Published in Cell on June 01, 1981
Possible role of flanking nucleotides in recognition of the AUG initiator codon by eukaryotic ribosomes. Nucleic Acids Res (1981) 18.27
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A (1981) 12.00
Expression and regulation of immunoglobulin heavy chain gene transfected into lymphoid cells. EMBO J (1983) 10.00
Cytokine-secreting follicular T cells shape the antibody repertoire. Nat Immunol (2009) 5.59
Organization, structure, and assembly of immunoglobulin heavy chain diversity DNA segments. J Exp Med (1982) 5.37
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. I. The architecture and dynamics of responding cell populations. J Exp Med (1991) 4.98
Mapping of sequences required for mouse neurovirulence of poliovirus type 2 Lansing. J Virol (1986) 4.91
Cloning immunoglobulin variable domains for expression by the polymerase chain reaction. Proc Natl Acad Sci U S A (1989) 3.99
Isolation of high affinity human antibodies directly from large synthetic repertoires. EMBO J (1994) 3.68
RAG-2-deficient blastocyst complementation: an assay of gene function in lymphocyte development. Proc Natl Acad Sci U S A (1993) 3.65
Most peripheral B cells in mice are ligand selected. J Exp Med (1991) 3.50
Movement of yeast transposable elements by gene conversion. Proc Natl Acad Sci U S A (1982) 3.35
Intervening sequences increase efficiency of RNA 3' processing and accumulation of cytoplasmic RNA. Nucleic Acids Res (1990) 3.34
Meiotic recombination between duplicated genetic elements in Saccharomyces cerevisiae. Genetics (1985) 3.19
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. II. A common clonal origin for periarteriolar lymphoid sheath-associated foci and germinal centers. J Exp Med (1992) 3.13
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. III. The kinetics of V region mutation and selection in germinal center B cells. J Exp Med (1993) 3.13
Matrix program to analyze primary structure homology. Nucleic Acids Res (1982) 3.10
The extent of affinity maturation differs between the memory and antibody-forming cell compartments in the primary immune response. EMBO J (1997) 3.09
In situ studies of the primary immune response to (4-hydroxy-3-nitrophenyl)acetyl. V. Affinity maturation develops in two stages of clonal selection. J Exp Med (1998) 3.04
Antibody engineering for the analysis of affinity maturation of an anti-hapten response. EMBO J (1988) 2.81
cDNA cloning of the complete genome of tobacco mosaic virus and production of infectious transcripts. Proc Natl Acad Sci U S A (1986) 2.66
New markers for murine memory B cells that define mutated and unmutated subsets. J Exp Med (2007) 2.65
Secondary genomic rearrangement events in pre-B cells: VHDJH replacement by a LINE-1 sequence and directed class switching. EMBO J (1986) 2.62
PCR-based cDNA library construction: general cDNA libraries at the level of a few cells. Nucleic Acids Res (1989) 2.48
Dysregulation of germinal centres in autoimmune disease. Nat Rev Immunol (2009) 2.43
Kinetic and affinity limits on antibodies produced during immune responses. Proc Natl Acad Sci U S A (1995) 2.41
Deletions in immunoglobulin mu chains. EMBO J (1982) 2.35
Antigen-driven B cell differentiation in vivo. J Exp Med (1993) 2.35
Clonal recruitment and somatic mutation in the generation of immunological memory to the hapten NP. EMBO J (1986) 2.35
Mutations and selection in the generation of class II histocompatibility antigen polymorphism. EMBO J (1984) 2.34
Construction of a modular dihydrofolate reductase cDNA gene: analysis of signals utilized for efficient expression. Mol Cell Biol (1982) 2.33
Somatic mutation creates diversity in the major group of mouse immunoglobulin kappa light chains. J Exp Med (1984) 2.33
