Published in Nitric Oxide on March 24, 2006
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (2008) 3.99
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med (2007) 3.29
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Dietary nitrite supplementation protects against myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2007) 2.02
Dietary nitrate ameliorates pulmonary hypertension: cytoprotective role for endothelial nitric oxide synthase and xanthine oxidoreductase. Circulation (2012) 1.94
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res (2007) 1.69
Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. J Clin Invest (2011) 1.30
Strategies to increase nitric oxide signalling in cardiovascular disease. Nat Rev Drug Discov (2015) 1.18
Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response. Free Radic Biol Med (2009) 1.12
Inorganic nitrate ingestion improves vascular compliance but does not alter flow-mediated dilatation in healthy volunteers. Nitric Oxide (2012) 1.10
The reemergence of nitric oxide and cancer. Nitric Oxide (2008) 1.09
Nitrite in pulmonary arterial hypertension: therapeutic avenues in the setting of dysregulated arginine/nitric oxide synthase signalling. Cardiovasc Res (2010) 1.05
Nitrite in organ protection. Br J Pharmacol (2014) 0.93
Plasma nitrate and nitrite are increased by a high-nitrate supplement but not by high-nitrate foods in older adults. Nutr Res (2012) 0.92
Effect of beetroot juice on lowering blood pressure in free-living, disease-free adults: a randomized, placebo-controlled trial. Nutr J (2012) 0.90
A 21 day Daniel Fast improves selected biomarkers of antioxidant status and oxidative stress in men and women. Nutr Metab (Lond) (2011) 0.90
Nitrates and glucosinolates as strong determinants of the nutritional quality in rocket leafy salads. Nutrients (2014) 0.89
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol (2013) 0.88
Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress. Antioxid Redox Signal (2015) 0.86
Is nitric oxide a hormone? Iran Biomed J (2011) 0.86
Preserving vessel function during ischemic disease: new possibilities of inorganic nitrite therapy. Expert Rev Cardiovasc Ther (2008) 0.83
Impact of short-term dietary modification on postprandial oxidative stress. Nutr J (2012) 0.82
Single-dose pharmacokinetics of different oral sodium nitrite formulations in diabetes patients. Diabetes Technol Ther (2012) 0.82
Impact of flavonoid-rich black tea and beetroot juice on postprandial peripheral vascular resistance and glucose homeostasis in obese, insulin-resistant men: a randomized controlled trial. Nutr Metab (Lond) (2016) 0.78
Peripheral artery disease, redox signaling, oxidative stress - Basic and clinical aspects. Redox Biol (2017) 0.77
Beetroot juice reduces infarct size and improves cardiac function following ischemia-reperfusion injury: Possible involvement of endogenous H2S. Exp Biol Med (Maywood) (2014) 0.76
Visualization of NO3-/NO2- Dynamics in Living Cells by Fluorescence Resonance Energy Transfer (FRET) Imaging Employing a Rhizobial Two-component Regulatory System. J Biol Chem (2015) 0.75
Enterosalivary nitrate metabolism and the microbiome: intersection of microbial metabolism, nitric oxide and diet in cardiac and pulmonary vascular health. Free Radic Biol Med (2016) 0.75
Effects of spinach nitrate on insulin resistance, endothelial dysfunction markers and inflammation in mice with high-fat and high-fructose consumption. Food Nutr Res (2016) 0.75
The Protective Effect of Antioxidants Consumption on Diabetes and Vascular Complications. Diseases (2016) 0.75
The nitrate-nitrite-nitric oxide pathway in physiology and therapeutics. Nat Rev Drug Discov (2008) 7.58
Commensal anaerobic gut bacteria attenuate inflammation by regulating nuclear-cytoplasmic shuttling of PPAR-gamma and RelA. Nat Immunol (2003) 5.87
Nitrite is a signaling molecule and regulator of gene expression in mammalian tissues. Nat Chem Biol (2005) 3.46
