Published in Structure on May 01, 2006
Rassf family of tumor suppressor polypeptides. J Biol Chem (2008) 1.63
T cell receptor "inside-out" pathway via signaling module SKAP1-RapL regulates T cell motility and interactions in lymph nodes. Immunity (2010) 1.29
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J (2008) 1.21
Dynamics of RASSF1A/MOAP-1 association with death receptors. Mol Cell Biol (2008) 1.10
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem (2010) 1.01
RASSF1A: Not a prototypical Ras effector. Small GTPases (2011) 0.90
Probing the determinants of diacylglycerol binding affinity in the C1B domain of protein kinase Cα. J Mol Biol (2011) 0.88
Binding the atypical RA domain of Ste50p to the unfolded Opy2p cytoplasmic tail is essential for the high-osmolarity glycerol pathway. Mol Biol Cell (2009) 0.86
RASSF Signalling and DNA Damage: Monitoring the Integrity of the Genome? Mol Biol Int (2012) 0.83
Insight into the structural and biological relevance of the T/R transition of the N-terminus of the B-chain in human insulin. Biochemistry (2014) 0.82
The growth and tumor suppressors NORE1A and RASSF1A are targets for calpain-mediated proteolysis. PLoS One (2008) 0.81
Rational steering of insulin binding specificity by intra-chain chemical crosslinking. Sci Rep (2016) 0.81
RASSF1 Polymorphisms in Cancer. Mol Biol Int (2012) 0.80
Expression, purification, crystallization and preliminary X-ray analysis of the human NORE1 SARAH domain. Acta Crystallogr Sect F Struct Biol Cryst Commun (2012) 0.77
Diacylglycerol lactones targeting the structural features that distinguish the atypical C1 domains of protein kinase C ζ and ι from typical C1 domains. J Med Chem (2014) 0.76
The RAS-Effector Interface: Isoform-Specific Differences in the Effector Binding Regions. PLoS One (2016) 0.75
Structural and functional study of the GlnB22-insulin mutant responsible for maturity-onset diabetes of the young. PLoS One (2014) 0.75
Probing Receptor Specificity by Sampling the Conformational Space of the Insulin-like Growth Factor II C-domain. J Biol Chem (2016) 0.75
Structural studies of the yeast DNA damage-inducible protein Ddi1 reveal domain architecture of this eukaryotic protein family. Sci Rep (2016) 0.75
Structural characterization of CAS SH3 domain selectivity and regulation reveals new CAS interaction partners. Sci Rep (2017) 0.75
Intrinsic protein disorder in oncogenic KRAS signaling. Cell Mol Life Sci (2017) 0.75
Mutations in the DJ-1 gene associated with autosomal recessive early-onset parkinsonism. Science (2002) 9.90
A series of PDB related databases for everyday needs. Nucleic Acids Res (2010) 3.60
Specification of SUMO1- and SUMO2-interacting motifs. J Biol Chem (2006) 3.59
Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. J Biol Chem (2002) 2.04
A mutation in the fibroblast growth factor 14 gene is associated with autosomal dominant cerebellar ataxia [corrected]. Am J Hum Genet (2002) 2.02
How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92
Reduced expression of ATP7B affected by Wilson disease-causing mutations is rescued by pharmacological folding chaperones 4-phenylbutyrate and curcumin. Hepatology (2009) 1.92
Recognizing and defining true Ras binding domains I: biochemical analysis. J Mol Biol (2005) 1.76
Folding defects in P-type ATP 8B1 associated with hereditary cholestasis are ameliorated by 4-phenylbutyrate. Hepatology (2010) 1.76
Identification of different binding sites in the dendritic cell-specific receptor DC-SIGN for intercellular adhesion molecule 3 and HIV-1. J Biol Chem (2002) 1.71
The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria. Proc Natl Acad Sci U S A (2002) 1.66
Association between mycophenolic acid 12-h trough levels and clinical endpoints in patients with autoimmune disease on mycophenolate mofetil. Nephrol Dial Transplant (2008) 1.59
