Published in Exp Hematol on May 01, 2006
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A (2010) 2.02
The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33
Molecular basis of inherited microcytic anemia due to defects in iron acquisition or heme synthesis. Haematologica (2009) 1.32
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. Proc Natl Acad Sci U S A (2009) 1.31
Normal and disordered reticulocyte maturation. Curr Opin Hematol (2011) 1.16
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Cellular and mitochondrial iron homeostasis in vertebrates. Biochim Biophys Acta (2012) 1.05
Out of balance--systemic iron homeostasis in iron-related disorders. Nutrients (2013) 0.92
Physiology of iron metabolism. Transfus Med Hemother (2014) 0.84
Differential regulation of the Menkes and Wilson disease copper transporters by hormones: an integrated model of metal transport in the placenta. Biochem J (2007) 0.80
Characterization of Putative Erythroid Regulators of Hepcidin in Mouse Models of Anemia. PLoS One (2017) 0.76
An unusual case of iron deficiency anemia is associated with extremely low level of transferrin receptor. Int J Clin Exp Pathol (2015) 0.75
Iron overload in human disease. N Engl J Med (2012) 3.77
A class of iron chelators with a wide spectrum of potent antitumor activity that overcomes resistance to chemotherapeutics. Proc Natl Acad Sci U S A (2006) 2.36
Identification of a human mutation of DMT1 in a patient with microcytic anemia and iron overload. Blood (2004) 2.12
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A (2010) 2.02
Iron trafficking in the mitochondrion: novel pathways revealed by disease. Blood (2004) 2.00
New insights into erythropoiesis: the roles of folate, vitamin B12, and iron. Annu Rev Nutr (2004) 1.71
Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis. Blood (2004) 1.62
Direct interorganellar transfer of iron from endosome to mitochondrion. Blood (2007) 1.59
Heme oxygenase 1 is expressed in murine erythroid cells where it controls the level of regulatory heme. Blood (2014) 1.59
The long history of iron in the Universe and in health and disease. Biochim Biophys Acta (2011) 1.33
Elucidation of the mechanism of mitochondrial iron loading in Friedreich's ataxia by analysis of a mouse mutant. Proc Natl Acad Sci U S A (2009) 1.31
Antitumor activity of metal-chelating compound Dp44mT is mediated by formation of a redox-active copper complex that accumulates in lysosomes. Cancer Res (2011) 1.28
Nramp1 promotes efficient macrophage recycling of iron following erythrophagocytosis in vivo. Proc Natl Acad Sci U S A (2009) 1.25
The MCK mouse heart model of Friedreich's ataxia: Alterations in iron-regulated proteins and cardiac hypertrophy are limited by iron chelation. Proc Natl Acad Sci U S A (2008) 1.22
Hepcidin, the hormone of iron metabolism, is bound specifically to alpha-2-macroglobulin in blood. Blood (2009) 1.18
Iron inactivates the RNA polymerase NS5B and suppresses subgenomic replication of hepatitis C Virus. J Biol Chem (2005) 1.17
S-nitrosylation of IRP2 regulates its stability via the ubiquitin-proteasome pathway. Mol Cell Biol (2004) 1.16
Nitrogen monoxide-mediated control of ferritin synthesis: implications for macrophage iron homeostasis. Proc Natl Acad Sci U S A (2002) 1.14
The prolyl 4-hydroxylase inhibitor ethyl-3,4-dihydroxybenzoate generates effective iron deficiency in cultured cells. FEBS Lett (2002) 1.09
Hypoxia. 5. Hypoxia and hematopoiesis. Am J Physiol Cell Physiol (2011) 1.07
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Nitrogen monoxide (NO)-mediated iron release from cells is linked to NO-induced glutathione efflux via multidrug resistance-associated protein 1. Proc Natl Acad Sci U S A (2006) 1.06
Intracellular kinetics of iron in reticulocytes: evidence for endosome involvement in iron targeting to mitochondria. Blood (2004) 1.03
Dysregulation of iron homeostasis in the CNS contributes to disease progression in a mouse model of amyotrophic lateral sclerosis. J Neurosci (2009) 1.03
Human CIA2A-FAM96A and CIA2B-FAM96B integrate iron homeostasis and maturation of different subsets of cytosolic-nuclear iron-sulfur proteins. Cell Metab (2013) 1.02
