Published in Cell Metab on May 01, 2006
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The role of gut hormones in glucose homeostasis. J Clin Invest (2007) 3.36
Islet G protein-coupled receptors as potential targets for treatment of type 2 diabetes. Nat Rev Drug Discov (2009) 3.26
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron (2012) 2.30
Glucose and weight control in mice with a designed ghrelin O-acyltransferase inhibitor. Science (2010) 2.12
Ghrelin O-acyltransferase (GOAT) is essential for growth hormone-mediated survival of calorie-restricted mice. Proc Natl Acad Sci U S A (2010) 2.06
Ghrelin suppresses glucose-stimulated insulin secretion and deteriorates glucose tolerance in healthy humans. Diabetes (2010) 2.01
Association between gastric Helicobacter pylori colonization and glycated hemoglobin levels. J Infect Dis (2012) 1.84
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology (2007) 1.64
Induced ablation of ghrelin cells in adult mice does not decrease food intake, body weight, or response to high-fat diet. Cell Metab (2014) 1.63
Ghrelin infusion in humans induces acute insulin resistance and lipolysis independent of growth hormone signaling. Diabetes (2008) 1.59
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects. Endocrinology (2012) 1.50
Vaccination against weight gain. Proc Natl Acad Sci U S A (2006) 1.45
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Role of ghrelin in food reward: impact of ghrelin on sucrose self-administration and mesolimbic dopamine and acetylcholine receptor gene expression. Addict Biol (2011) 1.28
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell (2011) 1.21
Colocalization of ghrelin O-acyltransferase and ghrelin in gastric mucosal cells. Am J Physiol Endocrinol Metab (2009) 1.21
Central nervous system regulation of energy metabolism: ghrelin versus leptin. Ann N Y Acad Sci (2008) 1.20
Brain regulation of appetite and satiety. Endocrinol Metab Clin North Am (2008) 1.15
Ghrelin directly stimulates glucagon secretion from pancreatic alpha-cells. Mol Endocrinol (2011) 1.13
Ghrelin-producing epsilon cells in the developing and adult human pancreas. Diabetologia (2008) 1.09
Vertical sleeve gastrectomy improves glucose and lipid metabolism and delays diabetes onset in UCD-T2DM rats. Endocrinology (2012) 1.09
Characterization of a novel ghrelin cell reporter mouse. Regul Pept (2009) 1.08
Actions and therapeutic pathways of ghrelin for gastrointestinal disorders. Nat Rev Gastroenterol Hepatol (2009) 1.06
Central ghrelin regulates peripheral lipid metabolism in a growth hormone-independent fashion. Endocrinology (2009) 1.04
Modification of ghrelin receptor signaling by somatostatin receptor-5 regulates insulin release. Proc Natl Acad Sci U S A (2012) 1.02
Ablations of ghrelin and ghrelin receptor exhibit differential metabolic phenotypes and thermogenic capacity during aging. PLoS One (2011) 1.02
Peptides and food intake. Front Endocrinol (Lausanne) (2014) 1.01
Postprandial inhibition of gastric ghrelin secretion by long-chain fatty acid through GPR120 in isolated gastric ghrelin cells and mice. Am J Physiol Gastrointest Liver Physiol (2012) 0.99
Mice with hyperghrelinemia are hyperphagic and glucose intolerant and have reduced leptin sensitivity. Diabetes (2009) 0.98
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Functional implications of limited leptin receptor and ghrelin receptor coexpression in the brain. J Comp Neurol (2012) 0.97
Modulation of ghrelin O-acyltransferase expression in pancreatic islets. Cell Physiol Biochem (2010) 0.97
