Published in Trials on April 07, 2006
SPIRIT 2013 explanation and elaboration: guidance for protocols of clinical trials. BMJ (2013) 9.01
Implementation of self management support for long term conditions in routine primary care settings: cluster randomised controlled trial. BMJ (2013) 3.49
Increasing value and reducing waste in biomedical research regulation and management. Lancet (2014) 3.03
A reinvestigation of recruitment to randomised, controlled, multicenter trials: a review of trials funded by two UK funding agencies. Trials (2013) 3.03
Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open (2013) 2.59
Improving the recruitment activity of clinicians in randomised controlled trials: a systematic review. BMJ Open (2012) 2.50
Reasons for participating in randomised controlled trials: conditional altruism and considerations for self. Trials (2010) 2.25
Preliminary evaluation of factors associated with premature trial closure and feasibility of accrual benchmarks in phase III oncology trials. Clin Trials (2010) 2.24
Recruitment to multicentre trials--lessons from UKCTOCS: descriptive study. BMJ (2008) 2.10
The challenges faced in the design, conduct and analysis of surgical randomised controlled trials. Trials (2009) 2.03
Why is recruitment to trials difficult? An investigation into recruitment difficulties in an RCT of supported employment in patients with severe mental illness. Contemp Clin Trials (2008) 2.00
Disclosure of investigators' recruitment performance in multicenter clinical trials: a further step for research transparency. PLoS Med (2011) 1.86
Clear obstacles and hidden challenges: understanding recruiter perspectives in six pragmatic randomised controlled trials. Trials (2014) 1.82
A review of reporting of participant recruitment and retention in RCTs in six major journals. Trials (2009) 1.64
The attitudes of 1066 patients with cancer towards participation in randomised clinical trials. Br J Cancer (2010) 1.60
Interventions to improve recruitment and retention in clinical trials: a survey and workshop to assess current practice and future priorities. Trials (2014) 1.49
The National Cancer Institute-American Society of Clinical Oncology Cancer Trial Accrual Symposium: summary and recommendations. J Oncol Pract (2013) 1.48
Achieving sufficient accrual to address the primary endpoint in phase III clinical trials from U.S. Cooperative Oncology Groups. Clin Cancer Res (2011) 1.42
Exploring treatment preferences facilitated recruitment to randomized controlled trials. J Clin Epidemiol (2011) 1.40
The intellectual challenges and emotional consequences of equipoise contributed to the fragility of recruitment in six randomized controlled trials. J Clin Epidemiol (2014) 1.35
Recruitment and retention in a multicentre randomised controlled trial in Bell's palsy: a case study. BMC Med Res Methodol (2007) 1.34
Confronting challenges in intervention research with ethnically diverse older adults: the USC Well Elderly II Trial. Clin Trials (2009) 1.31
A thematic analysis of factors influencing recruitment to maternal and perinatal trials. BMC Pregnancy Childbirth (2008) 1.27
Workflow to improve patient recruitment for clinical trials within hospital information systems - a case-study. Trials (2008) 1.27
Pragmatic trials in primary care. Methodological challenges and solutions demonstrated by the DIAMOND-study. BMC Med Res Methodol (2007) 1.24
Social media and internet driven study recruitment: evaluating a new model for promoting collaborator engagement and participation. PLoS One (2015) 1.24
Trials within trials? Researcher, funder and ethical perspectives on the practicality and acceptability of nesting trials of recruitment methods in existing primary care trials. BMC Med Res Methodol (2010) 1.22
Identifying strategies to maximise recruitment and retention of practices and patients in a multicentre randomised controlled trial of an intervention to optimise secondary prevention for coronary heart disease in primary care. BMC Med Res Methodol (2009) 1.21
Marketing and clinical trials: a case study. Trials (2007) 1.17
