Published in J Neurochem on March 29, 2006
Molecular dissection of reactive astrogliosis and glial scar formation. Trends Neurosci (2009) 7.15
Rapamycin prevents epilepsy in a mouse model of tuberous sclerosis complex. Ann Neurol (2008) 5.55
Transporters for L-glutamate: an update on their molecular pharmacology and pathological involvement. Br J Pharmacol (2006) 2.00
Inhibition of the mammalian target of rapamycin signaling pathway suppresses dentate granule cell axon sprouting in a rodent model of temporal lobe epilepsy. J Neurosci (2009) 1.85
Alexander disease mutant glial fibrillary acidic protein compromises glutamate transport in astrocytes. J Neuropathol Exp Neurol (2010) 1.64
Reactive astrocytes as therapeutic targets for CNS disorders. Neurotherapeutics (2010) 1.60
Role of excitatory amino acid transporter-2 (EAAT2) and glutamate in neurodegeneration: opportunities for developing novel therapeutics. J Cell Physiol (2011) 1.50
Spatiotemporal dynamics of the electrical network activity in the root apex. Proc Natl Acad Sci U S A (2009) 1.32
Suppression of GFAP toxicity by alphaB-crystallin in mouse models of Alexander disease. Hum Mol Genet (2009) 1.14
The inflammatory cytokine, interleukin-1 beta, mediates loss of astroglial glutamate transport and drives excitotoxic motor neuron injury in the spinal cord during acute viral encephalomyelitis. J Neurochem (2008) 1.10
Strategies for treatment in Alexander disease. Neurotherapeutics (2010) 0.98
Effects of MS-153 on chronic ethanol consumption and GLT1 modulation of glutamate levels in male alcohol-preferring rats. Front Behav Neurosci (2014) 0.97
Interleukin-1 beta enhances endocytosis of glial glutamate transporters in the spinal dorsal horn through activating protein kinase C. Glia (2014) 0.95
Nuclear factor-κB contributes to neuron-dependent induction of glutamate transporter-1 expression in astrocytes. J Neurosci (2011) 0.95
IGF-I signaling is essential for FSH stimulation of AKT and steroidogenic genes in granulosa cells. Mol Endocrinol (2013) 0.92
Altered astrocyte glutamate transporter regulation of hypothalamic neurosecretory neurons in heart failure rats. Am J Physiol Regul Integr Comp Physiol (2012) 0.89
Effects of ceftriaxone on GLT1 isoforms, xCT and associated signaling pathways in P rats exposed to ethanol. Psychopharmacology (Berl) (2015) 0.89
Ginsenoside Rd promotes glutamate clearance by up-regulating glial glutamate transporter GLT-1 via PI3K/AKT and ERK1/2 pathways. Front Pharmacol (2013) 0.89
Inhibition of glycogen synthase kinase 3β activity with lithium prevents and attenuates paclitaxel-induced neuropathic pain. Neuroscience (2013) 0.89
Partial Loss of the Glutamate Transporter GLT-1 Alters Brain Akt and Insulin Signaling in a Mouse Model of Alzheimer's Disease. J Alzheimers Dis (2015) 0.88
Glycogen synthase kinase 3 beta regulates glial glutamate transporter protein expression in the spinal dorsal horn in rats with neuropathic pain. Exp Neurol (2013) 0.86
GLT-1 Promoter Activity in Astrocytes and Neurons of Mouse Hippocampus and Somatic Sensory Cortex. Front Neuroanat (2010) 0.85
Effects of ampicillin, cefazolin and cefoperazone treatments on GLT-1 expressions in the mesocorticolimbic system and ethanol intake in alcohol-preferring rats. Neuroscience (2015) 0.83
FSH Regulates IGF-2 Expression in Human Granulosa Cells in an AKT-Dependent Manner. J Clin Endocrinol Metab (2015) 0.81
Runx2 activates PI3K/Akt signaling via mTORC2 regulation in invasive breast cancer cells. Breast Cancer Res (2014) 0.81
Amoxicillin and amoxicillin/clavulanate reduce ethanol intake and increase GLT-1 expression as well as AKT phosphorylation in mesocorticolimbic regions. Brain Res (2015) 0.79
Differential expression of the glutamate transporter GLT-1 in pancreas. J Histochem Cytochem (2011) 0.79
Genetic dys-regulation of astrocytic glutamate transporter EAAT2 and its implications in neurological disorders and manganese toxicity. Neurochem Res (2014) 0.78
Transcriptional Regulation of Glutamate Transporters: From Extracellular Signals to Transcription Factors. Adv Pharmacol (2016) 0.76
Involvement of glutamatergic neurotransmission in the antidepressant-like effect of zinc in the chronic unpredictable stress model of depression. J Neural Transm (Vienna) (2016) 0.76