G protein-coupled receptor 39 deficiency is associated with pancreatic islet dysfunction. Endocrinology (2009) 0.96
Ghrelin attenuates cAMP-PKA signaling to evoke insulinostatic cascade in islet β-cells. Diabetes (2011) 0.94
Regulation of ghrelin signaling by a leptin-induced gene, negative regulatory element-binding protein, in the hypothalamic neurons. J Biol Chem (2010) 0.94
Ghrelin's second life: from appetite stimulator to glucose regulator. World J Gastroenterol (2012) 0.93
Glucose-mediated control of ghrelin release from primary cultures of gastric mucosal cells. Am J Physiol Endocrinol Metab (2012) 0.93
Uncoupling protein-2 decreases the lipogenic actions of ghrelin. Endocrinology (2010) 0.90
In search of an effective obesity treatment: a shot in the dark or a shot in the arm? Proc Natl Acad Sci U S A (2006) 0.89
The β-cell GHSR and downstream cAMP/TRPM2 signaling account for insulinostatic and glycemic effects of ghrelin. Sci Rep (2015) 0.89
Effect of ghrelin on glucose-insulin homeostasis: therapeutic implications. Int J Pept (2010) 0.88
Signaling molecules involved in lipid-induced pancreatic beta-cell dysfunction. DNA Cell Biol (2013) 0.88
Physiological roles revealed by ghrelin and ghrelin receptor deficient mice. Peptides (2011) 0.87
Characterization of the insulin sensitivity of ghrelin receptor KO mice using glycemic clamps. BMC Physiol (2011) 0.86
Ghrelin and eating behavior: evidence and insights from genetically-modified mouse models. Front Neurosci (2013) 0.86
Ghrelin and growth hormone: story in reverse. Proc Natl Acad Sci U S A (2010) 0.86
Acute peripheral metabolic effects of intraarterial ghrelin infusion in healthy young men. J Clin Endocrinol Metab (2010) 0.86
Ablation of ghrelin receptor in leptin-deficient ob/ob mice has paradoxical effects on glucose homeostasis when compared with ablation of ghrelin in ob/ob mice. Am J Physiol Endocrinol Metab (2012) 0.85
Slow and steady is the key to beta-cell replication. J Cell Mol Med (2009) 0.85
Ghrelin: much more than a hunger hormone. Curr Opin Clin Nutr Metab Care (2013) 0.85
Modulation of food intake by mTOR signalling in the dorsal motor nucleus of the vagus in male rats: focus on ghrelin and nesfatin-1. Exp Physiol (2013) 0.84
Ghrelin O-acyltransferase assays and inhibition. Methods Enzymol (2012) 0.83
Ghrelin contributes to derangements of glucose metabolism induced by rapamycin in mice. Diabetologia (2012) 0.82
Ghrelin Impairs Prandial Glucose Tolerance and Insulin Secretion in Healthy Humans Despite Increasing GLP-1. J Clin Endocrinol Metab (2016) 0.81
Is there altered sensitivity to ghrelin-receptor ligands in leptin-deficient mice?: importance of satiety state and time of day. Psychopharmacology (Berl) (2011) 0.81
Ablation of ghrelin O-acyltransferase does not improve glucose intolerance or body adiposity in mice on a leptin-deficient ob/ob background. PLoS One (2013) 0.80
Role of SST, CORT and ghrelin and its receptors at the endocrine pancreas. Front Endocrinol (Lausanne) (2012) 0.80
Assessing interactions between Ghsr and Mc3r reveals a role for AgRP in the expression of food anticipatory activity in male mice. Endocrinology (2014) 0.80
Interactions of gastrointestinal peptides: ghrelin and its anorexigenic antagonists. Int J Pept (2010) 0.80
Expression of Serum Retinol Binding Protein and Transthyretin within Mouse Gastric Ghrelin Cells. PLoS One (2013) 0.79
Ghrelin receptor regulates HFCS-induced adipose inflammation and insulin resistance. Nutr Diabetes (2013) 0.79
Ghrelin--a new player in glucose homeostasis? Cell Metab (2006) 0.78
