Intraclonal diversity of the Pseudomonas aeruginosa cystic fibrosis airway isolates TBCF10839 and TBCF121838: distinct signatures of transcriptome, proteome, metabolome, adherence and pathogenicity despite an almost identical genome sequence.

PubWeight™: 0.97‹?› | Rank: Top 15%

🔗 View Article (PMID 22882573)

Published in Environ Microbiol on August 08, 2012

Authors

Jens Klockgether1, Norbert Miethke, Peter Kubesch, Yu-Sing Bohn, Inka Brockhausen, Nina Cramer, Leo Eberl, Joachim Greipel, Christian Herrmann, Susanne Herrmann, Sonja Horatzek, Meike Lingner, Liliana Luciano, Prabhakar Salunkhe, Dietmar Schomburg, Maria Wehsling, Lutz Wiehlmann, Colin F Davenport, Burkhard Tümmler

Author Affiliations

1: Klinische Forschergruppe, Zentrum Biochemie und Zentrum Kinder- und Jugendmedizin, OE 6710, D-30625 Hannover, Germany. klockgether.jens@mhhannover.de

Articles by these authors

BRENDA, the enzyme database: updates and major new developments. Nucleic Acids Res (2004) 8.21

BRENDA, enzyme data and metabolic information. Nucleic Acids Res (2002) 7.92

Attenuation of Pseudomonas aeruginosa virulence by quorum sensing inhibitors. EMBO J (2003) 5.78

BRENDA, AMENDA and FRENDA the enzyme information system: new content and tools in 2009. Nucleic Acids Res (2008) 4.75

IntEnz, the integrated relational enzyme database. Nucleic Acids Res (2004) 4.65

QMEAN: A comprehensive scoring function for model quality assessment. Proteins (2008) 3.90

BRENDA, the enzyme information system in 2011. Nucleic Acids Res (2010) 3.83

Ceramide accumulation mediates inflammation, cell death and infection susceptibility in cystic fibrosis. Nat Med (2008) 3.41

Inhibition of quorum sensing in Pseudomonas aeruginosa biofilm bacteria by a halogenated furanone compound. Microbiology (2002) 3.37

GC-MS libraries for the rapid identification of metabolites in complex biological samples. FEBS Lett (2005) 3.29

BRENDA, AMENDA and FRENDA: the enzyme information system in 2007. Nucleic Acids Res (2007) 2.94

Population structure of Pseudomonas aeruginosa. Proc Natl Acad Sci U S A (2007) 2.56

Activities of Pseudomonas aeruginosa effectors secreted by the Type III secretion system in vitro and during infection. Infect Immun (2005) 2.51

Peptidomimetic antibiotics target outer-membrane biogenesis in Pseudomonas aeruginosa. Science (2010) 2.49

The rhizosphere as a reservoir for opportunistic human pathogenic bacteria. Environ Microbiol (2005) 2.42

CUPSAT: prediction of protein stability upon point mutations. Nucleic Acids Res (2006) 2.38

BRENDA in 2013: integrated reactions, kinetic data, enzyme function data, improved disease classification: new options and contents in BRENDA. Nucleic Acids Res (2012) 2.33

Identification of Burkholderia pseudomallei genes required for the intracellular life cycle and in vivo virulence. Infect Immun (2006) 2.24

Highly adherent small-colony variants of Pseudomonas aeruginosa in cystic fibrosis lung infection. J Med Microbiol (2003) 2.17

MetaboliteDetector: comprehensive analysis tool for targeted and nontargeted GC/MS based metabolome analysis. Anal Chem (2009) 2.17

Gene islands integrated into tRNA(Gly) genes confer genome diversity on a Pseudomonas aeruginosa clone. J Bacteriol (2002) 2.14

Quorum sensing: the power of cooperation in the world of Pseudomonas. Environ Microbiol (2005) 2.12

Screening for quorum-sensing inhibitors (QSI) by use of a novel genetic system, the QSI selector. J Bacteriol (2005) 2.09

Pseudomonas aeruginosa microevolution during cystic fibrosis lung infection establishes clones with adapted virulence. Am J Respir Crit Care Med (2009) 2.08