Effects of dietary nitrate on blood pressure in healthy volunteers. N Engl J Med (2006) 3.29
The emerging biology of the nitrite anion. Nat Chem Biol (2005) 2.88
Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83
Supplementation with nitrate and nitrite salts in exercise: a word of caution. J Appl Physiol (1985) (2011) 2.71
Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab (2011) 2.61
Impaired expression of peroxisome proliferator-activated receptor gamma in ulcerative colitis. Gastroenterology (2003) 2.59
Nitrate, bacteria and human health. Nat Rev Microbiol (2004) 2.44
Cellular targets and mechanisms of nitros(yl)ation: an insight into their nature and kinetics in vivo. Proc Natl Acad Sci U S A (2004) 2.33
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15
Plasma nitroso compounds are decreased in patients with endothelial dysfunction. J Am Coll Cardiol (2006) 1.91
The increase in plasma nitrite after a dietary nitrate load is markedly attenuated by an antibacterial mouthwash. Nitric Oxide (2008) 1.87
A mammalian functional nitrate reductase that regulates nitrite and nitric oxide homeostasis. Nat Chem Biol (2008) 1.85
Plasma nitrite concentrations reflect the degree of endothelial dysfunction in humans. Free Radic Biol Med (2005) 1.85
A biochemical rationale for the discrete behavior of nitroxyl and nitric oxide in the cardiovascular system. Proc Natl Acad Sci U S A (2003) 1.78
Brief periods of nitric oxide inhalation protect against myocardial ischemia-reperfusion injury. Anesthesiology (2008) 1.77
Cardioprotective effects of thioredoxin in myocardial ischemia and reperfusion: role of S-nitrosation [corrected]. Proc Natl Acad Sci U S A (2004) 1.76
Concomitant presence of N-nitroso and S-nitroso proteins in human plasma. Free Radic Biol Med (2002) 1.71
Oxidation and nitrosation of thiols at low micromolar exposure to nitric oxide. Evidence for a free radical mechanism. J Biol Chem (2003) 1.68
NO generation from nitrite and its role in vascular control. Arterioscler Thromb Vasc Biol (2005) 1.58
Cerebral microdialysis of patients with severe traumatic brain injury exhibits highly individualistic patterns as visualized by cluster analysis with self-organizing maps. Crit Care Med (2004) 1.58
Roles of dietary inorganic nitrate in cardiovascular health and disease. Cardiovasc Res (2010) 1.58
Dietary inorganic nitrate reverses features of metabolic syndrome in endothelial nitric oxide synthase-deficient mice. Proc Natl Acad Sci U S A (2010) 1.56
Intragastric nitric oxide is abolished in intubated patients and restored by nitrite. Crit Care Med (2005) 1.53
Dietary nitrate attenuates oxidative stress, prevents cardiac and renal injuries, and reduces blood pressure in salt-induced hypertension. Cardiovasc Res (2010) 1.53
Cardiomyocyte-specific overexpression of NO synthase-3 protects against myocardial ischemia-reperfusion injury. Arterioscler Thromb Vasc Biol (2006) 1.49
Chemical nature of nitric oxide storage forms in rat vascular tissue. Proc Natl Acad Sci U S A (2002) 1.49
Modulation of nitrosative stress by S-nitrosoglutathione reductase is critical for thermotolerance and plant growth in Arabidopsis. Plant Cell (2008) 1.47
Dietary nitrate reduces maximal oxygen consumption while maintaining work performance in maximal exercise. Free Radic Biol Med (2009) 1.46
Evidence for in vivo transport of bioactive nitric oxide in human plasma. J Clin Invest (2002) 1.42
Nitrite in saliva increases gastric mucosal blood flow and mucus thickness. J Clin Invest (2004) 1.42
The chemistry of nitrosative stress induced by nitric oxide and reactive nitrogen oxide species. Putting perspective on stressful biological situations. Biol Chem (2004) 1.37
Measurement of nitric oxide levels in the red cell: validation of tri-iodide-based chemiluminescence with acid-sulfanilamide pretreatment. J Biol Chem (2006) 1.36