Interaction of nephrocystin-4 and RPGRIP1 is disrupted by nephronophthisis or Leber congenital amaurosis-associated mutations. Proc Natl Acad Sci U S A (2005) 1.55
CING: an integrated residue-based structure validation program suite. J Biomol NMR (2012) 1.52
IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization. J Biol Chem (2003) 1.49
Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases. Mol Cell (2004) 1.48
Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science (2009) 1.44
A detailed thermodynamic analysis of ras/effector complex interfaces. J Mol Biol (2004) 1.42
Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. J Mol Biol (2004) 1.35
Recognizing and defining true Ras binding domains II: in silico prediction based on homology modelling and energy calculations. J Mol Biol (2005) 1.33
Gain-of-function mutation in ADULT syndrome reveals the presence of a second transactivation domain in p63. Hum Mol Genet (2002) 1.29
Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25
Structural analysis of the mitotic regulator hPin1 in solution: insights into domain architecture and substrate binding. J Biol Chem (2003) 1.24
Sulindac-derived Ras pathway inhibitors target the Ras-Raf interaction and downstream effectors in the Ras pathway. Angew Chem Int Ed Engl (2004) 1.21
Novel type of Ras effector interaction established between tumour suppressor NORE1A and Ras switch II. EMBO J (2008) 1.21
Reconstruction of the complete ouabain-binding pocket of Na,K-ATPase in gastric H,K-ATPase by substitution of only seven amino acids. J Biol Chem (2005) 1.20
Autocatalytic processing of Clostridium difficile toxin B. Binding of inositol hexakisphosphate. J Biol Chem (2008) 1.19
Crystal structure of full-length Apaf-1: how the death signal is relayed in the mitochondrial pathway of apoptosis. Structure (2011) 1.14
Quantitative evaluation of experimental NMR restraints. J Am Chem Soc (2003) 1.12
Tumor tracking and motion compensation with an adaptive tumor tracking system (ATTS): system description and prototype testing. Med Phys (2008) 1.11
Structure and function of the phenazine biosynthetic protein PhzF from Pseudomonas fluorescens. Proc Natl Acad Sci U S A (2004) 1.11
The precision of NMR structure ensembles revisited. J Biomol NMR (2003) 1.09
The human Vps29 retromer component is a metallo-phosphoesterase for a cation-independent mannose 6-phosphate receptor substrate peptide. Biochem J (2006) 1.09
Host-targeting protein 1 (SpHtp1) from the oomycete Saprolegnia parasitica translocates specifically into fish cells in a tyrosine-O-sulphate-dependent manner. Proc Natl Acad Sci U S A (2012) 1.09
MPP5 recruits MPP4 to the CRB1 complex in photoreceptors. Invest Ophthalmol Vis Sci (2005) 1.09
Identification and molecular modelling of a mutation in the motor head domain of myosin VIIA in a family with autosomal dominant hearing impairment (DFNA11). Hum Genet (2004) 1.07
Fluorescence methods in the study of small GTP-binding proteins. Methods Mol Biol (2002) 1.05
A new model for the transition of APAF-1 from inactive monomer to caspase-activating apoptosome. J Biol Chem (2009) 1.04
The crystal structure of human PAPS synthetase 1 reveals asymmetry in substrate binding. J Mol Biol (2005) 1.03
Slow conformational dynamics of the guanine nucleotide-binding protein Ras complexed with the GTP analogue GTPgammaS. FEBS J (2007) 1.02
Elevated levels of kappa free light chains in CSF support the diagnosis of multiple sclerosis. J Neurol (2008) 1.01
Ras homolog enriched in brain (Rheb) enhances apoptotic signaling. J Biol Chem (2010) 1.01
Intracellular trafficking of guanylate-binding proteins is regulated by heterodimerization in a hierarchical manner. PLoS One (2010) 1.01
MYO15A (DFNB3) mutations in Turkish hearing loss families and functional modeling of a novel motor domain mutation. Am J Med Genet A (2007) 0.99