Traumatic Brain Injury Induces Alterations in Cortical Glutamate Uptake without a Reduction in Glutamate Transporter-1 Protein Expression. J Neurotrauma (2016) 0.75
The transcription factor Pax6 contributes to the induction of GLT-1 expression in astrocytes through an interaction with a distal enhancer element. J Neurochem (2015) 0.75
Glutamate Neurotransmission in Rodent Models of Traumatic Brain Injury. J Neurotrauma (2016) 0.75
Ceftriaxone reverses ketamine-induced lasting EEG and astrocyte alterations in juvenile mice. Drug Alcohol Depend (2015) 0.75
Glutamate transporters in brain ischemia: to modulate or not? Acta Pharmacol Sin (2014) 0.75
Glutamate Deregulation in Ketamine-Induced Psychosis-A Potential Role of PSD95, NMDA Receptor and PMCA Interaction. Front Cell Neurosci (2017) 0.75
The role of glutamate transporters in the pathophysiology of neuropsychiatric disorders. NPJ Schizophr (2017) 0.75
Brain endothelial cells induce astrocytic expression of the glutamate transporter GLT-1 by a Notch-dependent mechanism. J Neurochem (2017) 0.75
A hexanucleotide repeat expansion in C9ORF72 is the cause of chromosome 9p21-linked ALS-FTD. Neuron (2011) 18.73
Safety and efficacy of gene transfer for Leber's congenital amaurosis. N Engl J Med (2008) 17.21
Beta-lactam antibiotics offer neuroprotection by increasing glutamate transporter expression. Nature (2005) 7.19
Age-dependent effects of RPE65 gene therapy for Leber's congenital amaurosis: a phase 1 dose-escalation trial. Lancet (2009) 6.71
Oligodendroglia metabolically support axons and contribute to neurodegeneration. Nature (2012) 4.95
Retrograde viral delivery of IGF-1 prolongs survival in a mouse ALS model. Science (2003) 4.52
Focal loss of the glutamate transporter EAAT2 in a transgenic rat model of SOD1 mutant-mediated amyotrophic lateral sclerosis (ALS). Proc Natl Acad Sci U S A (2002) 4.37
Mechanisms of Disease: astrocytes in neurodegenerative disease. Nat Clin Pract Neurol (2006) 3.42
Trial of celecoxib in amyotrophic lateral sclerosis. Ann Neurol (2006) 3.39
Reversal of blindness in animal models of leber congenital amaurosis using optimized AAV2-mediated gene transfer. Mol Ther (2008) 3.28
RNA toxicity from the ALS/FTD C9ORF72 expansion is mitigated by antisense intervention. Neuron (2013) 3.25
NG2+ CNS glial progenitors remain committed to the oligodendrocyte lineage in postnatal life and following neurodegeneration. Neuron (2010) 3.08
Degeneration and impaired regeneration of gray matter oligodendrocytes in amyotrophic lateral sclerosis. Nat Neurosci (2013) 2.71
Focal transplantation-based astrocyte replacement is neuroprotective in a model of motor neuron disease. Nat Neurosci (2008) 2.67
Transduction characteristics of adeno-associated virus vectors expressing cap serotypes 7, 8, 9, and Rh10 in the mouse brain. Mol Ther (2006) 2.67
Variations in promoter activity reveal a differential expression and physiology of glutamate transporters by glia in the developing and mature CNS. J Neurosci (2007) 2.53
Presynaptic regulation of astroglial excitatory neurotransmitter transporter GLT1. Neuron (2009) 2.48
Spectrin mutations cause spinocerebellar ataxia type 5. Nat Genet (2006) 2.34
RAN proteins and RNA foci from antisense transcripts in C9ORF72 ALS and frontotemporal dementia. Proc Natl Acad Sci U S A (2013) 2.31
Selective induction of astrocytic gliosis generates deficits in neuronal inhibition. Nat Neurosci (2010) 2.30
Human nasal olfactory epithelium as a dynamic marker for CNS therapy development. Exp Neurol (2011) 2.13
The role of glutamate transporters in neurodegenerative diseases and potential opportunities for intervention. Neurochem Int (2007) 2.11
Expanded repertoire of AAV vector serotypes mediate unique patterns of transduction in mouse brain. Mol Ther (2008) 2.06
A pilot study of in vivo liver-directed gene transfer with an adenoviral vector in partial ornithine transcarbamylase deficiency. Hum Gene Ther (2002) 1.96
A single injection of an adeno-associated virus vector into nuclei with divergent connections results in widespread vector distribution in the brain and global correction of a neurogenetic disease. J Neurosci (2007) 1.91
Recovery from paralysis in adult rats using embryonic stem cells. Ann Neurol (2006) 1.69
A neuronal glutamate transporter contributes to neurotransmitter GABA synthesis and epilepsy. J Neurosci (2002) 1.69