Apo-Ghrelin Receptor (apo-GHSR1a) Regulates Dopamine Signaling in the Brain. Front Endocrinol (Lausanne) (2014) 0.78
Suppression of Ghrelin Exacerbates HFCS-Induced Adiposity and Insulin Resistance. Int J Mol Sci (2017) 0.78
Suppression of GHS-R in AgRP Neurons Mitigates Diet-Induced Obesity by Activating Thermogenesis. Int J Mol Sci (2017) 0.77
CRF type 2 receptors mediate the metabolic effects of ghrelin in C2C12 cells. Obesity (Silver Spring) (2013) 0.77
Ghrelin Protects against Dexamethasone-Induced INS-1 Cell Apoptosis via ERK and p38MAPK Signaling. Int J Endocrinol (2016) 0.77
Dietary Caprylic Acid (C8:0) Does Not Increase Plasma Acylated Ghrelin but Decreases Plasma Unacylated Ghrelin in the Rat. PLoS One (2015) 0.77
Lipocalin-2 plasmatic levels are reduced in patients with long-term type 2 diabetes mellitus. Int J Clin Exp Med (2015) 0.76
β1-Adrenergic receptor deficiency in ghrelin-expressing cells causes hypoglycemia in susceptible individuals. J Clin Invest (2016) 0.75
Gastric mammalian target of rapamycin signaling, hormone production and energy metabolism. World J Gastrointest Pathophysiol (2011) 0.75
Hexarelin Protects Rodent Pancreatic Β-Cells Function from Cytotoxic Effects of Streptozotocin Involving Mitochondrial Signalling Pathways In Vivo and In Vitro. PLoS One (2016) 0.75
Therapeutic Potential of Targeting the Ghrelin Pathway. Int J Mol Sci (2017) 0.75
Pharmacokinetics and pharmacodynamics of PF-05190457: The first oral ghrelin receptor inverse agonist to be profiled in healthy subjects. Br J Clin Pharmacol (2016) 0.75
Vertical sleeve gastrectomy reduces blood pressure and hypothalamic endoplasmic reticulum stress in mice. Dis Model Mech (2017) 0.75
Metabolic Benefit of Chronic Caloric Restriction and Activation of Hypothalamic AGRP/NPY Neurons in Male Mice Is Independent of Ghrelin. Endocrinology (2016) 0.75
Ghrelin receptor gene polymorphisms and body size in children and adults. J Clin Endocrinol Metab (2008) 0.75
Hypoglycemic Effect of Combined Ghrelin and Glucagon Receptor Blockade. Diabetes (2017) 0.75
Tissue-specific and inducible Cre-mediated recombination in the gut epithelium. Genesis (2004) 6.83
T-cell accumulation and regulated on activation, normal T cell expressed and secreted upregulation in adipose tissue in obesity. Circulation (2007) 6.23
Cbfa1-independent decrease in osteoblast proliferation, osteopenia, and persistent embryonic eye vascularization in mice deficient in Lrp5, a Wnt coreceptor. J Cell Biol (2002) 6.20
The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05
Reversal of obesity by targeted ablation of adipose tissue. Nat Med (2004) 4.23
A guide to analysis of mouse energy metabolism. Nat Methods (2011) 3.82
Farnesoid X receptor is essential for normal glucose homeostasis. J Clin Invest (2006) 3.44
NeuroD-betacellulin gene therapy induces islet neogenesis in the liver and reverses diabetes in mice. Nat Med (2003) 3.26
Absence of the SRC-2 coactivator results in a glycogenopathy resembling Von Gierke's disease. Science (2008) 3.17
Adiponectin regulates albuminuria and podocyte function in mice. J Clin Invest (2008) 3.11
Ghrelin stimulation of growth hormone release and appetite is mediated through the growth hormone secretagogue receptor. Proc Natl Acad Sci U S A (2004) 2.99
Atherosclerosis: evidence for impairment of resolution of vascular inflammation governed by specific lipid mediators. FASEB J (2008) 2.78
Deletion of ghrelin impairs neither growth nor appetite. Mol Cell Biol (2003) 2.73
Protection against fatty liver but normal adipogenesis in mice lacking adipose differentiation-related protein. Mol Cell Biol (2006) 2.63
