Published in Proc Natl Acad Sci U S A on February 01, 1967
Active Site of alpha-Chymotrypsin Activation by Association-Desolvation. Proc Natl Acad Sci U S A (1970) 1.16
Probing the topography of the active site of alpha-chymotrypsin. Proc Natl Acad Sci U S A (1967) 0.85
Phenothiazine-N-carbonyl chloride, a specific inactivator of chymotrypsin. Biochem J (1970) 0.75
Two steps in the reaction of chymotrypsin with acetyl-L-phenylalanine ethyl ester. Biochem J (1955) 2.68
An interpretation of the kinetic behavior of model substrates of alpha-chymotrypsin. Proc Natl Acad Sci U S A (1961) 1.58
ACTION OF ALPHA-CHYMOTRYPSIN ON DIETHYL N-ACETYLASPARTATE AND ON DIETHYL N-METHYL-N-ACETYLASPARTATE. Biochemistry (1964) 0.98
Association of substrates with alpha-chymotrypsin, diethyl alpha-acetoxysuccinate, and diethyl malate. J Am Chem Soc (1966) 0.97
Action of alpha-chymotrypsin on the diethyl esters of fumaric, maleic, and acetylenedicarboxylic acids. J Am Chem Soc (1966) 0.96
Stereospecificity in hydrolysis by alpha-chymotrypsin of esters of alpha, alpha-disubstituted acetic and beta, beta-disubstituted propionic acids. J Am Chem Soc (1966) 0.92
Selective reduction of dormant maternal mRNAs in mouse oocytes by RNA interference. Development (2000) 3.70
Differential effects of culture on imprinted H19 expression in the preimplantation mouse embryo. Biol Reprod (2000) 3.33
LY231514, a pyrrolo[2,3-d]pyrimidine-based antifolate that inhibits multiple folate-requiring enzymes. Cancer Res (1997) 2.83
Regulation of transcriptional activity during the first and second cell cycles in the preimplantation mouse embryo. Dev Biol (1997) 2.42
Regulation of mouse oocyte meiotic maturation: implication of a decrease in oocyte cAMP and protein dephosphorylation in commitment to resume meiosis. Dev Biol (1983) 2.03
Functional identity between murine gamma interferon and macrophage activating factor. Nature (1983) 1.89
Cultural and antigenic properties of newly established cell strains derived from adenocarcinomas of the human colon and rectum. J Natl Cancer Inst (1974) 1.86
Preimplantation development of mouse embryos in KSOM: augmentation by amino acids and analysis of gene expression. Mol Reprod Dev (1995) 1.83
Histone macroH2A1 is concentrated in the inactive X chromosome of female preimplantation mouse embryos. Development (2000) 1.66
Interferon: an inducer of macrophage activation by polyanions. Science (1977) 1.59
Apoptosis during mouse blastocyst formation: evidence for a role for survival factors including transforming growth factor alpha. Biol Reprod (1997) 1.55
Regulation of macrophage tumoricidal function: a role for prostaglandins of the E series. Science (1978) 1.51
RNAi in mouse oocytes and preimplantation embryos: effectiveness of hairpin dsRNA. Biochem Biophys Res Commun (2001) 1.49
Elevated threshold for thyrotropin suppression in congenital hypothyroidism. Am J Dis Child (1980) 1.48
Maturation of mouse oocytes in serum-free medium. Hum Reprod (1996) 1.40
Multiple folate enzyme inhibition: mechanism of a novel pyrrolopyrimidine-based antifolate LY231514 (MTA). Adv Enzyme Regul (1998) 1.37
Expression of MSY2 in mouse oocytes and preimplantation embryos. Biol Reprod (2001) 1.30
Relationship between the developmental programs controlling nuclear and cytoplasmic maturation of mouse oocytes. Dev Biol (1994) 1.28
Embryonic genome activation. Front Biosci (2001) 1.28
Inner cell mass-specific expression of a cell adhesion molecule (PECAM-1/CD31) in the mouse blastocyst. Dev Biol (2001) 1.27
Regulation of zygotic gene activation in the preimplantation mouse embryo: global activation and repression of gene expression. Biol Reprod (2001) 1.24
