Functional analysis of the regulatory requirements of B-Raf and the B-Raf(V600E) oncoprotein.

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🔗 View Article (PMID 16702958)

Published in Oncogene on May 15, 2006

Authors

T Brummer1, P Martin, S Herzog, Y Misawa, R J Daly, M Reth

Author Affiliations

1: Cancer Research Program, The Garvan Institute of Medical Research, Sydney, NSW, Australia. t.brummer@garvan.org.au

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1994 Consensus Conference on Acute GVHD Grading. Bone Marrow Transplant (1995) 24.01

Validation of questionnaire information on risk factors and disease outcomes in a prospective cohort study of women. Am J Epidemiol (1986) 10.84

Heavy chain variable region contribution to the NPb family of antibodies: somatic mutation evident in a gamma 2a variable region. Cell (1981) 9.54

The SH2 and SH3 domain-containing protein GRB2 links receptor tyrosine kinases to ras signaling. Cell (1992) 8.20

Antigen receptor tail clue. Nature (1989) 7.32

The repair of double-strand breaks in the nuclear DNA of Saccharomyces cerevisiae and its genetic control. Mol Gen Genet (1976) 6.89

Nucleotide sequence of the tetM tetracycline resistance determinant of the streptococcal conjugative shuttle transposon Tn1545. Nucleic Acids Res (1986) 4.47

HEL cells: a new human erythroleukemia cell line with spontaneous and induced globin expression. Science (1982) 4.07

Analysis of the repertoire of anti-NP antibodies in C57BL/6 mice by cell fusion. I. Characterization of antibody families in the primary and hyperimmune response. Eur J Immunol (1978) 3.48

Recombinant interferon alfa therapy for chronic hepatitis C. A randomized, double-blind, placebo-controlled trial. N Engl J Med (1989) 3.45

Inducible site-directed recombination in mouse embryonic stem cells. Nucleic Acids Res (1996) 3.37

Testing gene function early in the B cell lineage in mb1-cre mice. Proc Natl Acad Sci U S A (2006) 3.32

Bupropion: a review of its mechanism of antidepressant activity. J Clin Psychiatry (1995) 3.30

An association between viral genes and human oncogenic alterations: the adenovirus E1A induces the Ewing tumor fusion transcript EWS-FLI1. Nat Med (1999) 3.27

Molecular components of the B-cell antigen receptor complex of the IgM class. Nature (1990) 3.06

Targeted disruption of the zetaPKC gene results in the impairment of the NF-kappaB pathway. Mol Cell (2001) 3.05

Aberrant B cell development and immune response in mice with a compromised BCR complex. Science (1996) 3.01

Analysis of the repertoire of anti-(4-hydroxy-3-nitrophenyl)acetyl (NP) antibodies in C 57 BL/6 mice by cell fusion. II. Characterization of idiotopes by monoclonal anti-idiotope antibodies. Eur J Immunol (1979) 2.87

A novel VH to VHDJH joining mechanism in heavy-chain-negative (null) pre-B cells results in heavy-chain production. Nature (1986) 2.83

SH2 domains prevent tyrosine dephosphorylation of the EGF receptor: identification of Tyr992 as the high-affinity binding site for SH2 domains of phospholipase C gamma. EMBO J (1992) 2.82

Dynamic actin-based epithelial adhesion and cell matching during Drosophila dorsal closure. Curr Biol (2000) 2.78

X-linked Alport syndrome: natural history in 195 families and genotype- phenotype correlations in males. J Am Soc Nephrol (2000) 2.71

Mechanisms of epithelial fusion and repair. Nat Cell Biol (2001) 2.63

Common defects of different retinoic acid resistant promyelocytic leukemia cells are persistent telomerase activity and nuclear body disorganization. Differentiation (1997) 2.58

Detection of serum antibodies to Borna disease virus in patients with psychiatric disorders. Science (1985) 2.57

Failure of silicone gel breast implants: analysis of literature data for 1652 explanted prostheses. Plast Reconstr Surg (1997) 2.56

Nucleotide sequence of the human c-myc locus: provocative open reading frame within the first exon. EMBO J (1984) 2.55

Secondary cancers after bone marrow transplantation for leukemia or aplastic anemia. N Engl J Med (1989) 2.42

Absolute and relative contraindications to pegylated-interferon or ribavirin in the US general patient population with chronic hepatitis C: results from a US database of over 45 000 HCV-infected, evaluated patients. Aliment Pharmacol Ther (2013) 2.38

