Screening drug-induced arrhythmia [corrected] using human induced pluripotent stem cell-derived cardiomyocytes and low-impedance microelectrode arrays.

PubWeight™: 1.54‹?› | Rank: Top 4%

🔗 View Article (PMC 3855862)

Published in Circulation on September 10, 2013

Authors

Enrique G Navarrete1, Ping Liang, Feng Lan, Verónica Sanchez-Freire, Chelsey Simmons, Tingyu Gong, Arun Sharma, Paul W Burridge, Bhagat Patlolla, Andrew S Lee, Haodi Wu, Ramin E Beygui, Sean M Wu, Robert C Robbins, Donald M Bers, Joseph C Wu

Author Affiliations

1: Department of Medicine, Division of Cardiology, Stanford University School of Medicine, Stanford, CA (E.G.N., P.L., F.L., V.S.-F., T.G., A.S., P.W.B., A.S.L., H.W., S.M.W., J.C.W.); Institute for Stem Cell Biology and Regenerative Medicine, Stanford, CA (E.G.N., P.L., F.L., V.S.-F., T.G., A.S., P.W.B., A.S.L., H.W., S.M.W.); Stanford Cardiovascular Institute, Stanford, CA (E.G.N., P.L., F.L., V.S.-F., C.S., T.G., P.W.B., B.P., A.S.L., H.W., R.E.B., S.M.W., R.C.R., J.C.W.); Department of Radiology, Stanford, CA (E.G.N., P.L., F.L., V.S.-F., T.G., P.W.B., A.S.L., H.W., J.C.W.); School of Mechanical Engineering, Stanford, CA (C.S.); Department of Cardiothoracic Surgery, Stanford, CA (B.P., R.E.B., R.C.R.); Department of Pharmacology, University of California, Davis, CA (D.M.B.).

Articles citing this

Recessive cardiac phenotypes in induced pluripotent stem cell models of Jervell and Lange-Nielsen syndrome: disease mechanisms and pharmacological rescue. Proc Natl Acad Sci U S A (2014) 1.36

Current status of pluripotent stem cells: moving the first therapies to the clinic. Nat Rev Drug Discov (2015) 1.18

Induced pluripotent stem cells: at the heart of cardiovascular precision medicine. Nat Rev Cardiol (2016) 1.13

Atrial-like cardiomyocytes from human pluripotent stem cells are a robust preclinical model for assessing atrial-selective pharmacology. EMBO Mol Med (2015) 1.08

Human iPSC-based cardiac microphysiological system for drug screening applications. Sci Rep (2015) 1.04

Human induced pluripotent stem cell-derived cardiomyocytes: insights into molecular, cellular, and functional phenotypes. Circ Res (2015) 1.02

Evolution of strategies to improve preclinical cardiac safety testing. Nat Rev Drug Discov (2016) 1.01

Controlling expansion and cardiomyogenic differentiation of human pluripotent stem cells in scalable suspension culture. Stem Cell Reports (2014) 0.98

Finding the rhythm of sudden cardiac death: new opportunities using induced pluripotent stem cell-derived cardiomyocytes. Circ Res (2015) 0.96

Human Engineered Heart Tissue: Analysis of Contractile Force. Stem Cell Reports (2016) 0.92

A non-invasive platform for functional characterization of stem-cell-derived cardiomyocytes with applications in cardiotoxicity testing. Stem Cell Reports (2015) 0.90

Functional and pharmacological analysis of cardiomyocytes differentiated from human peripheral blood mononuclear-derived pluripotent stem cells. Stem Cell Reports (2014) 0.88

Miniaturized iPS-Cell-Derived Cardiac Muscles for Physiologically Relevant Drug Response Analyses. Sci Rep (2016) 0.87

Rigorous Phenotyping of Cardiac iPSC Preparations Requires Knowledge of Their Resting Potential(s). Biophys J (2016) 0.85

Translation of Human-Induced Pluripotent Stem Cells: From Clinical Trial in a Dish to Precision Medicine. J Am Coll Cardiol (2016) 0.85

