Published in Diabetes on May 01, 2006
A genome-wide association study in the Japanese population identifies susceptibility loci for type 2 diabetes at UBE2E2 and C2CD4A-C2CD4B. Nat Genet (2010) 2.81
β-cell dysfunctional ERAD/ubiquitin/proteasome system in type 2 diabetes mediated by islet amyloid polypeptide-induced UCH-L1 deficiency. Diabetes (2010) 1.10
Proteasomal degradation of retinoid X receptor alpha reprograms transcriptional activity of PPARgamma in obese mice and humans. J Clin Invest (2010) 1.09
The UPS in diabetes and obesity. BMC Biochem (2008) 1.08
Degradation of cAMP-responsive element-binding protein by the ubiquitin-proteasome pathway contributes to glucotoxicity in beta-cells and human pancreatic islets. Diabetes (2009) 1.02
Type 2 diabetes as a protein misfolding disease. Trends Mol Med (2015) 0.91
Nutrigenomics of high fat diet induced obesity in mice suggests relationships between susceptibility to fatty liver disease and the proteasome. PLoS One (2013) 0.91
Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction. DNA Cell Biol (2013) 0.88
Comparison of metabolic and neuropathy profiles of rats with streptozotocin-induced overt and moderate insulinopenia. Neuroscience (2010) 0.86
UCHL1 deficiency exacerbates human islet amyloid polypeptide toxicity in β-cells: evidence of interplay between the ubiquitin/proteasome system and autophagy. Autophagy (2014) 0.83
Evaluation of a SNP map of 6q24-27 confirms diabetic nephropathy loci and identifies novel associations in type 2 diabetes patients with nephropathy from an African-American population. Hum Genet (2008) 0.82
Proteasome dysfunction mediates high glucose-induced apoptosis in rodent beta cells and human islets. PLoS One (2014) 0.80
Identification of the ubiquitin-like domain of midnolin as a new glucokinase interaction partner. J Biol Chem (2013) 0.79
Phosphorylation and degradation of tomosyn-2 de-represses insulin secretion. J Biol Chem (2014) 0.77
Nitric oxide affects UbcH10 levels differently in type 1 and type 2 diabetic rats. J Surg Res (2015) 0.77
Proteasomal Degradation of Proinsulin Requires Derlin-2, HRD1 and p97. PLoS One (2015) 0.77
Synergistic Effect of Hyperglycemia and p27(kip1) Suppression on Adult Mouse Islet Beta Cell Replication. Int J Endocrinol (2012) 0.76
Substrate-favored lysosomal and proteasomal pathways participate in the normal balance control of insulin precursor maturation and disposal in β-cells. PLoS One (2011) 0.76
Npas4 Transcription Factor Expression Is Regulated by Calcium Signaling Pathways and Prevents Tacrolimus-induced Cytotoxicity in Pancreatic Beta Cells. J Biol Chem (2015) 0.75
Type 2 Diabetes Risk Allele UBE2E2 Is Associated With Decreased Glucose-Stimulated Insulin Release in Elderly Chinese Han Individuals. Medicine (Baltimore) (2016) 0.75
SVMRFE based approach for prediction of most discriminatory gene target for type II diabetes. Genom Data (2017) 0.75
Beta-cell deficit and increased beta-cell apoptosis in humans with type 2 diabetes. Diabetes (2003) 16.62
p16INK4a induces an age-dependent decline in islet regenerative potential. Nature (2006) 9.09
Five stages of evolving beta-cell dysfunction during progression to diabetes. Diabetes (2004) 4.73
Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A (2008) 4.01
Selective beta-cell loss and alpha-cell expansion in patients with type 2 diabetes mellitus in Korea. J Clin Endocrinol Metab (2003) 3.87
Large-gap quantum spin Hall insulators in tin films. Phys Rev Lett (2013) 3.60
New sources of pancreatic beta-cells. Nat Biotechnol (2005) 3.11
In vivo imaging of islet transplantation. Nat Med (2005) 2.97
Residual insulin production and pancreatic ß-cell turnover after 50 years of diabetes: Joslin Medalist Study. Diabetes (2010) 2.94
A visitor's guide to effect sizes: statistical significance versus practical (clinical) importance of research findings. Adv Health Sci Educ Theory Pract (2004) 2.78
A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62
Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A (2002) 2.45
Fat redistribution and adipocyte transformation in uninephrectomized rats. Kidney Int (2008) 2.18
The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes (2004) 2.06
Tetra-aqua-bis[4-(4-pyrid-yl)pyrimidine-2-sulfonato]copper(II) dihydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 2.00
Downregulation of GLP-1 and GIP receptor expression by hyperglycemia: possible contribution to impaired incretin effects in diabetes. Diabetes (2007) 1.99
Influence of heterozygosity for parkin mutation on onset age in familial Parkinson disease: the GenePD study. Arch Neurol (2006) 1.94
Beta-cell growth and regeneration: replication is only part of the story. Diabetes (2010) 1.92
Increased interleukin (IL)-1beta messenger ribonucleic acid expression in beta -cells of individuals with type 2 diabetes and regulation of IL-1beta in human islets by glucose and autostimulation. J Clin Endocrinol Metab (2008) 1.91
The Nkx6.1 homeodomain transcription factor suppresses glucagon expression and regulates glucose-stimulated insulin secretion in islet beta cells. Proc Natl Acad Sci U S A (2005) 1.88
Turn-off, drop-out: functional state switching of cadherins. Dev Dyn (2002) 1.85
Islet β cell mass in diabetes and how it relates to function, birth, and death. Ann N Y Acad Sci (2013) 1.84
Curative and beta cell regenerative effects of alpha1-antitrypsin treatment in autoimmune diabetic NOD mice. Proc Natl Acad Sci U S A (2008) 1.83
Involvement of c-Jun N-terminal kinase in oxidative stress-mediated suppression of insulin gene expression. J Biol Chem (2002) 1.76
A stirred microchamber for oxygen consumption rate measurements with pancreatic islets. Biotechnol Bioeng (2007) 1.73
The HNF-1 target collectrin controls insulin exocytosis by SNARE complex formation. Cell Metab (2005) 1.72
Use of paediatric face mask for adult ventilation in a patient with nasal tumour. Indian J Anaesth (2010) 1.72
Suppression of beta cell energy metabolism and insulin release by PGC-1alpha. Dev Cell (2003) 1.71
mirTools: microRNA profiling and discovery based on high-throughput sequencing. Nucleic Acids Res (2010) 1.70
Gene expression of purified beta-cell tissue obtained from human pancreas with laser capture microdissection. J Clin Endocrinol Metab (2007) 1.68
Gene expression profiles of Beta-cell enriched tissue obtained by laser capture microdissection from subjects with type 2 diabetes. PLoS One (2010) 1.68
Tissue-specific disallowance of housekeeping genes: the other face of cell differentiation. Genome Res (2010) 1.67
Critical reduction in beta-cell mass results in two distinct outcomes over time. Adaptation with impaired glucose tolerance or decompensated diabetes. J Biol Chem (2002) 1.67
In vivo imaging of immune rejection in transplanted pancreatic islets. Diabetes (2006) 1.65
Mechanism of insulin gene regulation by the pancreatic transcription factor Pdx-1: application of pre-mRNA analysis and chromatin immunoprecipitation to assess formation of functional transcriptional complexes. J Biol Chem (2005) 1.65
Polymorphisms of ERCC1 C118T/C8092A and MDR1 C3435T predict outcome of platinum-based chemotherapies in advanced non-small cell lung cancer: a meta-analysis. Arch Med Res (2011) 1.55
Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays. Circulation (2013) 1.54
Increased expression of antioxidant and antiapoptotic genes in islets that may contribute to beta-cell survival during chronic hyperglycemia. Diabetes (2002) 1.51
Tetra-aqua-bis{2-[4-(3-pyrid-yl)pyrimidin-2-ylsulfan-yl]acetato}manganese(II) dihydrate. Acta Crystallogr Sect E Struct Rep Online (2009) 1.51
Low-dose sequential combined-spinal epidural anesthesia for Cesarean section in patient with uncorrected tetrology of Fallot. Saudi J Anaesth (2011) 1.51
Differentiation of affinity-purified human pancreatic duct cells to beta-cells. Diabetes (2007) 1.50