Glutamate transporters: animal models to neurologic disease. Neurobiol Dis (2004) 1.62
Evidence that accumulation of ceramides and cholesterol esters mediates oxidative stress-induced death of motor neurons in amyotrophic lateral sclerosis. Ann Neurol (2002) 1.61
Analysis of IFT74 as a candidate gene for chromosome 9p-linked ALS-FTD. BMC Neurol (2006) 1.60
Dosage thresholds for AAV2 and AAV8 photoreceptor gene therapy in monkey. Sci Transl Med (2011) 1.54
Cyclooxygenase 2 inhibition protects motor neurons and prolongs survival in a transgenic mouse model of ALS. Ann Neurol (2002) 1.52
Characterization of a recombinant adeno-associated virus type 2 Reference Standard Material. Hum Gene Ther (2010) 1.51
Therapeutic neonatal hepatic gene therapy in mucopolysaccharidosis VII dogs. Proc Natl Acad Sci U S A (2002) 1.50
Molecular comparison of GLT1+ and ALDH1L1+ astrocytes in vivo in astroglial reporter mice. Glia (2011) 1.49
Axonal growth of embryonic stem cell-derived motoneurons in vitro and in motoneuron-injured adult rats. Proc Natl Acad Sci U S A (2004) 1.45
Motor neuron disease occurring in a mutant dynactin mouse model is characterized by defects in vesicular trafficking. J Neurosci (2008) 1.45
Enhancing GABA(A) receptor alpha 1 subunit levels in hippocampal dentate gyrus inhibits epilepsy development in an animal model of temporal lobe epilepsy. J Neurosci (2006) 1.45
Reality and immortality--neural stem cells for therapies. Nat Biotechnol (2004) 1.44
Viral-induced spinal motor neuron death is non-cell-autonomous and involves glutamate excitotoxicity. J Neurosci (2004) 1.40
Loss of beta-III spectrin leads to Purkinje cell dysfunction recapitulating the behavior and neuropathology of spinocerebellar ataxia type 5 in humans. J Neurosci (2010) 1.39
Reduced expression of glutamate transporter EAAT2 and impaired glutamate transport in human primary astrocytes exposed to HIV-1 or gp120. Virology (2003) 1.39
Targeted transduction patterns in the mouse brain by lentivirus vectors pseudotyped with VSV, Ebola, Mokola, LCMV, or MuLV envelope proteins. Mol Ther (2002) 1.39
Mechanisms for reversible regulation between G13 and Rho exchange factors. J Biol Chem (2001) 1.37
Effective gene therapy for an inherited CNS disease in a large animal model. Ann Neurol (2005) 1.35
Messenger RNA oxidation occurs early in disease pathogenesis and promotes motor neuron degeneration in ALS. PLoS One (2008) 1.34
Astrocyte glutamate transporters regulate metabotropic glutamate receptor-mediated excitation of hippocampal interneurons. J Neurosci (2004) 1.31
Human embryonic germ cell derivatives facilitate motor recovery of rats with diffuse motor neuron injury. J Neurosci (2003) 1.31
Thrombin and lysophosphatidic acid receptors utilize distinct rhoGEFs in prostate cancer cells. J Biol Chem (2004) 1.30
Distribution of a lysosomal enzyme in the adult brain by axonal transport and by cells of the rostral migratory stream. J Neurosci (2002) 1.28
Signal-crosstalk between Rho/ROCK and c-Jun NH2-terminal kinase mediates migration of vascular smooth muscle cells stimulated by angiotensin II. Arterioscler Thromb Vasc Biol (2005) 1.27
Behavioral and neurochemical alterations in mice lacking the RNA-binding protein translin. J Neurosci (2006) 1.25
Epigenetic regulation of neuron-dependent induction of astroglial synaptic protein GLT1. Glia (2010) 1.25
Selective up-regulation of the glial Na+-dependent glutamate transporter GLT1 by a neuroimmunophilin ligand results in neuroprotection. Neurobiol Dis (2005) 1.23
Progress in gene therapy for neurological disorders. Nat Rev Neurol (2013) 1.22
Climbing fiber activation of EAAT4 transporters and kainate receptors in cerebellar Purkinje cells. J Neurosci (2004) 1.21
AAV-mediated expression of galactocerebrosidase in brain results in attenuated symptoms and extended life span in murine models of globoid cell leukodystrophy. Mol Ther (2005) 1.20
Neural stem cells protect against glutamate-induced excitotoxicity and promote survival of injured motor neurons through the secretion of neurotrophic factors. Mol Cell Neurosci (2004) 1.20
Intraparenchymal spinal cord delivery of adeno-associated virus IGF-1 is protective in the SOD1G93A model of ALS. Brain Res (2007) 1.20
Design and initial results of a multi-phase randomized trial of ceftriaxone in amyotrophic lateral sclerosis. PLoS One (2013) 1.19