TFEB controls cellular lipid metabolism through a starvation-induced autoregulatory loop. Nat Cell Biol (2013) 2.62
Molecular characterization of the role of orphan receptor small heterodimer partner in development of fatty liver. Hepatology (2007) 2.53
Patatin-like phospholipase domain-containing 3/adiponutrin deficiency in mice is not associated with fatty liver disease. Hepatology (2010) 2.47
C-reactive protein accelerates the progression of atherosclerosis in apolipoprotein E-deficient mice. Circulation (2004) 2.43
Increased beta -oxidation but no insulin resistance or glucose intolerance in mice lacking adiponectin. J Biol Chem (2002) 2.33
Apo-ghrelin receptor forms heteromers with DRD2 in hypothalamic neurons and is essential for anorexigenic effects of DRD2 agonism. Neuron (2012) 2.30
Adiponectin cardioprotection after myocardial ischemia/reperfusion involves the reduction of oxidative/nitrative stress. Circulation (2007) 2.28
Prevalence of extensively drug-resistant tuberculosis among patients with multidrug-resistant tuberculosis: a retrospective hospital-based study. Indian J Med Res (2009) 2.28
Mutations in NR4A2 associated with familial Parkinson disease. Nat Genet (2002) 2.27
Reduced inflammation and tissue damage in transgenic rabbits overexpressing 15-lipoxygenase and endogenous anti-inflammatory lipid mediators. J Immunol (2003) 2.23
Adiponectin deficiency increases leukocyte-endothelium interactions via upregulation of endothelial cell adhesion molecules in vivo. J Clin Invest (2007) 2.03
Absence of p21Waf1/Cip1/Sdi1 modulates macrophage differentiation and inflammatory response and protects against atherosclerosis. Circulation (2004) 2.00
Neurogenin3 is sufficient for transdetermination of hepatic progenitor cells into neo-islets in vivo but not transdifferentiation of hepatocytes. Dev Cell (2009) 2.00
Hyperhomocysteinemia decreases circulating high-density lipoprotein by inhibiting apolipoprotein A-I Protein synthesis and enhancing HDL cholesterol clearance. Circ Res (2006) 1.95
Cellular energy depletion resets whole-body energy by promoting coactivator-mediated dietary fuel absorption. Cell Metab (2011) 1.89
The orphan nuclear receptor SHP regulates PGC-1alpha expression and energy production in brown adipocytes. Cell Metab (2005) 1.89
Ghrelin promotes thymopoiesis during aging. J Clin Invest (2007) 1.83
A role for lipid bodies in the cross-presentation of phagocytosed antigens by MHC class I in dendritic cells. Immunity (2009) 1.82
Targeted inactivation of MLL3 histone H3-Lys-4 methyltransferase activity in the mouse reveals vital roles for MLL3 in adipogenesis. Proc Natl Acad Sci U S A (2008) 1.80
Adiponectin deficiency promotes endothelial activation and profoundly exacerbates sepsis-related mortality. Am J Physiol Endocrinol Metab (2008) 1.79
Activation of nuclear receptor CAR ameliorates diabetes and fatty liver disease. Proc Natl Acad Sci U S A (2009) 1.77
Endothelial lipase is a major genetic determinant for high-density lipoprotein concentration, structure, and metabolism. Proc Natl Acad Sci U S A (2003) 1.74
A peptidomimetic targeting white fat causes weight loss and improved insulin resistance in obese monkeys. Sci Transl Med (2011) 1.74
Genetic deficiency of adiponectin protects against acute kidney injury. Kidney Int (2013) 1.71
Metabolic adaptations in the absence of perilipin: increased beta-oxidation and decreased hepatic glucose production associated with peripheral insulin resistance but normal glucose tolerance in perilipin-null mice. J Biol Chem (2004) 1.69
