Published in Proc Natl Acad Sci U S A on August 20, 2007
Concern Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet (2011) 11.45
Heart regeneration. Nature (2011) 5.91
Evidence for human lung stem cells. N Engl J Med (2011) 5.67
Bone marrow mesenchymal stem cells stimulate cardiac stem cell proliferation and differentiation. Circ Res (2010) 5.47
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56
Direct comparison of different stem cell types and subpopulations reveals superior paracrine potency and myocardial repair efficacy with cardiosphere-derived cells. J Am Coll Cardiol (2012) 3.48
Engraftment, differentiation, and functional benefits of autologous cardiosphere-derived cells in porcine ischemic cardiomyopathy. Circulation (2009) 3.45
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation (2010) 3.42
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res (2008) 3.07
Validation of the cardiosphere method to culture cardiac progenitor cells from myocardial tissue. PLoS One (2009) 2.89
Administration of cardiac stem cells in patients with ischemic cardiomyopathy: the SCIPIO trial: surgical aspects and interim analysis of myocardial function and viability by magnetic resonance. Circulation (2012) 2.83
Cardiomyogenesis in the adult human heart. Circ Res (2010) 2.79
Role of cardiac stem cells in cardiac pathophysiology: a paradigm shift in human myocardial biology. Circ Res (2011) 2.76
Clonality of mouse and human cardiomyogenesis in vivo. Proc Natl Acad Sci U S A (2009) 2.60
Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58
Enhanced effect of combining human cardiac stem cells and bone marrow mesenchymal stem cells to reduce infarct size and to restore cardiac function after myocardial infarction. Circulation (2012) 2.57
Origins and fates of cardiovascular progenitor cells. Cell (2008) 2.55
Cardiomyogenic potential of C-kit(+)-expressing cells derived from neonatal and adult mouse hearts. Circulation (2010) 2.52
Aging and disease as modifiers of efficacy of cell therapy. Circ Res (2008) 2.51
Human cardiac stem cell differentiation is regulated by a mircrine mechanism. Circulation (2011) 2.38
Cardiomyocyte precursors and telocytes in epicardial stem cell niche: electron microscope images. J Cell Mol Med (2010) 2.33
Identification of a coronary vascular progenitor cell in the human heart. Proc Natl Acad Sci U S A (2009) 2.23
Growth properties of cardiac stem cells are a novel biomarker of patients' outcome after coronary bypass surgery. Circulation (2013) 2.19
Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol (2012) 2.18
Human cardiomyocyte progenitor cells differentiate into functional mature cardiomyocytes: an in vitro model for studying human cardiac physiology and pathophysiology. Nat Protoc (2009) 2.16
Strategies to promote donor cell survival: combining preconditioning approach with stem cell transplantation. J Mol Cell Cardiol (2008) 2.16
Cardiac renewing: interstitial Cajal-like cells nurse cardiomyocyte progenitors in epicardial stem cell niches. J Cell Mol Med (2009) 2.15
Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation (2011) 1.99
Functionally competent cardiac stem cells can be isolated from endomyocardial biopsies of patients with advanced cardiomyopathies. Circ Res (2011) 1.98
Nerve growth factor promotes cardiac repair following myocardial infarction. Circ Res (2010) 1.94
Dedifferentiation and proliferation of mammalian cardiomyocytes. PLoS One (2010) 1.89
Isolation and expansion of functionally-competent cardiac progenitor cells directly from heart biopsies. J Mol Cell Cardiol (2010) 1.88
Cardiac stem cell therapy and the promise of heart regeneration. Cell Stem Cell (2013) 1.86
Cardiac muscle regeneration: lessons from development. Genes Dev (2011) 1.86
Regenerating new heart with stem cells. J Clin Invest (2013) 1.83
Stem and progenitor cell-based therapy in ischaemic heart disease: promise, uncertainties, and challenges. Eur Heart J (2011) 1.80
Evolution of the c-kit-positive cell response to pathological challenge in the myocardium. Stem Cells (2008) 1.80
Insulin-like growth factor-1 receptor identifies a pool of human cardiac stem cells with superior therapeutic potential for myocardial regeneration. Circ Res (2011) 1.77
