Published in Cancer Res on April 15, 2006
Predicting drug susceptibility of non-small cell lung cancers based on genetic lesions. J Clin Invest (2009) 5.07
Integrative genomic analysis of medulloblastoma identifies a molecular subgroup that drives poor clinical outcome. J Clin Oncol (2010) 4.48
Inhibition of GLI-mediated transcription and tumor cell growth by small-molecule antagonists. Proc Natl Acad Sci U S A (2007) 4.15
Tumour-initiating cells: challenges and opportunities for anticancer drug discovery. Nat Rev Drug Discov (2009) 4.12
A primary xenograft model of small-cell lung cancer reveals irreversible changes in gene expression imposed by culture in vitro. Cancer Res (2009) 3.38
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Genetically engineered mouse models of brain cancer and the promise of preclinical testing. Brain Pathol (2009) 1.66
Targeting human medulloblastoma: oncolytic virotherapy with myxoma virus is enhanced by rapamycin. Cancer Res (2007) 1.50
N-myc alters the fate of preneoplastic cells in a mouse model of medulloblastoma. Genes Dev (2009) 1.45
The hedgehog regulated oncogenes Gli1 and Gli2 block myoblast differentiation by inhibiting MyoD-mediated transcriptional activation. Oncogene (2006) 1.32
Medulloblastoma: from molecular pathology to therapy. Clin Cancer Res (2008) 1.30
Cyclopamine inhibition of human breast cancer cell growth independent of Smoothened (Smo). Breast Cancer Res Treat (2008) 1.27
Hedgehog-Gli signaling pathway inhibitors as anticancer agents. J Med Chem (2009) 1.14
GLI1 is a central mediator of EWS/FLI1 signaling in Ewing tumors. PLoS One (2009) 1.10
Inhibition of the hedgehog pathway targets the tumor-associated stroma in pancreatic cancer. Mol Cancer Res (2012) 1.07
Disruption of the PACAP gene promotes medulloblastoma in ptc1 mutant mice. Dev Biol (2007) 1.00
A single intravenous injection of oncolytic picornavirus SVV-001 eliminates medulloblastomas in primary tumor-based orthotopic xenograft mouse models. Neuro Oncol (2010) 1.00
Gli1/DNA interaction is a druggable target for Hedgehog-dependent tumors. EMBO J (2014) 0.94
O6-methylguanine-DNA methyltransferase is downregulated in transformed astrocyte cells: implications for anti-glioma therapies. Mol Cancer (2007) 0.93
Gli1 maintains cell survival by up-regulating IGFBP6 and Bcl-2 through promoter regions in parallel manner in pancreatic cancer cells. J Carcinog (2009) 0.91
Pituitary adenylyl cyclase activating polypeptide inhibits gli1 gene expression and proliferation in primary medulloblastoma derived tumorsphere cultures. BMC Cancer (2010) 0.90
Establishment of murine basal cell carcinoma allografts: a potential model for preclinical drug testing and for molecular analysis. J Invest Dermatol (2011) 0.88
RAS/MAPK Activation Drives Resistance to Smo Inhibition, Metastasis, and Tumor Evolution in Shh Pathway-Dependent Tumors. Cancer Res (2015) 0.87
Critical role of zinc finger protein 521 in the control of growth, clonogenicity and tumorigenic potential of medulloblastoma cells. Oncotarget (2013) 0.86
Initiation and characterization of small cell lung cancer patient-derived xenografts from ultrasound-guided transbronchial needle aspirates. PLoS One (2015) 0.85
GPCR-like signaling mediated by smoothened contributes to acquired chemoresistance through activating Gli. Mol Cancer (2014) 0.85
Notch signaling is not essential in sonic hedgehog-activated medulloblastoma. Oncogene (2010) 0.85
In vitro models of pancreatic cancer for translational oncology research. Expert Opin Drug Discov (2009) 0.84