Restoration of type VII collagen expression and function in dystrophic epidermolysis bullosa. Nat Genet (2002) 1.67
Des-acyl ghrelin induces food intake by a mechanism independent of the growth hormone secretagogue receptor. Endocrinology (2006) 1.67
Extrapancreatic insulin-producing cells in multiple organs in diabetes. Proc Natl Acad Sci U S A (2004) 1.67
Characterization of adult ghrelin and ghrelin receptor knockout mice under positive and negative energy balance. Endocrinology (2007) 1.64
Post-translational modifications of the four conserved lysine residues within the collagenous domain of adiponectin are required for the formation of its high molecular weight oligomeric complex. J Biol Chem (2006) 1.64
Glucose-dependent transcriptional regulation by an evolutionarily conserved glucose-sensing module. Diabetes (2006) 1.61
Functional compensation for adipose differentiation-related protein (ADFP) by Tip47 in an ADFP null embryonic cell line. J Biol Chem (2006) 1.53
Ghrelin amplifies dopamine signaling by cross talk involving formation of growth hormone secretagogue receptor/dopamine receptor subtype 1 heterodimers. Mol Endocrinol (2006) 1.53
An age-dependent interaction with leptin unmasks ghrelin's bone-protective effects. Endocrinology (2012) 1.50
Deficiency of adipose differentiation-related protein impairs foam cell formation and protects against atherosclerosis. Circ Res (2008) 1.48
The triterpenoid 2-cyano-3,12-dioxooleana-1,9-dien-28-oic-acid methyl ester has potent anti-diabetic effects in diet-induced diabetic mice and Lepr(db/db) mice. J Biol Chem (2010) 1.44
Targeted disruption of the melanin-concentrating hormone receptor-1 results in hyperphagia and resistance to diet-induced obesity. Endocrinology (2002) 1.44
FoxP3+ regulatory T cells suppress effector T-cell function at pathologic site in miliary tuberculosis. Am J Respir Crit Care Med (2009) 1.43
Active ghrelin levels and active to total ghrelin ratio in cancer-induced cachexia. J Clin Endocrinol Metab (2005) 1.42
Apolipoprotein A-I and its role in lymphocyte cholesterol homeostasis and autoimmunity. Arterioscler Thromb Vasc Biol (2009) 1.38
The nuclear orphan receptor COUP-TFII plays an essential role in adipogenesis, glucose homeostasis, and energy metabolism. Cell Metab (2009) 1.38
Enteric-coated mycophenolate sodium can be safely administered in maintenance renal transplant patients: results of a 1-year study. Am J Transplant (2004) 1.38
Normal and gene-corrected dystrophic epidermolysis bullosa fibroblasts alone can produce type VII collagen at the basement membrane zone. J Invest Dermatol (2003) 1.37
Suppression of atherosclerotic plaque progression and instability by tissue inhibitor of metalloproteinase-2: involvement of macrophage migration and apoptosis. Circulation (2006) 1.36
Endothelial lipase modulates HDL but has no effect on atherosclerosis development in apoE-/- and LDLR-/- mice. J Lipid Res (2005) 1.35
Adiponectin primes human monocytes into alternative anti-inflammatory M2 macrophages. Am J Physiol Heart Circ Physiol (2010) 1.34
The human lipodystrophy gene product Berardinelli-Seip congenital lipodystrophy 2/seipin plays a key role in adipocyte differentiation. Endocrinology (2009) 1.32
Adiponectin deficiency protects mice from chemically induced colonic inflammation. Gastroenterology (2006) 1.32
Type 1 diabetes promotes disruption of advanced atherosclerotic lesions in LDL receptor-deficient mice. Proc Natl Acad Sci U S A (2008) 1.28
Aging leads to a programmed loss of brown adipocytes in murine subcutaneous white adipose tissue. Aging Cell (2012) 1.26
