Published in Am J Physiol Regul Integr Comp Physiol on May 09, 2012
Oxygen consumption and usage during physical exercise: the balance between oxidative stress and ROS-dependent adaptive signaling. Antioxid Redox Signal (2012) 1.60
Voluntary resistance wheel exercise from mid-life prevents sarcopenia and increases markers of mitochondrial function and autophagy in muscles of old male and female C57BL/6J mice. Skelet Muscle (2016) 1.39
Mitochondrial dysfunction and sarcopenia of aging: from signaling pathways to clinical trials. Int J Biochem Cell Biol (2013) 1.38
After the banquet: mitochondrial biogenesis, mitophagy, and cell survival. Autophagy (2013) 1.17
Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol (2013) 1.12
Skeletal muscle aging and the mitochondrion. Trends Endocrinol Metab (2013) 1.10
Markers of human skeletal muscle mitochondrial biogenesis and quality control: effects of age and aerobic exercise training. J Gerontol A Biol Sci Med Sci (2013) 0.95
Mitochondrial involvement and impact in aging skeletal muscle. Front Aging Neurosci (2014) 0.93
Differential Effect of Endurance Training on Mitochondrial Protein Damage, Degradation, and Acetylation in the Context of Aging. J Gerontol A Biol Sci Med Sci (2014) 0.92
Testosterone plus low-intensity physical training in late life improves functional performance, skeletal muscle mitochondrial biogenesis, and mitochondrial quality control in male mice. PLoS One (2012) 0.86
Mitochondrial biogenesis-associated factors underlie the magnitude of response to aerobic endurance training in rats. Pflugers Arch (2014) 0.83
Alterations in proton leak, oxidative status and uncoupling protein 3 content in skeletal muscle subsarcolemmal and intermyofibrillar mitochondria in old rats. BMC Geriatr (2014) 0.82
Endurance training-induced increase in circulating irisin levels is associated with reduction of abdominal visceral fat in middle-aged and older adults. PLoS One (2015) 0.81
Skeletal muscle mitochondrial energetic efficiency and aging. Int J Mol Sci (2015) 0.79
Exercise Increases Markers of Spermatogenesis in Rats Selectively Bred for Low Running Capacity. PLoS One (2014) 0.79
Treadmill training increases SIRT-1 and PGC-1 α protein levels and AMPK phosphorylation in quadriceps of middle-aged rats in an intensity-dependent manner. Mediators Inflamm (2014) 0.78
Acute exercise increases resistance to oxidative stress in young but not older adults. Age (Dordr) (2014) 0.77
The Frequency-Dependent Aerobic Exercise Effects of Hypothalamic GABAergic Expression and Cardiovascular Functions in Aged Rats. Front Aging Neurosci (2017) 0.76
Voluntary aerobic exercise increases arterial resilience and mitochondrial health with aging in mice. Aging (Albany NY) (2016) 0.75
Age-related changes in skeletal muscle mitochondria: the role of exercise. Integr Med Res (2016) 0.75
The Role of Exercise and TFAM in Preventing Skeletal Muscle Atrophy. J Cell Physiol (2016) 0.75
Mitochondrial Lon protease in human disease and aging: Including an etiologic classification of Lon-related diseases and disorders. Free Radic Biol Med (2016) 0.75
Gene expression profile of aging and its retardation by caloric restriction. Science (1999) 8.06
SIRT1 functionally interacts with the metabolic regulator and transcriptional coactivator PGC-1{alpha}. J Biol Chem (2005) 5.93
Biochemical adaptations in muscle. Effects of exercise on mitochondrial oxygen uptake and respiratory enzyme activity in skeletal muscle. J Biol Chem (1967) 5.20
Mitochondrial dynamics--fusion, fission, movement, and mitophagy--in neurodegenerative diseases. Hum Mol Genet (2009) 5.15
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58