Targeted treatment for sonic hedgehog-dependent medulloblastoma. Neuro Oncol (2014) 0.83
Human prostate cancer heterotransplants: a review on this experimental model. Asian J Androl (2010) 0.83
Investigations on inhibitors of hedgehog signal pathway: a quantitative structure-activity relationship study. Int J Mol Sci (2011) 0.82
Primary orthotopic glioma xenografts recapitulate infiltrative growth and isocitrate dehydrogenase I mutation. J Vis Exp (2014) 0.82
Structure-activity relationships and cancer-cell selective toxicity of novel inhibitors of glioma-associated oncogene homologue 1 (Gli1) mediated transcription. J Med Chem (2009) 0.81
A Brain Tumor/Organotypic Slice Co-culture System for Studying Tumor Microenvironment and Targeted Drug Therapies. J Vis Exp (2015) 0.80
Molecular dynamics simulations of sonic hedgehog-receptor and inhibitor complexes and their applications for potential anticancer agent discovery. PLoS One (2013) 0.79
DJ-1 is activated in medulloblastoma and is associated with cell proliferation and differentiation. World J Surg Oncol (2014) 0.78
A PTCH1 homolog transcriptionally activated by p53 suppresses Hedgehog signaling. J Biol Chem (2014) 0.77
Mouse models and mouse supermodels. EMBO Mol Med (2010) 0.77
PTHrP treatment fails to rescue bone defects caused by Hedgehog pathway inhibition in young mice. Toxicol Pathol (2011) 0.76
Inhibition of Hedgehog-dependent tumors and cancer stem cells by a newly identified naturally occurring chemotype. Cell Death Dis (2016) 0.76
Norrin/Frizzled4 signalling in the preneoplastic niche blocks medulloblastoma initiation. Elife (2016) 0.75
Hedgehog Signaling in Malignant Pleural Mesothelioma. Genes (Basel) (2015) 0.75
Prediction of central nervous system embryonal tumour outcome based on gene expression. Nature (2002) 15.36
A perivascular niche for brain tumor stem cells. Cancer Cell (2007) 11.55
The genetic landscape of the childhood cancer medulloblastoma. Science (2010) 8.34
Puma is an essential mediator of p53-dependent and -independent apoptotic pathways. Cancer Cell (2003) 7.60
The transcription factor Myc controls metabolic reprogramming upon T lymphocyte activation. Immunity (2011) 6.00
Genomics identifies medulloblastoma subgroups that are enriched for specific genetic alterations. J Clin Oncol (2006) 5.96
Suppression of the Shh pathway using a small molecule inhibitor eliminates medulloblastoma in Ptc1(+/-)p53(-/-) mice. Cancer Cell (2004) 5.95
Subtypes of medulloblastoma have distinct developmental origins. Nature (2010) 5.94
Radial glia cells are candidate stem cells of ependymoma. Cancer Cell (2005) 5.21
Novel mutations target distinct subgroups of medulloblastoma. Nature (2012) 4.82
Inactivation of the p53 pathway in retinoblastoma. Nature (2006) 4.57
Phosphorylation of SMC1 is a critical downstream event in the ATM-NBS1-BRCA1 pathway. Genes Dev (2004) 3.76
Cross-species genomics matches driver mutations and cell compartments to model ependymoma. Nature (2010) 3.70
IL-35-mediated induction of a potent regulatory T cell population. Nat Immunol (2010) 3.43
BGEM: an in situ hybridization database of gene expression in the embryonic and adult mouse nervous system. PLoS Biol (2006) 3.24
The neurodegenerative disease protein aprataxin resolves abortive DNA ligation intermediates. Nature (2006) 2.86
A mouse model of ATR-Seckel shows embryonic replicative stress and accelerated aging. Nat Genet (2009) 2.68
A molecular fingerprint for medulloblastoma. Cancer Res (2003) 2.66
The Hedgehog's tale: developing strategies for targeting cancer. Nat Rev Cancer (2011) 2.60