Co-compartmentalization of the astroglial glutamate transporter, GLT-1, with glycolytic enzymes and mitochondria. J Neurosci (2011) 1.18
Localization of a toxic form of superoxide dismutase 1 protein to pathologically affected tissues in familial ALS. Proc Natl Acad Sci U S A (2012) 1.17
Translating the genomics revolution: the need for an international gene therapy consortium for monogenic diseases. Mol Ther (2013) 1.16
Degeneration of respiratory motor neurons in the SOD1 G93A transgenic rat model of ALS. Neurobiol Dis (2005) 1.16
Altered expression of the glutamate transporter EAAT2b in neurological disease. Ann Neurol (2004) 1.16
Glutamate receptor antagonists protect from virus-induced neural degeneration. Ann Neurol (2004) 1.16
Oligodendroglia: metabolic supporters of axons. Trends Cell Biol (2013) 1.15
Protein kinase C activation decreases cell surface expression of the GLT-1 subtype of glutamate transporter. Requirement of a carboxyl-terminal domain and partial dependence on serine 486. J Biol Chem (2002) 1.15
Reticulon RTN2B regulates trafficking and function of neuronal glutamate transporter EAAC1. J Biol Chem (2007) 1.14
Neural progenitor cells engineered to secrete GDNF show enhanced survival, neuronal differentiation and improve cognitive function following traumatic brain injury. Eur J Neurosci (2006) 1.14
Rapid trafficking of the neuronal glutamate transporter, EAAC1: evidence for distinct trafficking pathways differentially regulated by protein kinase C and platelet-derived growth factor. J Biol Chem (2004) 1.14
Adeno-associated virus vector-mediated transduction in the cat brain. Gene Ther (2003) 1.14
The glutamate-aspartate transporter GLAST mediates glutamate uptake at inner hair cell afferent synapses in the mammalian cochlea. J Neurosci (2006) 1.13
Amyotrophic lateral sclerosis 2-deficiency leads to neuronal degeneration in amyotrophic lateral sclerosis through altered AMPA receptor trafficking. J Neurosci (2006) 1.13
Undetectable transcription of cap in a clinical AAV vector: implications for preformed capsid in immune responses. Mol Ther (2008) 1.11
Multimodal actions of neural stem cells in a mouse model of ALS: a meta-analysis. Sci Transl Med (2012) 1.10
The blood-brain barrier: an engineering perspective. Front Neuroeng (2013) 1.09
Real-time monitoring of coronary care mortality: a comparison and combination of two monitoring tools. Int J Cardiol (2005) 1.09
Increased expression of the neuronal glutamate transporter (EAAT3/EAAC1) in hippocampal and neocortical epilepsy. Epilepsia (2002) 1.08
Regulation of the glutamate transporter EAAT1 by the ubiquitin ligase Nedd4-2 and the serum and glucocorticoid-inducible kinase isoforms SGK1/3 and protein kinase B. J Neurochem (2003) 1.08
Specific AAV serotypes stably transduce primary hippocampal and cortical cultures with high efficiency and low toxicity. Brain Res (2007) 1.07
TDP-43 in amyotrophic lateral sclerosis: pathophysiology or patho-babel? Ann Neurol (2007) 1.07
Lentiviral vector transduction of male germ line stem cells in mice. FEBS Lett (2002) 1.05
Harmine, a natural beta-carboline alkaloid, upregulates astroglial glutamate transporter expression. Neuropharmacology (2010) 1.04
Role of monocyte chemoattractant protein-1 (MCP-1/CCL2) in migration of neural progenitor cells toward glial tumors. J Neurosci Res (2009) 1.04
β-III spectrin is critical for development of purkinje cell dendritic tree and spine morphogenesis. J Neurosci (2011) 1.03
Caveolin-1 regulates the delivery and endocytosis of the glutamate transporter, excitatory amino acid carrier 1. J Biol Chem (2007) 1.03
Identification of motifs involved in endoplasmic reticulum retention-forward trafficking of the GLT-1 subtype of glutamate transporter. J Neurosci (2004) 1.02
Of mice and men: reconciling preclinical ALS mouse studies and human clinical trials. Ann Neurol (2003) 1.02
Transduction of brain by herpes simplex virus vectors. Mol Ther (2007) 1.02
Neuronal activity regulates glutamate transporter dynamics in developing astrocytes. Glia (2011) 1.01
Comparison of transfection conditions for a lentivirus vector produced in large volumes. Hum Gene Ther (2003) 1.01
Magnetic resonance spectroscopy of the occipital cortex and the cerebellar vermis distinguishes individual cats affected with alpha-mannosidosis from normal cats. NMR Biomed (2010) 1.00