Free radicals and tissue damage produced by exercise. Biochem Biophys Res Commun (1982) 3.36
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol (2002) 2.88
Effects of low-intensity prolonged exercise on PGC-1 mRNA expression in rat epitrochlearis muscle. Biochem Biophys Res Commun (2002) 2.75
Aging-associated reductions in AMP-activated protein kinase activity and mitochondrial biogenesis. Cell Metab (2007) 2.64
Moderate exercise is an antioxidant: upregulation of antioxidant genes by training. Free Radic Biol Med (2007) 2.61
Mitochondrial fusion, fission and autophagy as a quality control axis: the bioenergetic view. Biochim Biophys Acta (2008) 2.56
PNPASE regulates RNA import into mitochondria. Cell (2010) 2.54
Control of mitochondrial transcription specificity factors (TFB1M and TFB2M) by nuclear respiratory factors (NRF-1 and NRF-2) and PGC-1 family coactivators. Mol Cell Biol (2005) 2.46
Effects of exercise on mitochondrial content and function in aging human skeletal muscle. J Gerontol A Biol Sci Med Sci (2006) 2.23
Mitochondrial fission and fusion mediators, hFis1 and OPA1, modulate cellular senescence. J Biol Chem (2007) 2.22
Coordination of metabolic plasticity in skeletal muscle. J Exp Biol (2006) 2.09
Exercise, oxidative stress and hormesis. Ageing Res Rev (2007) 1.99
PGC-1{alpha} and PGC-1{beta} regulate mitochondrial density in neurons. J Biol Chem (2009) 1.78
Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. FASEB J (2004) 1.65
Mitochondrial shape changes: orchestrating cell pathophysiology. EMBO Rep (2010) 1.61
Molecular mechanisms and physiologic functions of mitochondrial dynamics. J Biochem (2011) 1.55
Mitochondrial fusion and division: Regulation and role in cell viability. Semin Cell Dev Biol (2009) 1.51
HSP70 and other possible heat shock or oxidative stress proteins are induced in skeletal muscle, heart, and liver during exercise. Free Radic Biol Med (1991) 1.50
Mammalian polynucleotide phosphorylase is an intermembrane space RNase that maintains mitochondrial homeostasis. Mol Cell Biol (2006) 1.49
Regulation by exercise of skeletal muscle content of mitochondria and GLUT4. J Physiol Pharmacol (2008) 1.46
Exercise increases mitochondrial PGC-1alpha content and promotes nuclear-mitochondrial cross-talk to coordinate mitochondrial biogenesis. J Biol Chem (2011) 1.46
Reduced satellite cell numbers and myogenic capacity in aging can be alleviated by endurance exercise. PLoS One (2010) 1.42
Aging and its effects on inflammation in skeletal muscle at rest and following exercise-induced muscle injury. Am J Physiol Regul Integr Comp Physiol (2010) 1.34
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett (2002) 1.32
Caloric restriction prevents age-associated accrual of oxidative damage to mouse skeletal muscle mitochondria. Free Radic Biol Med (1998) 1.32
Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch (2002) 1.31
PGC-1alpha-mediated adaptations in skeletal muscle. Pflugers Arch (2010) 1.29
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev (2009) 1.29
Mitochondrial function as a determinant of life span. Pflugers Arch (2009) 1.27
Identification and cloning of human polynucleotide phosphorylase, hPNPase old-35, in the context of terminal differentiation and cellular senescence. Proc Natl Acad Sci U S A (2002) 1.20
Oxidized mitochondrial protein degradation and repair in aging and oxidative stress. Antioxid Redox Signal (2010) 1.19
Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med (2009) 1.18
H2O2-induced mitochondrial fragmentation in C2C12 myocytes. Free Radic Biol Med (2010) 1.14
