Published in Drug Metab Dispos on December 13, 2011
Contribution of ABCC4-mediated gastric transport to the absorption and efficacy of dasatinib. Clin Cancer Res (2013) 0.98
In vivo absorption and disposition of cefadroxil after escalating oral doses in wild-type and PepT1 knockout mice. Pharm Res (2013) 0.85
Effect of transporter inhibition on the distribution of cefadroxil in rat brain. Fluids Barriers CNS (2014) 0.83
Impact of lipopolysaccharide-induced inflammation on the disposition of the aminocephalosporin cefadroxil. Antimicrob Agents Chemother (2013) 0.78
Influence of peptide transporter 2 (PEPT2) on the distribution of cefadroxil in mouse brain: A microdialysis study. Biochem Pharmacol (2017) 0.75
Identification of multidrug resistance protein 1 (MRP1/ABCC1) as a molecular gate for cellular export of cobalamin. Blood (2009) 2.49
Serum autotaxin is increased in pruritus of cholestasis, but not of other origin, and responds to therapeutic interventions. Hepatology (2012) 2.39
Selective induction of chemotherapy resistance of mammary tumors in a conditional mouse model for hereditary breast cancer. Proc Natl Acad Sci U S A (2007) 2.39
Complete OATP1B1 and OATP1B3 deficiency causes human Rotor syndrome by interrupting conjugated bilirubin reuptake into the liver. J Clin Invest (2012) 2.33
Sodium taurocholate cotransporting polypeptide (SLC10A1) deficiency: conjugated hypercholanemia without a clear clinical phenotype. Hepatology (2014) 2.19
Lysophosphatidic acid is a potential mediator of cholestatic pruritus. Gastroenterology (2010) 2.18
ATP8B1 requires an accessory protein for endoplasmic reticulum exit and plasma membrane lipid flippase activity. Hepatology (2008) 1.95
Ae2a,b-deficient mice develop antimitochondrial antibodies and other features resembling primary biliary cirrhosis. Gastroenterology (2008) 1.87
Atp8b1 deficiency in mice reduces resistance of the canalicular membrane to hydrophobic bile salts and impairs bile salt transport. Hepatology (2006) 1.71
Direct intestinal cholesterol secretion contributes significantly to total fecal neutral sterol excretion in mice. Gastroenterology (2007) 1.69
Multidrug resistance-associated proteins 3, 4, and 5. Pflugers Arch (2006) 1.58
Pathophysiology and current management of pruritus in liver disease. Clin Res Hepatol Gastroenterol (2011) 1.57
Evaluation of a new immortalized human fetal liver cell line (cBAL111) for application in bioartificial liver. J Hepatol (2007) 1.55
Orlistat treatment of unconjugated hyperbilirubinemia in Crigler-Najjar disease: a randomized controlled trial. Pediatr Res (2007) 1.54
P4 ATPases - lipid flippases and their role in disease. Biochim Biophys Acta (2009) 1.50
Lentiviral vectors for efficient transduction of isolated primary quiescent hepatocytes. J Hepatol (2002) 1.43
Function and pathophysiological importance of ABCB4 (MDR3 P-glycoprotein). Pflugers Arch (2006) 1.43
Does the absence of ABCC6 (multidrug resistance protein 6) in patients with Pseudoxanthoma elasticum prevent the liver from providing sufficient vitamin K to the periphery? Cell Cycle (2008) 1.37
ABCC6 prevents ectopic mineralization seen in pseudoxanthoma elasticum by inducing cellular nucleotide release. Proc Natl Acad Sci U S A (2013) 1.31
Mice lacking Mrp3 (Abcc3) have normal bile salt transport, but altered hepatic transport of endogenous glucuronides. J Hepatol (2005) 1.29
Altered disposition of acetaminophen in mice with a disruption of the Mrp3 gene. Hepatology (2005) 1.28
Hepatocanalicular transport defects: pathophysiologic mechanisms of rare diseases. Gastroenterology (2006) 1.28
Scavenger receptor class B type I mediates biliary cholesterol secretion independent of ATP-binding cassette transporter g5/g8 in mice. Hepatology (2009) 1.20