Automated matching software for clinical trials eligibility: measuring efficiency and flexibility. Contemp Clin Trials (2010) 1.16
Financial considerations in the conduct of multi-centre randomised controlled trials: evidence from a qualitative study. Trials (2006) 1.15
Therapeutic hypothermia after pediatric cardiac arrest trials: the vanguard phase experience and implications for other trials. Pediatr Crit Care Med (2013) 1.15
Sample size determinations in original research protocols for randomised clinical trials submitted to UK research ethics committees: review. BMJ (2013) 1.15
Sample size requirements to estimate key design parameters from external pilot randomised controlled trials: a simulation study. Trials (2014) 1.13
The Primary Care Research Object Model (PCROM): a computable information model for practice-based primary care research. J Am Med Inform Assoc (2008) 1.12
Learning from failure--rationale and design for a study about discontinuation of randomized trials (DISCO study). BMC Med Res Methodol (2012) 1.10
Trends in Recruitment Rates for Acute Stroke Trials, 1990-2014. Stroke (2017) 1.08
Recruitment challenges of a multicenter randomized controlled varicocelectomy trial. Fertil Steril (2011) 1.05
An evaluation of the effectiveness of recruitment methods: the staying well after depression randomized controlled trial. Clin Trials (2014) 1.04
Terminated Trials in the ClinicalTrials.gov Results Database: Evaluation of Availability of Primary Outcome Data and Reasons for Termination. PLoS One (2015) 1.02
Factors influencing recruitment to research: qualitative study of the experiences and perceptions of research teams. BMC Med Res Methodol (2014) 1.02
Acceptability and perceived barriers and facilitators to creating a national research register to enable 'direct to patient' enrolment into research: the Scottish Health Research Register (SHARE). BMC Health Serv Res (2013) 1.02
Recruiting and engaging new mothers in nutrition research studies: lessons from the Australian NOURISH randomised controlled trial. Int J Behav Nutr Phys Act (2012) 1.00
Optimising recruitment and informed consent in randomised controlled trials: the development and implementation of the Quintet Recruitment Intervention (QRI). Trials (2016) 0.98
Studying a disease with no home--lessons in trial recruitment from the PATCH II study. Trials (2010) 0.96
A model for the design and implementation of a participant recruitment registry for clinical studies of older adults. Clin Trials (2012) 0.96
Recruitment of young women to a trial of chlamydia screening - as easy as it sounds? Trials (2007) 0.95
Recruitment to publicly funded trials--are surgical trials really different? Contemp Clin Trials (2008) 0.94
Barriers to recruitment for surgical trials in head and neck oncology: a survey of trial investigators. BMJ Open (2013) 0.94
Researchers' and clinicians' perceptions of recruiting participants to clinical research: a thematic meta-synthesis. J Clin Med Res (2014) 0.93
Strategies for improving patient recruitment to focus groups in primary care: a case study reflective paper using an analytical framework. BMC Med Res Methodol (2009) 0.93
Using registries to recruit subjects for clinical trials. Contemp Clin Trials (2014) 0.92
A European inventory of common electronic health record data elements for clinical trial feasibility. Trials (2014) 0.92
Recruiting older people to a randomised controlled dietary intervention trial--how hard can it be? BMC Med Res Methodol (2010) 0.91
Workplace restructurings in intervention studies - a challenge for design, analysis and interpretation. BMC Med Res Methodol (2008) 0.91
Missing steps in a staircase: a qualitative study of the perspectives of key stakeholders on the use of adaptive designs in confirmatory trials. Trials (2015) 0.91
Systematic techniques for assisting recruitment to trials (START): study protocol for embedded, randomized controlled trials. Trials (2014) 0.91
Guidelines for reporting embedded recruitment trials. Trials (2016) 0.90