Reprogramming and transdifferentiation for cardiovascular development and regenerative medicine: where do we stand? EMBO Mol Med (2015) 0.85

Screening out irrelevant cell-based models of disease. Nat Rev Drug Discov (2016) 0.83

Interleukin-18 deteriorates Fabry cardiomyopathy and contributes to the development of left ventricular hypertrophy in Fabry patients with GLA IVS4+919 G>A mutation. Oncotarget (2016) 0.82

Cardiomyopathy in a dish: using human inducible pluripotent stem cells to model inherited cardiomyopathies. J Card Fail (2015) 0.82

Multi-cellular interactions sustain long-term contractility of human pluripotent stem cell-derived cardiomyocytes. Am J Transl Res (2014) 0.81

Modeling susceptibility to drug-induced long QT with a panel of subject-specific induced pluripotent stem cells. Elife (2017) 0.81

A new hERG allosteric modulator rescues genetic and drug-induced long-QT syndrome phenotypes in cardiomyocytes from isogenic pairs of patient induced pluripotent stem cells. EMBO Mol Med (2016) 0.81

Human-induced pluripotent stem cell models of inherited cardiomyopathies. Curr Opin Cardiol (2014) 0.81

A near-infrared fluorescent voltage-sensitive dye allows for moderate-throughput electrophysiological analyses of human induced pluripotent stem cell-derived cardiomyocytes. Am J Physiol Heart Circ Physiol (2014) 0.81

Real-Time Force and Frequency Analysis of Engineered Human Heart Tissue Derived from Induced Pluripotent Stem Cells Using Magnetic Sensing. Tissue Eng Part C Methods (2016) 0.81

Nanopatterned Human iPSC-based Model of a Dystrophin-Null Cardiomyopathic Phenotype. Cell Mol Bioeng (2015) 0.80

Developmental changes in electrophysiological characteristics of human-induced pluripotent stem cell-derived cardiomyocytes. Heart Rhythm (2016) 0.80

High throughput physiological screening of iPSC-derived cardiomyocytes for drug development. Biochim Biophys Acta (2016) 0.80

Human iPSC-derived cardiomyocytes and tissue engineering strategies for disease modeling and drug screening. Biotechnol Adv (2016) 0.79

Tissue engineering the cardiac microenvironment: Multicellular microphysiological systems for drug screening. Adv Drug Deliv Rev (2015) 0.79

Directed Differentiation of Embryonic Stem Cells Into Cardiomyocytes by Bacterial Injection of Defined Transcription Factors. Sci Rep (2015) 0.77

Generation of highly purified human cardiomyocytes from peripheral blood mononuclear cell-derived induced pluripotent stem cells. PLoS One (2015) 0.77

Supervised Machine Learning for Classification of the Electrophysiological Effects of Chronotropic Drugs on Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes. PLoS One (2015) 0.77

Real-time quantitative monitoring of hiPSC-based model of macular degeneration on Electric Cell-substrate Impedance Sensing microelectrodes. Biosens Bioelectron (2015) 0.77

Effects of cardioactive drugs on human induced pluripotent stem cell derived long QT syndrome cardiomyocytes. Springerplus (2016) 0.76

Ca(2+)-Currents in Human Induced Pluripotent Stem Cell-Derived Cardiomyocytes Effects of Two Different Culture Conditions. Front Pharmacol (2016) 0.76

Spatiotemporal stability of neonatal rat cardiomyocyte monolayers spontaneous activity is dependent on the culture substrate. PLoS One (2015) 0.75

Doxorubicin induces cardiotoxicity through upregulation of death receptors mediated apoptosis in cardiomyocytes. Sci Rep (2017) 0.75

Extracellular Recordings of Patterned Human Pluripotent Stem Cell-Derived Cardiomyocytes on Aligned Fibers. Stem Cells Int (2016) 0.75

Subtype-specific promoter-driven action potential imaging for precise disease modelling and drug testing in hiPSC-derived cardiomyocytes. Eur Heart J (2017) 0.75

