Published in FEBS J on May 01, 2006
Down syndrome--recent progress and future prospects. Hum Mol Genet (2009) 1.85
Overexpression of Dyrk1A contributes to neurofibrillary degeneration in Down syndrome. FASEB J (2008) 1.43
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J (2006) 1.22
Glycogen synthase kinase 3 β-dependent Snail degradation directs hepatocyte proliferation in normal liver regeneration. Proc Natl Acad Sci U S A (2011) 1.11
The genomically mosaic brain: aneuploidy and more in neural diversity and disease. Semin Cell Dev Biol (2013) 1.05
Calcineurin regulation in fungi and beyond. Eukaryot Cell (2007) 1.02
Prokineticin 1 modulates IL-8 expression via the calcineurin/NFAT signaling pathway. Biochim Biophys Acta (2009) 1.02
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis (2011) 0.98
Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J (2011) 0.95
Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem (2009) 0.94
Molecular responses of the Ts65Dn and Ts1Cje mouse models of Down syndrome to MK-801. Genes Brain Behav (2008) 0.92
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem (2012) 0.91
Meeting at the crossroads: common mechanisms in Fragile X and Down syndrome. Trends Neurosci (2013) 0.85
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease. Free Radic Biol Med (2013) 0.84
The Role of GSK3 in Presynaptic Function. Int J Alzheimers Dis (2011) 0.83
Regulator of calcineurin 1 (Rcan1) is required for the development of pulmonary eosinophilia in allergic inflammation in mice. Am J Pathol (2011) 0.81
Overexpression of Rcan1-1L inhibits hypoxia-induced cell apoptosis through induction of mitophagy. Mol Cells (2014) 0.80
A major role for RCAN1 in atherosclerosis progression. EMBO Mol Med (2013) 0.80
"Down syndrome: an insight of the disease". J Biomed Sci (2015) 0.77
Role of calcineurin in the VTA in rats behaviorally sensitized to methamphetamine. Psychopharmacology (Berl) (2011) 0.76
The Proteasome and Oxidative Stress in Alzheimer's Disease. Antioxid Redox Signal (2016) 0.75
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol (2002) 2.88
Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol (2002) 2.37
Free radical biology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol (2006) 2.25
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem (2002) 2.16
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol (2004) 2.15
Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun (2003) 2.15
Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic Biol Med (2005) 2.06
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med (2010) 1.72
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J (2010) 1.65
Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem (2012) 1.46
The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J (2002) 1.42
Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal (2005) 1.40
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett (2002) 1.32
Protein turnover by the proteasome in aging and disease. Free Radic Biol Med (2002) 1.30
The proteasomal system and HNE-modified proteins. Mol Aspects Med (2003) 1.29
Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J Mol Cell Cardiol (2006) 1.28
Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med (2007) 1.24
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J (2006) 1.22
Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med (2009) 1.18
Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. Ann N Y Acad Sci (2007) 1.17
Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol (2013) 1.12
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers. Am J Pathol (2005) 1.12
Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins. Free Radic Biol Med (2005) 1.11
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med (2011) 1.11
Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci (2012) 1.07
Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys (2012) 1.05
Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med (2012) 1.02
Age-associated declines in mitochondrial biogenesis and protein quality control factors are minimized by exercise training. Am J Physiol Regul Integr Comp Physiol (2012) 1.02
Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic Biol Med (2007) 1.01
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett (2003) 1.01
Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med (2005) 1.00
Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol (2013) 1.00
Potential roles of protein oxidation and the immunoproteasome in MHC class I antigen presentation: the 'PrOxI' hypothesis. Arch Biochem Biophys (2004) 0.99
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis (2011) 0.98
RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. FEBS J (2007) 0.98
Free radical biology - terminology and critical thinking. FEBS Lett (2004) 0.96
A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol (2012) 0.96
Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J (2011) 0.95
Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem (2009) 0.94
Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci (2011) 0.94
Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med (2012) 0.92
Free radicals and exercise: an introduction. Free Radic Biol Med (2007) 0.91
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem (2012) 0.91
Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells. Arch Biochem Biophys (2002) 0.89
DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease? IUBMB Life (2003) 0.89
DSCR1(Adapt78) modulates expression of SOD1. FASEB J (2004) 0.88
Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells. FASEB J (2002) 0.87
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. Neurobiol Aging (2008) 0.87
Cytotoxic effect of doxycycline and its implications for tet-on gene expression systems. Anal Biochem (2003) 0.87
Tau protein degradation is catalyzed by the ATP/ubiquitin-independent 20S proteasome under normal cell conditions. Arch Biochem Biophys (2010) 0.86
Atherosclerosis: another protein misfolding disease? Trends Mol Med (2002) 0.84
Chronic high levels of the RCAN1-1 protein may promote neurodegeneration and Alzheimer disease. Free Radic Biol Med (2013) 0.84
The evolution of Free Radical Biology & Medicine: a 20-year history. Free Radic Biol Med (2005) 0.83
Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch (2014) 0.83
A simple fluorescence labeling method for studies of protein oxidation, protein modification, and proteolysis. Free Radic Biol Med (2011) 0.81
Competition of nuclear factor-erythroid 2 factors related transcription factor isoforms, Nrf1 and Nrf2, in antioxidant enzyme induction. Redox Biol (2013) 0.78
Differential display: a critical analysis. Gene Expr (2002) 0.78
Genetic aberrations in Chernobyl-related thyroid cancers: implications for possible future nuclear accidents or nuclear attacks. IUBMB Life (2003) 0.78
Analysis of gene expression following oxidative stress. Methods Mol Biol (2002) 0.77
Characterization of adapt33, a stress-inducible riboregulator. Gene Expr (2003) 0.76
Gene expression in Alzheimer's disease. Drugs Today (Barc) (2002) 0.75
Reactive oxygen and nitrogen species in neurodegeneration. Free Radic Biol Med (2013) 0.75