Response of mitochondrial fusion and fission protein gene expression to exercise in rat skeletal muscle. Biochim Biophys Acta (2009) 1.10
Mitochondrial biogenesis in exercise and in ageing. Adv Drug Deliv Rev (2009) 1.10
Defining the domains of human polynucleotide phosphorylase (hPNPaseOLD-35) mediating cellular senescence. Mol Cell Biol (2005) 1.09
Systemic and mitochondrial adaptive responses to moderate exercise in rodents. Free Radic Biol Med (2007) 1.06
Human polynucleotide phosphorylase protein in response to oxidative stress. Biochemistry (2006) 1.00
Nitric oxide synthase inhibition attenuates the skeletal muscle VEGF mRNA response to exercise. J Appl Physiol (1985) (2000) 0.97
A bichaperone (Hsp70-Hsp78) system restores mitochondrial DNA synthesis following thermal inactivation of Mip1p polymerase. J Biol Chem (2002) 0.96
The ClpB homolog Hsp78 is required for the efficient degradation of proteins in the mitochondrial matrix. J Biol Chem (2002) 0.96
Redefining the role of mitochondria in exercise: a dynamic remodeling. Ann N Y Acad Sci (2010) 0.93
Muscle mitochondrial bioenergetics, oxygen supply, and work capacity during dietary iron deficiency and repletion. Am J Physiol (1982) 0.93
Enhanced mitochondrial biogenesis is associated with increased expression of the mitochondrial ATP-dependent Lon protease. FEBS Lett (1999) 0.92
Exercise preconditioning against hydrogen peroxide-induced oxidative damage in proteins of rat myocardium. Arch Biochem Biophys (2000) 0.92
Interplay of oxidants and antioxidants during exercise: implications for muscle health. Phys Sportsmed (2009) 0.91
Release of superoxide from skeletal muscle of adult and old mice: an experimental test of the reductive hotspot hypothesis. Aging Cell (2007) 0.90
Increased expression of mitochondrial transcription factor A and nuclear respiratory factor-1 in skeletal muscle from aged human subjects. FEBS Lett (2001) 0.89
Muscle type-specific response of PGC-1 alpha and oxidative enzymes during voluntary wheel running in mouse skeletal muscle. Acta Physiol (Oxf) (2006) 0.87
Ubisemiquinone radicals in liver: implications for a mitochondrial Q cycle in vivo. Biochem Biophys Res Commun (1982) 0.87
Prolonged Nrf1 overexpression triggers adipocyte inflammation and insulin resistance. J Cell Biochem (2010) 0.86
Human polynucleotide phosphorylase (hPNPase old-35): an RNA degradation enzyme with pleiotrophic biological effects. Cell Cycle (2006) 0.86
Effects of aerobic training on reactive capacity: an animal model. J Gerontol (1981) 0.78
A moderate intensity exercise program did not increase the oxidative stress in older adults. Arch Gerontol Geriatr (2011) 0.77
Measuring reactive oxygen and nitrogen species with fluorescent probes: challenges and limitations. Free Radic Biol Med (2011) 3.58
Lon protease preferentially degrades oxidized mitochondrial aconitase by an ATP-stimulated mechanism. Nat Cell Biol (2002) 2.88
Senescence marker protein-30 protects mice lungs from oxidative stress, aging, and smoking. Am J Respir Crit Care Med (2006) 2.87
Calcium and oxidative stress: from cell signaling to cell death. Mol Immunol (2002) 2.37
Free radical biology and medicine: it's a gas, man! Am J Physiol Regul Integr Comp Physiol (2006) 2.25
Ubiquitin conjugation is not required for the degradation of oxidized proteins by proteasome. J Biol Chem (2002) 2.16
Decreased proteolysis caused by protein aggregates, inclusion bodies, plaques, lipofuscin, ceroid, and 'aggresomes' during oxidative stress, aging, and disease. Int J Biochem Cell Biol (2004) 2.15
Selective degradation of oxidatively modified protein substrates by the proteasome. Biochem Biophys Res Commun (2003) 2.15