Period doubling cascades of limit cycles in cardiac action potential models as precursors to chaotic early Afterdepolarizations. BMC Syst Biol (2017) 0.75

Solving the puzzle of pluripotent stem cell-derived cardiomyocyte maturation: piece by piece. Ann Transl Med (2017) 0.75

Two dimensional electrophysiological characterization of human pluripotent stem cell-derived cardiomyocyte system. Sci Rep (2017) 0.75

Machine learning plus optical flow: a simple and sensitive method to detect cardioactive drugs. Sci Rep (2015) 0.75

Tissue-Mimicking Geometrical Constraints Stimulate Tissue-Like Constitution and Activity of Mouse Neonatal and Human-Induced Pluripotent Stem Cell-Derived Cardiac Myocytes. J Funct Biomater (2016) 0.75

Cryopreservation of Human Pluripotent Stem Cell-Derived Cardiomyocytes: Strategies, Challenges, and Future Directions. Adv Exp Med Biol (2016) 0.75

Human iPS cell models of Jervell and Lange-Nielsen syndrome. Rare Dis (2015) 0.75

CMOS nanoelectrode array for all-electrical intracellular electrophysiological imaging. Nat Nanotechnol (2017) 0.75

Cardiotoxicity evaluation using human embryonic stem cells and induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Res Ther (2017) 0.75

A human pluripotent stem cell model of catecholaminergic polymorphic ventricular tachycardia recapitulates patient-specific drug responses. Dis Model Mech (2016) 0.75

21st Century Cardio-Oncology: Identifying Cardiac Safety Signals in the Era of Personalized Medicine. JACC Basic Transl Sci (2016) 0.75

The Promise and Challenge of Induced Pluripotent Stem Cells for Cardiovascular Applications. JACC Basic Transl Sci (2016) 0.75

Articles cited by this

Drug-induced prolongation of the QT interval. N Engl J Med (2004) 10.96

Human cardiovascular progenitor cells develop from a KDR+ embryonic-stem-cell-derived population. Nature (2008) 10.27

Patient-specific induced pluripotent stem-cell models for long-QT syndrome. N Engl J Med (2010) 9.19

A model for neural development and treatment of Rett syndrome using human induced pluripotent stem cells. Cell (2010) 7.51

Functional cardiomyocytes derived from human induced pluripotent stem cells. Circ Res (2009) 7.09

Modelling the long QT syndrome with induced pluripotent stem cells. Nature (2011) 5.68

Relationships between preclinical cardiac electrophysiology, clinical QT interval prolongation and torsade de pointes for a broad range of drugs: evidence for a provisional safety margin in drug development. Cardiovasc Res (2003) 5.39

Human embryonic stem cells develop into multiple types of cardiac myocytes: action potential characterization. Circ Res (2003) 5.12

Patient-specific induced pluripotent stem-cell-derived models of LEOPARD syndrome. Nature (2010) 4.38

Using induced pluripotent stem cells to investigate cardiac phenotypes in Timothy syndrome. Nature (2011) 4.10

A structural basis for drug-induced long QT syndrome. Proc Natl Acad Sci U S A (2000) 4.06

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Early afterdepolarizations: mechanism of induction and block. A role for L-type Ca2+ current. Circ Res (1989) 3.57

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53

The impact of drug-induced QT interval prolongation on drug discovery and development. Nat Rev Drug Discov (2003) 3.19

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

High purity human-induced pluripotent stem cell-derived cardiomyocytes: electrophysiological properties of action potentials and ionic currents. Am J Physiol Heart Circ Physiol (2011) 2.65

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57

Drug-induced long QT syndrome. Pharmacol Rev (2010) 2.55

Perforated-patch recording with gramicidin avoids artifactual changes in intracellular chloride concentration. J Neurosci Methods (1995) 2.49

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

Generation of endoderm-derived human induced pluripotent stem cells from primary hepatocytes. Hepatology (2010) 2.31

Developmental changes in cardiomyocytes differentiated from human embryonic stem cells: a molecular and electrophysiological approach. Stem Cells (2007) 2.28