Six3 repression of Wnt signaling in the anterior neuroectoderm is essential for vertebrate forebrain development. Genes Dev (2003) 2.59
Slug, a highly conserved zinc finger transcriptional repressor, protects hematopoietic progenitor cells from radiation-induced apoptosis in vivo. Cancer Cell (2002) 2.48
Transient inhibition of the Hedgehog pathway in young mice causes permanent defects in bone structure. Cancer Cell (2008) 2.42
DNA ligase III promotes alternative nonhomologous end-joining during chromosomal translocation formation. PLoS Genet (2011) 2.22
Human leukocyte antigen-B-associated transcript 3 is released from tumor cells and engages the NKp30 receptor on natural killer cells. Immunity (2007) 2.20
A zebrafish bmyb mutation causes genome instability and increased cancer susceptibility. Proc Natl Acad Sci U S A (2005) 2.19
Clinical, histopathologic, and molecular markers of prognosis: toward a new disease risk stratification system for medulloblastoma. J Clin Oncol (2004) 2.16
A mouse model of the most aggressive subgroup of human medulloblastoma. Cancer Cell (2012) 2.15
The tumor suppressors Ink4c and p53 collaborate independently with Patched to suppress medulloblastoma formation. Genes Dev (2005) 2.14
Mice heterozygous for mutation in Atm, the gene involved in ataxia-telangiectasia, have heightened susceptibility to cancer. Nat Genet (2002) 2.11
Host genetic variation affects resistance to infection with a highly pathogenic H5N1 influenza A virus in mice. J Virol (2009) 2.08
Comparison of frozen and RNALater solid tissue storage methods for use in RNA expression microarrays. BMC Genomics (2004) 2.05
Stability and function of regulatory T cells is maintained by a neuropilin-1-semaphorin-4a axis. Nature (2013) 1.99
Gli1 is important for medulloblastoma formation in Ptc1+/- mice. Oncogene (2005) 1.92
TDP1 facilitates chromosomal single-strand break repair in neurons and is neuroprotective in vivo. EMBO J (2007) 1.85
Medullomyoblastoma: a radiographic and clinicopathologic analysis of six cases and review of the literature. Cancer (2004) 1.84
Crucial role for DNA ligase III in mitochondria but not in Xrcc1-dependent repair. Nature (2011) 1.80
H2AX prevents CtIP-mediated DNA end resection and aberrant repair in G1-phase lymphocytes. Nature (2010) 1.78
Selective utilization of nonhomologous end-joining and homologous recombination DNA repair pathways during nervous system development. Proc Natl Acad Sci U S A (2006) 1.77
Loss of epigenetic modification driven by the Foxp3 transcription factor leads to regulatory T cell insufficiency. Immunity (2012) 1.61
A knowledge-based clustering algorithm driven by Gene Ontology. J Biopharm Stat (2004) 1.59
ERBB receptor signaling promotes ependymoma cell proliferation and represents a potential novel therapeutic target for this disease. Clin Cancer Res (2002) 1.58
Organic anion transporting polypeptide 1B transporters modulate hydroxyurea pharmacokinetics. Am J Physiol Cell Physiol (2013) 1.56
Hedgehog signaling regulates the generation of ameloblast progenitors in the continuously growing mouse incisor. Development (2010) 1.55
The hedgehog pathway and neurological disorders. Annu Rev Neurosci (2006) 1.51
Deletion of Shp2 in the brain leads to defective proliferation and differentiation in neural stem cells and early postnatal lethality. Mol Cell Biol (2007) 1.48
Bat3 promotes T cell responses and autoimmunity by repressing Tim-3–mediated cell death and exhaustion. Nat Med (2012) 1.48
DNA ligase III is critical for mtDNA integrity but not Xrcc1-mediated nuclear DNA repair. Nature (2011) 1.45