Downregulation of the human Lon protease impairs mitochondrial structure and function and causes cell death. Free Radic Biol Med (2005) 2.06
Exercise, oxidative stress and hormesis. Ageing Res Rev (2007) 1.99
Systemic adaptation to oxidative challenge induced by regular exercise. Free Radic Biol Med (2007) 1.74
Mitochondrial fission and cristae disruption increase the response of cell models of Huntington's disease to apoptotic stimuli. EMBO Mol Med (2010) 1.72
Age-associated increase in oxidative stress and nuclear factor kappaB activation are attenuated in rat liver by regular exercise. FASEB J (2004) 1.65
The immunoproteasome, the 20S proteasome and the PA28αβ proteasome regulator are oxidative-stress-adaptive proteolytic complexes. Biochem J (2010) 1.65
Nrf2-dependent induction of proteasome and Pa28αβ regulator are required for adaptation to oxidative stress. J Biol Chem (2012) 1.46
The DSCR1 (Adapt78) isoform 1 protein calcipressin 1 inhibits calcineurin and protects against acute calcium-mediated stress damage, including transient oxidative stress. FASEB J (2002) 1.42
Oxidized and ubiquitinated proteins may predict recovery of postischemic cardiac function: essential role of the proteasome. Antioxid Redox Signal (2005) 1.40
Exercise and hormesis: oxidative stress-related adaptation for successful aging. Biogerontology (2005) 1.40
Senescence marker protein 30 functions as gluconolactonase in L-ascorbic acid biosynthesis, and its knockout mice are prone to scurvy. Proc Natl Acad Sci U S A (2006) 1.37
Modulation of Lon protease activity and aconitase turnover during aging and oxidative stress. FEBS Lett (2002) 1.32
Exercise training decreases DNA damage and increases DNA repair and resistance against oxidative stress of proteins in aged rat skeletal muscle. Pflugers Arch (2002) 1.31
Activation of ras signaling pathway by 8-oxoguanine DNA glycosylase bound to its excision product, 8-oxoguanine. J Biol Chem (2012) 1.30
Protein turnover by the proteasome in aging and disease. Free Radic Biol Med (2002) 1.30
Endurance exercise increases the SIRT1 and peroxisome proliferator-activated receptor gamma coactivator-1alpha protein expressions in rat skeletal muscle. Metabolism (2008) 1.30
The proteasomal system and HNE-modified proteins. Mol Aspects Med (2003) 1.29
The effects of training and detraining on memory, neurotrophins and oxidative stress markers in rat brain. Neurochem Int (2006) 1.29
Exercise alters SIRT1, SIRT6, NAD and NAMPT levels in skeletal muscle of aged rats. Mech Ageing Dev (2009) 1.29
Optimal determination of heart tissue 26S-proteasome activity requires maximal stimulating ATP concentrations. J Mol Cell Cardiol (2006) 1.28
Production, detection, and adaptive responses to free radicals in exercise. Free Radic Biol Med (2007) 1.24
Increased susceptibility of MER5 (peroxiredoxin III) knockout mice to LPS-induced oxidative stress. Biochem Biophys Res Commun (2007) 1.23
Phosphorylation inhibits turnover of the tau protein by the proteasome: influence of RCAN1 and oxidative stress. Biochem J (2006) 1.22
Serum brain-derived neurotrophic factor level is increased and associated with obesity in newly diagnosed female patients with type 2 diabetes mellitus. Metabolism (2006) 1.20
Mitochondrial Lon protease is a human stress protein. Free Radic Biol Med (2009) 1.18
Traumatic brain injury: oxidative stress and neuroprotection. Antioxid Redox Signal (2013) 1.18
Importance of the lon protease in mitochondrial maintenance and the significance of declining lon in aging. Ann N Y Acad Sci (2007) 1.17
Age-associated neurodegeneration and oxidative damage to lipids, proteins and DNA. Mol Aspects Med (2011) 1.14
