Published in Cell Mol Neurobiol on April 22, 2006
Mechanisms of neurodegeneration and regeneration in alcoholism. Alcohol Alcohol (2008) 2.52
Induction of innate immune genes in brain create the neurobiology of addiction. Brain Behav Immun (2011) 1.77
Combined medication of lovastatin with rolipram suppresses severity of experimental autoimmune encephalomyelitis. Exp Neurol (2008) 1.54
NADPH oxidase and reactive oxygen species contribute to alcohol-induced microglial activation and neurodegeneration. J Neuroinflammation (2012) 1.49
Role of NMDA receptor-dependent activation of SREBP1 in excitotoxic and ischemic neuronal injuries. Nat Med (2009) 1.36
High mobility group box 1/Toll-like receptor danger signaling increases brain neuroimmune activation in alcohol dependence. Biol Psychiatry (2012) 1.33
Neuroscience of alcoholism: molecular and cellular mechanisms. Cell Mol Life Sci (2009) 1.32
The CREB/CRE transcriptional pathway: protection against oxidative stress-mediated neuronal cell death. J Neurochem (2009) 1.21
Adolescent binge drinking increases expression of the danger signal receptor agonist HMGB1 and Toll-like receptors in the adult prefrontal cortex. Neuroscience (2012) 1.20
Chronic ethanol increases systemic TLR3 agonist-induced neuroinflammation and neurodegeneration. J Neuroinflammation (2012) 1.11
The role of reactive-oxygen-species in microbial persistence and inflammation. Int J Mol Sci (2011) 1.08
Mechanisms of neuroimmune gene induction in alcoholism. Psychopharmacology (Berl) (2015) 1.07
Inflammasome-IL-1β Signaling Mediates Ethanol Inhibition of Hippocampal Neurogenesis. Front Neurosci (2012) 1.06
Ethanol-BDNF interactions: still more questions than answers. Pharmacol Ther (2008) 1.06
NR4A orphan nuclear receptors as mediators of CREB-dependent neuroprotection. Proc Natl Acad Sci U S A (2010) 1.05
Release of neuronal HMGB1 by ethanol through decreased HDAC activity activates brain neuroimmune signaling. PLoS One (2014) 1.04
Antiinflammatory and neuroprotective actions of COX2 inhibitors in the injured brain. Brain Behav Immun (2007) 0.94
ATP-P2X7 receptor signaling controls basal and TNFα-stimulated glial cell proliferation. Glia (2012) 0.94
Transcriptional control of maladaptive and protective responses in alcoholics: a role of the NF-κB system. Brain Behav Immun (2010) 0.90
Immune function genes, genetics, and the neurobiology of addiction. Alcohol Res (2012) 0.90
Transcriptomic responses in mouse brain exposed to chronic excess of the neurotransmitter glutamate. BMC Genomics (2010) 0.89
Linking binge alcohol-induced neurodamage to brain edema and potential aquaporin-4 upregulation: evidence in rat organotypic brain slice cultures and in vivo. J Neurotrauma (2009) 0.88
Fetal alcohol spectrum disorders and neuroimmune changes. Int Rev Neurobiol (2014) 0.88
Effects of ethanol on immune response in the brain: region-specific changes in aged mice. J Neuroinflammation (2013) 0.86
Addiction, adolescence, and innate immune gene induction. Front Psychiatry (2011) 0.86
Relationship between liver function and brain shrinkage in patients with alcohol dependence. Alcohol Clin Exp Res (2011) 0.85
Temporal changes in innate immune signals in a rat model of alcohol withdrawal in emotional and cardiorespiratory homeostatic nuclei. J Neuroinflammation (2012) 0.84
Neuroimmune Function and the Consequences of Alcohol Exposure. Alcohol Res (2015) 0.84
Protection against alcohol-induced neuronal and cognitive damage by the PPARγ receptor agonist pioglitazone. Brain Behav Immun (2017) 0.82
Fetal alcohol-induced hyperactivity is reversed by treatment with the PPARα agonist fenofibrate in a rat model. Psychopharmacology (Berl) (2010) 0.82
Long term running biphasically improves methylglyoxal-related metabolism, redox homeostasis and neurotrophic support within adult mouse brain cortex. PLoS One (2012) 0.80
Adolescent Alcohol Exposure Persistently Impacts Adult Neurobiology and Behavior. Pharmacol Rev (2016) 0.78
Developing a Deeper Understanding of Autism: Connecting Knowledge through Literature Mining. Autism Res Treat (2011) 0.78
Chronic Drinking During Adolescence Predisposes the Adult Rat for Continued Heavy Drinking: Neurotrophin and Behavioral Adaptation after Long-Term, Continuous Ethanol Exposure. PLoS One (2016) 0.77
