Published in N Engl J Med on April 27, 2006
Clozapine alone versus clozapine and risperidone with refractory schizophrenia. N Engl J Med (2006) 4.16
The choice of drugs for schizophrenia. N Engl J Med (2006) 1.75
Cotransplantation of HLA-identical sibling culture-expanded mesenchymal stem cells and hematopoietic stem cells in hematologic malignancy patients. Biol Blood Marrow Transplant (2005) 2.82
Metabolic regulation by the mitochondrial phosphatase PTPMT1 is required for hematopoietic stem cell differentiation. Cell Stem Cell (2013) 2.12
Targeted modulation of MGMT: clinical implications. Clin Cancer Res (2006) 1.83
DNA repair defects in stem cell function and aging. Annu Rev Med (2005) 1.74
Long-term-infected telomerase-immortalized endothelial cells: a model for Kaposi's sarcoma-associated herpesvirus latency in vitro and in vivo. J Virol (2006) 1.63
Phase I trial of fludarabine, bortezomib and rituximab for relapsed and refractory indolent and mantle cell non-Hodgkin lymphoma. Br J Haematol (2009) 1.56
Endothelial Kruppel-like factor 4 protects against atherothrombosis in mice. J Clin Invest (2012) 1.46
Humans accumulate microsatellite instability with acquired loss of MLH1 protein in hematopoietic stem and progenitor cells as a function of age. Blood (2012) 1.45
Repopulating defect of mismatch repair-deficient hematopoietic stem cells. Blood (2003) 1.44
A phase I and pharmacodynamic study of sequential topotecan and etoposide in patients with relapsed or refractory acute myelogenous and lymphoblastic leukemia. Leuk Res (2003) 1.39
Non-lineage/stage-restricted effects of a gain-of-function mutation in tyrosine phosphatase Ptpn11 (Shp2) on malignant transformation of hematopoietic cells. J Exp Med (2011) 1.37
The role of DNA damage repair in aging of adult stem cells. Nucleic Acids Res (2007) 1.35
Therapeutic impact of methoxyamine: blocking repair of abasic sites in the base excision repair pathway. Curr Opin Investig Drugs (2004) 1.27
Synergistic actions of hematopoietic and mesenchymal stem/progenitor cells in vascularizing bioengineered tissues. PLoS One (2008) 1.26
In vivo selection of MGMT(P140K) lentivirus-transduced human NOD/SCID repopulating cells without pretransplant irradiation conditioning. J Clin Invest (2003) 1.26
Base excision repair as a therapeutic target in colon cancer. Clin Cancer Res (2002) 1.25
Candidate gene analysis identifies a polymorphism in HLA-DQB1 associated with clozapine-induced agranulocytosis. J Clin Psychiatry (2010) 1.16
Phase I and correlative study of combination bryostatin 1 and vincristine in relapsed B-cell malignancies. Clin Cancer Res (2003) 1.09
Cytokines, including stem cell factor alone, enhance lentiviral transduction in nondividing human LTCIC and NOD/SCID repopulating cells. Mol Ther (2003) 1.06
Phase II trial of the O6-alkylguanine DNA alkyltransferase inhibitor O6-benzylguanine and 1,3-bis(2-chloroethyl)-1-nitrosourea in advanced melanoma. Clin Cancer Res (2005) 1.05
Combined treatment with temozolomide and methoxyamine: blocking apurininc/pyrimidinic site repair coupled with targeting topoisomerase IIalpha. Clin Cancer Res (2007) 1.02
Blockage of abasic site repair enhances antitumor efficacy of 1,3-bis-(2-chloroethyl)-1-nitrosourea in colon tumor xenografts. Mol Cancer Ther (2003) 1.02
Elevated AF1q expression is a poor prognostic marker for adult acute myeloid leukemia patients with normal cytogenetics. Am J Hematol (2009) 0.98
Cancer gene therapy: scientific basis. Annu Rev Med (2002) 0.98
Lentiviral transduction of P140K MGMT into human CD34(+) hematopoietic progenitors at low multiplicity of infection confers significant resistance to BG/BCNU and allows selection in vitro. Mol Ther (2002) 0.98
Spontaneous autologous graft-versus-host disease in plasma cell myeloma autograft recipients: flow cytometric analysis of hematopoietic progenitor cell grafts. Biol Blood Marrow Transplant (2011) 0.97
Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest (2016) 0.96
Phase I trial of VNP40101M (Cloretazine) in children with recurrent brain tumors: a pediatric brain tumor consortium study. Clin Cancer Res (2008) 0.94
Transcriptional profiling of human mesenchymal stem cells transduced with reporter genes for imaging. Physiol Genomics (2008) 0.93
Identification of 6-benzylthioinosine as a myeloid leukemia differentiation-inducing compound. Cancer Res (2008) 0.91
Myeloablation is not required to select and maintain expression of the drug-resistance gene, mutant MGMT, in primary and secondary recipients. Mol Ther (2003) 0.90
A randomized phase I and pharmacological trial of sequences of 1,3-bis(2-chloroethyl)-1-nitrosourea and temozolomide in patients with advanced solid neoplasms. Clin Cancer Res (2004) 0.90
Exonuclease 1 is a critical mediator of survival during DNA double strand break repair in nonquiescent hematopoietic stem and progenitor cells. Stem Cells (2014) 0.89
N-benzoylstaurosporine (PKC412) inhibits Akt kinase inducing apoptosis in multiple myeloma cells. Leuk Lymphoma (2005) 0.88