Sodium channel block with mexiletine is effective in reducing dispersion of repolarization and preventing torsade des pointes in LQT2 and LQT3 models of the long-QT syndrome. Circulation (1997) 2.20

Cellular mechanisms underlying the long QT syndrome. Curr Opin Cardiol (2002) 2.19

Drug evaluation in cardiomyocytes derived from human induced pluripotent stem cells carrying a long QT syndrome type 2 mutation. Eur Heart J (2011) 2.18

Prediction of drug-induced cardiotoxicity using human embryonic stem cell-derived cardiomyocytes. Stem Cell Res (2009) 2.13

Drug-induced long QT and torsade de pointes: recent advances. Curr Opin Cardiol (2007) 2.04

Assessing predictors of drug-induced torsade de pointes. Trends Pharmacol Sci (2003) 1.97

Genetics of acquired long QT syndrome. J Clin Invest (2005) 1.96

"Run-down" of the Ca current during long whole-cell recordings in guinea pig heart cells: role of phosphorylation and intracellular calcium. Pflugers Arch (1988) 1.87

Organotypic slice culture from human adult ventricular myocardium. Cardiovasc Res (2011) 1.78

Mechanism of spontaneous excitability in human embryonic stem cell derived cardiomyocytes. J Physiol (2004) 1.71

A model for early afterdepolarizations: induction with the Ca2+ channel agonist Bay K 8644. Circ Res (1988) 1.66

In vitro electrophysiological drug testing using human embryonic stem cell derived cardiomyocytes. Stem Cells Dev (2010) 1.65

Progressive maturation in contracting cardiomyocytes derived from human embryonic stem cells: Qualitative effects on electrophysiological responses to drugs. Stem Cell Res (2010) 1.58

Physicochemical features of the HERG channel drug binding site. J Biol Chem (2003) 1.54

Genome-wide transcriptional profiling of human embryonic stem cells differentiating to cardiomyocytes. Stem Cells (2006) 1.52

Quantified proarrhythmic potential of selected human embryonic stem cell-derived cardiomyocytes. Stem Cell Res (2010) 1.51

Estimating the risk of drug-induced proarrhythmia using human induced pluripotent stem cell-derived cardiomyocytes. Toxicol Sci (2011) 1.45

The action potential and comparative pharmacology of stem cell-derived human cardiomyocytes. J Pharmacol Toxicol Methods (2010) 1.44

Induction and isolation of vascular cells from human induced pluripotent stem cells--brief report. Arterioscler Thromb Vasc Biol (2009) 1.42

Action potential prolongation and induction of abnormal automaticity by low quinidine concentrations in canine Purkinje fibers. Relationship to potassium and cycle length. Circ Res (1985) 1.39

Quinidine-induced action potential prolongation, early afterdepolarizations, and triggered activity in canine Purkinje fibers. Effects of stimulation rate, potassium, and magnesium. Circulation (1989) 1.32

Simultaneous voltage and calcium mapping of genetically purified human induced pluripotent stem cell-derived cardiac myocyte monolayers. Circ Res (2012) 1.24

Calcium homeostasis in human induced pluripotent stem cell-derived cardiomyocytes. Stem Cell Rev (2011) 1.23

The utility of hERG and repolarization assays in evaluating delayed cardiac repolarization: influence of multi-channel block. J Cardiovasc Pharmacol (2004) 1.23

Maximum diastolic potential of human induced pluripotent stem cell-derived cardiomyocytes depends critically on I(Kr). PLoS One (2012) 1.23

Pluripotent stem cell models of cardiac disease and their implication for drug discovery and development. Trends Mol Med (2011) 1.18

Dynamic monitoring of beating periodicity of stem cell-derived cardiomyocytes as a predictive tool for preclinical safety assessment. Br J Pharmacol (2012) 1.17

Alfuzosin delays cardiac repolarization by a novel mechanism. J Pharmacol Exp Ther (2007) 1.14