Matching Diabetes and Alcoholism: Oxidative Stress, Inflammation, and Neurogenesis Are Commonly Involved. Mediators Inflamm (2015) 0.76
Alcohol-related neurodegeneration and recovery: mechanisms from animal models. Alcohol Res Health (2008) 0.76
Ethanol transiently suppresses choline-acetyltransferase in basal nucleus of Meynert slices. Brain Res (2012) 0.76
The role of neuroimmune signaling in alcoholism. Neuropharmacology (2017) 0.76
Adenyl cyclase activator forskolin protects against Huntington's disease-like neurodegenerative disorders. Neural Regen Res (2017) 0.75
High Resolution Genomic Scans Reveal Genetic Architecture Controlling Alcohol Preference in Bidirectionally Selected Rat Model. PLoS Genet (2016) 0.75
NF-kappa B and Rel proteins: evolutionarily conserved mediators of immune responses. Annu Rev Immunol (1998) 21.48
Neurotrophins: roles in neuronal development and function. Annu Rev Neurosci (2001) 11.40
Function and regulation of CREB family transcription factors in the nervous system. Neuron (2002) 7.99
The many faces of CREB. Trends Neurosci (2005) 5.58
CREB and memory. Annu Rev Neurosci (1998) 4.76
NF-kappa B: a crucial transcription factor for glial and neuronal cell function. Trends Neurosci (1997) 3.72
Disruption of CREB function in brain leads to neurodegeneration. Nat Genet (2002) 3.54
NF-kappa B functions in synaptic signaling and behavior. Nat Neurosci (2003) 3.40
Mediation by a CREB family transcription factor of NGF-dependent survival of sympathetic neurons. Science (1999) 3.13
CREB: a major mediator of neuronal neurotrophin responses. Neuron (1997) 3.04
NF-kappaB is activated and promotes cell death in focal cerebral ischemia. Nat Med (1999) 2.96
NF-kappaB in neuronal plasticity and neurodegenerative disorders. J Clin Invest (2001) 2.78
Evidence that reactive oxygen species do not mediate NF-kappaB activation. EMBO J (2003) 2.13
Neuroinflammatory processes in Parkinson's disease. Ann Neurol (2003) 2.10
Tumor necrosis factors protect neurons against metabolic-excitotoxic insults and promote maintenance of calcium homeostasis. Neuron (1994) 2.09
Common molecular and cellular substrates of addiction and memory. Neurobiol Learn Mem (2002) 1.90
A new mechanism of neurodegeneration: a proinflammatory cytokine inhibits receptor signaling by a survival peptide. Proc Natl Acad Sci U S A (1999) 1.90
Physiological functions for brain NF-kappaB. Trends Neurosci (2005) 1.85
Redox regulation of NF-kappa B activation. Free Radic Biol Med (1997) 1.83
TNF alpha potentiates glutamate neurotoxicity by inhibiting glutamate uptake in organotypic brain slice cultures: neuroprotection by NF kappa B inhibition. Brain Res (2005) 1.77
Phosphorylation of cAMP response element-binding protein in hippocampal neurons as a protective response after exposure to glutamate in vitro and ischemia in vivo. J Neurosci (2001) 1.72
Coupling of extrasynaptic NMDA receptors to a CREB shut-off pathway is developmentally regulated. Biochim Biophys Acta (2002) 1.66
Neuroinflammation of the nigrostriatal pathway during progressive 6-OHDA dopamine degeneration in rats monitored by immunohistochemistry and PET imaging. Eur J Neurosci (2002) 1.57
Activity-dependent neuroprotection and cAMP response element-binding protein (CREB): kinase coupling, stimulus intensity, and temporal regulation of CREB phosphorylation at serine 133. J Neurosci (2005) 1.51
Is CREB a key to neuronal survival? Trends Neurosci (2000) 1.48
Localization of phosphorylated cAMP response element-binding protein in immature neurons of adult hippocampus. J Neurosci (2002) 1.44
CREB and its associated proteins act as survival factors for human melanoma cells. J Biol Chem (1998) 1.37
Tumor necrosis factor-alpha induces cFOS and strongly potentiates glutamate-mediated cell death in the rat spinal cord. Neurobiol Dis (2001) 1.36
Markers for neuronal degeneration in organotypic slice cultures. Brain Res Brain Res Protoc (1999) 1.34
Alcohol-induced neurodegeneration: when, where and why? Alcohol Clin Exp Res (2004) 1.27
Neuroprotective role of IL-4 against activated microglia. J Immunol (1993) 1.26
CREB phosphorylation promotes nerve cell survival. J Neurochem (1999) 1.24
Acute ethanol intoxication suppresses the pulmonary inflammatory response in rats challenged with intrapulmonary endotoxin. Alcohol Clin Exp Res (1997) 1.21
