Published in Hum Mol Genet on April 21, 2006
Mitochondrial membrane potential regulates PINK1 import and proteolytic destabilization by PARL. J Cell Biol (2010) 3.68
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
Where genotype is not predictive of phenotype: towards an understanding of the molecular basis of reduced penetrance in human inherited disease. Hum Genet (2013) 2.44
Genetic etiology of Parkinson disease associated with mutations in the SNCA, PARK2, PINK1, PARK7, and LRRK2 genes: a mutation update. Hum Mutat (2010) 2.29
Characterization of PINK1 processing, stability, and subcellular localization. J Neurochem (2008) 2.29
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A (2006) 2.08
The role of oxidative stress in Parkinson's disease. J Parkinsons Dis (2013) 1.86
Role of reactive oxygen species in the neurotoxicity of environmental agents implicated in Parkinson's disease. Free Radic Biol Med (2008) 1.38
Next generation sequencing and the future of genetic diagnosis. Neurotherapeutics (2014) 1.38
Digenic inheritance in medical genetics. J Med Genet (2013) 1.38
Mitochondrial dysfunction in the limelight of Parkinson's disease pathogenesis. Biochim Biophys Acta (2008) 1.35
Absence of nigral degeneration in aged parkin/DJ-1/PINK1 triple knockout mice. J Neurochem (2009) 1.34
FOXO3a-dependent regulation of Pink1 (Park6) mediates survival signaling in response to cytokine deprivation. Proc Natl Acad Sci U S A (2009) 1.32
Mitochondrial dysfunction and oxidative stress in Parkinson's disease. Prog Neurobiol (2013) 1.20
Regulation of intracellular manganese homeostasis by Kufor-Rakeb syndrome-associated ATP13A2 protein. J Biol Chem (2011) 1.19
DJ-1 modulates alpha-synuclein aggregation state in a cellular model of oxidative stress: relevance for Parkinson's disease and involvement of HSP70. PLoS One (2008) 1.18
DJ-1, PINK1, and their effects on mitochondrial pathways. Mov Disord (2010) 1.17
Neuroprotective function of DJ-1 in Parkinson's disease. Oxid Med Cell Longev (2013) 1.12
The role of PTEN-induced kinase 1 in mitochondrial dysfunction and dynamics. Int J Biochem Cell Biol (2009) 1.05
Oxidative modifications, mitochondrial dysfunction, and impaired protein degradation in Parkinson's disease: how neurons are lost in the Bermuda triangle. Mol Neurodegener (2009) 1.05
Structural effects of Parkinson's disease linked DJ-1 mutations. Protein Sci (2008) 1.02
Protein degradation in Parkinson disease revisited: it's complex. J Clin Invest (2009) 0.95
Molecular profiles of Quadriceps muscle in myostatin-null mice reveal PI3K and apoptotic pathways as myostatin targets. BMC Genomics (2009) 0.95
Structural impact of three Parkinsonism-associated missense mutations on human DJ-1. Biochemistry (2008) 0.94
Genetics in Parkinson disease: Mendelian versus non-Mendelian inheritance. J Neurochem (2016) 0.91
BAG5 protects against mitochondrial oxidative damage through regulating PINK1 degradation. PLoS One (2014) 0.89
PINK1-Interacting Proteins: Proteomic Analysis of Overexpressed PINK1. Parkinsons Dis (2011) 0.89
Structural determinants of PINK1 topology and dual subcellular distribution. BMC Cell Biol (2010) 0.88
Parkin and PINK1 parkinsonism may represent nigral mitochondrial cytopathies distinct from Lewy body Parkinson's disease. Parkinsonism Relat Disord (2009) 0.87
Mitochondria: A Therapeutic Target for Parkinson's Disease? Int J Mol Sci (2015) 0.85
Cell-based therapies for Parkinson's disease: past, present, and future. Antioxid Redox Signal (2009) 0.85
Clinical and molecular characterisation of a Parkinson family with a novel PINK1 mutation. J Neurol (2008) 0.82
Mutation analysis of Parkin, PINK1 and DJ-1 genes in Chinese patients with sporadic early onset parkinsonism. J Neurol (2010) 0.82
Pathogenic connexin-31 forms constitutively active hemichannels to promote necrotic cell death. PLoS One (2012) 0.81
Parkinson disease protein DJ-1 binds metals and protects against metal-induced cytotoxicity. J Biol Chem (2013) 0.80
Neuroprotective effects of protocatechuic aldehyde against neurotoxin-induced cellular and animal models of Parkinson's disease. PLoS One (2013) 0.78
Parkinson's disease proteins: Novel mitochondrial targets for cardioprotection. Pharmacol Ther (2015) 0.78
DJ1 represses glycolysis and cell proliferation by transcriptionally up-regulating Pink1. Biochem J (2015) 0.78