A novel 34-kd protein co-isolated with the IgM molecule in surface IgM-expressing cells. EMBO J (1988) 2.38

Increased T-cell apoptosis and terminal B-cell differentiation induced by inactivation of the Ets-1 proto-oncogene. Nature (1995) 2.33

Replication of Borna disease virus in cell cultures. Med Microbiol Immunol (1980) 2.24

Safeguards for research using large scale DNA collections. BMJ (2000) 2.22

env sequences of simian immunodeficiency viruses from chimpanzees in Cameroon are strongly related to those of human immunodeficiency virus group N from the same geographic area. J Virol (2000) 2.17

Minimal criteria for placement of adults on the liver transplant waiting list: a report of a national conference organized by the American Society of Transplant Physicians and the American Association for the Study of Liver Diseases. Liver Transpl Surg (1997) 2.16

An immunohistochemical method that differentiates Cryptococcus neoformans varieties and serotypes in formalin-fixed paraffin-embedded tissues. Med Mycol (2001) 2.16

Somatic variants of murine immunoglobulin lambda light chains. Nature (1982) 2.15

Meta-analysis of observational studies: hepatitis C and survival after renal transplant. J Viral Hepat (2013) 2.15

Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells. Proc Natl Acad Sci U S A (2000) 2.15

Sequencing the erbA gene of avian erythroblastosis virus reveals a new type of oncogene. Science (1984) 2.12

Healing of incisional wounds in the embryonic chick wing bud: characterization of the actin purse-string and demonstration of a requirement for Rho activation. J Cell Biol (1996) 2.12

Behavioral disease in rats caused by immunopathological responses to persistent borna virus in the brain. Science (1983) 2.10

Immune reconstitution after allogeneic marrow transplantation compared with blood stem cell transplantation. Blood (2001) 2.04

Adjuvant chemotherapy improves survival after liver transplantation for hepatocellular carcinoma. Ann Surg (1995) 2.03

[Hypodontia due to ectodermal dysplasia: rehabilitation with very early dental implants]. Rev Stomatol Chir Maxillofac Chir Orale (2013) 1.97

Hypodontia due to ectodermal dysplasia: rehabilitation with very early dental implants. Rev Stomatol Chir Maxillofac Chir Orale (2013) 1.97

The IgM antigen receptor of B lymphocytes is associated with prohibitin and a prohibitin-related protein. EMBO J (1994) 1.94

Impaired wound healing in embryonic and adult mice lacking vimentin. J Cell Sci (2000) 1.92

Long-term survival after retransplantation of the liver. Ann Surg (1997) 1.91

Use of OKT3 is associated with early and severe recurrence of hepatitis C after liver transplantation. Am J Gastroenterol (1997) 1.91

Abnormal development and function of B lymphocytes in mice deficient for the signaling adaptor protein SLP-65. Immunity (1999) 1.84

Meta-analysis: interferon for the treatment of chronic hepatitis C in dialysis patients. Aliment Pharmacol Ther (2003) 1.82

Identification of grandchildless loci whose products are required for normal germ-line development in the nematode Caenorhabditis elegans. Genetics (1991) 1.81

Transforming viruses directly reduce the cellular growth requirement for a platelet derived growth factor. J Cell Physiol (1978) 1.79

Rad52 partially substitutes for the Rad51 paralog XRCC3 in maintaining chromosomal integrity in vertebrate cells. EMBO J (2001) 1.79

SLP-65: a new signaling component in B lymphocytes which requires expression of the antigen receptor for phosphorylation. J Exp Med (1998) 1.78

Monomeric and oligomeric complexes of the B cell antigen receptor. Immunity (2000) 1.77

Validation of a model of colon cancer progression. J Pathol (2000) 1.76

Macrophage recruitment during limb development and wound healing in the embryonic and foetal mouse. J Cell Sci (1994) 1.74

99mTc-tagged chicken liver as a marker of solid food in the human stomach. Am J Dig Dis (1976) 1.74

Effects of captopril related to increased levels of prostacyclin and angiotensin-(1-7) in essential hypertension. J Hypertens (1996) 1.73

MiR-1 and miR-200 inhibit EMT via Slug-dependent and tumorigenesis via Slug-independent mechanisms. Oncogene (2012) 1.73

The products of pre-B cell-specific genes (lambda 5 and VpreB) and the immunoglobulin mu chain form a complex that is transported onto the cell surface. J Exp Med (1990) 1.72