Spontaneously beating cardiomyocytes derived from white mature adipocytes. Cardiovasc Res (2010) 1.76
Cardiac regenerative capacity and mechanisms. Annu Rev Cell Dev Biol (2012) 1.70
Increased cardiac myocyte progenitors in failing human hearts. Circulation (2008) 1.68
Activation of Toll-like receptor 3 amplifies mesenchymal stem cell trophic factors and enhances therapeutic potency. Am J Physiol Cell Physiol (2012) 1.67
Heart failure therapy mediated by the trophic activities of bone marrow mesenchymal stem cells: a noninvasive therapeutic regimen. Am J Physiol Heart Circ Physiol (2009) 1.64
Tracking chromatid segregation to identify human cardiac stem cells that regenerate extensively the infarcted myocardium. Circ Res (2012) 1.63
Anthracycline cardiomyopathy is mediated by depletion of the cardiac stem cell pool and is rescued by restoration of progenitor cell function. Circulation (2009) 1.62
Cardiac cell repair therapy: a clinical perspective. Mayo Clin Proc (2009) 1.62
Age-associated defects in EphA2 signaling impair the migration of human cardiac progenitor cells. Circulation (2013) 1.61
Pregenerative medicine: developmental paradigms in the biology of cardiovascular regeneration. J Clin Invest (2010) 1.57
Effects of age and heart failure on human cardiac stem cell function. Am J Pathol (2011) 1.57
Cardiogenic differentiation and transdifferentiation of progenitor cells. Circ Res (2008) 1.54
Mechanobiology of cardiomyocyte development. J Biomech (2009) 1.54
Intracoronary delivery of autologous cardiac stem cells improves cardiac function in a porcine model of chronic ischemic cardiomyopathy. Circulation (2013) 1.53
CD44posCD49fhiCD133/2hi defines xenograft-initiating cells in estrogen receptor-negative breast cancer. Cancer Res (2010) 1.52
Telocytes as supporting cells for myocardial tissue organization in developing and adult heart. J Cell Mol Med (2010) 1.52
Embryonic stem cell-derived exosomes promote endogenous repair mechanisms and enhance cardiac function following myocardial infarction. Circ Res (2015) 1.46
The advancing field of cell-based therapy: insights and lessons from clinical trials. J Am Heart Assoc (2013) 1.40
Relationships between telocytes and cardiomyocytes during pre- and post-natal life. J Cell Mol Med (2010) 1.40
Identification and functionality of proteomes secreted by rat cardiac stem cells and neonatal cardiomyocytes. Proteomics (2010) 1.38
Cardiomyogenesis in the developing heart is regulated by c-kit-positive cardiac stem cells. Circ Res (2012) 1.37
Mesenchymal stem cells and cardiac repair. J Cell Mol Med (2008) 1.37
Intracoronary administration of cardiac stem cells in mice: a new, improved technique for cell therapy in murine models. Basic Res Cardiol (2011) 1.36
Recent progress on tissue-resident adult stem cell biology and their therapeutic implications. Stem Cell Rev (2008) 1.36
Cell therapy for ischaemic heart disease: focus on the role of resident cardiac stem cells. Neth Heart J (2009) 1.35
Human cardiospheres are a source of stem cells with cardiomyogenic potential. Stem Cells (2010) 1.33
Bone-derived stem cells repair the heart after myocardial infarction through transdifferentiation and paracrine signaling mechanisms. Circ Res (2013) 1.33
Spontaneous calcium oscillations regulate human cardiac progenitor cell growth. Circ Res (2009) 1.32
Role of stem cells in cardiovascular biology. J Thromb Haemost (2011) 1.31
Cell-based therapy for prevention and reversal of myocardial remodeling. Am J Physiol Heart Circ Physiol (2012) 1.31
Structural coupling of cardiomyocytes and noncardiomyocytes: quantitative comparisons using a novel micropatterned cell pair assay. Am J Physiol Heart Circ Physiol (2008) 1.28
Magnetic enhancement of cell retention, engraftment, and functional benefit after intracoronary delivery of cardiac-derived stem cells in a rat model of ischemia/reperfusion. Cell Transplant (2012) 1.28
Stem cells for myocardial repair with use of a transarterial catheter. Circulation (2009) 1.26
Cardiac telocytes: serial dynamic images in cell culture. J Cell Mol Med (2010) 1.26
Empowering adult stem cells for myocardial regeneration. Circ Res (2011) 1.25
The heme oxygenase 1 inducer (CoPP) protects human cardiac stem cells against apoptosis through activation of the extracellular signal-regulated kinase (ERK)/NRF2 signaling pathway and cytokine release. J Biol Chem (2012) 1.24