Activation of V kappa gene rearrangement in pre-B cells follows the expression of membrane-bound immunoglobulin heavy chains. EMBO J (1987) 2.31
Immunoglobulin V region variants in hybridoma cells. II. Recombination between V genes. EMBO J (1982) 2.31
Non-immunoglobulin-associated DNA rearrangements in mouse plasmacytomas. Proc Natl Acad Sci U S A (1982) 2.30
Patterns of somatic mutations in immunoglobulin variable genes. Genetics (1987) 2.24
Multiple differences between the nucleic acid sequences of the IgG2aa and IgG2ab alleles of the mouse. Proc Natl Acad Sci U S A (1981) 2.23
Simple DNA sequences in homologous flanking regions near immunoglobulin VH genes: a role in gene interaction? Nucleic Acids Res (1982) 2.19
Organization and evolution of immunoglobulin VH gene subgroups. Proc Natl Acad Sci U S A (1982) 2.18
The smaller human VH gene families display remarkably little polymorphism. EMBO J (1989) 2.15
Recombination between antibody heavy chain variable-region genes: evidence for gene conversion. Proc Natl Acad Sci U S A (1983) 2.03
Hypermutation at the immunoglobulin heavy chain locus in a pre-B-cell line. Proc Natl Acad Sci U S A (1985) 2.02
Isolation and characterization of full-length functional cDNA clones for human carcinoembryonic antigen. Mol Cell Biol (1987) 1.99
VH genes encoding the immune response to beta-(1,6)-galactan: somatic mutation in IgM molecules. EMBO J (1984) 1.98
Exon-intron organization and complete nucleotide sequence of a human major histocompatibility antigen DC beta gene. Proc Natl Acad Sci U S A (1983) 1.85
Developmentally regulated and strain-specific expression of murine VH gene families. J Exp Med (1988) 1.85
Distribution of mutations around rearranged heavy-chain antibody variable-region genes. Mol Cell Biol (1990) 1.83
Low frequency of somatic mutation in beta-chain variable region genes of human T-cell receptors. Proc Natl Acad Sci U S A (1985) 1.80
Deletion of the IgH enhancer does not reduce immunoglobulin heavy chain production of a hybridoma IgD class switch variant. EMBO J (1984) 1.78
Members of novel VH gene families are found in VDJ regions of polyclonally activated B-lymphocytes. EMBO J (1985) 1.75
Evolutionary aspects of immunoglobulin heavy chain variable region (VH) gene subgroups. Proc Natl Acad Sci U S A (1983) 1.72
Germline antibody V regions as determinants of clonal persistence and malignant growth in the B cell compartment. EMBO J (1988) 1.69
Evolution of mouse immunoglobulin lambda genes. Proc Natl Acad Sci U S A (1982) 1.68
Multiple point mutations in a shuttle vector propagated in human cells: evidence for an error-prone DNA polymerase activity. Proc Natl Acad Sci U S A (1987) 1.66
Gene conversion between murine class II major histocompatibility complex loci. Functional and molecular evidence from the bm 12 mutant. J Exp Med (1984) 1.66
Complex Antigens Drive Permissive Clonal Selection in Germinal Centers. Immunity (2016) 1.66
Public and private V beta T cell receptor repertoires against hen egg white lysozyme (HEL) in nontransgenic versus HEL transgenic mice. J Exp Med (1994) 1.63
The intron requirement for immunoglobulin gene expression is dependent upon the promoter. Nucleic Acids Res (1988) 1.60
Somatic diversification of immunoglobulins. Proc Natl Acad Sci U S A (1984) 1.59
Tandem linkage and unusual RNA splicing of the T-cell receptor beta-chain variable-region genes. Proc Natl Acad Sci U S A (1987) 1.58
Conservation of sequence in recombination signal sequence spacers. Nucleic Acids Res (1994) 1.58
Antigen-specific B cell memory: expression and replenishment of a novel b220(-) memory b cell compartment. J Exp Med (2000) 1.58
Assembly of functional antibodies from immunoglobulin heavy and light chains synthesised in E. coli. Nucleic Acids Res (1984) 1.57
The influence of messenger RNA secondary structure on expression of an immunoglobulin heavy chain in Escherichia coli. Nucleic Acids Res (1984) 1.56