Cyclin D3 maintains growth-inhibitory activity of C/EBPalpha by stabilizing C/EBPalpha-cdk2 and C/EBPalpha-Brm complexes. Mol Cell Biol (2006) 1.22
Ablation of ghrelin receptor reduces adiposity and improves insulin sensitivity during aging by regulating fat metabolism in white and brown adipose tissues. Aging Cell (2011) 1.21
Absence of adipose differentiation related protein upregulates hepatic VLDL secretion, relieves hepatosteatosis, and improves whole body insulin resistance in leptin-deficient mice. J Lipid Res (2010) 1.19
Ghrelin and growth hormone secretagogue receptor expression in mice during aging. Endocrinology (2006) 1.18
Desensitization and endocytosis mechanisms of ghrelin-activated growth hormone secretagogue receptor 1a. Endocrinology (2003) 1.17
Berardinelli-seip congenital lipodystrophy 2/seipin is a cell-autonomous regulator of lipolysis essential for adipocyte differentiation. Mol Cell Biol (2012) 1.17
IFATS collection: Combinatorial peptides identify alpha5beta1 integrin as a receptor for the matricellular protein SPARC on adipose stromal cells. Stem Cells (2008) 1.16
Adiponectin: an indispensable molecule in rosiglitazone cardioprotection following myocardial infarction. Circ Res (2009) 1.16
Endothelial dysfunction in adiponectin deficiency and its mechanisms involved. J Mol Cell Cardiol (2008) 1.15
Mammary glands of adipophilin-null mice produce an amino-terminally truncated form of adipophilin that mediates milk lipid droplet formation and secretion. J Lipid Res (2007) 1.15
An essential component in steroid synthesis, the steroidogenic acute regulatory protein, is expressed in discrete regions of the brain. J Neurosci (2002) 1.15
The fusion of bone-marrow-derived proinsulin-expressing cells with nerve cells underlies diabetic neuropathy. Proc Natl Acad Sci U S A (2005) 1.14
Nicotine induces proinflammatory responses in macrophages and the aorta leading to acceleration of atherosclerosis in low-density lipoprotein receptor(-/-) mice. Arterioscler Thromb Vasc Biol (2005) 1.13
The Krüppel-like zinc finger protein Glis3 directly and indirectly activates insulin gene transcription. Nucleic Acids Res (2009) 1.13
Glucose-mediated transactivation of carbohydrate response element-binding protein requires cooperative actions from Mondo conserved regions and essential trans-acting factor 14-3-3. Mol Endocrinol (2008) 1.11
The coactivator SRC-1 is an essential coordinator of hepatic glucose production. Cell Metab (2010) 1.11
Glucose-6-phosphate mediates activation of the carbohydrate responsive binding protein (ChREBP). Biochem Biophys Res Commun (2010) 1.10
Coordinated upregulation of oxidative pathways and downregulation of lipid biosynthesis underlie obesity resistance in perilipin knockout mice: a microarray gene expression profile. Diabetes (2003) 1.09
Adiponectin promotes monocyte-to-fibroblast transition in renal fibrosis. J Am Soc Nephrol (2013) 1.09
Macrophage-specific p53 expression plays a crucial role in atherosclerosis development and plaque remodeling. Arterioscler Thromb Vasc Biol (2003) 1.09
Regulatable atrial natriuretic peptide gene therapy for hypertension. Proc Natl Acad Sci U S A (2005) 1.09
Inactivation of TNF-α ameliorates diabetic neuropathy in mice. Am J Physiol Endocrinol Metab (2011) 1.08
Adiponectin is expressed by skeletal muscle fibers and influences muscle phenotype and function. Am J Physiol Cell Physiol (2008) 1.08
Mitochondrial dysfunction contributes to the increased vulnerabilities of adiponectin knockout mice to liver injury. Hepatology (2008) 1.07