Sequence analysis of the mobile genome island pKLC102 of Pseudomonas aeruginosa C. J Bacteriol (2004) 2.04

Ligand discrimination by TPR domains. Relevance and selectivity of EEVD-recognition in Hsp70 x Hop x Hsp90 complexes. J Biol Chem (2002) 2.04

BRENDA: a resource for enzyme data and metabolic information. Trends Biochem Sci (2002) 1.97

How guanylate-binding proteins achieve assembly-stimulated processive cleavage of GTP to GMP. Nature (2006) 1.92

Identification and characterization of a novel bacterial virulence factor that shares homology with mammalian Toll/interleukin-1 receptor family proteins. Infect Immun (2006) 1.91

Two GacA-dependent small RNAs modulate the quorum-sensing response in Pseudomonas aeruginosa. J Bacteriol (2006) 1.85

Microbial landscapes: new paths to biofilm research. Nat Rev Microbiol (2007) 1.85

The neglected intrinsic resistome of bacterial pathogens. PLoS One (2008) 1.82

Who is who in litter decomposition? Metaproteomics reveals major microbial players and their biogeochemical functions. ISME J (2012) 1.79

Recognizing and defining true Ras binding domains I: biochemical analysis. J Mol Biol (2005) 1.76

Killing of Caenorhabditis elegans by Burkholderia cepacia is controlled by the cep quorum-sensing system. Cell Microbiol (2003) 1.75

A cystic fibrosis epidemic strain of Pseudomonas aeruginosa displays enhanced virulence and antimicrobial resistance. J Bacteriol (2005) 1.74

Genome diversity of Pseudomonas aeruginosa PAO1 laboratory strains. J Bacteriol (2009) 1.73

Mutations in the amiloride-sensitive epithelial sodium channel in patients with cystic fibrosis-like disease. Hum Mutat (2009) 1.71

The BRENDA Tissue Ontology (BTO): the first all-integrating ontology of all organisms for enzyme sources. Nucleic Acids Res (2010) 1.71

Garlic blocks quorum sensing and promotes rapid clearing of pulmonary Pseudomonas aeruginosa infections. Microbiology (2005) 1.70

Microevolution of the major common Pseudomonas aeruginosa clones C and PA14 in cystic fibrosis lungs. Environ Microbiol (2011) 1.70

Plant-dependent genotypic and phenotypic diversity of antagonistic rhizobacteria isolated from different Verticillium host plants. Appl Environ Microbiol (2002) 1.69

Identity and effects of quorum-sensing inhibitors produced by Penicillium species. Microbiology (2005) 1.67

The membrane protein FeoB contains an intramolecular G protein essential for Fe(II) uptake in bacteria. Proc Natl Acad Sci U S A (2002) 1.66

Genetic analysis of functions involved in the late stages of biofilm development in Burkholderia cepacia H111. Mol Microbiol (2002) 1.63

The structure of an inverting GH43 beta-xylosidase from Geobacillus stearothermophilus with its substrate reveals the role of the three catalytic residues. J Mol Biol (2006) 1.63

Intestinal current measurement for diagnostic classification of patients with questionable cystic fibrosis: validation and reference data. Thorax (2010) 1.61

Induction of systemic resistance in tomato by N-acyl-L-homoserine lactone-producing rhizosphere bacteria. Plant Cell Environ (2006) 1.59

Metabolic pathway analysis web service (Pathway Hunter Tool at CUBIC). Bioinformatics (2004) 1.56

Discovery of complex mixtures of novel long-chain quorum sensing signals in free-living and host-associated marine alphaproteobacteria. Chembiochem (2005) 1.56

Impact of violacein-producing bacteria on survival and feeding of bacterivorous nanoflagellates. Appl Environ Microbiol (2004) 1.55

SYSTOMONAS--an integrated database for systems biology analysis of Pseudomonas. Nucleic Acids Res (2007) 1.55

IIGP1, an interferon-gamma-inducible 47-kDa GTPase of the mouse, showing cooperative enzymatic activity and GTP-dependent multimerization. J Biol Chem (2003) 1.49