Efficient differentiation of human induced pluripotent stem cells generates cardiac cells that provide protection following myocardial infarction in the rat. Stem Cells Dev (2012) 1.20
c-kit+ Cardiac stem cells alleviate post-myocardial infarction left ventricular dysfunction despite poor engraftment and negligible retention in the recipient heart. PLoS One (2014) 1.20
Stem cells in the heart: what's the buzz all about? Part 2: Arrhythmic risks and clinical studies. Heart Rhythm (2008) 1.19
Cardiac stem cell genetic engineering using the alphaMHC promoter. Regen Med (2009) 1.18
Cardiac regeneration. Curr Top Dev Biol (2012) 1.17
A highly sensitive and accurate method to quantify absolute numbers of c-kit+ cardiac stem cells following transplantation in mice. Basic Res Cardiol (2013) 1.17
Rebuilding the damaged heart: the potential of cytokines and growth factors in the treatment of ischemic heart disease. J Am Coll Cardiol (2010) 1.17
Developmental and regenerative biology of multipotent cardiovascular progenitor cells. Circ Res (2011) 1.16
Cardiac repair and regeneration: the Rubik's cube of cell therapy for heart disease. Dis Model Mech (2009) 1.16
c-Kit-positive cardiac stem cells nested in hypoxic niches are activated by stem cell factor reversing the aging myopathy. Circ Res (2013) 1.15
The ephrin A1-EphA2 system promotes cardiac stem cell migration after infarction. Circ Res (2011) 1.14
Human cardiac stem cells isolated from atrial appendages stably express c-kit. PLoS One (2011) 1.14
Early stem cell engraftment predicts late cardiac functional recovery: preclinical insights from molecular imaging. Circ Cardiovasc Imaging (2012) 1.13
Wnt signaling exerts an antiproliferative effect on adult cardiac progenitor cells through IGFBP3. Circ Res (2011) 1.13
Stem cells in the heart: what's the buzz all about?--Part 1: preclinical considerations. Heart Rhythm (2008) 1.11
Isolation of alveolar epithelial type II progenitor cells from adult human lungs. Lab Invest (2010) 1.11
Increased potency of cardiac stem cells compared with bone marrow mesenchymal stem cells in cardiac repair. Stem Cells Transl Med (2012) 1.10
Concise review: the role of clinical trials in deciphering mechanisms of action of cardiac cell-based therapy. Stem Cells Transl Med (2011) 1.09
Comparative study of immune regulatory properties of stem cells derived from different tissues. Stem Cells Dev (2013) 1.08
Strategies for cardiac regeneration and repair. Sci Transl Med (2014) 1.08
Concise review: heart regeneration and the role of cardiac stem cells. Stem Cells Transl Med (2013) 1.08
Resident c-kit(+) cells in the heart are not cardiac stem cells. Nat Commun (2015) 1.07
HMGB1 attenuates cardiac remodelling in the failing heart via enhanced cardiac regeneration and miR-206-mediated inhibition of TIMP-3. PLoS One (2011) 1.07
THY-1 receptor expression differentiates cardiosphere-derived cells with divergent cardiogenic differentiation potential. Stem Cell Reports (2014) 1.06
Active Wnt signaling in response to cardiac injury. Basic Res Cardiol (2010) 1.06
Progenitor cells from the explanted heart generate immunocompatible myocardium within the transplanted donor heart. Circ Res (2009) 1.06
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
Chimerism of the transplanted heart. N Engl J Med (2002) 8.69
Isolation and expansion of adult cardiac stem cells from human and murine heart. Circ Res (2004) 8.41
Cell intrinsic alterations underlie hematopoietic stem cell aging. Proc Natl Acad Sci U S A (2005) 6.32
Multipotent flk-1+ cardiovascular progenitor cells give rise to the cardiomyocyte, endothelial, and vascular smooth muscle lineages. Dev Cell (2006) 6.19
Developmental origin of a bipotential myocardial and smooth muscle cell precursor in the mammalian heart. Cell (2006) 5.03
Telomere length dynamics in human lymphocyte subpopulations measured by flow cytometry. Nat Biotechnol (1998) 4.68
Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A (2006) 4.58
Cardioprotective c-kit+ cells are from the bone marrow and regulate the myocardial balance of angiogenic cytokines. J Clin Invest (2006) 4.51
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A (2005) 3.93
Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev (2005) 3.30