Dopaminergic innervation of the human striatum in Parkinson's disease. Mov Disord (2005) 1.44
Rescue of ataxia and preplate splitting by ectopic expression of Reelin in reeler mice. Neuron (2002) 1.43
Crystal structures of the Dab homology domains of mouse disabled 1 and 2. J Biol Chem (2003) 1.43
The genesis of cerebellar interneurons and the prevention of neural DNA damage require XRCC1. Nat Neurosci (2009) 1.43
Crk and Crk-like play essential overlapping roles downstream of disabled-1 in the Reelin pathway. J Neurosci (2008) 1.41
The reaper-binding protein scythe modulates apoptosis and proliferation during mammalian development. Mol Cell Biol (2005) 1.39
Lost in translation: the future of cancer research? Clin Cancer Res (2005) 1.38
Cardiovascular and craniofacial defects in Crk-null mice. Mol Cell Biol (2006) 1.37
Recurrent genomic alterations characterize medulloblastoma arising from DNA double-strand break repair deficiency. Proc Natl Acad Sci U S A (2009) 1.37
Differential DNA damage signaling accounts for distinct neural apoptotic responses in ATLD and NBS. Genes Dev (2009) 1.36
Targeting medulloblastoma: small-molecule inhibitors of the Sonic Hedgehog pathway as potential cancer therapeutics. Cancer Res (2005) 1.35
DNA ligase IV suppresses medulloblastoma formation. Cancer Res (2002) 1.34
A mouse model of rhabdomyosarcoma originating from the adipocyte lineage. Cancer Cell (2012) 1.32
Distinct domains in Nbs1 regulate irradiation-induced checkpoints and apoptosis. J Exp Med (2007) 1.32
Robust chromosomal DNA repair via alternative end-joining in the absence of X-ray repair cross-complementing protein 1 (XRCC1). Proc Natl Acad Sci U S A (2012) 1.31
DNA strand breaks, neurodegeneration and aging in the brain. Mech Ageing Dev (2008) 1.27
Scythe regulates apoptosis-inducing factor stability during endoplasmic reticulum stress-induced apoptosis. J Biol Chem (2007) 1.27
Crk1/2-dependent signaling is necessary for podocyte foot process spreading in mouse models of glomerular disease. J Clin Invest (2012) 1.25
Binding of purified Reelin to ApoER2 and VLDLR mediates tyrosine phosphorylation of Disabled-1. Brain Res Mol Brain Res (2003) 1.23
The TLR2-MyD88-NOD2-RIPK2 signalling axis regulates a balanced pro-inflammatory and IL-10-mediated anti-inflammatory cytokine response to Gram-positive cell walls. Cell Microbiol (2008) 1.23
A mutation in separase causes genome instability and increased susceptibility to epithelial cancer. Genes Dev (2007) 1.23
Mouse embryos cloned from brain tumors. Cancer Res (2003) 1.22
H5N1 influenza virus pathogenesis in genetically diverse mice is mediated at the level of viral load. MBio (2011) 1.22
BRCA2 is required for neurogenesis and suppression of medulloblastoma. EMBO J (2007) 1.21
Transcription factor Late SV40 Factor (LSF) functions as an oncogene in hepatocellular carcinoma. Proc Natl Acad Sci U S A (2010) 1.20
Phase I study of vismodegib in children with recurrent or refractory medulloblastoma: a pediatric brain tumor consortium study. Clin Cancer Res (2013) 1.20
Transcription repression in oncogenic transformation: common targets of epigenetic repression in cells transformed by Fos, Ras or Dnmt1. Oncogene (2004) 1.18
Patched2 modulates tumorigenesis in patched1 heterozygous mice. Cancer Res (2006) 1.16
Defective DNA ligation during short-patch single-strand break repair in ataxia oculomotor apraxia 1. Mol Cell Biol (2008) 1.16
Synergistic decrease of DNA single-strand break repair rates in mouse neural cells lacking both Tdp1 and aprataxin. DNA Repair (Amst) (2009) 1.16