A randomised controlled trial on the effectiveness of bracing patients with idiopathic scoliosis: failure to include patients and lessons to be learnt. Eur Spine J (2010) 0.90
Participant experiences of an internet-based intervention and randomised control trial: interview study. BMC Public Health (2013) 0.90
Exploring patients' reasons for declining contact in a cognitive behavioural therapy randomised controlled trial in primary care. Br J Gen Pract (2012) 0.88
Employing computers for the recruitment into clinical trials: a comprehensive systematic review. J Med Internet Res (2014) 0.87
A re-randomisation design for clinical trials. BMC Med Res Methodol (2015) 0.87
Uncovering the emotional aspects of working on a clinical trial: a qualitative study of the experiences and views of staff involved in a type 1 diabetes trial. Trials (2015) 0.86
Laparoscopic sigmoid resection for diverticular disease has no advantages over open approach: midterm results of a randomized controlled trial. Langenbecks Arch Surg (2011) 0.86
Evaluating predictive modeling algorithms to assess patient eligibility for clinical trials from routine data. BMC Med Inform Decis Mak (2013) 0.85
Implementing and evaluating the first german young-carers project: intentions, pitfalls and the need for piloting complex interventions. Open Nurs J (2011) 0.85
A pilot randomised controlled trial of negative pressure wound therapy to treat grade III/IV pressure ulcers [ISRCTN69032034]. Trials (2012) 0.85
Overcoming recruitment barriers revealed high readiness to participate and low dropout rate among people with schizophrenia in a randomized controlled trial testing the effect of a Guided Self-Determination intervention. BMC Psychiatry (2014) 0.85
Strategies to engage clinical staff in subject recruitment. J Res Nurs (2011) 0.85
Cross-sectional study of Pfizer-sponsored clinical trials: assessment of time to publication and publication history. BMJ Open (2016) 0.84
Defining dimensions of research readiness: a conceptual model for primary care research networks. BMC Fam Pract (2014) 0.84
Evaluating protocol lifecycle time intervals in HIV/AIDS clinical trials. Clin Trials (2014) 0.84
Great expectations for participatory research: what have we achieved in the last ten years? World Psychiatry (2014) 0.84
Reasons for and against participation in studies of medicinal therapies for women with breast cancer: a debate. BMC Med Res Methodol (2012) 0.83
Unique perception of clinical trials by Korean cancer patients. BMC Cancer (2012) 0.83
Quality of reporting on randomized controlled trials on recurrent spontaneous abortion in China. Trials (2015) 0.82
Comparison of characteristics and outcomes by initial study contact (website versus staff) for participants enrolled in a weight management study. Clin Trials (2012) 0.82
Mindfulness-based cognitive therapy for inflammatory bowel disease patients: findings from an exploratory pilot randomised controlled trial. Trials (2015) 0.82
Barriers to recruitment in psycho-oncology: unique challenges in conducting research focusing on sexual health in female survivorship. Psychooncology (2014) 0.82
Specifying the target difference in the primary outcome for a randomised controlled trial: guidance for researchers. Trials (2015) 0.81
Lack of timely accrual information in oncology clinical trials: a cross-sectional analysis. Trials (2014) 0.81
Recruiting and consenting into a peripartum trial in an emergency setting: a qualitative study of the experiences and views of women and healthcare professionals. Trials (2016) 0.80
Ciprofloxacin for the prevention of postoperative recurrence in patients with Crohn's disease: a randomized, double-blind, placebo-controlled pilot study. Inflamm Bowel Dis (2013) 0.80
Initial Readability Assessment of Clinical Trial Eligibility Criteria. AMIA Annu Symp Proc (2015) 0.80
'Putting Life in Years' (PLINY) telephone friendship groups research study: pilot randomised controlled trial. Trials (2014) 0.80
Challenges in recruitment to a randomized controlled study of cardiovascular disease reduction in sleep apnea: an analysis of alternative strategies. Sleep (2014) 0.80
