Published in Nat Chem Biol on November 01, 2005
Acute blood pressure lowering, vasoprotective, and antiplatelet properties of dietary nitrate via bioconversion to nitrite. Hypertension (2008) 3.99
Nitrite augments tolerance to ischemia/reperfusion injury via the modulation of mitochondrial electron transfer. J Exp Med (2007) 3.29
Inhaled NO accelerates restoration of liver function in adults following orthotopic liver transplantation. J Clin Invest (2007) 3.22
Nitrate and nitrite in biology, nutrition and therapeutics. Nat Chem Biol (2009) 2.29
Endothelial nitric oxide synthase in red blood cells: key to a new erythrocrine function? Redox Biol (2014) 2.18
Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2008) 2.17
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Nitrite anion provides potent cytoprotective and antiapoptotic effects as adjunctive therapy to reperfusion for acute myocardial infarction. Circulation (2008) 2.14
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Methods to detect nitric oxide and its metabolites in biological samples. Free Radic Biol Med (2007) 1.81
Hemoglobin research and the origins of molecular medicine. Blood (2008) 1.78
Role of the anion nitrite in ischemia-reperfusion cytoprotection and therapeutics. Cardiovasc Res (2007) 1.69
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Nitrite-generated NO circumvents dysregulated arginine/NOS signaling to protect against intimal hyperplasia in Sprague-Dawley rats. J Clin Invest (2011) 1.30
Vascular effects of dietary nitrate (as found in green leafy vegetables and beetroot) via the nitrate-nitrite-nitric oxide pathway. Br J Clin Pharmacol (2013) 1.26
Nitrite reductase activity of cytochrome c. J Biol Chem (2008) 1.25
Characterization of the mechanism and magnitude of cytoglobin-mediated nitrite reduction and nitric oxide generation under anaerobic conditions. J Biol Chem (2012) 1.23
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Acute effect of a high nitrate diet on brain perfusion in older adults. Nitric Oxide (2010) 1.17
Myocardial protection by nitrite. Cardiovasc Res (2009) 1.16
Dietary nitrate and nitrite modulate blood and organ nitrite and the cellular ischemic stress response. Free Radic Biol Med (2009) 1.12
Dietary nitrate supplementation and exercise performance. Sports Med (2014) 1.11
Regulation of nitrite transport in red blood cells by hemoglobin oxygen fractional saturation. Am J Physiol Heart Circ Physiol (2009) 1.07
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Nitric oxide from nitrite reduction by hemoglobin in the plasma and erythrocytes. Nitric Oxide (2007) 1.03
Measurement of plasma nitrite by chemiluminescence without interference of S-, N-nitroso and nitrated species. Free Radic Biol Med (2007) 1.03
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Effect of blood nitrite and nitrate levels on murine platelet function. PLoS One (2013) 1.00
The potential role of the red blood cell in nitrite-dependent regulation of blood flow. Cardiovasc Res (2010) 1.00
Nitrite signaling in pulmonary hypertension: mechanisms of bioactivation, signaling, and therapeutics. Antioxid Redox Signal (2012) 0.99
Thrombospondin-1-CD47 blockade and exogenous nitrite enhance ischemic tissue survival, blood flow and angiogenesis via coupled NO-cGMP pathway activation. Nitric Oxide (2009) 0.99
Targeting the mitochondria to augment myocardial protection. Curr Opin Pharmacol (2008) 0.97
Cardioprotective effects of nitrite during exercise. Cardiovasc Res (2010) 0.96
Mechanisms of nitrite reduction to nitric oxide in the heart and vessel wall. Nitric Oxide (2010) 0.96
Acyloxy nitroso compounds as nitroxyl (HNO) donors: kinetics, reactions with thiols, and vasodilation properties. J Med Chem (2011) 0.96
Sodium nitrite therapy attenuates the hypertensive effects of HBOC-201 via nitrite reduction. Biochem J (2009) 0.92
Nitrite reductase activity of hemoglobin as a systemic nitric oxide generator mechanism to detoxify plasma hemoglobin produced during hemolysis. Am J Physiol Heart Circ Physiol (2008) 0.91
Blood substitutes: evolution from noncarrying to oxygen- and gas-carrying fluids. ASAIO J (2013) 0.91
Cross-talk Between Nitrate-Nitrite-NO and NO Synthase Pathways in Control of Vascular NO Homeostasis. Antioxid Redox Signal (2014) 0.90
Antihypertensive and antioxidant effects of a single daily dose of sodium nitrite in a model of renovascular hypertension. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.89
HBOC vasoactivity: interplay between nitric oxide scavenging and capacity to generate bioactive nitric oxide species. Antioxid Redox Signal (2013) 0.89