Environmental impacts of water use in global crop production: hotspots and trade-offs with land use. Environ Sci Technol (2011) 0.98
Protein stabilization by macromolecular crowding through enthalpy rather than entropy. J Am Chem Soc (2014) 0.98
PEX14 is required for microtubule-based peroxisome motility in human cells. J Cell Sci (2011) 0.98
Homology modelling and spectroscopy, a never-ending love story. Eur Biophys J (2009) 0.97
Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence. Environ Microbiol (2012) 0.97
Identification of potent Ras signaling inhibitors by pathway-selective phenotype-based screening. Angew Chem Int Ed Engl (2004) 0.96
Structure and function of the FeoB G-domain from Methanococcus jannaschii. J Mol Biol (2009) 0.96
Phosphorylation of the N-terminal domain regulates subcellular localization and DNA binding properties of the peptidyl-prolyl cis/trans isomerase hPar14. J Mol Biol (2003) 0.95
Solution structure of the ribosome-associated cold shock response protein Yfia of Escherichia coli. Biochem Biophys Res Commun (2002) 0.95
MPP1 links the Usher protein network and the Crumbs protein complex in the retina. Hum Mol Genet (2007) 0.95
The N-terminal basic domain of human parvulin hPar14 is responsible for the entry to the nucleus and high-affinity DNA-binding. J Mol Biol (2002) 0.94
Conformational states of Ras complexed with the GTP analogue GppNHp or GppCH2p: implications for the interaction with effector proteins. Biochemistry (2005) 0.93
What makes Ras an efficient molecular switch: a computational, biophysical, and structural study of Ras-GDP interactions with mutants of Raf. J Mol Biol (2010) 0.92
Nucleotide binding and self-stimulated GTPase activity of human guanylate-binding protein 1 (hGBP1). Methods Enzymol (2005) 0.92
Probing the sensory rhodopsin II binding domain of its cognate transducer by calorimetry and electrophysiology. J Mol Biol (2003) 0.92
Interaction of yeast Rab geranylgeranyl transferase with its protein and lipid substrates. Biochemistry (2002) 0.91
How ionic liquids can help to stabilize native proteins. Phys Chem Chem Phys (2011) 0.91
Supplementation with mixed fruit and vegetable juice concentrates increased serum antioxidants and folate in healthy adults. J Am Coll Nutr (2004) 0.91
Functional role of arginine 375 in transmembrane helix 6 of multidrug resistance protein 4 (MRP4/ABCC4). Mol Pharmacol (2008) 0.91
Metal-bis(2-picolyl)amine complexes as state 1(T) inhibitors of activated Ras protein. Angew Chem Int Ed Engl (2012) 0.90
Crystal structure of the C3bot-RalA complex reveals a novel type of action of a bacterial exoenzyme. EMBO J (2005) 0.90
The activation of RalGDS can be achieved independently of its Ras binding domain. Implications of an activation mechanism in Ras effector specificity and signal distribution. J Biol Chem (2001) 0.90
Drug effect unveils inter-head cooperativity and strain-dependent ADP release in fast skeletal actomyosin. J Biol Chem (2009) 0.90
Characterization of a Ras mutant with identical GDP- and GTP-bound structures . Biochemistry (2009) 0.89
Transient kinetic investigation of GTP hydrolysis catalyzed by interferon-gamma-induced hGBP1 (human guanylate binding protein 1). J Biol Chem (2006) 0.89
Protein denaturation by ionic liquids and the Hofmeister series: a case study of aqueous solutions of ribonuclease A. Angew Chem Int Ed Engl (2007) 0.87
Small family with key contacts: par14 and par17 parvulin proteins, relatives of pin1, now emerge in biomedical research. Perspect Medicin Chem (2008) 0.87
CpeS is a lyase specific for attachment of 3Z-PEB to Cys82 of {beta}-phycoerythrin from Prochlorococcus marinus MED4. J Biol Chem (2010) 0.87
Mechanism of GTPase-activity-induced self-assembly of human guanylate binding protein 1. J Mol Biol (2010) 0.87