Induced pluripotent stem cells as a disease modeling and drug screening platform. J Cardiovasc Pharmacol (2012) 1.09

A review of human pluripotent stem cell-derived cardiomyocytes for high-throughput drug discovery, cardiotoxicity screening, and publication standards. J Cardiovasc Transl Res (2012) 1.00

Functional expression and regulation of the hyperpolarization activated non-selective cation current in embryonic stem cell-derived cardiomyocytes. J Physiol (2000) 0.96

Cardiotoxicity testing using pluripotent stem cell-derived human cardiomyocytes and state-of-the-art bioanalytics: a review. J Appl Toxicol (2011) 0.95

Impedance-based detection of beating rhythm and proarrhythmic effects of compounds on stem cell-derived cardiomyocytes. Assay Drug Dev Technol (2011) 0.93

A mutation in HERG associated with notched T waves in long QT syndrome. J Mol Cell Cardiol (1996) 0.91

A cytoplasmic factor, calpastatin and ATP together reverse run-down of Ca2+ channel activity in guinea-pig heart. J Physiol (1999) 0.84

Mechanism of arrhythmogenicity of the short-long cardiac sequence that precedes ventricular tachyarrhythmias in the long QT syndrome. J Am Coll Cardiol (1999) 0.83

Models of torsades de pointes: effects of FPL64176, DPI201106, dofetilide, and chromanol 293B in isolated rabbit and guinea pig hearts. J Pharmacol Toxicol Methods (2009) 0.83

Lack of action potential-prolonging effect of terfenadine on rabbit myocardial tissue preparations. Biol Pharm Bull (2004) 0.82

The distinct roles of calmodulin and calmodulin kinase II in the reversal of run-down of L-type Ca(2+) channels in guinea-pig ventricular myocytes. J Pharmacol Sci (2009) 0.81

Articles by these authors

Haematopoietic stem cells adopt mature haematopoietic fates in ischaemic myocardium. Nature (2004) 8.36

Epicardial progenitors contribute to the cardiomyocyte lineage in the developing heart. Nature (2008) 7.03

Ca2+/calmodulin-dependent protein kinase modulates cardiac ryanodine receptor phosphorylation and sarcoplasmic reticulum Ca2+ leak in heart failure. Circ Res (2005) 5.34

A physical map of the mouse genome. Nature (2002) 4.97

In vivo visualization of embryonic stem cell survival, proliferation, and migration after cardiac delivery. Circulation (2006) 4.48

A nonviral minicircle vector for deriving human iPS cells. Nat Methods (2010) 4.42

dbRIP: a highly integrated database of retrotransposon insertion polymorphisms in humans. Hum Mutat (2006) 4.23

The deltaC isoform of CaMKII is activated in cardiac hypertrophy and induces dilated cardiomyopathy and heart failure. Circ Res (2003) 4.13

Carbonic anhydrase II-positive pancreatic cells are progenitors for both endocrine and exocrine pancreas after birth. Proc Natl Acad Sci U S A (2008) 4.01

Local InsP3-dependent perinuclear Ca2+ signaling in cardiac myocyte excitation-transcription coupling. J Clin Invest (2006) 3.72

A mathematical treatment of integrated Ca dynamics within the ventricular myocyte. Biophys J (2004) 3.72

Production of de novo cardiomyocytes: human pluripotent stem cell differentiation and direct reprogramming. Cell Stem Cell (2012) 3.66

Feeder-free derivation of induced pluripotent stem cells from adult human adipose stem cells. Proc Natl Acad Sci U S A (2009) 3.57

Patient-specific induced pluripotent stem cells as a model for familial dilated cardiomyopathy. Sci Transl Med (2012) 3.53

Ca2+ scraps: local depletions of free [Ca2+] in cardiac sarcoplasmic reticulum during contractions leave substantial Ca2+ reserve. Circ Res (2003) 3.47

Beta-adrenergic enhancement of sarcoplasmic reticulum calcium leak in cardiac myocytes is mediated by calcium/calmodulin-dependent protein kinase. Circ Res (2007) 3.46

