Published in Liver Int on April 01, 2006
ABC transporters in cancer: more than just drug efflux pumps. Nat Rev Cancer (2010) 3.44
Transcriptional regulation of renal cytoprotective genes by Nrf2 and its potential use as a therapeutic target to mitigate cisplatin-induced nephrotoxicity. J Pharmacol Exp Ther (2010) 1.32
Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J Biol Chem (2009) 1.14
Disruption of cAMP and prostaglandin E2 transport by multidrug resistance protein 4 deficiency alters cAMP-mediated signaling and nociceptive response. Mol Pharmacol (2007) 1.03
Comparative transcriptional profiling of renal cortex in rats with inherited stress-induced arterial hypertension and normotensive Wistar Albino Glaxo rats. BMC Genet (2016) 0.97
Multidrug resistance protein 1 (MRP1, ABCC1), a "multitasking" ATP-binding cassette (ABC) transporter. J Biol Chem (2014) 0.94
Colorectal neoplasia goes with the flow: prostaglandin transport and termination. Cancer Prev Res (Phila) (2008) 0.79
Research Progress on the Role of ABC Transporters in the Drug Resistance Mechanism of Intractable Epilepsy. Biomed Res Int (2015) 0.77
Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase. J Lipid Res (2013) 0.77
ATP-binding cassette transporters in reproduction: a new frontier. Hum Reprod Update (2015) 0.75
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology (2012) 2.39
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest (2012) 2.33
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology (2014) 2.19
Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology (2010) 2.18
ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity. Hepatology (2008) 1.95
Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology (2008) 1.87
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology (2006) 1.71
Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology (2007) 1.69
Pathophysiology and current management of pruritus in liver disease. Clin Res Hepatol Gastroenterol (2011) 1.57
Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver. J Hepatol (2007) 1.55
Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial. Pediatr Res (2007) 1.54
P4 ATPases - lipid flippases and their role in disease. Biochim Biophys Acta (2009) 1.50
Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes. J Hepatol (2002) 1.43
Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch (2006) 1.43
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology (2006) 1.28
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology (2005) 1.28
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. Hepatology (2009) 1.20
A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Hum Mol Genet (2004) 1.18
Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.17
Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. Eur J Pharmacol (2009) 1.16
Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J Biol Chem (2009) 1.14
Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. Mutat Res (2005) 1.14
Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats. Mol Ther (2006) 1.11
A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology (2012) 1.11
Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology (2011) 1.07
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate. Clin Cancer Res (2008) 1.07
Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice. Gastroenterology (2008) 1.04
The ins and outs of reverse cholesterol transport. Ann Med (2004) 1.04
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. Clin Cancer Res (2009) 1.01
Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J (2009) 0.99
Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Am J Pathol (2006) 0.98
Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1. Hepatology (2009) 0.98
Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes. Mol Ther (2005) 0.98
Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat. Blood Purif (2007) 0.98
Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. J Lipid Res (2009) 0.97
Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer. Mol Ther (2003) 0.96
P4 ATPases: flippases in health and disease. Int J Mol Sci (2013) 0.95
Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem (2010) 0.95
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology (2004) 0.92
IgG4-associated cholangitis: a comprehensive review. Clin Rev Allergy Immunol (2015) 0.91
Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein. J Pharmacol Exp Ther (2010) 0.91
Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim Biophys Acta (2011) 0.90
Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices. World J Gastroenterol (2009) 0.90
Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Hepatology (2005) 0.88
The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. J Lipid Res (2006) 0.87
Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3)(-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3)(-) exchange. Hepatology (2010) 0.87
Strain background modifies phenotypes in the ATP8B1-deficient mouse. PLoS One (2010) 0.86
Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice. FEBS Lett (2010) 0.85
Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review. Clin Rev Allergy Immunol (2015) 0.84
Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo. World J Gastroenterol (2009) 0.84
Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity. Hepatology (2013) 0.83
Oral availability of cefadroxil depends on ABCC3 and ABCC4. Drug Metab Dispos (2011) 0.83
Intestinal bile salt absorption in Atp8b1 deficient mice. J Hepatol (2007) 0.83
Intrahepatic cholestasis of pregnancy: when should you look further? World J Gastroenterol (2009) 0.82
Advances in pathogenesis and management of pruritus in cholestasis. Dig Dis (2014) 0.82
Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors. Hum Gene Ther (2011) 0.82
A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer. Int J Oncol (2010) 0.82
N-acetylcysteine reduces oxidative stress in sickle cell patients. Ann Hematol (2012) 0.82
Diseases of intramembranous lipid transport. FEBS Lett (2006) 0.82
Advances in pathogenesis and treatment of pruritus. Clin Liver Dis (2012) 0.82
Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos (2009) 0.81
Enhanced glucocorticoid feedback inhibition of hypothalamo-pituitary-adrenal responses to stress in adult rats neonatally treated with dexamethasone. Neuroendocrinology (2002) 0.81
Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases. J Histochem Cytochem (2012) 0.81
Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies. Biochim Biophys Acta (2013) 0.81
Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy. A study with wild-type and Atp8b1-deficient mice. Mol Pharm (2006) 0.80
Liver progenitor cell line HepaRG differentiated in a bioartificial liver effectively supplies liver support to rats with acute liver failure. PLoS One (2012) 0.80
Assessment of in vitro applicability of reversibly immortalized NKNT-3 cells and clonal derivatives. Cell Transplant (2006) 0.79
Alteration of viral lipid composition by expression of the phospholipid floppase ABCB4 reduces HIV vector infectivity. Retrovirology (2008) 0.79
Bone marrow-derived multidrug resistance protein ABCB4 protects against atherosclerotic lesion development in LDL receptor knockout mice. Cardiovasc Res (2007) 0.79
Serum Autotaxin Activity Correlates With Pruritus in Pediatric Cholestatic Disorders. J Pediatr Gastroenterol Nutr (2016) 0.79
Anion exchanger 2 is critical for CD8(+) T cells to maintain pHi homeostasis and modulate immune responses. Eur J Immunol (2014) 0.78
Insulin-like growth factor 1 enhances bile-duct proliferation and fibrosis in Abcb4(-/-) mice. Biochim Biophys Acta (2013) 0.78
A pyruvate-buffered dialysis fluid induces less peritoneal angiogenesis and fibrosis than a conventional solution. Perit Dial Int (2008) 0.78
The role of epoxidation and electrophile-responsive element-regulated gene transcription in the potentially beneficial and harmful effects of the coffee components cafestol and kahweol. J Nutr Biochem (2009) 0.78
The flip side of cardiolipin import. Nat Med (2011) 0.77
Lipid transport into bile and role in bile formation. Curr Drug Targets Immune Endocr Metabol Disord (2005) 0.76
ATP8B1 and ATP11C: Two Lipid Flippases Important for Hepatocyte Function. Dig Dis (2015) 0.75
The Emerging Role of Soluble Adenylyl Cyclase in Primary Biliary Cholangitis. Dig Dis (2017) 0.75
Actual Usage and Quality of Experimental Colitis Models in Preclinical Efficacy Testing: A Scoping Review. Inflamm Bowel Dis (2016) 0.75
[Risks of intrahepatic cholestasis of pregnancy]. Ned Tijdschr Geneeskd (2014) 0.75
Extended Abstract: Deficiency of Sodium Taurocholate Cotransporting Polypeptide (SLC10A1): A New Inborn Error of Metabolism with an Attenuated Phenotype. Dig Dis (2017) 0.75