Human TPST1 transmembrane domain triggers enzyme dimerisation and localisation to the Golgi compartment. J Mol Biol (2006) 0.87
Differences between the interaction of beta-catenin with non-phosphorylated and single-mimicked phosphorylated 20-amino acid residue repeats of the APC protein. J Mol Biol (2003) 0.86
The DNA binding parvulin Par17 is targeted to the mitochondrial matrix by a recently evolved prepeptide uniquely present in Hominidae. BMC Biol (2007) 0.86
Evolution from the prokaryotic to the higher plant chloroplast signal recognition particle: the signal recognition particle RNA is conserved in plastids of a wide range of photosynthetic organisms. Plant Cell (2012) 0.86
The drug diazaborine blocks ribosome biogenesis by inhibiting the AAA-ATPase Drg1. J Biol Chem (2013) 0.86
Influence of continuous table motion on patient breathing patterns. Int J Radiat Oncol Biol Phys (2010) 0.86
Characterization of novel elongated Parvulin isoforms that are ubiquitously expressed in human tissues and originate from alternative transcription initiation. BMC Mol Biol (2006) 0.86
Human PAPS synthase isoforms are dynamically regulated enzymes with access to nucleus and cytoplasm. PLoS One (2012) 0.86
Structural and thermodynamic characterization of Nore1-SARAH: a small, helical module important in signal transduction networks. Biochemistry (2013) 0.85
Patterns of protein unfolding and protein aggregation in ionic liquids. Phys Chem Chem Phys (2010) 0.85
A conformation-specific interhelical salt bridge in the K+ binding site of gastric H,K-ATPase. J Biol Chem (2004) 0.85
Gamma interferon-induced guanylate binding protein 1 is a novel actin cytoskeleton remodeling factor. Mol Cell Biol (2013) 0.85
Biochemical properties of the human guanylate binding protein 5 and a tumor-specific truncated splice variant. FEBS J (2010) 0.84
Triphosphate induced dimerization of human guanylate binding protein 1 involves association of the C-terminal helices: a joint double electron-electron resonance and FRET study. Biochemistry (2014) 0.84
Dimerization-induced folding of MST1 SARAH and the influence of the intrinsically unstructured inhibitory domain: low thermodynamic stability of monomer. Biochemistry (2011) 0.83
Subsurface urban heat islands in German cities. Sci Total Environ (2012) 0.83
Identification of hPin1 inhibitors that induce apoptosis in a mammalian Ras transformed cell line. Chem Commun (Camb) (2004) 0.83
Improved binding of raf to Ras.GDP is correlated with biological activity. J Biol Chem (2009) 0.83
Comparison of a multileaf collimator tracking system and a robotic treatment couch tracking system for organ motion compensation during radiotherapy. Med Phys (2012) 0.82
Structure and dynamics of the first archaeal parvulin reveal a new functionally important loop in parvulin-type prolyl isomerases. J Biol Chem (2010) 0.82
Pharmacokinetics of enteric-coated mycophenolate sodium: comparative study in patients with autoimmune disease and renal allograft. Expert Opin Pharmacother (2008) 0.82
Growth and tumor suppressor NORE1A is a regulatory node between Ras signaling and microtubule nucleation. J Biol Chem (2010) 0.82
Long-term evolution of anthropogenic heat fluxes into a subsurface urban heat island. Environ Sci Technol (2013) 0.82
Nucleotide dependent cysteine reactivity of hGBP1 uncovers a domain movement during GTP hydrolysis. FEBS Lett (2009) 0.82
Crystallographic proof for an extended hydrogen-bonding network in small prolyl isomerases. J Am Chem Soc (2011) 0.81
Bisphenol A binds to Ras proteins and competes with guanine nucleotide exchange: implications for GTPase-selective antagonists. J Med Chem (2013) 0.81
Tetramerization of human guanylate-binding protein 1 is mediated by coiled-coil formation of the C-terminal α-helices. FEBS J (2012) 0.81