Human tissue-engineered blood vessels for adult arterial revascularization. Nat Med (2006) 3.39

Ca2+/calmodulin-dependent protein kinase II regulates cardiac Na+ channels. J Clin Invest (2006) 3.33

Ca2+/Calmodulin-dependent protein kinase II phosphorylation of ryanodine receptor does affect calcium sparks in mouse ventricular myocytes. Circ Res (2006) 3.26

Human genomic deletions mediated by recombination between Alu elements. Am J Hum Genet (2006) 3.15

An antibody against SSEA-5 glycan on human pluripotent stem cells enables removal of teratoma-forming cells. Nat Biotechnol (2011) 3.05

Fluctuation analysis CalculatOR: a web tool for the determination of mutation rate using Luria-Delbruck fluctuation analysis. Bioinformatics (2009) 3.05

Elevated sarcoplasmic reticulum Ca2+ leak in intact ventricular myocytes from rabbits in heart failure. Circ Res (2003) 3.04

Transgenic CaMKIIdeltaC overexpression uniquely alters cardiac myocyte Ca2+ handling: reduced SR Ca2+ load and activated SR Ca2+ release. Circ Res (2003) 3.04

Cellular basis of triggered arrhythmias in heart failure. Trends Cardiovasc Med (2004) 2.97

Quantitative assessment of the SR Ca2+ leak-load relationship. Circ Res (2002) 2.93

Transplantation for idiopathic pulmonary arterial hypertension: improvement in the lung allocation score era. Circulation (2013) 2.87

Cellular basis of abnormal calcium transients of failing human ventricular myocytes. Circ Res (2003) 2.86

Persistent donor cell gene expression among human induced pluripotent stem cells contributes to differences with human embryonic stem cells. PLoS One (2010) 2.86

Transcriptional and functional profiling of human embryonic stem cell-derived cardiomyocytes. PLoS One (2008) 2.85

Hypercontractile female hearts exhibit increased S-nitrosylation of the L-type Ca2+ channel alpha1 subunit and reduced ischemia/reperfusion injury. Circ Res (2006) 2.84

SparkMaster: automated calcium spark analysis with ImageJ. Am J Physiol Cell Physiol (2007) 2.84

Inefficient reprogramming of fibroblasts into cardiomyocytes using Gata4, Mef2c, and Tbx5. Circ Res (2012) 2.74

Single cell transcriptional profiling reveals heterogeneity of human induced pluripotent stem cells. J Clin Invest (2011) 2.69

CaMKII in myocardial hypertrophy and heart failure. J Mol Cell Cardiol (2011) 2.65

A switch from MafB to MafA expression accompanies differentiation to pancreatic beta-cells. Dev Biol (2006) 2.62

Generation of functional ventricular heart muscle from mouse ventricular progenitor cells. Science (2009) 2.60

Imaging survival and function of transplanted cardiac resident stem cells. J Am Coll Cardiol (2009) 2.58

Drug screening using a library of human induced pluripotent stem cell-derived cardiomyocytes reveals disease-specific patterns of cardiotoxicity. Circulation (2013) 2.57

Increased sarcoplasmic reticulum calcium leak but unaltered contractility by acute CaMKII overexpression in isolated rabbit cardiac myocytes. Circ Res (2005) 2.50

Identification of beta-cell-specific insulin gene transcription factor RIPE3b1 as mammalian MafA. Proc Natl Acad Sci U S A (2002) 2.45

MicroRNA profiling of human-induced pluripotent stem cells. Stem Cells Dev (2009) 2.44

Association between statin-associated myopathy and skeletal muscle damage. CMAJ (2009) 2.41

A novel computational model of the human ventricular action potential and Ca transient. J Mol Cell Cardiol (2009) 2.36

Short-term immunosuppression promotes engraftment of embryonic and induced pluripotent stem cells. Cell Stem Cell (2011) 2.35

Abnormal calcium handling properties underlie familial hypertrophic cardiomyopathy pathology in patient-specific induced pluripotent stem cells. Cell Stem Cell (2013) 2.33