Expression and rearrangement of homologous immunoglobulin VH genes in two mouse strains. Proc Natl Acad Sci U S A (1984) 1.54
Type I IFN enhances follicular B cell contribution to the T cell-independent antibody response. J Exp Med (2010) 1.54
cDNA cloning of portions of the bacteriophage phi 6 genome. J Bacteriol (1985) 1.51
Rapid induction of transcription of unrearranged S gamma 1 switch regions in activated murine B cells by interleukin 4. EMBO J (1989) 1.49
Genotypic analysis of B cell colonies by in situ hybridization. Stoichiometric expression of three VH families in adult C57BL/6 and BALB/c mice. J Exp Med (1987) 1.49
Preferential localization of IgG memory B cells adjacent to contracted germinal centers. Proc Natl Acad Sci U S A (2010) 1.48
Genes encoding the T-cell receptor alpha and beta subunits are transcribed in an ordered manner during intrathymic ontogeny. Proc Natl Acad Sci U S A (1985) 1.47
Adult B-cell repertoire is biased toward two heavy-chain variable-region genes that rearrange frequently in fetal pre-B cells. Proc Natl Acad Sci U S A (1987) 1.46
Single amino acid substitution altering antigen-binding specificity. Proc Natl Acad Sci U S A (1982) 1.46
Cloning of terminal transferase cDNA by antibody screening. Proc Natl Acad Sci U S A (1984) 1.45
Poliovirus type 3: molecular cloning of the genome and nucleotide sequence of the region encoding the protease and polymerase proteins. Nucleic Acids Res (1983) 1.43
Deletion of Cmu genes in mouse B lymphocytes upon stimulation with LPS. EMBO J (1983) 1.42
B cell function in mice transgenic for mCTLA4-H gamma 1: lack of germinal centers correlated with poor affinity maturation and class switching despite normal priming of CD4+ T cells. J Exp Med (1994) 1.42
Structural and functional implications of a restricted antibody response to a defined antigenic region on the influenza virus hemagglutinin. EMBO J (1986) 1.40
The specificity of cross-reactivity: promiscuous antibody binding involves specific hydrogen bonds rather than nonspecific hydrophobic stickiness. Protein Sci (2003) 1.38
The organization of the mouse Igh-V locus. Dispersion, interspersion, and the evolution of VH gene family clusters. J Exp Med (1988) 1.36
High-frequency expression of a conserved kappa light-chain variable-region gene in chronic lymphocytic leukemia. Proc Natl Acad Sci U S A (1987) 1.35
The activation-induced deaminase functions in a postcleavage step of the somatic hypermutation process. J Exp Med (2002) 1.34
Complete nucleotide sequences of three VH genes in Caiman, a phylogenetically ancient reptile: evolutionary diversification in coding segments and variation in the structure and organization of recombination elements. Proc Natl Acad Sci U S A (1985) 1.34
Molecular basis of an isogeneic anti-idiotypic response. EMBO J (1984) 1.34
Relative contribution of T and B cells to hypermutation and selection of the antibody repertoire in germinal centers of aged mice. J Exp Med (1996) 1.34
Analysis of a human V beta gene subfamily. J Exp Med (1986) 1.33
T cell receptor genes in an alloreactive CTL clone: implications for rearrangement and germline diversity of variable gene segments. EMBO J (1986) 1.31
Natural occurrence and origin of somatically mutated memory B cells in mice. J Exp Med (1992) 1.31
Polymeric immunoglobulin M is secreted by transfectants of non-lymphoid cells in the absence of immunoglobulin J chain. EMBO J (1987) 1.30
A processed pseudogene in an intron of the HLA-DP beta 1 chain gene is a member of the ribosomal protein L32 gene family. Nucleic Acids Res (1985) 1.30
Galactan-binding antibodies. Diversity and structure of idiotypes. J Exp Med (1983) 1.30
Autoantibodies encoded by the most Jh-proximal human immunoglobulin heavy chain variable region gene. J Exp Med (1989) 1.30