In vivo tumor growth is inhibited by cytosolic iron deprivation caused by the expression of mitochondrial ferritin. Blood (2006) 1.02
Effects of nitrogen monoxide and carbon monoxide on molecular and cellular iron metabolism: mirror-image effector molecules that target iron. Biochem J (2003) 0.98
Identification of nonferritin mitochondrial iron deposits in a mouse model of Friedreich ataxia. Proc Natl Acad Sci U S A (2012) 0.97
Nramp1 equips macrophages for efficient iron recycling. Exp Hematol (2008) 0.96
Both Nramp1 and DMT1 are necessary for efficient macrophage iron recycling. Exp Hematol (2010) 0.94
Lysosomal proteolysis is the primary degradation pathway for cytosolic ferritin and cytosolic ferritin degradation is necessary for iron exit. Antioxid Redox Signal (2010) 0.94
Functional consequences of the human DMT1 (SLC11A2) mutation on protein expression and iron uptake. Blood (2005) 0.93
Hydrolysis of pyridoxal isonicotinoyl hydrazone and its analogs. Biochim Biophys Acta (2003) 0.92
Severe hypochromic microcytic anemia caused by a congenital defect of the iron transport pathway in erythroid cells. Blood (2004) 0.91
The ins and outs of mitochondrial iron-loading: the metabolic defect in Friedreich's ataxia. J Mol Med (Berl) (2009) 0.91
Pyridoxal isonicotinoyl hydrazone analogs induce apoptosis in hematopoietic cells due to their iron-chelating properties. Biochem Pharmacol (2003) 0.91
Mitochondrial iron metabolism and sideroblastic anemia. Acta Haematol (2009) 0.89
Non-heme induction of heme oxygenase-1 does not alter cellular iron metabolism. J Biol Chem (2007) 0.87
Ceruloplasmin protects injured spinal cord from iron-mediated oxidative damage. J Neurosci (2008) 0.87
Chapter 12 Controlled expression of iron-sulfur cluster assembly components for respiratory chain complexes in mammalian cells. Methods Enzymol (2009) 0.86
Nitric oxide storage and transport in cells are mediated by glutathione S-transferase P1-1 and multidrug resistance protein 1 via dinitrosyl iron complexes. J Biol Chem (2011) 0.86
Nitric oxide-mediated modulation of iron regulatory proteins: implication for cellular iron homeostasis. Blood Cells Mol Dis (2003) 0.85
Overexpression of mitochondrial ferritin sensitizes cells to oxidative stress via an iron-mediated mechanism. Antioxid Redox Signal (2009) 0.85
Oxidative stress mediates toxicity of pyridoxal isonicotinoyl hydrazone analogs. Arch Biochem Biophys (2004) 0.82
Role of nitric oxide in cellular iron metabolism. Biometals (2003) 0.81
Iron regulatory protein-independent regulation of ferritin synthesis by nitrogen monoxide. FEBS J (2006) 0.80
Use of Nramp2-transfected Chinese hamster ovary cells and reticulocytes from mk/mk mice to study iron transport mechanisms. Exp Hematol (2008) 0.80
Pyridoxal isonicotinoyl hydrazone and its analogues. Adv Exp Med Biol (2002) 0.80
Mitochondrial ferritin, a new target for inhibiting neuronal tumor cell proliferation. Cell Mol Life Sci (2014) 0.79
Hepcidin bound to α2-macroglobulin reduces ferroportin-1 expression and enhances its activity at reducing serum iron levels. J Biol Chem (2013) 0.79
Alternative treatment paradigm for thalassemia using iron chelators. Exp Hematol (2008) 0.79
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake. Biochem J (2010) 0.79
Human cytomegalovirus-induced host cell enlargement is iron dependent. Am J Physiol Cell Physiol (2004) 0.78
Ferritin does not donate its iron for haem synthesis in macrophages. Biochem J (2010) 0.78
Nitrogen monoxide inhibits haem synthesis in mouse reticulocytes. Biochem J (2013) 0.77
Lipophilicity of analogs of pyridoxal isonicotinoyl hydrazone (PIH) determines the efflux of iron complexes and toxicity in K562 cells. Biochem Pharmacol (2003) 0.77
Mobilization of intracellular iron by analogs of pyridoxal isonicotinoyl hydrazone (PIH) is determined by the membrane permeability of the iron-chelator complexes. Biochem Pharmacol (2002) 0.75
Molecular basis of hereditary iron homeostasis defects. Hematology (2010) 0.75
Transferrin receptor hyperexpression in primary erythroblasts is lost on transformation by avian erythroblastosis virus. Blood (2002) 0.75