Resveratrol enhances exercise training responses in rats selectively bred for high running performance. Food Chem Toxicol (2013) 1.12
Defining the mitochondrial proteomes from five rat organs in a physiologically significant context using 2D blue-native/SDS-PAGE. J Proteome Res (2006) 1.12
Proteasome inhibition and aggresome formation in sporadic inclusion-body myositis and in amyloid-beta precursor protein-overexpressing cultured human muscle fibers. Am J Pathol (2005) 1.12
Age-related changes of mitochondrial structure and function in Caenorhabditis elegans. Mech Ageing Dev (2006) 1.12
Aggregates of oxidized proteins (lipofuscin) induce apoptosis through proteasome inhibition and dysregulation of proapoptotic proteins. Free Radic Biol Med (2005) 1.11
Effect of aging and late onset dietary restriction on antioxidant enzymes and proteasome activities, and protein carbonylation of rat skeletal muscle and tendon. Exp Gerontol (2002) 1.11
HSP70 mediates dissociation and reassociation of the 26S proteasome during adaptation to oxidative stress. Free Radic Biol Med (2011) 1.11
Activation of cellular signaling by 8-oxoguanine DNA glycosylase-1-initiated DNA base excision repair. DNA Repair (Amst) (2013) 1.08
RCAN1 (DSCR1 or Adapt78) stimulates expression of GSK-3beta. FEBS J (2006) 1.08
Degradation of damaged proteins: the main function of the 20S proteasome. Prog Mol Biol Transl Sci (2012) 1.07
Differential roles of proteasome and immunoproteasome regulators Pa28αβ, Pa28γ and Pa200 in the degradation of oxidized proteins. Arch Biochem Biophys (2012) 1.05
Protein oxidation during aging of the nematode Caenorhabditis elegans. Free Radic Biol Med (2002) 1.04
Regular exercise reduces 8-oxodG in the nuclear and mitochondrial DNA and modulates the DNA repair activity in the liver of old rats. Exp Gerontol (2007) 1.03
Caloric restriction optimizes the proteasome pathway with aging in rat plantaris muscle: implications for sarcopenia. Am J Physiol Regul Integr Comp Physiol (2008) 1.02
Nrf2-regulated phase II enzymes are induced by chronic ambient nanoparticle exposure in young mice with age-related impairments. Free Radic Biol Med (2012) 1.02
Is vitamin E an antioxidant, a regulator of signal transduction and gene expression, or a 'junk' food? Comments on the two accompanying papers: "Molecular mechanism of alpha-tocopherol action" by A. Azzi and "Vitamin E, antioxidant and nothing more" by M. Traber and J. Atkinson. Free Radic Biol Med (2007) 1.01
Proteasome inhibitors induce intracellular protein aggregation and cell death by an oxygen-dependent mechanism. FEBS Lett (2003) 1.01
Protein oxidation and degradation during postmitotic senescence. Free Radic Biol Med (2005) 1.00
Down-regulation of 8-oxoguanine DNA glycosylase 1 expression in the airway epithelium ameliorates allergic lung inflammation. DNA Repair (Amst) (2012) 1.00
Upregulation of the mitochondrial Lon Protease allows adaptation to acute oxidative stress but dysregulation is associated with chronic stress, disease, and aging. Redox Biol (2013) 1.00
The effects of moderate-, strenuous- and over-training on oxidative stress markers, DNA repair, and memory, in rat brain. Neurochem Int (2005) 0.99
Potential roles of protein oxidation and the immunoproteasome in MHC class I antigen presentation: the 'PrOxI' hypothesis. Arch Biochem Biophys (2004) 0.99
High altitude and oxidative stress. Respir Physiol Neurobiol (2007) 0.99
Active oligomeric ATP synthases in mammalian mitochondria. Biochem Biophys Res Commun (2005) 0.98
RCAN1-1L is overexpressed in neurons of Alzheimer's disease patients. FEBS J (2007) 0.98