A mouse genetic model for familial cholestasis caused by ATP8B1 mutations reveals perturbed bile salt homeostasis but no impairment in bile secretion. Hum Mol Genet (2004) 1.18
Altered myocardial substrate metabolism is associated with myocardial dysfunction in early diabetic cardiomyopathy in rats: studies using positron emission tomography. Cardiovasc Diabetol (2009) 1.18
Regulation of direct transintestinal cholesterol excretion in mice. Am J Physiol Gastrointest Liver Physiol (2008) 1.17
Experimental non-alcoholic fatty liver disease results in decreased hepatic uptake transporter expression and function in rats. Eur J Pharmacol (2009) 1.16
Mice lacking multidrug resistance protein 3 show altered morphine pharmacokinetics and morphine-6-glucuronide antinociception. Proc Natl Acad Sci U S A (2005) 1.14
Activity of the bile salt export pump (ABCB11) is critically dependent on canalicular membrane cholesterol content. J Biol Chem (2009) 1.14
Ionizing radiation-induced foci formation of mammalian Rad51 and Rad54 depends on the Rad51 paralogs, but not on Rad52. Mutat Res (2005) 1.14
Adeno-associated virus vector serotypes mediate sustained correction of bilirubin UDP glucuronosyltransferase deficiency in rats. Mol Ther (2006) 1.11
A biliary HCO3- umbrella constitutes a protective mechanism against bile acid-induced injury in human cholangiocytes. Hepatology (2012) 1.11
Complementary functions of the flippase ATP8B1 and the floppase ABCB4 in maintaining canalicular membrane integrity. Gastroenterology (2011) 1.07
Impact of Abcc2 (Mrp2) and Abcc3 (Mrp3) on the in vivo elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate. Clin Cancer Res (2008) 1.07
Abcg5/8 independent biliary cholesterol excretion in Atp8b1-deficient mice. Gastroenterology (2008) 1.04
The ins and outs of reverse cholesterol transport. Ann Med (2004) 1.04
Contribution of the drug transporter ABCG2 (breast cancer resistance protein) to resistance against anticancer nucleosides. Mol Cancer Ther (2008) 1.02
Functionally overlapping roles of Abcg2 (Bcrp1) and Abcc2 (Mrp2) in the elimination of methotrexate and its main toxic metabolite 7-hydroxymethotrexate in vivo. Clin Cancer Res (2009) 1.01
Ae2(a,b)-deficient mice exhibit osteopetrosis of long bones but not of calvaria. FASEB J (2009) 0.99
Differential effects of progressive familial intrahepatic cholestasis type 1 and benign recurrent intrahepatic cholestasis type 1 mutations on canalicular localization of ATP8B1. Hepatology (2009) 0.98
Kupffer cells and not liver sinusoidal endothelial cells prevent lentiviral transduction of hepatocytes. Mol Ther (2005) 0.98
Inefficient chronic activation of parietal cells in Ae2a,b(-/-) mice. Am J Pathol (2006) 0.98
Cyclosporin A induces peritoneal fibrosis and angiogenesis during chronic peritoneal exposure to a glucose-based, lactate-buffered dialysis solution in the rat. Blood Purif (2007) 0.98
Peroxisome proliferator-activated receptor delta activation leads to increased transintestinal cholesterol efflux. J Lipid Res (2009) 0.97
Long-term correction of bilirubin UDPglucuronyltransferase deficiency in rats by in utero lentiviral gene transfer. Mol Ther (2003) 0.96
P4 ATPases: flippases in health and disease. Int J Mol Sci (2013) 0.95
Glutamine synthetase in muscle is required for glutamine production during fasting and extrahepatic ammonia detoxification. J Biol Chem (2010) 0.95
Abcc2 (Mrp2), Abcc3 (Mrp3), and Abcg2 (Bcrp1) are the main determinants for rapid elimination of methotrexate and its toxic metabolite 7-hydroxymethotrexate in vivo. Mol Cancer Ther (2009) 0.92
Consequences of bile duct obstruction on intestinal expression and function of multidrug resistance-associated protein 2. Gastroenterology (2004) 0.92