Configuring the patient as clinical research subject in the UK national health service. Anthropol Med (2015) 0.79
Why do - or don't - patients with urinary tract infection participate in a clinical trial? A qualitative study in German family medicine. Ger Med Sci (2015) 0.79
Challenges to undertaking randomised trials with looked after children in social care settings. Trials (2015) 0.79
Factors influencing women's decision to participate or not in a surgical randomised controlled trial for surgical treatment of female stress urinary incontinence. Biomed Res Int (2013) 0.79
Challenges in quantifying the patient-reported burden of herpes zoster and post-herpetic neuralgia in the UK: learnings from the Zoster Quality of Life (ZQOL) study. BMC Res Notes (2013) 0.79
Factors that limit the quality, number and progress of randomised controlled trials. Health Technol Assess (1999) 7.00
Ethical issues in the design and conduct of cluster randomised controlled trials. BMJ (1999) 6.89
Descriptive survey of non-commercial randomised controlled trials in the United Kingdom, 1980-2002. BMJ (2003) 6.86
Making sense of randomization; responses of parents of critically ill babies to random allocation of treatment in a clinical trial. Soc Sci Med (1997) 6.73
Recruitment to randomised trials: strategies for trial enrollment and participation study. The STEPS study. Health Technol Assess (2007) 6.55
Perceptions of equipoise are crucial to trial participation: a qualitative study of men in the ProtecT study. Control Clin Trials (2003) 2.70
Increasing response rates to postal questionnaires: systematic review. BMJ (2002) 19.50
CONSORT statement: extension to cluster randomised trials. BMJ (2004) 16.50
Reporting of noninferiority and equivalence randomized trials: an extension of the CONSORT statement. JAMA (2006) 11.87
Methods to increase response to postal and electronic questionnaires. Cochrane Database Syst Rev (2009) 10.85
The importance of early treatment with tranexamic acid in bleeding trauma patients: an exploratory analysis of the CRASH-2 randomised controlled trial. Lancet (2011) 9.31
Smoking cessation support delivered via mobile phone text messaging (txt2stop): a single-blind, randomised trial. Lancet (2011) 8.19
Consort 2010 statement: extension to cluster randomised trials. BMJ (2012) 7.47
Decision aids for people facing health treatment or screening decisions. Cochrane Database Syst Rev (2009) 6.66
Meta-analysis of breast cancer outcomes in adjuvant trials of aromatase inhibitors versus tamoxifen. J Clin Oncol (2009) 6.51
Where is the evidence that animal research benefits humans? BMJ (2004) 5.99
No surgical innovation without evaluation: the IDEAL recommendations. Lancet (2009) 5.57
Identification of randomized controlled trials in systematic reviews: accuracy and reliability of screening records. Stat Med (2002) 5.35
Comparison of treatment effects between animal experiments and clinical trials: systematic review. BMJ (2006) 5.05
Interventions to improve water quality for preventing diarrhoea: systematic review and meta-analysis. BMJ (2007) 4.79
Effect of consent rituals on mortality in emergency care research. Lancet (2011) 4.74
Reporting of noninferiority and equivalence randomized trials: extension of the CONSORT 2010 statement. JAMA (2012) 4.73
Public health benefits of strategies to reduce greenhouse-gas emissions: urban land transport. Lancet (2009) 4.60
Predicting outcome after traumatic brain injury: practical prognostic models based on large cohort of international patients. BMJ (2008) 4.60
Predicting outcome after traumatic brain injury: development and international validation of prognostic scores based on admission characteristics. PLoS Med (2008) 4.60
The method of minimization for allocation to clinical trials. a review. Control Clin Trials (2002) 4.23
Final results of MRC CRASH, a randomised placebo-controlled trial of intravenous corticosteroid in adults with head injury-outcomes at 6 months. Lancet (2005) 3.70