Amyloid-β toxicity and tau hyperphosphorylation are linked via RCAN1 in Alzheimer's disease. J Alzheimers Dis (2011) 0.98
Modulation of gene expression of SMP-30 by LPS and calorie restriction during aging process. Exp Gerontol (2004) 0.97
A conserved role for the 20S proteasome and Nrf2 transcription factor in oxidative stress adaptation in mammals, Caenorhabditis elegans and Drosophila melanogaster. J Exp Biol (2012) 0.96
Free radical biology - terminology and critical thinking. FEBS Lett (2004) 0.96
8-Oxoguanosine and uracil repair of nuclear and mitochondrial DNA in red and white skeletal muscle of exercise-trained old rats. J Appl Physiol (1985) (2007) 0.96
Do RCAN1 proteins link chronic stress with neurodegeneration? FASEB J (2011) 0.95
Complete lack of vitamin C intake generates pulmonary emphysema in senescence marker protein-30 knockout mice. Am J Physiol Lung Cell Mol Physiol (2010) 0.95
Biological significance of protein modifications in aging and calorie restriction. Ann N Y Acad Sci (2010) 0.94
Regulator of calcineurin (RCAN1-1L) is deficient in Huntington disease and protective against mutant huntingtin toxicity in vitro. J Biol Chem (2009) 0.94
Exercise improves import of 8-oxoguanine DNA glycosylase into the mitochondrial matrix of skeletal muscle and enhances the relative activity. Free Radic Biol Med (2008) 0.94
Impairment of lon-induced protection against the accumulation of oxidized proteins in senescent wi-38 fibroblasts. J Gerontol A Biol Sci Med Sci (2011) 0.94
Decreased serum brain-derived neurotrophic factor in trained men. Neurosci Lett (2008) 0.94
Marathon running alters the DNA base excision repair in human skeletal muscle. Life Sci (2003) 0.92
Lactoferrin decreases LPS-induced mitochondrial dysfunction in cultured cells and in animal endotoxemia model. Innate Immun (2009) 0.92
8-oxoguanine DNA glycosylase-1 augments proinflammatory gene expression by facilitating the recruitment of site-specific transcription factors. J Immunol (2014) 0.92
Cigarette smoke extract stimulates epithelial-mesenchymal transition through Src activation. Free Radic Biol Med (2012) 0.92
Chronic expression of RCAN1-1L protein induces mitochondrial autophagy and metabolic shift from oxidative phosphorylation to glycolysis in neuronal cells. J Biol Chem (2012) 0.91
Beneficial biochemical outcomes of late-onset dietary restriction in rodents. Ann N Y Acad Sci (2007) 0.91
Effects of exercise on brain function: role of free radicals. Appl Physiol Nutr Metab (2007) 0.91
The effects of moderate, strenuous, and overtraining on oxidative stress markers and DNA repair in rat liver. Can J Appl Physiol (2005) 0.91
Free radicals and exercise: an introduction. Free Radic Biol Med (2007) 0.91
Age-related difference of site-specific histone modifications in rat liver. Biogerontology (2008) 0.90
DSCR1(Adapt78)--a Janus gene providing stress protection but causing Alzheimer's disease? IUBMB Life (2003) 0.89
Proteasome-dependent turnover of protein disulfide isomerase in oxidatively stressed cells. Arch Biochem Biophys (2002) 0.89
DSCR1(Adapt78) modulates expression of SOD1. FASEB J (2004) 0.88
Ezrin turnover and cell shape changes catalyzed by proteasome in oxidatively stressed cells. FASEB J (2002) 0.87
Decreased SIRT1 deacetylase activity in sporadic inclusion-body myositis muscle fibers. Neurobiol Aging (2008) 0.87
Cytotoxic effect of doxycycline and its implications for tet-on gene expression systems. Anal Biochem (2003) 0.87
Attenuation of the development of murine solid leukemia tumor by physical exercise. Antioxid Redox Signal (2002) 0.87
Redox-regulating sirtuins in aging, caloric restriction, and exercise. Free Radic Biol Med (2013) 0.86