Genetic overexpression of eNOS attenuates hepatic ischemia-reperfusion injury. Am J Physiol Heart Circ Physiol (2006) 1.33
Nitric oxide is consumed, rather than conserved, by reaction with oxyhemoglobin under physiological conditions. Proc Natl Acad Sci U S A (2002) 1.30
NO adducts in mammalian red blood cells: too much or too little? Nat Med (2003) 1.30
NO-synthase independent NO generation in mammals. Biochem Biophys Res Commun (2010) 1.30
Nitroxyl affords thiol-sensitive myocardial protective effects akin to early preconditioning. Free Radic Biol Med (2003) 1.28
Transfusion of stored autologous blood does not alter reactive hyperemia index in healthy volunteers. Anesthesiology (2012) 1.20
Guide for the use of nitric oxide (NO) donors as probes of the chemistry of NO and related redox species in biological systems. Methods Enzymol (2002) 1.20
Dietary nitrate increases tetanic [Ca2+]i and contractile force in mouse fast-twitch muscle. J Physiol (2012) 1.19
Gastroprotective and blood pressure lowering effects of dietary nitrate are abolished by an antiseptic mouthwash. Free Radic Biol Med (2009) 1.18
Comparison of a single indicator and gravimetric technique for estimation of extravascular lung water in endotoxemic pigs. Crit Care Med (2006) 1.18
Physiological role for nitrate-reducing oral bacteria in blood pressure control. Free Radic Biol Med (2012) 1.18
Circulating NO pool: assessment of nitrite and nitroso species in blood and tissues. Free Radic Biol Med (2004) 1.15
Orthogonal properties of the redox siblings nitroxyl and nitric oxide in the cardiovascular system: a novel redox paradigm. Am J Physiol Heart Circ Physiol (2003) 1.15
The role of nitrogen oxides in human adaptation to hypoxia. Sci Rep (2011) 1.14
Therapeutic uses of inorganic nitrite and nitrate: from the past to the future. Circulation (2008) 1.13
Plasma nitrosothiols contribute to the systemic vasodilator effects of intravenously applied NO: experimental and clinical Study on the fate of NO in human blood. Circ Res (2002) 1.11
Human red blood cells at work: identification and visualization of erythrocytic eNOS activity in health and disease. Blood (2012) 1.11
Dietary nitrate supplementation improves revascularization in chronic ischemia. Circulation (2012) 1.10
Technology insight: calprotectin, lactoferrin and nitric oxide as novel markers of inflammatory bowel disease. Nat Clin Pract Gastroenterol Hepatol (2005) 1.05
Nitrated oleic acid up-regulates PPARgamma and attenuates experimental inflammatory bowel disease. Free Radic Biol Med (2009) 1.04
Outcome of traumatic brain injuries in 1,508 patients: impact of prehospital care. J Neurotrauma (2002) 1.04
Thiols enhance NO formation from nitrate photolysis. Free Radic Biol Med (2003) 1.03
Mechanistic insights into nitrite-induced cardioprotection using an integrated metabolomic/proteomic approach. Circ Res (2009) 1.03
Autologous transfusion of stored red blood cells increases pulmonary artery pressure. Am J Respir Crit Care Med (2014) 1.02
Biology of nitrogen oxides in the gastrointestinal tract. Gut (2012) 1.02
Dietary nitrate increases gastric mucosal blood flow and mucosal defense. Am J Physiol Gastrointest Liver Physiol (2006) 1.02
Differential nitros(yl)ation of blood and tissue constituents during glyceryl trinitrate biotransformation in vivo. Proc Natl Acad Sci U S A (2004) 1.02
Comparison of the reactivity of nitric oxide and nitroxyl with heme proteins. A chemical discussion of the differential biological effects of these redox related products of NOS. J Inorg Biochem (2003) 1.00
Extended analysis of early computed tomography scans of traumatic brain injured patients and relations to outcome. J Neurotrauma (2010) 0.99
Performance of diamino fluorophores for the localization of sources and targets of nitric oxide. Free Radic Biol Med (2005) 0.99
Protection from nonsteroidal anti-inflammatory drug (NSAID)-induced gastric ulcers by dietary nitrate. Free Radic Biol Med (2006) 0.98