Mitochondrial Dysfunction in Cancer and Neurodegenerative Diseases: Spotlight on Fatty Acid Oxidation and Lipoperoxidation Products. Antioxidants (Basel) (2016) 0.77
Antioxidants put Parkinson flies back in the PINK. Proc Natl Acad Sci U S A (2006) 0.76
BAG5 Interacts with DJ-1 and Inhibits the Neuroprotective Effects of DJ-1 to Combat Mitochondrial Oxidative Damage. Oxid Med Cell Longev (2017) 0.75
A Physical Interaction between the Dopamine Transporter and DJ-1 Facilitates Increased Dopamine Reuptake. PLoS One (2015) 0.75
Warburg effect linked to cognitive-executive deficits in FMR1 premutation. FASEB J (2016) 0.75
Transient sampling of aggregation-prone conformations causes pathogenic instability of a parkinsonian mutant of DJ-1 at physiological temperature. Protein Sci (2015) 0.75
Early diagnosis and therapy of Parkinson's disease: can disease progression be curbed? J Neural Transm (Vienna) (2012) 0.75
The effects of variants in the PARK2 (parkin), PINK1, and PARK7 (DJ-1) genes along with evidence for their pathogenicity. Curr Protein Pept Sci (2016) 0.75
Analyzing structure-function relationships of artificial and cancer-associated PARP1 variants by reconstituting TALEN-generated HeLa PARP1 knock-out cells. Nucleic Acids Res (2016) 0.75
Parkin New Cargos: a New ROS Independent Role for Parkin in Regulating Cell Division. React Oxyg Species (Apex) (2016) 0.75
Structural and functional studies of SAV0551 from Staphylococcus aureus as a chaperone and glyoxalase III. Biosci Rep (2017) 0.75
Triple-negative breast cancer: clinical features and patterns of recurrence. Clin Cancer Res (2007) 16.79
Control of beta-catenin phosphorylation/degradation by a dual-kinase mechanism. Cell (2002) 10.34
Ancestral polyploidy in seed plants and angiosperms. Nature (2011) 7.00
Acetylation of metabolic enzymes coordinates carbon source utilization and metabolic flux. Science (2010) 6.04
Human embryonic stem cells derived by somatic cell nuclear transfer. Cell (2013) 5.91
Unique physiological and pathogenic features of Leptospira interrogans revealed by whole-genome sequencing. Nature (2003) 5.04
Mitochondrial gene replacement in primate offspring and embryonic stem cells. Nature (2009) 4.98
Immuno gold nanocages with tailored optical properties for targeted photothermal destruction of cancer cells. Nano Lett (2007) 4.37
Salpingo-oophorectomy and the risk of ovarian, fallopian tube, and peritoneal cancers in women with a BRCA1 or BRCA2 Mutation. JAMA (2006) 4.09
Widespread genome duplications throughout the history of flowering plants. Genome Res (2006) 4.07
A small molecule inhibitor of beta-catenin/CREB-binding protein transcription [corrected]. Proc Natl Acad Sci U S A (2004) 3.95
Anti-tumor activity of GW572016: a dual tyrosine kinase inhibitor blocks EGF activation of EGFR/erbB2 and downstream Erk1/2 and AKT pathways. Oncogene (2002) 3.87
Contralateral breast cancer in BRCA1 and BRCA2 mutation carriers. J Clin Oncol (2004) 3.86
Towards germline gene therapy of inherited mitochondrial diseases. Nature (2012) 3.73
TGM6 identified as a novel causative gene of spinocerebellar ataxias using exome sequencing. Brain (2010) 3.66
Breast cancer risk following bilateral oophorectomy in BRCA1 and BRCA2 mutation carriers: an international case-control study. J Clin Oncol (2005) 3.44
p27 phosphorylation by Src regulates inhibition of cyclin E-Cdk2. Cell (2007) 3.40
The SCF(COI1) ubiquitin-ligase complexes are required for jasmonate response in Arabidopsis. Plant Cell (2002) 3.34
Oral contraceptives and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. J Natl Cancer Inst (2002) 3.25
Mental health system in China: history, recent service reform and future challenges. World Psychiatry (2011) 3.23
Parkin, PINK1, and DJ-1 form a ubiquitin E3 ligase complex promoting unfolded protein degradation. J Clin Invest (2009) 3.17
Control of rice grain-filling and yield by a gene with a potential signature of domestication. Nat Genet (2008) 3.09
Metagenomic analysis of fever, thrombocytopenia and leukopenia syndrome (FTLS) in Henan Province, China: discovery of a new bunyavirus. PLoS Pathog (2011) 2.95
Intramyocardial transplantation of autologous endothelial progenitor cells for therapeutic neovascularization of myocardial ischemia. Circulation (2003) 2.82
