In-tandem insight from basic science combined with clinical research: CD38 as both marker and key component of the pathogenetic network underlying chronic lymphocytic leukemia.

PubWeight™: 1.49‹?› | Rank: Top 4%

🔗 View Article (PMID 16621959)

Published in Blood on April 18, 2006

Authors

Silvia Deaglio1, Tiziana Vaisitti, Semra Aydin, Enza Ferrero, Fabio Malavasi

Author Affiliations

1: Laboratory of Immunogenetics, Department of Genetics, Biology and Biochemistry, University of Torino, Italy.

Articles citing this

Adenosine generation catalyzed by CD39 and CD73 expressed on regulatory T cells mediates immune suppression. J Exp Med (2007) 10.00

Cellular origin(s) of chronic lymphocytic leukemia: cautionary notes and additional considerations and possibilities. Blood (2010) 1.79

CD38 expression labels an activated subset within chronic lymphocytic leukemia clones enriched in proliferating B cells. Blood (2007) 1.69

Molecular and cellular mechanisms of CLL: novel therapeutic approaches. Nat Rev Clin Oncol (2009) 1.64

In vivo intraclonal and interclonal kinetic heterogeneity in B-cell chronic lymphocytic leukemia. Blood (2009) 1.40

CD38 and chronic lymphocytic leukemia: a decade later. Blood (2011) 1.33

Prognostic factors in chronic lymphocytic leukemia-what do we need to know? Nat Rev Clin Oncol (2010) 1.30

Signaling properties of CD38 in the mouse immune system: enzyme-dependent and -independent roles in immunity. Mol Med (2007) 1.24

CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity. Mol Med (2007) 1.08

Differential bone marrow homing capacity of VLA-4 and CD38 high expressing chronic lymphocytic leukemia cells. PLoS One (2011) 0.97

Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation. Haematologica (2009) 0.97

The CD38 ectoenzyme family: advances in basic science and clinical practice. Mol Med (2007) 0.94

CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med (2009) 0.93

Mechanism-based small molecule probes for labeling CD38 on live cells. J Am Chem Soc (2009) 0.90

CD38 plays a dual role in allergen-induced airway hyperresponsiveness. Am J Respir Cell Mol Biol (2008) 0.89

Design, synthesis and biological characterization of novel inhibitors of CD38. Org Biomol Chem (2011) 0.83

CD38 controls the innate immune response against Listeria monocytogenes. Infect Immun (2013) 0.83

The enzymatic activities of CD38 enhance CLL growth and trafficking: implications for therapeutic targeting. Leukemia (2014) 0.83

Potential role of daratumumab in the treatment of multiple myeloma. Onco Targets Ther (2014) 0.83

Phorbol myristate acetate, but not CD40L, induces the differentiation of CLL B cells into Ab-secreting cells. Immunol Cell Biol (2014) 0.78

CXCL12-induced chemotaxis is impaired in T cells from patients with ZAP-70-negative chronic lymphocytic leukemia. Haematologica (2010) 0.78

Comparison of Bcl-2, CD38 and ZAP-70 Expression in Chronic Lymphocytic Leukemia. Int J Clin Exp Pathol (2009) 0.77

STAT3 and NF-κB cooperatively control in vitro spontaneous apoptosis and poor chemo-responsiveness in patients with chronic lymphocytic leukemia. Oncotarget (2016) 0.76

CD38 ligation in peripheral blood mononuclear cells of myeloma patients induces release of protumorigenic IL-6 and impaired secretion of IFNγ cytokines and proliferation. Mediators Inflamm (2013) 0.75

Network Biomarkers Constructed from Gene Expression and Protein-Protein Interaction Data for Accurate Prediction of Leukemia. J Cancer (2017) 0.75

Articles by these authors

Evolution and function of the ADP ribosyl cyclase/CD38 gene family in physiology and pathology. Physiol Rev (2008) 2.92

The low-density lipoprotein receptor plays a role in the infection of primary human hepatocytes by hepatitis C virus. J Hepatol (2006) 2.74

Mutations of the SF3B1 splicing factor in chronic lymphocytic leukemia: association with progression and fludarabine-refractoriness. Blood (2011) 2.44

Functional role and prognostic significance of CD157 in ovarian carcinoma. J Natl Cancer Inst (2010) 2.08

CD38 is a signaling molecule in B-cell chronic lymphocytic leukemia cells. Blood (2003) 1.99

The coding genome of splenic marginal zone lymphoma: activation of NOTCH2 and other pathways regulating marginal zone development. J Exp Med (2012) 1.90

Disruption of BIRC3 associates with fludarabine chemorefractoriness in TP53 wild-type chronic lymphocytic leukemia. Blood (2012) 1.88

CD38 and CD100 lead a network of surface receptors relaying positive signals for B-CLL growth and survival. Blood (2004) 1.63