IgG4-associated cholangitis: a comprehensive review. Clin Rev Allergy Immunol (2015) 0.91
Hepatic transport mechanisms of cholyl-L-lysyl-fluorescein. J Pharmacol Exp Ther (2010) 0.91
Multidrug resistance associated protein 2 mediates transport of prostaglandin E2. Liver Int (2006) 0.91
Lipotoxicity and steatohepatitis in an overfed mouse model for non-alcoholic fatty liver disease. Biochim Biophys Acta (2011) 0.90
Ex-vivo evaluation of gene therapy vectors in human pancreatic (cancer) tissue slices. World J Gastroenterol (2009) 0.90
Transport of diclofenac by breast cancer resistance protein (ABCG2) and stimulation of multidrug resistance protein 2 (ABCC2)-mediated drug transport by diclofenac and benzbromarone. Drug Metab Dispos (2008) 0.89
Diosgenin-induced biliary cholesterol secretion in mice requires Abcg8. Hepatology (2005) 0.88
Bicarbonate secretion of mouse cholangiocytes involves Na(+)-HCO(3)(-) cotransport in addition to Na(+)-independent Cl(-)/HCO(3)(-) exchange. Hepatology (2010) 0.87
Transportomics: screening for substrates of ABC transporters in body fluids using vesicular transport assays. FASEB J (2011) 0.87
The mechanism of ABCG5/ABCG8 in biliary cholesterol secretion in mice. J Lipid Res (2006) 0.87
Strain background modifies phenotypes in the ATP8B1-deficient mouse. PLoS One (2010) 0.86
Ezetimibe stimulates faecal neutral sterol excretion depending on abcg8 function in mice. FEBS Lett (2010) 0.85
Fucosyltransferase 2: a genetic risk factor for primary sclerosing cholangitis and Crohn's disease--a comprehensive review. Clin Rev Allergy Immunol (2015) 0.84
Ephrin A2 receptor targeting does not increase adenoviral pancreatic cancer transduction in vivo. World J Gastroenterol (2009) 0.84
Polyinosinic acid blocks adeno-associated virus macrophage endocytosis in vitro and enhances adeno-associated virus liver-directed gene therapy in vivo. Hum Gene Ther (2013) 0.83
Defective bile salt biosynthesis and hydroxylation in mice with reduced cytochrome P450 activity. Hepatology (2013) 0.83
Intestinal bile salt absorption in Atp8b1 deficient mice. J Hepatol (2007) 0.83
Diseases of intramembranous lipid transport. FEBS Lett (2006) 0.82
N-acetylcysteine reduces oxidative stress in sickle cell patients. Ann Hematol (2012) 0.82
Intrahepatic cholestasis of pregnancy: when should you look further? World J Gastroenterol (2009) 0.82
Mycophenolate mofetil impairs transduction of single-stranded adeno-associated viral vectors. Hum Gene Ther (2011) 0.82
A fiber modified adenovirus vector that targets to the EphrinA2 receptor reveals enhanced gene transfer to ex vivo pancreatic cancer. Int J Oncol (2010) 0.82
Species-dependent transport and modulation properties of human and mouse multidrug resistance protein 2 (MRP2/Mrp2, ABCC2/Abcc2). Drug Metab Dispos (2008) 0.82
Advances in pathogenesis and treatment of pruritus. Clin Liver Dis (2012) 0.82
Advances in pathogenesis and management of pruritus in cholestasis. Dig Dis (2014) 0.82
Complex pharmacokinetic behavior of ezetimibe depends on abcc2, abcc3, and abcg2. Drug Metab Dispos (2009) 0.81
Enhanced glucocorticoid feedback inhibition of hypothalamo-pituitary-adrenal responses to stress in adult rats neonatally treated with dexamethasone. Neuroendocrinology (2002) 0.81
Cellular localization and biochemical analysis of mammalian CDC50A, a glycosylated β-subunit for P4 ATPases. J Histochem Cytochem (2012) 0.81
Fasting reduces liver fibrosis in a mouse model for chronic cholangiopathies. Biochim Biophys Acta (2013) 0.81
Increased serum concentrations of secondary bile salts during cholate feeding are due to coprophagy. A study with wild-type and Atp8b1-deficient mice. Mol Pharm (2006) 0.80