Palindromic sequences are associated with sites of DNA breakage during gene conversion. Nucleic Acids Res (1986) 1.28
Multiple VH gene segments encode murine antistreptococcal antibodies. J Exp Med (1984) 1.26
An immunoglobulin mutator that targets G.C base pairs. Proc Natl Acad Sci U S A (1996) 1.26
Construction of a retrovirus packaging mutant and its use to produce helper-free defective retrovirus. Cell (1983) 25.46
Interleukin-10-deficient mice develop chronic enterocolitis. Cell (1993) 22.57
Production of high-titer helper-free retroviruses by transient transfection. Proc Natl Acad Sci U S A (1993) 22.33
A new DNA binding and dimerization motif in immunoglobulin enhancer binding, daughterless, MyoD, and myc proteins. Cell (1989) 21.54
Inducible gene targeting in mice. Science (1995) 21.22
Multiple nuclear factors interact with the immunoglobulin enhancer sequences. Cell (1986) 20.08
RNA-dependent DNA polymerase in virions of RNA tumour viruses. Nature (1970) 19.38
An inducible transcription factor activates expression of human immunodeficiency virus in T cells. Nature (1987) 19.23
A new mouse myeloma cell line that has lost immunoglobulin expression but permits the construction of antibody-secreting hybrid cell lines. J Immunol (1979) 16.56
I kappa B: a specific inhibitor of the NF-kappa B transcription factor. Science (1988) 16.40
Immunoglobulin gene transcription is activated by downstream sequence elements. Cell (1983) 15.53
Inducibility of kappa immunoglobulin enhancer-binding protein Nf-kappa B by a posttranslational mechanism. Cell (1986) 15.30
A nuclear factor that binds to a conserved sequence motif in transcriptional control elements of immunoglobulin genes. Nature (1986) 14.34
An essential role for NF-kappaB in preventing TNF-alpha-induced cell death. Science (1996) 13.87
Deletion of a DNA polymerase beta gene segment in T cells using cell type-specific gene targeting. Science (1994) 13.47
A B cell-deficient mouse by targeted disruption of the membrane exon of the immunoglobulin mu chain gene. Nature (1991) 13.19
Isolation and properties of Moloney murine leukemia virus mutants: use of a rapid assay for release of virion reverse transcriptase. J Virol (1981) 13.11
NF-kappa B: ten years after. Cell (1996) 12.80
Cloned poliovirus complementary DNA is infectious in mammalian cells. Science (1981) 12.50
A cre-transgenic mouse strain for the ubiquitous deletion of loxP-flanked gene segments including deletion in germ cells. Nucleic Acids Res (1995) 12.21
Molecular cloning of poliovirus cDNA and determination of the complete nucleotide sequence of the viral genome. Proc Natl Acad Sci U S A (1981) 12.00
Ribonucleic acid synthesis of vesicular stomatitis virus, II. An RNA polymerase in the virion. Proc Natl Acad Sci U S A (1970) 11.83
Independent control of immunoglobulin switch recombination at individual switch regions evidenced through Cre-loxP-mediated gene targeting. Cell (1993) 11.76
Activation of DNA-binding activity in an apparently cytoplasmic precursor of the NF-kappa B transcription factor. Cell (1988) 11.62
NF-kappa B: a pleiotropic mediator of inducible and tissue-specific gene control. Cell (1989) 11.19
The "initiator" as a transcription control element. Cell (1989) 11.13
Induction of chronic myelogenous leukemia in mice by the P210bcr/abl gene of the Philadelphia chromosome. Science (1990) 10.59
Polypeptide cleavages in the formation of poliovirus proteins. Proc Natl Acad Sci U S A (1968) 10.43
Embryonic lethality and liver degeneration in mice lacking the RelA component of NF-kappa B. Nature (1995) 10.36
The V(D)J recombination activating gene, RAG-1. Cell (1989) 9.79
Temporal aspects of DNA and RNA synthesis during human immunodeficiency virus infection: evidence for differential gene expression. J Virol (1989) 9.37