TfR2 localizes in lipid raft domains and is released in exosomes to activate signal transduction along the MAPK pathway. J Cell Sci (2006) 1.55

Alteration of BIRC3 and multiple other NF-κB pathway genes in splenic marginal zone lymphoma. Blood (2011) 1.53

CD38 and ZAP-70 are functionally linked and mark CLL cells with high migratory potential. Blood (2007) 1.35

Two genetic variants of CD38 in subjects with autism spectrum disorder and controls. Neurosci Res (2010) 1.35

CD38/CD31, the CCL3 and CCL4 chemokines, and CD49d/vascular cell adhesion molecule-1 are interchained by sequential events sustaining chronic lymphocytic leukemia cell survival. Cancer Res (2009) 1.34

CD molecules 2005: human cell differentiation molecules. Blood (2005) 1.27

CD molecules 2006--human cell differentiation molecules. J Immunol Methods (2006) 1.23

The PD-1/PD-L1 axis contributes to T-cell dysfunction in chronic lymphocytic leukemia. Haematologica (2013) 1.21

CD38 orchestrates migration, survival, and Th1 immune response of human mature dendritic cells. Blood (2005) 1.20

Nicotinamide blocks proliferation and induces apoptosis of chronic lymphocytic leukemia cells through activation of the p53/miR-34a/SIRT1 tumor suppressor network. Cancer Res (2011) 1.13

CD38 is expressed on human mature monocyte-derived dendritic cells and is functionally involved in CD83 expression and IL-12 induction. Eur J Immunol (2004) 1.11

CD38/CD19: a lipid raft-dependent signaling complex in human B cells. Blood (2007) 1.11

CD73-generated extracellular adenosine in chronic lymphocytic leukemia creates local conditions counteracting drug-induced cell death. Blood (2011) 1.09

CD38 and CD157 as receptors of the immune system: a bridge between innate and adaptive immunity. Mol Med (2007) 1.08

A CD38/CD203a/CD73 ectoenzymatic pathway independent of CD39 drives a novel adenosinergic loop in human T lymphocytes. Oncoimmunology (2013) 1.07

Arsenic trioxide and breast cancer: analysis of the apoptotic, differentiative and immunomodulatory effects. Breast Cancer Res Treat (2002) 1.07

Exosomes from human lymphoblastoid B cells express enzymatically active CD38 that is associated with signaling complexes containing CD81, Hsc-70 and Lyn. Exp Cell Res (2010) 1.06

CD38 signaling in T cells is initiated within a subset of membrane rafts containing Lck and the CD3-zeta subunit of the T cell antigen receptor. J Biol Chem (2003) 1.05

CD38 is associated with lipid rafts and upon receptor stimulation leads to Akt/protein kinase B and Erk activation in the absence of the CD3-zeta immune receptor tyrosine-based activation motifs. J Biol Chem (2001) 1.03

IFN-gamma arms human dendritic cells to perform multiple effector functions. J Immunol (2008) 1.03

Oct-4+/Tenascin C+ neuroblastoma cells serve as progenitors of tumor-derived endothelial cells. Cell Res (2011) 1.02

CD38 and CD157: a long journey from activation markers to multifunctional molecules. Cytometry B Clin Cytom (2013) 1.01

Expression of ribosomal and translation-associated genes is correlated with a favorable clinical course in chronic lymphocytic leukemia. Blood (2002) 1.00

Transferrin receptor 2 is frequently expressed in human cancer cell lines. Blood Cells Mol Dis (2007) 0.98

Chronic lymphocytic leukemia microenvironment: shifting the balance from apoptosis to proliferation. Haematologica (2009) 0.97

CD38 at the junction between prognostic marker and therapeutic target. Trends Mol Med (2008) 0.96

CD157, the Janus of CD38 but with a unique personality. Cell Biochem Funct (2002) 0.96

Anti-CD38 antibody therapy: windows of opportunity yielded by the functional characteristics of the target molecule. Mol Med (2013) 0.95

Antigen-induced clustering of surface CD38 and recruitment of intracellular CD38 to the immunologic synapse. Blood (2008) 0.95

Chemotaxis of human tonsil B lymphocytes to CC chemokine receptor (CCR) 1, CCR2 and CCR4 ligands is restricted to non-germinal center cells. Int Immunol (2002) 0.95

CD38 gene polymorphism and chronic lymphocytic leukemia: a role in transformation to Richter syndrome? Blood (2008) 0.94

CD157 is an important mediator of neutrophil adhesion and migration. Blood (2004) 0.94

CD38/CD31 interactions activate genetic pathways leading to proliferation and migration in chronic lymphocytic leukemia cells. Mol Med (2009) 0.93

All-trans retinoic acid upregulates reduced CD38 transcription in lymphoblastoid cell lines from Autism spectrum disorder. Mol Med (2011) 0.93