Impulse oscillometry in adults with bronchiectasis. Ann Am Thorac Soc (2015) 1.49
A randomized controlled trial of zinc as adjuvant therapy for severe pneumonia in young children. Pediatrics (2012) 1.49
Association between angiotensin-converting enzyme insertion/deletion gene polymorphism and atrial fibrillation: a meta-analysis. Europace (2010) 1.49
Artifactual ST segment depression induced by electrocautery. Ann Card Anaesth (2011) 1.45
Palliative arterial switch for transposition of the great arteries, ventricular septal defect, and pulmonary vascular obstructive disease: midterm outcomes. J Thorac Cardiovasc Surg (2010) 1.44
Characteristics and determinants of sexual behavior among adolescents of migrant workers in Shangai (China). BMC Public Health (2009) 1.43
Overexpression of c-Myc in beta-cells of transgenic mice causes proliferation and apoptosis, downregulation of insulin gene expression, and diabetes. Diabetes (2002) 1.43
Quantitative analysis of cell composition and purity of human pancreatic islet preparations. Lab Invest (2010) 1.43
Current status of islet cell replacement and regeneration therapy. J Clin Endocrinol Metab (2010) 1.43
Genetic regulation of metabolic pathways in beta-cells disrupted by hyperglycemia. J Biol Chem (2002) 1.41
Ductal origin hypothesis of pancreatic regeneration under attack. Cell Metab (2010) 1.41
Activation of pancreatic-duct-derived progenitor cells during pancreas regeneration in adult rats. J Cell Sci (2010) 1.40
High proportion of mixed-species Plasmodium infections in India revealed by PCR diagnostic assay. Trop Med Int Health (2010) 1.40
Electroanatomic mapping and catheter ablation of atrial tachycardia originating from the tricuspid annulus. Int J Cardiol (2013) 1.39
Sex-related differences in leaf morphological and physiological responses in Hippophae rhamnoides along an altitudinal gradient. Tree Physiol (2007) 1.38
GLP-1/exendin-4 facilitates beta-cell neogenesis in rat and human pancreatic ducts. Diabetes Res Clin Pract (2006) 1.37
Pancreatic stem cells. J Pathol (2002) 1.36
Exogenous hydrogen sulfide postconditioning protects isolated rat hearts against ischemia-reperfusion injury. Eur J Pharmacol (2008) 1.36
Antagonistic basic helix-loop-helix/bZIP transcription factors form transcriptional modules that integrate light and reactive oxygen species signaling in Arabidopsis. Plant Cell (2013) 1.35
High-affinity lamprey VLRA and VLRB monoclonal antibodies. Proc Natl Acad Sci U S A (2009) 1.35
Modification of adverse inflammation is required to cure new-onset type 1 diabetic hosts. Proc Natl Acad Sci U S A (2007) 1.35
Cloning, expression, and initial characterization of a novel cytokine-like gene family. Genomics (2002) 1.34
PDX-1 protein containing its own antennapedia-like protein transduction domain can transduce pancreatic duct and islet cells. Diabetes (2003) 1.34
Radiation-induced enhancement of antioxidant contents of soybean (Glycine max Merrill). J Agric Food Chem (2004) 1.33
Genome-wide significance for a modifier of age at neurological onset in Huntington's disease at 6q23-24: the HD MAPS study. BMC Med Genet (2006) 1.30
Transdifferentiation of pancreatic ductal cells to endocrine beta-cells. Biochem Soc Trans (2008) 1.30
In vivo multimodal imaging of transplanted pancreatic islets. Nat Protoc (2006) 1.29
Overexpression of inducible cyclic AMP early repressor inhibits transactivation of genes and cell proliferation in pancreatic beta cells. Mol Cell Biol (2004) 1.28
Effect of recombinant adenovirus-p53 combined with radiotherapy on long-term prognosis of advanced nasopharyngeal carcinoma. J Clin Oncol (2008) 1.28
Prediction of marginal mass required for successful islet transplantation. J Invest Surg (2010) 1.23
Interlaboratory comparison of fetal male DNA detection from common maternal plasma samples by real-time PCR. Clin Chem (2004) 1.23
Structural basis for the recognition of mutant self by a tumor-specific, MHC class II-restricted T cell receptor. Nat Immunol (2007) 1.22