Intracellular Na(+) concentration is elevated in heart failure but Na/K pump function is unchanged. Circulation (2002) 2.32

MicroRNA-210 as a novel therapy for treatment of ischemic heart disease. Circulation (2010) 2.32

Ryanodine receptor phosphorylation by calcium/calmodulin-dependent protein kinase II promotes life-threatening ventricular arrhythmias in mice with heart failure. Circulation (2010) 2.32

Effects of cell number on teratoma formation by human embryonic stem cells. Cell Cycle (2009) 2.30

Role of Ca2+/calmodulin-dependent protein kinase (CaMK) in excitation-contraction coupling in the heart. Cardiovasc Res (2006) 2.30

Kinetics of FKBP12.6 binding to ryanodine receptors in permeabilized cardiac myocytes and effects on Ca sparks. Circ Res (2010) 2.29

Approximate model of cooperative activation and crossbridge cycling in cardiac muscle using ordinary differential equations. Biophys J (2008) 2.29

Sarcoplasmic reticulum Ca2+ and heart failure: roles of diastolic leak and Ca2+ transport. Circ Res (2003) 2.28

Sarcoplasmic reticulum and nuclear envelope are one highly interconnected Ca2+ store throughout cardiac myocyte. Circ Res (2006) 2.27

Cardiac alternans do not rely on diastolic sarcoplasmic reticulum calcium content fluctuations. Circ Res (2006) 2.25

Immunosuppressive therapy mitigates immunological rejection of human embryonic stem cell xenografts. Proc Natl Acad Sci U S A (2008) 2.25

Dynamic microRNA expression programs during cardiac differentiation of human embryonic stem cells: role for miR-499. Circ Cardiovasc Genet (2010) 2.24

Comparison of different adult stem cell types for treatment of myocardial ischemia. Circulation (2008) 2.22

Na(+)-Ca(2+) exchange current and submembrane [Ca(2+)] during the cardiac action potential. Circ Res (2002) 2.21

Differentiation, survival, and function of embryonic stem cell derived endothelial cells for ischemic heart disease. Circulation (2007) 2.21

Human cardiac progenitor cells engineered with Pim-I kinase enhance myocardial repair. J Am Coll Cardiol (2012) 2.18

Consensus conference report: maximizing use of organs recovered from the cadaver donor: cardiac recommendations, March 28-29, 2001, Crystal City, Va. Circulation (2002) 2.14

Termination of cardiac Ca2+ sparks: role of intra-SR [Ca2+], release flux, and intra-SR Ca2+ diffusion. Circ Res (2008) 2.12

Phospholamban ablation rescues sarcoplasmic reticulum Ca(2+) handling but exacerbates cardiac dysfunction in CaMKIIdelta(C) transgenic mice. Circ Res (2009) 2.12

Embryonic stem cell immunogenicity increases upon differentiation after transplantation into ischemic myocardium. Circulation (2005) 2.12

Diabetic hyperglycaemia activates CaMKII and arrhythmias by O-linked glycosylation. Nature (2013) 2.08

The pancreatic ductal epithelium serves as a potential pool of progenitor cells. Pediatr Diabetes (2004) 2.06

Protein kinase A phosphorylation of the ryanodine receptor does not affect calcium sparks in mouse ventricular myocytes. Circ Res (2002) 2.06

Patient-specific stem cells and cardiovascular drug discovery. JAMA (2013) 2.06

Dissecting the molecular relationship among various cardiogenic progenitor cells. Circ Res (2013) 2.06

Effects of intracoronary CD34+ stem cell transplantation in nonischemic dilated cardiomyopathy patients: 5-year follow-up. Circ Res (2012) 2.02

Ca²+ spark-dependent and -independent sarcoplasmic reticulum Ca²+ leak in normal and failing rabbit ventricular myocytes. J Physiol (2010) 2.01

Isolation of primitive endoderm, mesoderm, vascular endothelial and trophoblast progenitors from human pluripotent stem cells. Nat Biotechnol (2012) 2.00