Involvement of cAMP-dependent protein kinase and protein phosphorylation in regulation of mouse oocyte maturation. Dev Biol (1986) 1.23
Functional and morphologic characteristics of interferon-treated macrophages. Cell Immunol (1978) 1.23
Mouse sperm-egg plasma membrane interactions: analysis of roles of egg integrins and the mouse sperm homologue of PH-30 (fertilin) beta. J Cell Sci (1995) 1.21
Characterization of the binding of recombinant mouse sperm fertilin beta subunit to mouse eggs: evidence for adhesive activity via an egg beta1 integrin-mediated interaction. Dev Biol (1997) 1.20
Regulation of gene expression in the mouse oocyte and early preimplantation embryo: developmental changes in Sp1 and TATA box-binding protein, TBP. Development (1994) 1.20
Analysis of gene expression in the preimplantation mouse embryo: use of mRNA differential display. Proc Natl Acad Sci U S A (1994) 1.19
Specific macrophage immunity to vaccinia virus: macrophage-virus interaction. Infect Immun (1972) 1.19
Studies on the mechanism of phosphatidylinositol 3-kinase inhibition by wortmannin and related analogs. J Med Chem (1996) 1.18
Expression patterns of novel genes during mouse preimplantation embryogenesis. Mol Reprod Dev (1994) 1.18
Egg-induced modifications of the zona pellucida of mouse eggs: effects of microinjected inositol 1,4,5-trisphosphate. Dev Biol (1989) 1.16
Active Site of alpha-Chymotrypsin Activation by Association-Desolvation. Proc Natl Acad Sci U S A (1970) 1.16
Cell cycle effects of antifolate antimetabolites: implications for cytotoxicity and cytostasis. Cancer Chemother Pharmacol (1997) 1.15
Fetuin inhibits zona pellucida hardening and conversion of ZP2 to ZP2f during spontaneous mouse oocyte maturation in vitro in the absence of serum. Biol Reprod (1990) 1.12
Reporter gene expression in G2 of the 1-cell mouse embryo. Dev Biol (1993) 1.11
Temporally restricted spatial localization of acetylated isoforms of histone H4 and RNA polymerase II in the 2-cell mouse embryo. Development (1995) 1.09
Biochemical studies of mammalian oogenesis: synthesis and stability of various classes of RNA during growth of the mouse oocyte in vitro. Dev Biol (1981) 1.08
Igf2r and Igf2 gene expression in androgenetic, gynogenetic, and parthenogenetic preimplantation mouse embryos: absence of regulation by genomic imprinting. Genes Dev (1994) 1.08
Stage-specific expression of a family of proteins that are major products of zygotic gene activation in the mouse embryo. Dev Biol (1991) 1.08
Spontaneous activation of ovulated mouse eggs: time-dependent effects on M-phase exit, cortical granule exocytosis, maternal messenger ribonucleic acid recruitment, and inositol 1,4,5-trisphosphate sensitivity. Biol Reprod (1997) 1.07
Acquisition of a transcriptionally permissive state during the 1-cell stage of mouse embryogenesis. Dev Biol (1992) 1.07
Similarities among factors that render macrophages tumoricidal in lymphokine and interferon preparations. Cancer Res (1978) 1.05
Biochemical studies of mammalian oogenesis: Protein synthesis during oocyte growth and meiotic maturation in the mouse. J Cell Sci (1977) 1.05
Relationship between secreted urokinase plasminogen activator activity and metastatic potential in murine B16 cells transfected with human urokinase sense and antisense genes. Cancer Res (1990) 1.05
Similarities of murine gamma interferon and the lymphokine that renders macrophages cytotoxic. J Interferon Res (1982) 1.05
Dose-dependent pharmacokinetics of mezlocillin in relation to renal impairment. Antimicrob Agents Chemother (1982) 1.05
Effects of various inhibitors of arachidonic acid oxygenation on macrophage superoxide release and tumoricidal activity. J Immunol (1985) 1.03