Identification of PRRT2 as the causative gene of paroxysmal kinesigenic dyskinesias. Brain (2011) 2.80
Hormone therapy and the risk of breast cancer in BRCA1 mutation carriers. J Natl Cancer Inst (2008) 2.78
US Renal Data System 2013 Annual Data Report. Am J Kidney Dis (2014) 2.68
Pattern of metastatic spread in triple-negative breast cancer. Breast Cancer Res Treat (2008) 2.65
Antiemetic prophylaxis for office-based surgery: are the 5-HT3 receptor antagonists beneficial? Anesthesiology (2003) 2.64
A meta-analysis of teen cigarette smoking cessation. Health Psychol (2006) 2.63
The rice tapetum degeneration retardation gene is required for tapetum degradation and anther development. Plant Cell (2006) 2.62
Contralateral mastectomy and survival after breast cancer in carriers of BRCA1 and BRCA2 mutations: retrospective analysis. BMJ (2014) 2.60
Comparison of next generation sequencing technologies for transcriptome characterization. BMC Genomics (2009) 2.60
Nitrosative stress linked to sporadic Parkinson's disease: S-nitrosylation of parkin regulates its E3 ubiquitin ligase activity. Proc Natl Acad Sci U S A (2004) 2.55
US Renal Data System 2012 Annual Data Report. Am J Kidney Dis (2013) 2.54
Estrogen receptor status in BRCA1- and BRCA2-related breast cancer: the influence of age, grade, and histological type. Clin Cancer Res (2004) 2.51
CD34-positive cells exhibit increased potency and safety for therapeutic neovascularization after myocardial infarction compared with total mononuclear cells. Circulation (2006) 2.51
Identification of shared single copy nuclear genes in Arabidopsis, Populus, Vitis and Oryza and their phylogenetic utility across various taxonomic levels. BMC Evol Biol (2010) 2.50
Rapid mitochondrial DNA segregation in primate preimplantation embryos precedes somatic and germline bottleneck. Cell Rep (2012) 2.50
The excess microsporocytes1 gene encodes a putative leucine-rich repeat receptor protein kinase that controls somatic and reproductive cell fates in the Arabidopsis anther. Genes Dev (2002) 2.46
Tamoxifen and contralateral breast cancer in BRCA1 and BRCA2 carriers: an update. Int J Cancer (2006) 2.41
Generation of chimeric rhesus monkeys. Cell (2012) 2.41
Renaming the DSCR1/Adapt78 gene family as RCAN: regulators of calcineurin. FASEB J (2007) 2.30
Genome-wide analysis of basic/helix-loop-helix transcription factor family in rice and Arabidopsis. Plant Physiol (2006) 2.25
Sonic hedgehog myocardial gene therapy: tissue repair through transient reconstitution of embryonic signaling. Nat Med (2005) 2.24
Screening for founder mutations in BRCA1 and BRCA2 in unselected Jewish women. J Clin Oncol (2009) 2.20
Expression pattern shifts following duplication indicative of subfunctionalization and neofunctionalization in regulatory genes of Arabidopsis. Mol Biol Evol (2005) 2.18
Prospective study of breast cancer incidence in women with a BRCA1 or BRCA2 mutation under surveillance with and without magnetic resonance imaging. J Clin Oncol (2011) 2.17
International variation in rates of uptake of preventive options in BRCA1 and BRCA2 mutation carriers. Int J Cancer (2008) 2.13
Antioxidants protect PINK1-dependent dopaminergic neurons in Drosophila. Proc Natl Acad Sci U S A (2006) 2.08
Regulation of Arabidopsis tapetum development and function by DYSFUNCTIONAL TAPETUM1 (DYT1) encoding a putative bHLH transcription factor. Development (2006) 2.04
Role of dynamin, synaptojanin, and endophilin in podocyte foot processes. J Clin Invest (2012) 2.02
Acculturation, physical activity, and fast-food consumption among Asian-American and Hispanic adolescents. J Community Health (2004) 2.01
The evolution of the SEPALLATA subfamily of MADS-box genes: a preangiosperm origin with multiple duplications throughout angiosperm history. Genetics (2005) 1.95
Reproductive risk factors for ovarian cancer in carriers of BRCA1 or BRCA2 mutations: a case-control study. Lancet Oncol (2007) 1.89
The Arabidopsis AtRAD51 gene is dispensable for vegetative development but required for meiosis. Proc Natl Acad Sci U S A (2004) 1.85
Screening mammography and risk of breast cancer in BRCA1 and BRCA2 mutation carriers: a case-control study. Lancet Oncol (2006) 1.79
Oophorectomy after menopause and the risk of breast cancer in BRCA1 and BRCA2 mutation carriers. Cancer Epidemiol Biomarkers Prev (2012) 1.78