RAG-1 and RAG-2, adjacent genes that synergistically activate V(D)J recombination. Science (1990) 9.33
Activation in vitro of NF-kappa B by phosphorylation of its inhibitor I kappa B. Nature (1990) 9.31
Further evidence on the formation of poliovirus proteins. J Mol Biol (1970) 9.29
Cloning of the p50 DNA binding subunit of NF-kappa B: homology to rel and dorsal. Cell (1990) 9.24
Mice deficient in IL-1 beta-converting enzyme are defective in production of mature IL-1 beta and resistant to endotoxic shock. Cell (1995) 9.11
A detailed model of reverse transcription and tests of crucial aspects. Cell (1979) 8.93
Generation and analysis of interleukin-4 deficient mice. Science (1991) 8.80
A lymphoid-specific protein binding to the octamer motif of immunoglobulin genes. Nature (1986) 8.64
Joining of immunoglobulin heavy chain gene segments: implications from a chromosome with evidence of three D-JH fusions. Proc Natl Acad Sci U S A (1982) 8.53
Cell-type specificity of immunoglobulin gene expression is regulated by at least three DNA sequence elements. Cell (1985) 8.16
Covalent linkage of a protein to a defined nucleotide sequence at the 5'-terminus of virion and replicative intermediate RNAs of poliovirus. Proc Natl Acad Sci U S A (1977) 8.12
Identification of a ten-amino acid proline-rich SH3 binding site. Science (1993) 8.05
Protein-binding sites in Ig gene enhancers determine transcriptional activity and inducibility. Science (1987) 7.63
Targeted disruption of the p50 subunit of NF-kappa B leads to multifocal defects in immune responses. Cell (1995) 7.55
Intraclonal generation of antibody mutants in germinal centres. Nature (1991) 7.39
Antigen receptor tail clue. Nature (1989) 7.32
ATR disruption leads to chromosomal fragmentation and early embryonic lethality. Genes Dev (2000) 7.28
Defective viral particles and viral disease processes. Nature (1970) 7.24
In vivo ablation of surface immunoglobulin on mature B cells by inducible gene targeting results in rapid cell death. Cell (1997) 7.18
HIV-1 Nef protein protects infected primary cells against killing by cytotoxic T lymphocytes. Nature (1998) 6.94
A functional ribonucleoprotein complex forms around the 5' end of poliovirus RNA. Cell (1990) 6.85
Efficient and rapid induction of a chronic myelogenous leukemia-like myeloproliferative disease in mice receiving P210 bcr/abl-transduced bone marrow. Blood (1998) 6.81
The selective downregulation of class I major histocompatibility complex proteins by HIV-1 protects HIV-infected cells from NK cells. Immunity (1999) 6.80
5'-terminal structure of poliovirus polyribosomal RNA is pUp. Proc Natl Acad Sci U S A (1976) 6.78
Abelson murine leukaemia virus protein is phosphorylated in vitro to form phosphotyrosine. Nature (1980) 6.76
Structure of a cloned circular Moloney murine leukemia virus DNA molecule containing an inverted segment: implications for retrovirus integration. Proc Natl Acad Sci U S A (1980) 6.73
Gene conversion: some implications for immunoglobulin genes. Cell (1981) 6.70
Ordered rearrangement of immunoglobulin heavy chain variable region segments. EMBO J (1984) 6.67
DNA binding and I kappa B inhibition of the cloned p65 subunit of NF-kappa B, a rel-related polypeptide. Cell (1991) 6.63
Morphogenesis of poliovirus. I. Association of the viral RNA with coat protein. J Mol Biol (1968) 6.58
Activation of interleukin-6 gene expression through the NF-kappa B transcription factor. Mol Cell Biol (1990) 6.57
Functional activity of myogenic HLH proteins requires hetero-oligomerization with E12/E47-like proteins in vivo. Cell (1991) 6.48
Identification of an Abelson murine leukemia virus-encoded protein present in transformed fibroblast and lymphoid cells. Proc Natl Acad Sci U S A (1978) 6.38
Modular binding domains in signal transduction proteins. Cell (1995) 6.34