Blastocoel expansion in the preimplantation mouse embryo: role of extracellular sodium and chloride and possible apical routes of their entry. Dev Biol (1989) 1.02
DNA replication in the 1-cell mouse embryo: stimulatory effect of histone acetylation. Zygote (1999) 1.02
Role of folic acid in modulating the toxicity and efficacy of the multitargeted antifolate, LY231514. Anticancer Res (1998) 1.01
Specific changes in the pattern of protein synthesis during meiotic maturation of mammalian oocytes in vitro. Proc Natl Acad Sci U S A (1977) 1.01
Intercellular communication between granulosa cells and mouse oocytes: existence and possible nutritional role during oocyte growth. Dev Biol (1982) 1.01
Characterization of downstream Ras signals that induce alternative protease-dependent invasive phenotypes. J Biol Chem (1997) 1.00
Acquisition of meiotic competence in mouse oocytes: absolute amounts of p34(cdc2), cyclin B1, cdc25C, and wee1 in meiotically incompetent and competent oocytes. Biol Reprod (2000) 1.00
Roles of heterotrimeric and monomeric G proteins in sperm-induced activation of mouse eggs. Development (1994) 0.99
Developmental change in TATA-box utilization during preimplantation mouse development. Dev Biol (2000) 0.98
Macrophage immunity to vaccina virus: factors affecting macrophage immunity in vitro. J Reticuloendothel Soc (1974) 0.98
Regulation of mouse oocyte maturation: effect of elevating cumulus cell cAMP on oocyte cAMP levels. Biol Reprod (1985) 0.98
Selective neutralization by antiinterferon globulin of macrophage activation by L-cell interferon, Brucella abortus ether extract, Salmonella typhimurium lipopolysaccharide, and polyanions. Cell Immunol (1979) 0.97
Modulation of mouse preimplantation embryo development by acrogranin (epithelin/granulin precursor). Dev Biol (2000) 0.97
Sulfonimidamide analogs of oncolytic sulfonylureas. J Med Chem (1997) 0.96
Program of early development in the mammal: changes in patterns and absolute rates of tubulin and total protein synthesis during oogenesis and early embryogenesis in the mouse. Dev Biol (1979) 0.96
Posttranscriptional regulation of cyclin A1 and cyclin A2 during mouse oocyte meiotic maturation and preimplantation development. Biol Reprod (2001) 0.96
Assessment of DNA damage in individual hamster embryos by comet assay. Mol Reprod Dev (1999) 0.95
A novel class of monoglutamated antifolates exhibits tight-binding inhibition of human glycinamide ribonucleotide formyltransferase and potent activity against solid tumors. Cancer Res (1994) 0.95
Biochemical studies of mammalian oogenesis: kinetics of accumulation of total and poly(A)-containing RNA during growth of the mouse oocyte. J Exp Zool (1981) 0.94
Biochemistry and pharmacology of glycinamide ribonucleotide formyltransferase inhibitors: LY309887 and lometrexol. Invest New Drugs (1996) 0.94
Molecular cloning, characterization, and differential expression pattern of mouse lung surfactant convertase. Am J Physiol (1998) 0.94
Cytotoxic antibody response to tumors induced in adult and newborn rabbits by fibroma virus. Infect Immun (1972) 0.93
Association of macrophage activation with antitumor activity by synthetic and biological agents. Cancer Res (1977) 0.93
Involvement of inositol 1,4,5-trisphosphate-mediated Ca2+ release in early and late events of mouse egg activation. Development (1994) 0.93
Regulation of mouse egg activation: presence of ryanodine receptors and effects of microinjected ryanodine and cyclic ADP ribose on uninseminated and inseminated eggs. Development (1995) 0.93
Prevention of macrophage tumoricidal activity by agents known to increase cellular cyclic AMP. Cell Immunol (1979) 0.93