Rectal nitric oxide gas and stool cytokine levels during the course of infectious gastroenteritis. Clin Diagn Lab Immunol (2004) 0.95
The role of vascular myoglobin in nitrite-mediated blood vessel relaxation. Cardiovasc Res (2010) 0.95
NO generation from inorganic nitrate and nitrite: Role in physiology, nutrition and therapeutics. Arch Pharm Res (2009) 0.94
Bound NO in human red blood cells: fact or artifact? Nitric Oxide (2004) 0.92
Generation of NO by probiotic bacteria in the gastrointestinal tract. Free Radic Biol Med (2006) 0.91
Dietary nitrate reduces resting metabolic rate: a randomized, crossover study in humans. Am J Clin Nutr (2014) 0.91
A multilevel analytical approach for detection and visualization of intracellular NO production and nitrosation events using diaminofluoresceins. Free Radic Biol Med (2012) 0.91
Intravesical nitric oxide delivery for prevention of catheter-associated urinary tract infections. Antimicrob Agents Chemother (2005) 0.90
Rectal mucosal nitric oxide in differentiation of inflammatory bowel disease and irritable bowel syndrome. Clin Gastroenterol Hepatol (2005) 0.90
Dietary inorganic nitrate mobilizes circulating angiogenic cells. Free Radic Biol Med (2012) 0.90
Regulation of mitochondrial function and energetics by reactive nitrogen oxides. Free Radic Biol Med (2012) 0.90
The key role of nitric oxide in hypoxia: hypoxic vasodilation and energy supply-demand matching. Antioxid Redox Signal (2013) 0.90
Nitric oxide modulates endotoxin-induced platelet-endothelial cell adhesion in intestinal venules. Am J Physiol Heart Circ Physiol (2002) 0.90
Analyses of cerebral microdialysis in patients with traumatic brain injury: relations to intracranial pressure, cerebral perfusion pressure and catheter placement. BMC Med (2011) 0.88
Nitroso-redox status and vascular function in marginal and severe ascorbate deficiency. Antioxid Redox Signal (2012) 0.88
Autoinhibitory function of the sympathetic prejunctional neuropeptide Y Y(2) receptor evidenced by BIIE0246. Eur J Pharmacol (2002) 0.88
Inorganic nitrite stimulates pancreatic islet blood flow and insulin secretion. Free Radic Biol Med (2012) 0.88
Balancing role of nitric oxide in complement-mediated activation of platelets from mCd59a and mCd59b double-knockout mice. Am J Hematol (2009) 0.87
Intragastric generation of antimicrobial nitrogen oxides from saliva--physiological and therapeutic considerations. Free Radic Biol Med (2006) 0.87
Control of pathogen growth and biofilm formation using a urinary catheter that releases antimicrobial nitrogen oxides. Free Radic Biol Med (2013) 0.86
An integrated approach to assessing nitroso-redox balance in systemic inflammation. Free Radic Biol Med (2011) 0.86
Isotope tracing enhancement of chemiluminescence assays for nitric oxide research. Biol Chem (2009) 0.85
Totally implantable subcutaneous port system versus central venous catheter placed before induction chemotherapy in patients with acute leukaemia-a randomized study. Support Care Cancer (2003) 0.85
Endothelin receptor A antagonism attenuates renal medullary blood flow impairment in endotoxemic pigs. PLoS One (2011) 0.85
A Role for Sigma Factor σ(E) in Corynebacterium pseudotuberculosis Resistance to Nitric Oxide/Peroxide Stress. Front Microbiol (2012) 0.85
Contributions of nitric oxide synthases, dietary nitrite/nitrate, and other sources to the formation of NO signaling products. Antioxid Redox Signal (2012) 0.85
Exhaled nitric oxide monitoring in COPD using a portable analyzer. Pulm Pharmacol Ther (2008) 0.85
Integrating nitric oxide, nitrite and hydrogen sulfide signaling in the physiological adaptations to hypoxia: A comparative approach. Comp Biochem Physiol A Mol Integr Physiol (2012) 0.84
Impact of chronic congestive heart failure on pharmacokinetics and vasomotor effects of infused nitrite. Br J Pharmacol (2013) 0.84