Published in Biochim Biophys Acta on January 18, 2012
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
Steap4 plays a critical role in osteoclastogenesis in vitro by regulating cellular iron/reactive oxygen species (ROS) levels and cAMP response element-binding protein (CREB) activation. J Biol Chem (2013) 1.02
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
Iron status and survival in diabetic patients with coronary artery disease. Diabetes Care (2013) 0.88
Heme metabolism and erythropoiesis. Curr Opin Hematol (2012) 0.87
Haem-dependent dimerization of PGRMC1/Sigma-2 receptor facilitates cancer proliferation and chemoresistance. Nat Commun (2016) 0.87
Physiology of iron metabolism. Transfus Med Hemother (2014) 0.84
Siderocalin-mediated recognition, sensitization, and cellular uptake of actinides. Proc Natl Acad Sci U S A (2015) 0.81
Identification of the Mitochondrial Heme Metabolism Complex. PLoS One (2015) 0.81
Oxidative Stress in Dilated Cardiomyopathy Caused by MYBPC3 Mutation. Oxid Med Cell Longev (2015) 0.79
Characteristics of Mitochondrial Transformation into Human Cells. Sci Rep (2016) 0.78
Mechanisms and regulation of iron trafficking across the capillary endothelial cells of the blood-brain barrier. Front Mol Neurosci (2015) 0.78
A Putative Mitochondrial Iron Transporter MrsA in Aspergillus fumigatus Plays Important Roles in Azole-, Oxidative Stress Responses and Virulence. Front Microbiol (2016) 0.78
Novel p53-dependent anticancer strategy by targeting iron signaling and BNIP3L-induced mitophagy. Oncotarget (2016) 0.78
A reactivity-based probe of the intracellular labile ferrous iron pool. Nat Chem Biol (2016) 0.76
Respiratory disorders: Ironing out smoking-related airway disease. Nature (2016) 0.75
Molecular evolution of multiple-level control of heme biosynthesis pathway in animal kingdom. PLoS One (2014) 0.75
A role for iron deficiency in dopaminergic neurodegeneration. Proc Natl Acad Sci U S A (2016) 0.75
Mitochondria represent another locale for the divalent metal transporter 1 (DMT1). Channels (Austin) (2014) 0.75
Intracellular iron and heme trafficking and metabolism in developing erythroblasts. Metallomics (2017) 0.75
The role of microsporidian polar tube protein 4 (PTP4) in host cell infection. PLoS Pathog (2017) 0.75
Neutrophil gelatinase-associated lipocalin (NGAL) as a biomarker for acute renal injury after cardiac surgery. Lancet (2005) 13.77
Cloning and characterization of a mammalian proton-coupled metal-ion transporter. Nature (1997) 9.98
Lipocalin 2 mediates an innate immune response to bacterial infection by sequestrating iron. Nature (2004) 9.40
Balancing acts: molecular control of mammalian iron metabolism. Cell (2004) 7.82
Disorders of iron metabolism. N Engl J Med (1999) 7.49
Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter. Nature (2000) 7.46
Direct activation of human TRPC6 and TRPC3 channels by diacylglycerol. Nature (1999) 6.85
The neutrophil lipocalin NGAL is a bacteriostatic agent that interferes with siderophore-mediated iron acquisition. Mol Cell (2002) 6.81
Endocytic delivery of lipocalin-siderophore-iron complex rescues the kidney from ischemia-reperfusion injury. J Clin Invest (2005) 5.51
Blockade of current through single calcium channels by Cd2+, Mg2+, and Ca2+. Voltage and concentration dependence of calcium entry into the pore. J Gen Physiol (1986) 5.38
Microcytic anaemia mice have a mutation in Nramp2, a candidate iron transporter gene. Nat Genet (1997) 5.34
A novel duodenal iron-regulated transporter, IREG1, implicated in the basolateral transfer of iron to the circulation. Mol Cell (2000) 5.31
Siderophores: structure and function of microbial iron transport compounds. J Biol Chem (1995) 5.27
A novel mammalian iron-regulated protein involved in intracellular iron metabolism. J Biol Chem (2000) 5.21
Binding of apotransferrin to K562 cells: explanation of the transferrin cycle. Proc Natl Acad Sci U S A (1983) 4.68
Function and biogenesis of iron-sulphur proteins. Nature (2009) 4.56