Mood and behavioural changes with progestational agents. Br J Psychiatry (1967) 1.72

Molecular components of the B cell antigen receptor complex of class IgD differ partly from those of IgM. EMBO J (1990) 1.71

Interaction of SLP adaptors with the SH2 domain of Tec family kinases. Eur J Immunol (1999) 1.70

The 24K protein of Borna disease virus. J Gen Virol (1992) 1.69

Role of sympathectomy for hyperhidrosis. Br Med J (1971) 1.68

Localized two-dimensional shift correlated MR spectroscopy of human brain. Magn Reson Med (2001) 1.67

Pathogenesis of Borna disease in rats: immune-mediated viral ophthalmoencephalopathy causing blindness and behavioral abnormalities. J Infect Dis (1983) 1.66

Evaluation of a novel serotyping system for hepatitis C virus: strong correlation with standard genotyping methodologies. J Clin Microbiol (1995) 1.65

The influence of age, gender and ABO blood group on soluble endothelial cell markers and adhesion molecules. Br J Haematol (1996) 1.64

Correlation between donor age and the pattern of liver graft recovery after transplantation. Transplantation (1995) 1.63

Sinonasal and sino-orbital aspergillosis in 23 cats: aetiology, clinicopathological features and treatment outcomes. Vet J (2011) 1.63

Exposure of Gambian children to Anopheles gambiae malaria vectors in an irrigated rice production area. Med Vet Entomol (1995) 1.62

General practice patients on long-term psychotropic drugs. A controlled investigation. Br J Psychiatry (1988) 1.62

Evidence for a preformed transducer complex organized by the B cell antigen receptor. Proc Natl Acad Sci U S A (1996) 1.60

Ocular toxicity from ethambutol: a review of four cases and recommended precautions. N Z Med J (1998) 1.57

Export of cellubrevin from the endoplasmic reticulum is controlled by BAP31. J Cell Biol (1997) 1.56

Control idiotope expression by monoclonal anti-idiotope antibodies. Immunol Rev (1980) 1.56

Development and evaluation of the Liver Disease Quality of Life instrument in persons with advanced, chronic liver disease--the LDQOL 1.0. Am J Gastroenterol (2000) 1.53

Development and practice of an autonomous minor surgery unit in a general hospital. Br Med J (1971) 1.53

Coal gas and the brain. Br Med J (1968) 1.52

Meta-analysis: levamisole improves the immune response to hepatitis B vaccine in dialysis patients. Aliment Pharmacol Ther (2010) 1.51

Platelet aggregation during cardiopulmonary bypass evaluated by a laser light-scattering method. Ann Thorac Surg (1999) 1.50

Replication of Borna disease virus in rats: age-dependent differences in tissue distribution. Med Microbiol Immunol (1984) 1.48

Prophylaxis against hepatitis B recurrence following liver transplantation using combination lamivudine and hepatitis B immune globulin. Hepatology (1998) 1.48

Opioid substitution to reduce adverse effects in cancer pain management. Med J Aust (1999) 1.48

Hepatitis C screening strategies in hemodialysis patients. Am J Kidney Dis (2001) 1.48

On the surgery of atherosclerosis of the profunda femoris artery. Surgery (1972) 1.48

Detection and identification of mycobacteria in fixed stained smears and formalin-fixed paraffin-embedded tissues using PCR. J Small Anim Pract (2013) 1.47

Comparison of the tamoxifen regulated chimeric Cre recombinases MerCreMer and CreMer. Biol Chem (1999) 1.47

Retracted The remarkable cochlear amplifier. Hear Res (2010) 1.47

Leu-1+ (CD5+) B cells. A major lymphoid subpopulation in human fetal spleen: phenotypic and functional studies. J Immunol (1986) 1.46

Borna disease virus. A possible etiologic factor in human affective disorders? Arch Gen Psychiatry (1985) 1.46

Magnesium bioavailability from mineral water. A study in adult men. Eur J Clin Nutr (2002) 1.46

Location and type of mutation in the LIS1 gene do not predict phenotypic severity. Neurology (2007) 1.45

Increased soluble interleukin 2 receptor levels in schizophrenia. Schizophr Res (1998) 1.45

Cell cycle arrest and apoptosis induced by Notch1 in B cells. J Biol Chem (2000) 1.45

Activation of the Ras signalling pathway in human breast cancer cells overexpressing erbB-2. Oncogene (1994) 1.44