Crystal structures of manganese- and cobalt-substituted myoglobin in complex with NO and nitrite reveal unusual ligand conformations. J Inorg Biochem (2007) 0.89
Randomized phase 2 trial of intracoronary nitrite during acute myocardial infarction. Circ Res (2014) 0.89
Mechanisms of human erythrocytic bioactivation of nitrite. J Biol Chem (2014) 0.88
Atorvastatin and sildenafil lower blood pressure and improve endothelial dysfunction, but only atorvastatin increases vascular stores of nitric oxide in hypertension. Redox Biol (2013) 0.88
Therapeutic Potential of the Nitrite-Generated NO Pathway in Vascular Dysfunction. Front Immunol (2013) 0.88
Hemolysis-associated hypercoagulability in sickle cell disease: the plot (and blood) thickens! Haematologica (2008) 0.87
Vascular and perivascular nitric oxide release and transport: biochemical pathways of neuronal nitric oxide synthase (NOS1) and endothelial nitric oxide synthase (NOS3). Free Radic Biol Med (2006) 0.87
Normoxic cyclic GMP-independent oxidative signaling by nitrite enhances airway epithelial cell proliferation and wound healing. Nitric Oxide (2012) 0.86
Organic Nitrate Therapy, Nitrate Tolerance, and Nitrate-Induced Endothelial Dysfunction: Emphasis on Redox Biology and Oxidative Stress. Antioxid Redox Signal (2015) 0.86
The potential benefits of red beetroot supplementation in health and disease. Nutrients (2015) 0.85
Water-soluble poly(ethylenimine)-based nitric oxide donors: preparation, characterization, and potential application in hemodialysis. Biomacromolecules (2006) 0.85
Generic nitric oxide (NO) generating surface by immobilizing organoselenium species via layer-by-layer assembly. Langmuir (2008) 0.85
Dietary nitrate: where is the risk? Environ Health Perspect (2006) 0.85
Mitochondria as metabolizers and targets of nitrite. Nitric Oxide (2009) 0.85
Globin X is a six-coordinate globin that reduces nitrite to nitric oxide in fish red blood cells. Proc Natl Acad Sci U S A (2016) 0.84
Exploring the mechanisms of the reductase activity of neuroglobin by site-directed mutagenesis of the heme distal pocket. Biochemistry (2015) 0.83
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Modulation of circulating macrophage migration inhibitory factor in the elderly. Biomed Res Int (2014) 0.83
The reaction of cell-free oxyhemoglobin with nitrite under physiologically relevant conditions: Implications for nitrite-based therapies. Nitric Oxide (2008) 0.83
Bioanalytical profile of the L-arginine/nitric oxide pathway and its evaluation by capillary electrophoresis. J Chromatogr B Analyt Technol Biomed Life Sci (2007) 0.83
Nitric oxide and geriatrics: Implications in diagnostics and treatment of the elderly. J Geriatr Cardiol (2011) 0.82
A randomized clinical trial testing the anti-inflammatory effects of preemptive inhaled nitric oxide in human liver transplantation. PLoS One (2014) 0.82
Nitrate transport in salivary glands with implications for NO homeostasis. Proc Natl Acad Sci U S A (2012) 0.82
A Novel Animal Model of Nonalcoholic Steatohepatitis (NASH): Hypoxemia Enhances the Development of NASH. J Clin Biochem Nutr (2009) 0.82
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Nitric oxide and its metabolites in the critical phase of illness: rapid biomarkers in the making. Open Biochem J (2013) 0.80
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Effects of inorganic nitrate and beetroot supplementation on endothelial function: a systematic review and meta-analysis. Eur J Nutr (2015) 0.80
Consistent antioxidant and antihypertensive effects of oral sodium nitrite in DOCA-salt hypertension. Redox Biol (2015) 0.80
NO-Synthase Activity in Patients with Coronary Heart Disease Associated with Hypertension of Different Age Groups. J Med Biochem (2015) 0.79
Mechanisms for cellular NO oxidation and nitrite formation in lung epithelial cells. Free Radic Biol Med (2013) 0.79
Working with nitric oxide and hydrogen sulfide in biological systems. Am J Physiol Lung Cell Mol Physiol (2014) 0.79
Tempol improves xanthine oxidoreductase-mediated vascular responses to nitrite in experimental renovascular hypertension. Redox Biol (2016) 0.79
Nitric oxide generation from heme/copper assembly mediated nitrite reductase activity. J Biol Inorg Chem (2014) 0.79
Extreme differences between hemoglobins I and II of the clam Lucina pectinalis in their reactions with nitrite. Biochim Biophys Acta (2010) 0.79
Of reductionism and the pendulum swing: connecting toxicology and human health. Dose Response (2011) 0.79