Maturation of iron-sulfur proteins in eukaryotes: mechanisms, connected processes, and diseases. Annu Rev Biochem (2008) 4.34
A cell-surface receptor for lipocalin 24p3 selectively mediates apoptosis and iron uptake. Cell (2005) 4.32
Aconitase and mitochondrial iron-sulphur protein deficiency in Friedreich ataxia. Nat Genet (1997) 4.26
Nramp2 is mutated in the anemic Belgrade (b) rat: evidence of a role for Nramp2 in endosomal iron transport. Proc Natl Acad Sci U S A (1998) 4.07
Enterobactin: an archetype for microbial iron transport. Proc Natl Acad Sci U S A (2003) 3.94
Lipocalin 2-deficient mice exhibit increased sensitivity to Escherichia coli infection but not to ischemia-reperfusion injury. Proc Natl Acad Sci U S A (2006) 3.85
Interaction of the hereditary hemochromatosis protein HFE with transferrin receptor 2 is required for transferrin-induced hepcidin expression. Cell Metab (2009) 3.78
The lipocalin protein family: structural and sequence overview. Biochim Biophys Acta (2000) 3.48
An iron delivery pathway mediated by a lipocalin. Mol Cell (2002) 3.38
Identification of a ferrireductase required for efficient transferrin-dependent iron uptake in erythroid cells. Nat Genet (2005) 3.28
Molecular characterization and pattern of tissue expression of the gene for neutrophil gelatinase-associated lipocalin from humans. Genomics (1997) 3.16
Iron-sulfur cluster biogenesis and human disease. Trends Genet (2008) 3.03
Transferrin receptor is necessary for development of erythrocytes and the nervous system. Nat Genet (1999) 3.00
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
The TIM gene family: emerging roles in immunity and disease. Nat Rev Immunol (2003) 2.90
An iron-regulated ferric reductase associated with the absorption of dietary iron. Science (2001) 2.90
The type IV mucolipidosis-associated protein TRPML1 is an endolysosomal iron release channel. Nature (2008) 2.76
Siderocalin (Lcn 2) also binds carboxymycobactins, potentially defending against mycobacterial infections through iron sequestration. Structure (2005) 2.63
Stoichiometric and site characteristics of the binding of iron to human transferrin. J Biol Chem (1978) 2.63
Scara5 is a ferritin receptor mediating non-transferrin iron delivery. Dev Cell (2009) 2.60
Interleukin-6 regulates the zinc transporter Zip14 in liver and contributes to the hypozincemia of the acute-phase response. Proc Natl Acad Sci U S A (2005) 2.60
Molecular cloning of transferrin receptor 2. A new member of the transferrin receptor-like family. J Biol Chem (1999) 2.47
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Iron homeostasis: insights from genetics and animal models. Nat Rev Genet (2000) 2.38
L-type Ca2+ channels provide a major pathway for iron entry into cardiomyocytes in iron-overload cardiomyopathy. Nat Med (2003) 2.38
The Steap proteins are metalloreductases. Blood (2006) 2.37
Mutations in mitochondrial carrier family gene SLC25A38 cause nonsyndromic autosomal recessive congenital sideroblastic anemia. Nat Genet (2009) 2.37
Zip14 (Slc39a14) mediates non-transferrin-bound iron uptake into cells. Proc Natl Acad Sci U S A (2006) 2.35
Identification of a mammalian mitochondrial porphyrin transporter. Nature (2006) 2.28
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
Biosynthesis of heme in mammals. Biochim Biophys Acta (2006) 2.25
Sec15 is an effector for the Rab11 GTPase in mammalian cells. J Biol Chem (2004) 2.24
Functions of mitochondrial ISCU and cytosolic ISCU in mammalian iron-sulfur cluster biogenesis and iron homeostasis. Cell Metab (2006) 2.21
The human counterpart of zebrafish shiraz shows sideroblastic-like microcytic anemia and iron overload. Blood (2007) 2.16
Specific iron chelators determine the route of ferritin degradation. Blood (2009) 2.10
Iron traffics in circulation bound to a siderocalin (Ngal)-catechol complex. Nat Chem Biol (2010) 2.06
Serum ferritin is derived primarily from macrophages through a nonclassical secretory pathway. Blood (2010) 2.02
Mitochondrial iron trafficking and the integration of iron metabolism between the mitochondrion and cytosol. Proc Natl Acad Sci U S A (2010) 2.02