Public health benefits of strategies to reduce greenhouse-gas emissions: overview and implications for policy makers. Lancet (2009) 3.51
Applying systematic review methods to studies of people's views: an example from public health research. J Epidemiol Community Health (2004) 3.48
Personalised care planning for adults with chronic or long-term health conditions. Cochrane Database Syst Rev (2015) 3.47
Development of a cross-platform biomarker signature to detect renal transplant tolerance in humans. J Clin Invest (2010) 3.41
Effect of tranexamic acid on surgical bleeding: systematic review and cumulative meta-analysis. BMJ (2012) 3.05
Evaluation and stages of surgical innovations. Lancet (2009) 3.04
Population adiposity and climate change. Int J Epidemiol (2009) 2.92
Non-vigorous physical activity and all-cause mortality: systematic review and meta-analysis of cohort studies. Int J Epidemiol (2010) 2.90
Deaths from injury in children and employment status in family: analysis of trends in class specific death rates. BMJ (2006) 2.87
Challenges in evaluating surgical innovation. Lancet (2009) 2.86
Nutritional associations with bone loss during the menopausal transition: evidence of a beneficial effect of calcium, alcohol, and fruit and vegetable nutrients and of a detrimental effect of fatty acids. Am J Clin Nutr (2004) 2.83
Philosophy, health services and research: the importance of keeping conversations open. Health Expect (2011) 2.78
Incidence of fires and related injuries after giving out free smoke alarms: cluster randomised controlled trial. BMJ (2002) 2.77
Selective reporting in clinical trials: analysis of trial protocols accepted by The Lancet. Lancet (2008) 2.76
Safety education of pedestrians for injury prevention: a systematic review of randomised controlled trials. BMJ (2002) 2.68
Effect of increasing active travel in urban England and Wales on costs to the National Health Service. Lancet (2012) 2.63
War on the roads. BMJ (2002) 2.60
Methods to improve recruitment to randomised controlled trials: Cochrane systematic review and meta-analysis. BMJ Open (2013) 2.59
Medical versus surgical management for gastro-oesophageal reflux disease (GORD) in adults. Cochrane Database Syst Rev (2010) 2.51
Aberrant succination of proteins in fumarate hydratase-deficient mice and HLRCC patients is a robust biomarker of mutation status. J Pathol (2011) 2.45
Reducing the carbon footprint of medical conferences. BMJ (2007) 2.42
Patient safety requires a new way to publish clinical trials. PLoS Clin Trials (2006) 2.35
Colloids versus crystalloids for fluid resuscitation in critically ill patients. Cochrane Database Syst Rev (2013) 2.32
Prognosis research strategy (PROGRESS) 1: a framework for researching clinical outcomes. BMJ (2013) 2.31
Walking, cycling and transport safety: an analysis of child road deaths. J R Soc Med (2006) 2.30
Congestion charging and the walking classes. BMJ (2003) 2.30
Systematic review of prognostic models in traumatic brain injury. BMC Med Inform Decis Mak (2006) 2.29
Reasons for participating in randomised controlled trials: conditional altruism and considerations for self. Trials (2010) 2.25
Energy and transport. Lancet (2007) 2.23
A randomized trial comparing treatments for varicose veins. N Engl J Med (2014) 2.20
Minimal access surgery compared with medical management for chronic gastro-oesophageal reflux disease: UK collaborative randomised trial. BMJ (2008) 2.18
Vitamin D supplementation to prevent infections: a sub-study of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing (2007) 2.14
Public health benefits of strategies to reduce greenhouse-gas emissions: food and agriculture. Lancet (2009) 2.12
An integrated approach to consumer representation and involvement in a multicentre randomized controlled trial. Clin Trials (2005) 2.07
Are these data real? Statistical methods for the detection of data fabrication in clinical trials. BMJ (2005) 2.04
Saddam Hussein's medical examination should not have been broadcast: images were designed to humiliate. BMJ (2004) 2.03