Effect of nitrite on immunity of the white shrimp Litopenaeus vannamei at low temperture and low salinity. Ecotoxicology (2012) 0.78
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Sodium nitrite attenuates MMP-9 production by endothelial cells and may explain similar effects of atorvastatin. Naunyn Schmiedebergs Arch Pharmacol (2015) 0.77
Far red/near infrared light treatment promotes femoral artery collateralization in the ischemic hindlimb. J Mol Cell Cardiol (2013) 0.77
Heart failure management: the present and the future. Antioxid Redox Signal (2009) 0.77
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Geranylgeranylacetone attenuates myocardium ischemic/reperfusion injury through HSP70 and Akt/GSK-3β/eNOS pathway. Am J Transl Res (2017) 0.76
Detecting and monitoring NO, SNO and nitrite in vivo. Future Sci OA (2016) 0.76
Pulmonary hypertension as a risk factor for death in patients with sickle cell disease. N Engl J Med (2004) 10.51
Nitrite reduction to nitric oxide by deoxyhemoglobin vasodilates the human circulation. Nat Med (2003) 8.95
Cell-free hemoglobin limits nitric oxide bioavailability in sickle-cell disease. Nat Med (2002) 7.59
The ClinSeq Project: piloting large-scale genome sequencing for research in genomic medicine. Genome Res (2009) 6.83
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An official ATS clinical practice guideline: interpretation of exhaled nitric oxide levels (FENO) for clinical applications. Am J Respir Crit Care Med (2011) 5.53
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Cytoprotective effects of nitrite during in vivo ischemia-reperfusion of the heart and liver. J Clin Invest (2005) 4.14
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Pharmacologic ascorbic acid concentrations selectively kill cancer cells: action as a pro-drug to deliver hydrogen peroxide to tissues. Proc Natl Acad Sci U S A (2005) 3.30
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Concern Guidelines for pre-operative cardiac risk assessment and perioperative cardiac management in non-cardiac surgery. Eur Heart J (2009) 3.14
Myeloperoxidase, a leukocyte-derived vascular NO oxidase. Science (2002) 3.13
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SNO-hemoglobin is not essential for red blood cell-dependent hypoxic vasodilation. Nat Med (2008) 3.02
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Plasma nitrite reflects constitutive nitric oxide synthase activity in mammals. Free Radic Biol Med (2003) 2.83
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Hydrogen sulfide mediates the vasoactivity of garlic. Proc Natl Acad Sci U S A (2007) 2.77
Hypoxia, red blood cells, and nitrite regulate NO-dependent hypoxic vasodilation. Blood (2005) 2.76
Hemolysis-associated endothelial dysfunction mediated by accelerated NO inactivation by decompartmentalized oxyhemoglobin. J Clin Invest (2005) 2.75
Ceruloplasmin is a NO oxidase and nitrite synthase that determines endocrine NO homeostasis. Nat Chem Biol (2006) 2.75
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Granulocyte colony-stimulating factor mobilizes functional endothelial progenitor cells in patients with coronary artery disease. Arterioscler Thromb Vasc Biol (2004) 2.65
Dietary inorganic nitrate improves mitochondrial efficiency in humans. Cell Metab (2011) 2.61
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Mycobacterium tuberculosis DosS is a redox sensor and DosT is a hypoxia sensor. Proc Natl Acad Sci U S A (2007) 2.55
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Hemolysis in sickle cell mice causes pulmonary hypertension due to global impairment in nitric oxide bioavailability. Blood (2007) 2.30
Red blood cells express a functional endothelial nitric oxide synthase. Blood (2005) 2.30
Catalytic generation of N2O3 by the concerted nitrite reductase and anhydrase activity of hemoglobin. Nat Chem Biol (2007) 2.30
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CD47 is necessary for inhibition of nitric oxide-stimulated vascular cell responses by thrombospondin-1. J Biol Chem (2006) 2.23
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Nitrite reductase activity of myoglobin regulates respiration and cellular viability in myocardial ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2008) 2.17
Thrombospondin-1 inhibits endothelial cell responses to nitric oxide in a cGMP-dependent manner. Proc Natl Acad Sci U S A (2005) 2.17
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Nitrite as regulator of hypoxic signaling in mammalian physiology. Med Res Rev (2009) 2.15