Molecular mechanisms underlying activity-dependent regulation of BDNF expression. J Neurobiol (1999) 1.19
Neuroprotective effects of TNF binding protein in focal cerebral ischemia. Brain Res (1997) 1.17
Increased severity of alcoholic liver injury in female rats: role of oxidative stress, endotoxin, and chemokines. Am J Physiol Gastrointest Liver Physiol (2001) 1.11
TNF-alpha activates solitary nucleus neurons responsive to gastric distension. Am J Physiol Gastrointest Liver Physiol (2000) 1.09
CREB is required for acquisition of ischemic tolerance in gerbil hippocampal CA1 region. J Neurochem (2003) 1.07
Opposing roles for NF-kappa B/Rel factors p65 and c-Rel in the modulation of neuron survival elicited by glutamate and interleukin-1beta. J Biol Chem (2002) 1.04
p53 dependent apoptosis in glioma cell lines in response to hydrogen peroxide induced oxidative stress. Int J Biochem Cell Biol (2002) 1.01
Ethanol inhibits NMDA receptor-mediated excitotoxicity in rat primary neuronal cultures. Alcohol Clin Exp Res (1993) 1.01
Adenovirus-directed expression of a nonphosphorylatable mutant of CREB (cAMP response element-binding protein) adversely affects the survival, but not the differentiation, of rat granulosa cells. Mol Endocrinol (1999) 1.00
Apolipoprotein E protects against oxidative stress in mixed neuronal-glial cell cultures by reducing glutamate toxicity. Neurochem Int (2004) 0.99
CREB gene transcription factors: role in molecular mechanisms of alcohol and drug addiction. Alcohol Clin Exp Res (2005) 0.98
Persistent phosphorylation of cyclic AMP responsive element-binding protein and activating transcription factor-2 transcription factors following transient cerebral ischemia in rat brain. Neuroscience (1999) 0.96
Potential involvement of the transcription factor NF-kappa B in neurological disorders. Mol Aspects Med (1993) 0.93
Alcohol withdrawal increases neuropeptide Y immunoreactivity in rat brain. Alcohol Clin Exp Res (2003) 0.92
Transcriptional regulation of neuronal genes and its effect on neural functions: cumulative mRNA expression of PACAP and BDNF genes controlled by calcium and cAMP signals in neurons. J Pharmacol Sci (2005) 0.92
TNF-alpha-induced c-Fos generation in the nucleus of the solitary tract is blocked by NBQX and MK-801. Am J Physiol Regul Integr Comp Physiol (2001) 0.90
Nerve growth factor (NGF) expression in rat microglia is induced by adenosine A2a-receptors. Neurosci Lett (1997) 0.89
Possible role of NF-kappaB and p53 in the glutamate-induced pro-apoptotic neuronal pathway. Cell Death Differ (1999) 0.89
Immune-mediated oligodendrocyte injury in multiple sclerosis: molecular mechanisms and therapeutic interventions. Crit Rev Immunol (2002) 0.87
Nuclear transcription factors in the hippocampus. Prog Neurobiol (2002) 0.85
Antioxidants differentially regulate activation of nuclear factor-kappa B, activator protein-1, c-jun amino-terminal kinases, and apoptosis induced by tumor necrosis factor: evidence that JNK and NF-kappa B activation are not linked to apoptosis. Antioxid Redox Signal (1999) 0.84
Ethanol pretreatment enhances NMDA excitotoxicity in biogenic amine neurons: protection by brain derived neurotrophic factor. Alcohol Clin Exp Res (1999) 0.84
Synergistic effects of hydrogen peroxide and ethanol on cell viability loss in PC12 cells by increase in mitochondrial permeability transition. Biochem Pharmacol (2005) 0.82
Tumor necrosis factor-alpha induces neuronal death by silencing survival signals generated by the type I insulin-like growth factor receptor. Ann N Y Acad Sci (2000) 0.82
Activation of caspase-9 and -3 during H2O2-induced apoptosis of PC12 cells independent of ceramide formation. Neurol Res (2000) 0.81
Induction of innate immune gene expression cascades in brain slice cultures by ethanol: key role of NF-κB and proinflammatory cytokines. Alcohol Clin Exp Res (2010) 1.33
Automatic Skull-stripping of Rat MRI/DTI Scans and Atlas Building. Proc SPIE Int Soc Opt Eng (2011) 1.16
Alcohol withdrawal increases neuropeptide Y immunoreactivity in rat brain. Alcohol Clin Exp Res (2003) 0.92
Automatic cortical thickness analysis on rodent brain. Proc SPIE Int Soc Opt Eng (2011) 0.92
Impulsivity: its genetic, neurochemical and brain substrate determinants and the risks it entails for aberrant motivated behavior and psychopathology. Pharmacol Biochem Behav (2009) 0.75