Building a semantically annotated corpus of clinical texts. J Biomed Inform (2009) 2.03
Hypothermia for traumatic head injury. Cochrane Database Syst Rev (2009) 2.03
Generation of "neoheparin" from E. coli K5 capsular polysaccharide. J Med Chem (2005) 2.03
Follow-up by mail in clinical trials: does questionnaire length matter? Control Clin Trials (2004) 1.88
A qualitative study of the acceptability of routine screening of postnatal women using the Edinburgh Postnatal Depression Scale. Br J Gen Pract (2003) 1.86
Carbon cost of pragmatic randomised controlled trials: retrospective analysis of sample of trials. BMJ (2009) 1.86
Policies for accelerating access to clean energy, improving health, advancing development, and mitigating climate change. Lancet (2007) 1.84
Topical application of tranexamic acid for the reduction of bleeding. Cochrane Database Syst Rev (2013) 1.83
Intracluster correlation coefficients in cluster randomized trials: empirical insights into how should they be reported. BMC Med Res Methodol (2004) 1.81
The weight of nations: an estimation of adult human biomass. BMC Public Health (2012) 1.78
Prevalence of working smoke alarms in local authority inner city housing: randomised controlled trial. BMJ (2002) 1.77
Opportunities and challenges for improving the quality of reporting clinical research: CONSORT and beyond. CMAJ (2004) 1.77
The CLEF corpus: semantic annotation of clinical text. AMIA Annu Symp Proc (2007) 1.76
Randomized trial of intensive bisphosphonate treatment versus symptomatic management in Paget's disease of bone. J Bone Miner Res (2010) 1.73
The requirement for prior consent to participate on survey response rates: a population-based survey in Grampian. BMC Health Serv Res (2003) 1.71
Social class, ethnicity and attendance for antenatal care in the United Kingdom: a systematic review. J Public Health Med (2003) 1.70
Systematic reviews of animal experiments. Lancet (2002) 1.70
Lower estimates of net endogenous non-carbonic acid production are positively associated with indexes of bone health in premenopausal and perimenopausal women. Am J Clin Nutr (2004) 1.67
A prospective study of the use of cryosurgery for the treatment of actinic keratoses. Int J Dermatol (2004) 1.66
Meta-analysis of randomised trials of monetary incentives and response to mailed questionnaires. J Epidemiol Community Health (2005) 1.60
Are women and providers satisfied with antenatal care? Views on a standard and a simplified, evidence-based model of care in four developing countries. BMC Womens Health (2002) 1.59
Mannitol for acute traumatic brain injury. Cochrane Database Syst Rev (2013) 1.59
Randomised trial of glutamine, selenium, or both, to supplement parenteral nutrition for critically ill patients. BMJ (2011) 1.58
IDEAL framework for surgical innovation 1: the idea and development stages. BMJ (2013) 1.56
IDEAL framework for surgical innovation 2: observational studies in the exploration and assessment stages. BMJ (2013) 1.56
Cost-effectiveness analysis of administering tranexamic acid to bleeding trauma patients using evidence from the CRASH-2 trial. PLoS One (2011) 1.56
Acquisition of high-level chromosomal instability is associated with integration of human papillomavirus type 16 in cervical keratinocytes. Cancer Res (2004) 1.56
Vitamin D supplementation and type 2 diabetes: a substudy of a randomised placebo-controlled trial in older people (RECORD trial, ISRCTN 51647438). Age Ageing (2009) 1.53
Long-term follow-up for mortality and cancer in a randomized placebo-controlled trial of vitamin D(3) and/or calcium (RECORD trial). J Clin Endocrinol Metab (2011) 1.52
Diversity in conserved genes in tomato. BMC Genomics (2007) 1.52
The relative effects of group size on reading progress of older students with reading difficulties. Read Writ (2010) 1.51
Prevalence of virulence genes in Escherichia coli strains recently isolated from young pigs with diarrhea in the US. Vet Microbiol (2007) 1.50
The effect of scientific misconduct on the results of clinical trials: a Delphi survey. Contemp Clin Trials (2005) 1.45