A highly immunogenic recombinant and truncated protein of the secreted aspartic proteases family (rSap2t) of Candida albicans as a mucosal anticandidal vaccine. FEMS Immunol Med Microbiol (2011) 0.92

CD157 plays a pivotal role in neutrophil transendothelial migration. Blood (2006) 0.91

Role of CD31/platelet endothelial cell adhesion molecule-1 expression in in vitro and in vivo growth and differentiation of human breast cancer cells. Am J Pathol (2003) 0.91

Mechanism-based small molecule probes for labeling CD38 on live cells. J Am Chem Soc (2009) 0.90

Human CD38 and CD16 are functionally dependent and physically associated in natural killer cells. Blood (2002) 0.89

Retinoic acid-induced CD38 antigen as a target for immunotoxin-mediated killing of leukemia cells. Mol Cancer Ther (2004) 0.89

Use of genetic immunization to raise antibodies recognizing toxin-related cell surface ADP-ribosyltransferases in native conformation. Cell Immunol (2005) 0.89

Epigenetic silencing of the circadian clock gene CRY1 is associated with an indolent clinical course in chronic lymphocytic leukemia. PLoS One (2012) 0.88

Estrogen receptor alpha is a novel marker expressed by follicular dendritic cells in lymph nodes and tumor-associated lymphoid infiltrates. Am J Pathol (2003) 0.87

Structural, functional, and tissue distribution analysis of human transferrin receptor-2 by murine monoclonal antibodies and a polyclonal antiserum. Blood (2002) 0.87

The role of platelet/endothelial cell adhesion molecule 1 (CD31) and CD38 antigens in marrow microenvironmental retention of acute myelogenous leukemia cells. Cancer Res (2007) 0.87

ATRA-induced HL-60 myeloid leukemia cell differentiation depends on the CD38 cytosolic tail needed for membrane localization, but CD38 enzymatic activity is unnecessary. Exp Cell Res (2010) 0.87

The CD157-integrin partnership controls transendothelial migration and adhesion of human monocytes. J Biol Chem (2011) 0.87

Flow cytometric and immunoblot assays for cell surface ADP-ribosylation using a monoclonal antibody specific for ethenoadenosine. Anal Biochem (2003) 0.86

Are retinoids potential therapeutic agents in disorders of social cognition including autism? FEBS Lett (2011) 0.86

Human CD38 interferes with HIV-1 fusion through a sequence homologous to the V3 loop of the viral envelope glycoprotein gp120. FASEB J (2003) 0.85

CD38 ligation plays a direct role in the induction of IL-1beta, IL-6, and IL-10 secretion in resting human monocytes. Cell Immunol (2002) 0.85

HLA-G is a component of the chronic lymphocytic leukemia escape repertoire to generate immune suppression: impact of the HLA-G 14 base pair (rs66554220) polymorphism. Haematologica (2013) 0.85

Unraveling the contribution of ectoenzymes to myeloma life and survival in the bone marrow niche. Ann N Y Acad Sci (2014) 0.84

Prognostic significance of combined analysis of ZAP-70 and CD38 in chronic lymphocytic leukemia. Am J Hematol (2007) 0.84

Stable coordination of the inhibitory Ca2+ ion at the metal ion-dependent adhesion site in integrin CD11b/CD18 by an antibody-derived ligand aspartate: implications for integrin regulation and structure-based drug design. J Immunol (2011) 0.83

Role of transferrin receptor 2 in hepatic accumulation of iron in patients with chronic hepatitis C. J Gastroenterol Hepatol (2006) 0.83

CD38 as a molecular compass guiding topographical decisions of chronic lymphocytic leukemia cells. Semin Cancer Biol (2010) 0.82

Generation of potent neutralizing human monoclonal antibodies against cytomegalovirus infection from immune B cells. BMC Biotechnol (2008) 0.82

Functional, structural, and distribution analysis of the chorionic gonadotropin receptor using murine monoclonal antibodies. J Clin Endocrinol Metab (2003) 0.81

Ectoenzymes and innate immunity: the role of human CD157 in leukocyte trafficking. Front Biosci (Landmark Ed) (2009) 0.81

Purification of clinical-grade monoclonal antibodies by chromatographic methods. Methods Mol Biol (2005) 0.81

Expression of P2X7 ATP receptor mediating the IL8 and CCL20 release in human periodontal ligament stem cells. J Cell Biochem (2014) 0.80

A variant of the LRP4 gene affects the risk of chronic lymphocytic leukaemia transformation to Richter syndrome. Br J Haematol (2010) 0.80

Transferrin receptor 2 is frequently and highly expressed in glioblastomas. Transl Oncol (2010) 0.80

A panel of monoclonal antibodies recognizing GPI-anchored ADP-ribosyltransferase ART4, the carrier of the Dombrock blood group antigens. Cell Immunol (2005) 0.80

Targeting the microenvironment in chronic lymphocytic leukemia offers novel therapeutic options. Cancer Lett (2012) 0.80