
Potential and clinical utility of stem cells in cardiovascular disease. Stem Cells Cloning (2010) 0.75
Myocardial Viability on Cardiac Magnetic Resonance. Arq Bras Cardiol (2017) 0.75
Tilianin Post-Conditioning Attenuates Myocardial Ischemia/Reperfusion Injury via Mitochondrial Protection and Inhibition of Apoptosis. Med Sci Monit (2017) 0.75
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
Concern Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet (2011) 11.45
Chimerism of the transplanted heart. N Engl J Med (2002) 8.69
Human cardiac stem cells. Proc Natl Acad Sci U S A (2007) 7.76
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med (2007) 6.68
Evidence for human lung stem cells. N Engl J Med (2011) 5.67
Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A (2006) 4.58
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res (2004) 4.13
Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res (2005) 3.93
Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A (2005) 3.93
Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A (2005) 3.64
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation (2010) 3.42
Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res (2004) 3.39
Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev (2005) 3.30
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res (2008) 3.07
Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 2.95
Nuclear targeting of Akt enhances kinase activity and survival of cardiomyocytes. Circ Res (2004) 2.91
The ubiquitous role of nitric oxide in cardioprotection. J Mol Cell Cardiol (2005) 2.89
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation (2012) 2.83
Cardiomyogenesis in the adult human heart. Circ Res (2010) 2.79
Myocyte turnover in the aging human heart. Circ Res (2010) 2.77
Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res (2011) 2.76
Diabetes promotes cardiac stem cell aging and heart failure, which are prevented by deletion of the p66shc gene. Circ Res (2006) 2.71
Clonality of mouse and human cardiomyogenesis in vivo. Proc Natl Acad Sci U S A (2009) 2.60
Protein kinase Cepsilon interacts with and inhibits the permeability transition pore in cardiac mitochondria. Circ Res (2003) 2.52
Aging and disease as modifiers of efficacy of cell therapy. Circ Res (2008) 2.51
Cells expressing early cardiac markers reside in the bone marrow and are mobilized into the peripheral blood after myocardial infarction. Circ Res (2004) 2.50
Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res (2003) 2.45
Pim-1 regulates cardiomyocyte survival downstream of Akt. Nat Med (2007) 2.39
Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation (2011) 2.38
Adolescent feline heart contains a population of small, proliferative ventricular myocytes with immature physiological properties. Circ Res (2007) 2.38
Cardiac myocyte-specific expression of inducible nitric oxide synthase protects against ischemia/reperfusion injury by preventing mitochondrial permeability transition. Circulation (2008) 2.37
PI3K rescues the detrimental effects of chronic Akt activation in the heart during ischemia/reperfusion injury. J Clin Invest (2005) 2.36
Stromal cell derived factor-1 alpha confers protection against myocardial ischemia/reperfusion injury: role of the cardiac stromal cell derived factor-1 alpha CXCR4 axis. Circulation (2007) 2.35
Akt promotes increased cardiomyocyte cycling and expansion of the cardiac progenitor cell population. Circ Res (2006) 2.34
Exogenous high-mobility group box 1 protein induces myocardial regeneration after infarction via enhanced cardiac C-kit+ cell proliferation and differentiation. Circ Res (2005) 2.32
Activation of cardiac progenitor cells reverses the failing heart senescent phenotype and prolongs lifespan. Circ Res (2008) 2.31
Cardiac progenitor cells and biotinylated insulin-like growth factor-1 nanofibers improve endogenous and exogenous myocardial regeneration after infarction. Circulation (2009) 2.30
Recombinant human erythropoietin protects the myocardium from ischemia-reperfusion injury and promotes beneficial remodeling. Proc Natl Acad Sci U S A (2003) 2.28
Myocyte death, growth, and regeneration in cardiac hypertrophy and failure. Circ Res (2003) 2.26
Effect of aspirin on late preconditioning against myocardial stunning in conscious rabbits. J Am Coll Cardiol (2003) 2.23
Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci U S A (2009) 2.23
Notch1 regulates the fate of cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.22
Cardioprotective effects of short-term caloric restriction are mediated by adiponectin via activation of AMP-activated protein kinase. Circulation (2007) 2.20
Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery. Circulation (2013) 2.19
Retracted Cardiomyogenesis in the aging and failing human heart. Circulation (2012) 2.16
IL-6 plays an obligatory role in late preconditioning via JAK-STAT signaling and upregulation of iNOS and COX-2. Cardiovasc Res (2004) 2.12
Cardiac-specific IGF-1 expression attenuates dilated cardiomyopathy in tropomodulin-overexpressing transgenic mice. Circ Res (2002) 2.11
Dissecting the molecular relationship among various cardiogenic progenitor cells. Circ Res (2013) 2.06
Formation of large coronary arteries by cardiac progenitor cells. Proc Natl Acad Sci U S A (2008) 2.05
Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res (2011) 1.98
Postinfarct cytokine therapy regenerates cardiac tissue and improves left ventricular function. Circ Res (2006) 1.98
Myocardial induction of nucleostemin in response to postnatal growth and pathological challenge. Circ Res (2008) 1.97