Direct detection and quantification of abasic sites for in vivo studies of DNA damage and repair. Nucl Med Biol (2009) 0.87
Phase I study of temozolomide and laromustine (VNP40101M) in patients with relapsed or refractory leukemia. Clin Lymphoma Myeloma Leuk (2010) 0.87
Imaging stem cell implant for cellular-based therapies. Exp Biol Med (Maywood) (2008) 0.87
Bioluminescence imaging of hematopoietic stem cell repopulation in murine models. Methods Mol Biol (2008) 0.87
O6-benzylguanine and BCNU in multiple myeloma: a phase II trial. Cancer Chemother Pharmacol (2007) 0.86
An intrinsic BM hematopoietic niche occupancy defect of HSC in scid mice facilitates exogenous HSC engraftment. Blood (2011) 0.85
Limited lentiviral transgene expression with increasing copy number in an MGMT selection model: lack of copy number selection by drug treatment. Mol Ther (2004) 0.85
Chemotherapy-induced O(6)-benzylguanine-resistant alkyltransferase mutations in mismatch-deficient colon cancer. Cancer Res (2002) 0.84
A phase I and pharmacodynamic study of fludarabine, carboplatin, and topotecan in patients with relapsed, refractory, or high-risk acute leukemia. Clin Cancer Res (2004) 0.84
Derivation of a myeloid cell-binding adenovirus for gene therapy of inflammation. PLoS One (2012) 0.84
Targets of small interfering RNA restriction during human immunodeficiency virus type 1 replication. J Virol (2008) 0.84
Uracil-DNA glycosylase expression determines human lung cancer cell sensitivity to pemetrexed. Mol Cancer Ther (2013) 0.84
Adult bone marrow stem cells for cell and gene therapies: implications for greater use. J Cell Biochem Suppl (2002) 0.83
A bicistronic SIN-lentiviral vector containing G156A MGMT allows selection and metabolic correction of hematopoietic protoporphyric cell lines. J Gene Med (2003) 0.82
Bcl2 overexpression rescues the hematopoietic stem cell defects in Ku70-deficient mice by restoration of quiescence. Blood (2014) 0.82
Bone marrow-derived cells exhibiting lung epithelial cell characteristics are enriched in vivo using methylguanine DNA methyltransferase-mediated drug resistance. Stem Cells (2008) 0.82
Lung tumorigenesis associated with erb-B-2 and erb-B-3 overexpression in human erb-B-3 transgenic mice is enhanced by methylnitrosourea. Oncogene (2002) 0.81
Imaging stem cell-derived persistent foci after in vivo selection of lentiviral MGMT-P140K transduced murine bone marrow cells. Mol Ther (2011) 0.79
Peritransplant use of ultraviolet-B irradiation (UV-B) therapy is detrimental to allogeneic stem cell transplantation outcome. Biol Blood Marrow Transplant (2006) 0.79
A phase 1 study of TRC102, an inhibitor of base excision repair, and pemetrexed in patients with advanced solid tumors. Invest New Drugs (2012) 0.79
Telomerase inhibition and telomere erosion: a two-pronged strategy in cancer therapy. Trends Pharmacol Sci (2003) 0.79
High-dose carmustine, etoposide, and cisplatin for autologous stem cell transplantation with or without involved-field radiation for relapsed/refractory lymphoma: an effective regimen with low morbidity and mortality. Biol Blood Marrow Transplant (2005) 0.78
Differential competitive resistance to methylating versus chloroethylating agents among five O6-alkylguanine DNA alkyltransferases in human hematopoietic cells. Mol Cancer Ther (2006) 0.78
Drug selection of mutant methylguanine methyltransferase from different oncoretroviral backbones results in multilineage hematopoietic transgene expression in primary and secondary recipients. J Hematother Stem Cell Res (2003) 0.78
Pharmacokinetics of O6-benzylguanine (NSC637037) and its metabolite, 8-oxo-O6-benzylguanine. J Clin Pharmacol (2003) 0.77
Matricellular protein CCN3 mitigates abdominal aortic aneurysm. J Clin Invest (2016) 0.77
Randomised comparison of two B-cell purging protocols for patients with B-cell non-Hodgkin lymphoma: in vivo purging with rituximab versus ex vivo purging with CliniMACS CD34 cell enrichment device. Br J Haematol (2006) 0.77
Chemoselection of allogeneic HSC after murine neonatal transplantation without myeloablation or post-transplant immunosuppression. Mol Ther (2012) 0.77
Phase I clinical trial of O6-benzylguanine and topical carmustine in the treatment of cutaneous T-cell lymphoma, mycosis fungoides type. Arch Dermatol (2012) 0.77
Akt helps stem cells heal the heart. Nat Med (2003) 0.76
Two-photon fluorescent imaging of myelination in the spinal cord. ChemMedChem (2012) 0.76
Cotransduction with MGMT and Ubiquitous or Erythroid-Specific GFP Lentiviruses Allows Enrichment of Dual-Positive Hematopoietic Progenitor Cells In Vivo. ISRN Hematol (2012) 0.75
Development and validation of an LC-MS/MS method for pharmacokinetic study of methoxyamine in phase I clinical trial. J Chromatogr B Analyt Technol Biomed Life Sci (2012) 0.75
SarCNU mediates selection of P140K methylguanine-DNA-methyltransferase transduced human CD34(+) cells in vitro. Blood Cells Mol Dis (2003) 0.75
Measurement of anti-cancer agent methoxyamine in plasma by tandem mass spectrometry with on-line sample extraction. J Chromatogr B Analyt Technol Biomed Life Sci (2003) 0.75