Expression of hiwi gene in human gastric cancer was associated with proliferation of cancer cells. Int J Cancer (2006) 1.76
Hypertension and health-related quality of life: an epidemiological study in patients attending hospital clinics in China. J Hypertens (2005) 1.72
Origins and evolution of the recA/RAD51 gene family: evidence for ancient gene duplication and endosymbiotic gene transfer. Proc Natl Acad Sci U S A (2006) 1.72
Tobacco use among youth and adults in Mainland China: the China Seven Cities Study. Public Health (2006) 1.72
Evolution of F-box genes in plants: different modes of sequence divergence and their relationships with functional diversification. Proc Natl Acad Sci U S A (2009) 1.70
Valproic acid inhibits Abeta production, neuritic plaque formation, and behavioral deficits in Alzheimer's disease mouse models. J Exp Med (2008) 1.68
Specific inhibition of CBP/beta-catenin interaction rescues defects in neuronal differentiation caused by a presenilin-1 mutation. Proc Natl Acad Sci U S A (2005) 1.67
A susceptibility locus at chromosome 3p21 linked to familial nasopharyngeal carcinoma. Cancer Res (2004) 1.65
Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature (2010) 1.64
Frequency of premature menopause in women who carry a BRCA1 or BRCA2 mutation. Fertil Steril (2013) 1.62
Type I MADS-box genes have experienced faster birth-and-death evolution than type II MADS-box genes in angiosperms. Proc Natl Acad Sci U S A (2004) 1.62
Mutation analysis of the small heat shock protein 27 gene in chinese patients with Charcot-Marie-Tooth disease. Arch Neurol (2005) 1.59
Neuroprotection against spinal cord ischemia-reperfusion injury induced by different ischemic postconditioning methods: roles of phosphatidylinositol 3-kinase-Akt and extracellular signal-regulated kinase. Anesthesiology (2009) 1.59
Enhancing collaborative filtering by user interest expansion via personalized ranking. IEEE Trans Syst Man Cybern B Cybern (2011) 1.58
Predictors of contralateral prophylactic mastectomy in women with a BRCA1 or BRCA2 mutation: the Hereditary Breast Cancer Clinical Study Group. J Clin Oncol (2008) 1.57
Conservation and divergence in the AGAMOUS subfamily of MADS-box genes: evidence of independent sub- and neofunctionalization events. Evol Dev (2006) 1.57
Genome-wide analysis of the cyclin family in Arabidopsis and comparative phylogenetic analysis of plant cyclin-like proteins. Plant Physiol (2004) 1.56
Functional disruption of alpha4 integrin mobilizes bone marrow-derived endothelial progenitors and augments ischemic neovascularization. J Exp Med (2006) 1.56
STAT3 is a substrate of SYK tyrosine kinase in B-lineage leukemia/lymphoma cells exposed to oxidative stress. Proc Natl Acad Sci U S A (2010) 1.55
Simultaneous hybrid revascularization versus off-pump coronary artery bypass for multivessel coronary artery disease. Ann Thorac Surg (2011) 1.55
Floral gene resources from basal angiosperms for comparative genomics research. BMC Plant Biol (2005) 1.54
Coffee consumption and breast cancer risk among BRCA1 and BRCA2 mutation carriers. Int J Cancer (2006) 1.53
Adeno-associated virus type 2 (AAV2) capsid-specific cytotoxic T lymphocytes eliminate only vector-transduced cells coexpressing the AAV2 capsid in vivo. J Virol (2007) 1.52
Nanostructured bilayered vanadium oxide electrodes for rechargeable sodium-ion batteries. ACS Nano (2011) 1.52
Chemotherapy-induced amenorrhea in patients with breast cancer with a BRCA1 or BRCA2 mutation. J Clin Oncol (2013) 1.52
Tumor necrosis factor-alpha receptor p75 is required in ischemia-induced neovascularization. Circulation (2007) 1.51
The emergence of allenamides in organic synthesis. Acc Chem Res (2003) 1.50
Determination of bone marrow-derived endothelial progenitor cell significance in angiogenic growth factor-induced neovascularization in vivo. Exp Hematol (2002) 1.49
Effect of pregnancy as a risk factor for breast cancer in BRCA1/BRCA2 mutation carriers. Int J Cancer (2005) 1.48
Long-term ovarian cancer survival associated with mutation in BRCA1 or BRCA2. J Natl Cancer Inst (2012) 1.48
Genetics of meiotic prophase I in plants. Annu Rev Plant Biol (2006) 1.47
Leucine-Rich Repeat Kinase 2 interacts with Parkin, DJ-1 and PINK-1 in a Drosophila melanogaster model of Parkinson's disease. Hum Mol Genet (2009) 1.47