Regulation of hsp70 mRNA levels during oocyte maturation and zygotic gene activation in the mouse. Dev Biol (1991) 0.93
Roles of cell-to-cell communication in development. Biol Reprod (1985) 0.92
Role of mitogen-activated protein kinases and c-Jun/AP-1 trans-activating activity in the regulation of protease mRNAs and the malignant phenotype in NIH 3T3 fibroblasts. J Biol Chem (1999) 0.92
Stereospecificity in hydrolysis by alpha-chymotrypsin of esters of alpha, alpha-disubstituted acetic and beta, beta-disubstituted propionic acids. J Am Chem Soc (1966) 0.92
Serine proteinase requirement for the extra-cellular metabolism of pulmonary surfactant. Biochim Biophys Acta (1990) 0.92
Thermodynamics of binding to native alpha-chymotrypsin and to forms of alpha-chymotrypsin in which catalytically essential residues are modified; a study of "productive" and "nonproductive" associations. Biochemistry (1977) 0.92
Increased incidence of apoptosis in transforming growth factor alpha-deficient mouse blastocysts. Biol Reprod (1998) 0.91
Regulation of gene expression in the preimplantation mouse embryo: temporal and spatial patterns of expression of the transcription factor Sp1. Mol Reprod Dev (1997) 0.91
Effect of oxidative stress on development and DNA damage in in-vitro cultured bovine embryos by comet assay. Theriogenology (2000) 0.91
Stage-dependent redistributions of acetylated histones in nuclei of the early preimplantation mouse embryo. Mol Reprod Dev (1997) 0.91
Precocious loss of cortical granules during mouse oocyte meiotic maturation and correlation with an egg-induced modification of the zona pellucida. Dev Biol (1990) 0.91
Inhibition of oocyte maturation in the mouse: participation of cAMP, steroid hormones, and a putative maturation-inhibitory factor. Dev Biol (1983) 0.91
Synergistic activation of macrophages by lymphokine and lipopolysaccharide: evidence for lymphokine as the primer and interferon as the trigger. J Interferon Res (1982) 0.91
Roles of the disintegrin domains of mouse fertilins alpha and beta in fertilization. Biol Reprod (1998) 0.90
Preclinical cellular pharmacology of LY231514 (MTA): a comparison with methotrexate, LY309887 and raltitrexed for their effects on intracellular folate and nucleoside triphosphate pools in CCRF-CEM cells. Br J Cancer (1998) 0.90
Regulation of oocyte maturation in the mouse: possible roles of intercellular communication, cAMP, and testosterone. Dev Biol (1983) 0.90
Substrate specificity of mammalian folylpolyglutamate synthetase for 5,10-dideazatetrahydrofolate analogs. Mol Pharmacol (1995) 0.89
Comparison of the antitumor activity of gemcitabine and ara-C in a panel of human breast, colon, lung and pancreatic xenograft models. Invest New Drugs (1996) 0.89
Effects of whole body X-irradiation and cyclophosphamide treatment on induction of macrophage tumoricidal function in mice. Cell Immunol (1978) 0.89
Depressed cell-mediated immunity in newborn rabbits bearing fibroma virus-induced tumors. Infect Immun (1973) 0.89
Involvement of the cytoskeleton in the movement of cortical granules during oocyte maturation, and cortical granule anchoring in mouse eggs. Dev Biol (1998) 0.89
Effect of sodium and betaine in culture media on development and relative rates of protein synthesis in preimplantation mouse embryos in vitro. Mol Reprod Dev (1993) 0.89
Biochemical studies of mammalian oogenesis: metabolic cooperativity between granulosa cells and growing mouse oocytes. Dev Biol (1981) 0.88
Characterization of the binding of recombinant mouse sperm fertilin alpha subunit to mouse eggs: evidence for function as a cell adhesion molecule in sperm-egg binding. Dev Biol (1997) 0.88