Crystal structure of IIGP1: a paradigm for interferon-inducible p47 resistance GTPases. Mol Cell (2004) 1.48

Catalytic core of a membrane-associated eukaryotic polyphosphate polymerase. Science (2009) 1.44

Pseudomonas aeruginosa Genomic Structure and Diversity. Front Microbiol (2011) 1.43

Diversity of the abundant pKLC102/PAGI-2 family of genomic islands in Pseudomonas aeruginosa. J Bacteriol (2006) 1.43

Expression analysis of a highly adherent and cytotoxic small colony variant of Pseudomonas aeruginosa isolated from a lung of a patient with cystic fibrosis. J Bacteriol (2004) 1.43

A detailed thermodynamic analysis of ras/effector complex interfaces. J Mol Biol (2004) 1.42

Identification and characterization of an N-acylhomoserine lactone-dependent quorum-sensing system in Pseudomonas putida strain IsoF. Appl Environ Microbiol (2002) 1.40

The crystal structure of SdsA1, an alkylsulfatase from Pseudomonas aeruginosa, defines a third class of sulfatases. Proc Natl Acad Sci U S A (2006) 1.39

Global features of the Pseudomonas putida KT2440 genome sequence. Environ Microbiol (2002) 1.39

Crystal structure and snapshots along the reaction pathway of a family 51 alpha-L-arabinofuranosidase. EMBO J (2003) 1.35

The substrate specificity-determining amino acid code of 4-coumarate:CoA ligase. Proc Natl Acad Sci U S A (2003) 1.35

Identification of residues in the human guanylate-binding protein 1 critical for nucleotide binding and cooperative GTP hydrolysis. J Mol Biol (2004) 1.35

Global features of sequences of bacterial chromosomes, plasmids and phages revealed by analysis of oligonucleotide usage patterns. BMC Bioinformatics (2004) 1.34

Essence of life: essential genes of minimal genomes. Trends Cell Biol (2011) 1.34

Identification of quorum-sensing regulated proteins in the opportunistic pathogen Pseudomonas aeruginosa by proteomics. Environ Microbiol (2003) 1.33

Global regulation of quorum sensing and virulence by VqsR in Pseudomonas aeruginosa. Microbiology (2004) 1.32

Quorum-sensing-directed protein expression in Serratia proteamaculans B5a. Microbiology (2003) 1.30

Identification of a novel virulence factor in Burkholderia cenocepacia H111 required for efficient slow killing of Caenorhabditis elegans. Infect Immun (2004) 1.30

Biochemical characterization and identification of the catalytic residues of a family 43 beta-D-xylosidase from Geobacillus stearothermophilus T-6. Biochemistry (2005) 1.29

The importance of uniformity in reporting protein-function data. Trends Biochem Sci (2005) 1.27

Identification of specific and universal virulence factors in Burkholderia cenocepacia strains by using multiple infection hosts. Infect Immun (2009) 1.27

Observing local and global properties of metabolic pathways: 'load points' and 'choke points' in the metabolic networks. Bioinformatics (2006) 1.26

Genes that determine immunology and inflammation modify the basic defect of impaired ion conductance in cystic fibrosis epithelia. J Med Genet (2010) 1.26

Atomic resolution structures of R-specific alcohol dehydrogenase from Lactobacillus brevis provide the structural bases of its substrate and cosubstrate specificity. J Mol Biol (2005) 1.25

Stabilizing a weak binding state for effectors in the human ras protein by cyclen complexes. Angew Chem Int Ed Engl (2010) 1.25

Structure of Pseudomonas aeruginosa populations analyzed by single nucleotide polymorphism and pulsed-field gel electrophoresis genotyping. J Bacteriol (2004) 1.24

The crucial role of trehalose and structurally related oligosaccharides in the biosynthesis and transfer of mycolic acids in Corynebacterineae. J Biol Chem (2005) 1.24

Ajoene, a sulfur-rich molecule from garlic, inhibits genes controlled by quorum sensing. Antimicrob Agents Chemother (2012) 1.23

Expression of Pseudomonas aeruginosa exoS is controlled by quorum sensing and RpoS. Microbiology (2004) 1.22