Tissue distribution and clearance kinetics of non-transferrin-bound iron in the hypotransferrinemic mouse: a rodent model for hemochromatosis. Proc Natl Acad Sci U S A (1987) 2.02
A cytosolic iron chaperone that delivers iron to ferritin. Science (2008) 2.00
Binding and uptake of H-ferritin are mediated by human transferrin receptor-1. Proc Natl Acad Sci U S A (2010) 1.99
The endocytic receptor megalin binds the iron transporting neutrophil-gelatinase-associated lipocalin with high affinity and mediates its cellular uptake. FEBS Lett (2005) 1.96
A mammalian siderophore synthesized by an enzyme with a bacterial homolog involved in enterobactin production. Cell (2010) 1.85
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
TRP-ML1 is a lysosomal monovalent cation channel that undergoes proteolytic cleavage. J Biol Chem (2005) 1.75
A specific role of the yeast mitochondrial carriers MRS3/4p in mitochondrial iron acquisition under iron-limiting conditions. J Biol Chem (2003) 1.74
Ca2+ channel blockers reverse iron overload by a new mechanism via divalent metal transporter-1. Nat Med (2007) 1.73
ABC-me: a novel mitochondrial transporter induced by GATA-1 during erythroid differentiation. EMBO J (2000) 1.72
Human iron-sulfur cluster assembly, cellular iron homeostasis, and disease. Biochemistry (2010) 1.72
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Distinct iron-sulfur cluster assembly complexes exist in the cytosol and mitochondria of human cells. EMBO J (2000) 1.69
A human mitochondrial ferritin encoded by an intronless gene. J Biol Chem (2001) 1.69
Ferroportin-mediated mobilization of ferritin iron precedes ferritin degradation by the proteasome. EMBO J (2006) 1.66
C-terminal deletions in the ALAS2 gene lead to gain of function and cause X-linked dominant protoporphyria without anemia or iron overload. Am J Hum Genet (2008) 1.64
Lipocalins: unity in diversity. Biochim Biophys Acta (2000) 1.64
Microcytic anemia, erythropoietic protoporphyria, and neurodegeneration in mice with targeted deletion of iron-regulatory protein 2. Blood (2005) 1.64
Subcellular compartmentalization of human Nfu, an iron-sulfur cluster scaffold protein, and its ability to assemble a [4Fe-4S] cluster. Proc Natl Acad Sci U S A (2003) 1.63
Modern diagnosis and management of the porphyrias. Br J Haematol (2006) 1.63
Overexpression of mitochondrial ferritin causes cytosolic iron depletion and changes cellular iron homeostasis. Blood (2004) 1.62
Direct interorganellar transfer of iron from endosome to mitochondrion. Blood (2007) 1.59
Deletion of the mitochondrial carrier genes MRS3 and MRS4 suppresses mitochondrial iron accumulation in a yeast frataxin-deficient strain. J Biol Chem (2002) 1.55
Human ABC7 transporter: gene structure and mutation causing X-linked sideroblastic anemia with ataxia with disruption of cytosolic iron-sulfur protein maturation. Blood (2000) 1.54
Transferrin receptor 2: continued expression in mouse liver in the face of iron overload and in hereditary hemochromatosis. Proc Natl Acad Sci U S A (2000) 1.54
TIM-2 is expressed on B cells and in liver and kidney and is a receptor for H-ferritin endocytosis. J Exp Med (2005) 1.52
Structure-function analysis of a novel member of the LIV-1 subfamily of zinc transporters, ZIP14. FEBS Lett (2005) 1.50
Mitochondrial ferritin expression in erythroid cells from patients with sideroblastic anemia. Blood (2002) 1.49
Iron-sulfur proteins in health and disease. Trends Endocrinol Metab (2010) 1.49
Trafficking of heme and porphyrins in metazoa. Chem Rev (2009) 1.48
Differential role of transient receptor potential channels in Ca2+ entry and proliferation of prostate cancer epithelial cells. Cancer Res (2006) 1.48
The mitochondrial ATP-binding cassette transporter Abcb7 is essential in mice and participates in cytosolic iron-sulfur cluster biogenesis. Hum Mol Genet (2006) 1.47
Mammalian iron transport. Cell Mol Life Sci (2009) 1.42