Stable reprogrammed heterokaryons form spontaneously in Purkinje neurons after bone marrow transplant. Nat Cell Biol (2003) 3.03
Intense myocyte formation from cardiac stem cells in human cardiac hypertrophy. Proc Natl Acad Sci U S A (2003) 2.95
Transdifferentiation of blood-derived human adult endothelial progenitor cells into functionally active cardiomyocytes. Circulation (2003) 2.69
Senescence and death of primitive cells and myocytes lead to premature cardiac aging and heart failure. Circ Res (2003) 2.45
Cell-based cardiac repair: reflections at the 10-year point. Circulation (2005) 2.25
Stem cells: lost in translation. Nature (2004) 1.79
Gastrointestinal involvement in leukocytoclastic vasculitis and polyarteritis nodosa. J Rheumatol (1981) 1.42
Telomere length in subpopulations of human hematopoietic cells. Stem Cells (2003) 1.28
Human hepatic infarction: histopathological and postmortem angiological studies. Liver (1993) 1.23
Niche-dependent translineage commitment of endothelial progenitor cells, not cell fusion in general, into myocardial lineage cells. Arterioscler Thromb Vasc Biol (2005) 1.22
Acute renal infarction. J R Soc Med (2005) 1.12
Polyangitis overlap syndrome: a fatal case combined with adult Henoch-Schönlein purpura and polyarteritis nodosa. Pathol Int (2003) 1.10
Bone marrow embolism in sickle cell disease: a review. Am J Hematol (2005) 1.09
Patterns of myocardial histogenesis as revealed by mouse chimeras. Dev Biol (2005) 1.02
Adult cardiac stem cells are multipotent and support myocardial regeneration. Cell (2003) 18.09
Concern Cardiac stem cells in patients with ischaemic cardiomyopathy (SCIPIO): initial results of a randomised phase 1 trial. Lancet (2011) 11.45
Chimerism of the transplanted heart. N Engl J Med (2002) 8.69
Coronary bypass surgery with or without surgical ventricular reconstruction. N Engl J Med (2009) 7.71
Surgical treatment of moderate ischemic mitral regurgitation. N Engl J Med (2014) 7.23
Adult bone marrow-derived cells for cardiac repair: a systematic review and meta-analysis. Arch Intern Med (2007) 6.68
Myocardial viability and survival in ischemic left ventricular dysfunction. N Engl J Med (2011) 6.65
Mitral-valve repair versus replacement for severe ischemic mitral regurgitation. N Engl J Med (2013) 6.21
Evidence for human lung stem cells. N Engl J Med (2011) 5.67
Surgical ablation of atrial fibrillation during mitral-valve surgery. N Engl J Med (2015) 4.77
Stem cell niches in the adult mouse heart. Proc Natl Acad Sci U S A (2006) 4.58
Cardiac stem cell and myocyte aging, heart failure, and insulin-like growth factor-1 overexpression. Circ Res (2004) 4.13
Stem cells in the dog heart are self-renewing, clonogenic, and multipotent and regenerate infarcted myocardium, improving cardiac function. Proc Natl Acad Sci U S A (2005) 4.13
Cardiac stem cells possess growth factor-receptor systems that after activation regenerate the infarcted myocardium, improving ventricular function and long-term survival. Circ Res (2005) 3.93
Myocardial regeneration by activation of multipotent cardiac stem cells in ischemic heart failure. Proc Natl Acad Sci U S A (2005) 3.93
Cardiac stem cells delivered intravascularly traverse the vessel barrier, regenerate infarcted myocardium, and improve cardiac function. Proc Natl Acad Sci U S A (2005) 3.64
Cell therapy for heart failure: a comprehensive overview of experimental and clinical studies, current challenges, and future directions. Circ Res (2013) 3.56
Intracoronary administration of cardiac progenitor cells alleviates left ventricular dysfunction in rats with a 30-day-old infarction. Circulation (2010) 3.42
Bone marrow cells differentiate in cardiac cell lineages after infarction independently of cell fusion. Circ Res (2004) 3.39
Blood transfusion and infection after cardiac surgery. Ann Thorac Surg (2013) 3.35
Cardiac stem cells and mechanisms of myocardial regeneration. Physiol Rev (2005) 3.30
Two-Year Outcomes of Surgical Treatment of Severe Ischemic Mitral Regurgitation. N Engl J Med (2015) 3.11
Local activation or implantation of cardiac progenitor cells rescues scarred infarcted myocardium improving cardiac function. Circ Res (2008) 3.07
Bone marrow cells adopt the cardiomyogenic fate in vivo. Proc Natl Acad Sci U S A (2007) 3.06