Targeted disruption of ATM leads to growth retardation, chromosomal fragmentation during meiosis, immune defects, and thymic lymphoma. Genes Dev (1996) 6.32
Organization and reorganization of immunoglobulin genes in A-MULV-transformed cells: rearrangement of heavy but not light chain genes. Cell (1981) 6.31
Standardized and simplified nomenclature for proteins common to all retroviruses. J Virol (1988) 6.31
Poliovirus RNA synthesis utilizes an RNP complex formed around the 5'-end of viral RNA. EMBO J (1993) 6.29
The POU domain: a large conserved region in the mammalian pit-1, oct-1, oct-2, and Caenorhabditis elegans unc-86 gene products. Genes Dev (1988) 6.23
RNA metabolism of murine leukemia virus: detection of virus-specific RNA sequences in infected and uninfected cells and identification of virus-specific messenger RNA. J Mol Biol (1973) 6.19
RNA-directed DNA synthesis and RNA tumor viruses. Adv Virus Res (1972) 6.11
Immunoglobulin synthesis by lymphoid cells transformed in vitro by Abelson murine leukemia virus. Cell (1979) 6.03
Ribonucleic acid synthesis of vesicular stomatitis virus. 3. Multiple complementary messenger RNA molecules. Virology (1970) 5.99
Aspects of the synthesis of poliovirus RNA and the formation of virus particles. Virology (1966) 5.85
In vitro synthesis of a 9 kbp terminally redundant DNA carrying the infectivity of Moloney murine leukemia virus. Cell (1979) 5.78
Preferential utilization of the most JH-proximal VH gene segments in pre-B-cell lines. Nature (1984) 5.75
Ribonucleic acid synthesis of vesicular stomatitis virus. I. Species of ribonucleic acid found in Chinese hamster ovary cells infected with plaque-forming and defective particles. J Virol (1969) 5.73
High frequency of aberrant expression of Moloney murine leukemia virus in clonal infections. Cell (1978) 5.72
Structure of the Abelson murine leukemia virus genome and the homologous cellular gene: studies with cloned viral DNA. Cell (1980) 5.68
A 65-kappaD subunit of active NF-kappaB is required for inhibition of NF-kappaB by I kappaB. Genes Dev (1989) 5.61
The requirement of more than one antigenic determinant for immunogenicity. J Exp Med (1969) 5.61
Synthesis of secreted and membrane-bound immunoglobulin mu heavy chains is directed by mRNAs that differ at their 3' ends. Cell (1980) 5.59
Primer requirement and template specificity of the DNA polymerase of RNA tumor viruses. Proc Natl Acad Sci U S A (1971) 5.55
The involvement of NF-kappa B in beta-interferon gene regulation reveals its role as widely inducible mediator of signal transduction. Cell (1989) 5.50
B lymphocyte-specific, Cre-mediated mutagenesis in mice. Nucleic Acids Res (1997) 5.43
A new homeobox gene contributes the DNA binding domain of the t(1;19) translocation protein in pre-B ALL. Cell (1990) 5.39
From systemic T cell self-reactivity to organ-specific autoimmune disease via immunoglobulins. Immunity (1999) 5.38
Caspase-1 processes IFN-gamma-inducing factor and regulates LPS-induced IFN-gamma production. Nature (1997) 5.35
The mechanism of RNA recombination in poliovirus. Cell (1986) 5.35
Translation of MuLV and MSV RNAs in nuclease-treated reticulocyte extracts: enhancement of the gag-pol polypeptide with yeast suppressor tRNA. Cell (1978) 5.31
Varying the position of a retrovirus packaging sequence results in the encapsidation of both unspliced and spliced RNAs. J Virol (1985) 5.21
A quantitative assay for transformation of bone marrow cells by Abelson murine leukemia virus. J Exp Med (1976) 5.13
Lymphoid development in mice with a targeted deletion of the interleukin 2 receptor gamma chain. Proc Natl Acad Sci U S A (1995) 5.06
Biochemical and functional analysis of mice deficient in expression of the CD45-associated phosphoprotein LPAP. Eur J Immunol (1999) 5.02