RNA silencing of the mitochondrial ABCB7 transporter in HeLa cells causes an iron-deficient phenotype with mitochondrial iron overload. Blood (2006) 1.38
Identification by microsequencing of lipopolysaccharide-induced proteins secreted by mouse macrophages. J Immunol (1993) 1.37
The intracellular trafficking pathway of transferrin. Biochim Biophys Acta (2011) 1.36
Overexpression of wild-type and mutant mucolipin proteins in mammalian cells: effects on the late endocytic compartment organization. FEBS Lett (2004) 1.35
Iron and porphyrin trafficking in heme biogenesis. J Biol Chem (2010) 1.34
Glutaredoxin 5 deficiency causes sideroblastic anemia by specifically impairing heme biosynthesis and depleting cytosolic iron in human erythroblasts. J Clin Invest (2010) 1.32
Zip14 is a complex broad-scope metal-ion transporter whose functional properties support roles in the cellular uptake of zinc and nontransferrin-bound iron. Am J Physiol Cell Physiol (2011) 1.32
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood (2010) 1.31
Regulated secretion of glycosylated human ferritin from hepatocytes. Blood (2003) 1.29
Iron in cytosolic ferritin can be recycled through lysosomal degradation in human fibroblasts. Biochem J (1998) 1.27
The effect of the iron saturation of transferrin on its binding and uptake by rabbit reticulocytes. Biochem J (1984) 1.26
Heme-regulated eIF2alpha kinase modifies the phenotypic severity of murine models of erythropoietic protoporphyria and beta-thalassemia. J Clin Invest (2005) 1.26
ZRT/IRT-like protein 14 (ZIP14) promotes the cellular assimilation of iron from transferrin. J Biol Chem (2010) 1.23
Transplantation and in vivo imaging of multilineage engraftment in zebrafish bloodless mutants. Nat Immunol (2003) 5.73
A GATA-1-regulated microRNA locus essential for erythropoiesis. Proc Natl Acad Sci U S A (2008) 3.10
Mitoferrin is essential for erythroid iron assimilation. Nature (2006) 2.99
Analysis of thrombocyte development in CD41-GFP transgenic zebrafish. Blood (2005) 2.65
Discovery of genes essential for heme biosynthesis through large-scale gene expression analysis. Cell Metab (2009) 2.45
Deficiency of glutaredoxin 5 reveals Fe-S clusters are required for vertebrate haem synthesis. Nature (2005) 2.25
Mutations affecting the secretory COPII coat component SEC23B cause congenital dyserythropoietic anemia type II. Nat Genet (2009) 2.12
Haem homeostasis is regulated by the conserved and concerted functions of HRG-1 proteins. Nature (2008) 1.95
Abcb10 physically interacts with mitoferrin-1 (Slc25a37) to enhance its stability and function in the erythroid mitochondria. Proc Natl Acad Sci U S A (2009) 1.82
miR-451 protects against erythroid oxidant stress by repressing 14-3-3zeta. Genes Dev (2010) 1.80
Regulation of mitochondrial iron import through differential turnover of mitoferrin 1 and mitoferrin 2. Mol Cell Biol (2008) 1.71
Zebrafish SPI-1 (PU.1) marks a site of myeloid development independent of primitive erythropoiesis: implications for axial patterning. Dev Biol (2002) 1.70
Characterization of embryonic globin genes of the zebrafish. Dev Biol (2003) 1.65
L-Leucine improves the anemia and developmental defects associated with Diamond-Blackfan anemia and del(5q) MDS by activating the mTOR pathway. Blood (2012) 1.61
Mutation mapping and identification by whole-genome sequencing. Genome Res (2012) 1.51
The pu.1 promoter drives myeloid gene expression in zebrafish. Blood (2004) 1.49
Identification of ZBP-89 as a novel GATA-1-associated transcription factor involved in megakaryocytic and erythroid development. Mol Cell Biol (2008) 1.36
Iron and porphyrin trafficking in heme biogenesis. J Biol Chem (2010) 1.34
Ferrochelatase forms an oligomeric complex with mitoferrin-1 and Abcb10 for erythroid heme biosynthesis. Blood (2010) 1.31
The zebrafish spi1 promoter drives myeloid-specific expression in stable transgenic fish. Blood (2003) 1.24
Network of coregulated spliceosome components revealed by zebrafish mutant in recycling factor p110. Proc Natl Acad Sci U S A (2007) 1.24
Zebrafish kidney stromal cell lines support multilineage hematopoiesis. Blood (2009) 1.19
Intoxication of zebrafish and mammalian cells by cholera toxin depends on the flotillin/reggie proteins but not Derlin-1 or -2. J Clin Invest (2010) 1.19
The zebrafish mutant gene chardonnay (cdy) encodes divalent metal transporter 1 (DMT1). Blood (2002) 1.16
Zebrafish as a model of human hematologic disorders. Curr Opin Hematol (2004) 1.15
Carboxypeptidase A5 identifies a novel mast cell lineage in the zebrafish providing new insight into mast cell fate determination. Blood (2008) 1.10
Glucose metabolism impacts the spatiotemporal onset and magnitude of HSC induction in vivo. Blood (2013) 1.10
Zebrafish: a genetic model for vertebrate organogenesis and human disorders. Front Biosci (2003) 1.09
Mitochondrial Atpif1 regulates haem synthesis in developing erythroblasts. Nature (2012) 1.09
Snx3 regulates recycling of the transferrin receptor and iron assimilation. Cell Metab (2013) 1.06
The role and regulation of friend of GATA-1 (FOG-1) during blood development in the zebrafish. Blood (2009) 1.05
ABCB6 mutations cause ocular coloboma. Am J Hum Genet (2012) 1.04
Zebrafish mutants with disrupted early T-cell and thymus development identified in early pressure screen. Dev Dyn (2008) 1.04
Abnormal mitoferrin-1 expression in patients with erythropoietic protoporphyria. Exp Hematol (2011) 1.01
In vivo inactivation of MASTL kinase results in thrombocytopenia. Exp Hematol (2009) 0.98
Vascular endothelial growth factor receptor signaling is required for cardiac valve formation in zebrafish. Dev Dyn (2006) 0.97
Identification of distal cis-regulatory elements at mouse mitoferrin loci using zebrafish transgenesis. Mol Cell Biol (2011) 0.97
TMEM14C is required for erythroid mitochondrial heme metabolism. J Clin Invest (2014) 0.96
Targeted deletion of the mouse Mitoferrin1 gene: from anemia to protoporphyria. Blood (2011) 0.96
montalcino, A zebrafish model for variegate porphyria. Exp Hematol (2008) 0.95
Teleost growth factor independence (gfi) genes differentially regulate successive waves of hematopoiesis. Dev Biol (2012) 0.94
Characterization of zebrafish merlot/chablis as non-mammalian vertebrate models for severe congenital anemia due to protein 4.1 deficiency. Development (2002) 0.93
Critical function for the Ras-GTPase activating protein RASA3 in vertebrate erythropoiesis and megakaryopoiesis. Proc Natl Acad Sci U S A (2012) 0.91
Zebrafish slc4a2/ae2 anion exchanger: cDNA cloning, mapping, functional characterization, and localization. Am J Physiol Renal Physiol (2005) 0.91
Distinct neuroblastoma-associated alterations of PHOX2B impair sympathetic neuronal differentiation in zebrafish models. PLoS Genet (2013) 0.88
Cloning and characterization of an Mx gene and its corresponding promoter from the zebrafish, Danio rerio. Dev Comp Immunol (2004) 0.88
Heme metabolism and erythropoiesis. Curr Opin Hematol (2012) 0.87
Construction and application of a zebrafish array comparative genomic hybridization platform. Genes Chromosomes Cancer (2009) 0.87
Macrocytic anemia and mitochondriopathy resulting from a defect in sideroflexin 4. Am J Hum Genet (2013) 0.86
Zebrafish ae2.2 encodes a second slc4a2 anion exchanger. Am J Physiol Regul Integr Comp Physiol (2007) 0.80
Antagonistic roles of the ERK and p38 MAPK signalling pathways in globin expression, haem biosynthesis and iron uptake. Biochem J (2010) 0.79
Iron regulatory protein-1 protects against mitoferrin-1-deficient porphyria. J Biol Chem (2014) 0.78
Molecular cloning and functional characterization of zebrafish Slc4a3/Ae3 anion exchanger. Pflugers Arch (2014) 0.76
The scat mouse model highlights RASA3, a GTPase activating protein, as a key regulator of vertebrate erythropoiesis and megakaryopoiesis. Small GTPases (2012) 0.75
Characterization of genomic deletion efficiency mediated by clustered regularly interspaced short palindromic repeats (CRISPR)/Cas9 nuclease system in mammalian cells. J Biol Chem (2017) 0.75
Intracellular iron and heme trafficking and metabolism in developing erythroblasts. Metallomics (2017) 0.75