Published in Proc Natl Acad Sci U S A on May 17, 2006
Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature (2007) 7.04
Activation of the unfolded protein response and autophagy after hepatitis C virus infection suppresses innate antiviral immunity in vitro. J Clin Invest (2010) 2.68
Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci U S A (2010) 2.46
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe (2009) 2.33
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc Natl Acad Sci U S A (2007) 2.33
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe (2012) 2.25
Hepatitis C virus replication in transfected and serum-infected cultured human fetal hepatocytes. Am J Pathol (2007) 2.18
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Select paramyxoviral V proteins inhibit IRF3 activation by acting as alternative substrates for inhibitor of kappaB kinase epsilon (IKKe)/TBK1. J Biol Chem (2008) 1.45
Capsid protein of eastern equine encephalitis virus inhibits host cell gene expression. J Virol (2007) 1.35
Hepatitis C virus controls interferon production through PKR activation. PLoS One (2010) 1.21
Regulation of CXCL-8 (interleukin-8) induction by double-stranded RNA signaling pathways during hepatitis C virus infection. J Virol (2006) 1.12
Hepatitis C virus infection induces the beta interferon signaling pathway in immortalized human hepatocytes. J Virol (2007) 1.12
Hepatitis B virus regulatory HBx protein binds to adaptor protein IPS-1 and inhibits the activation of beta interferon. J Virol (2010) 1.12
Hepatitis C virus infection impairs IRF-7 translocation and Alpha interferon synthesis in immortalized human hepatocytes. J Virol (2010) 1.11
Hepatitis C virus infection in phenotypically distinct Huh7 cell lines. PLoS One (2009) 1.10
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The hepatitis C virus non-structural NS5A protein impairs both the innate and adaptive hepatic immune response in vivo. J Biol Chem (2009) 1.04
Hepatitis C virus core protein abrogates the DDX3 function that enhances IPS-1-mediated IFN-beta induction. PLoS One (2010) 1.04
The interferon inducing pathways and the hepatitis C virus. World J Gastroenterol (2007) 0.95
Impact of the autophagy machinery on hepatitis C virus infection. Viruses (2011) 0.95
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Innate host response in primary human hepatocytes with hepatitis C virus infection. PLoS One (2011) 0.93
Exploitation of lipid components by viral and host proteins for hepatitis C virus infection. Front Microbiol (2012) 0.92
Y-box-binding protein 1 interacts with hepatitis C virus NS3/4A and influences the equilibrium between viral RNA replication and infectious particle production. J Virol (2011) 0.91
Differential effects of donor and recipient IL28B and DDX58 SNPs on severity of HCV after liver transplantation. J Hepatol (2013) 0.90
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The Dual Role of Exosomes in Hepatitis A and C Virus Transmission and Viral Immune Activation. Viruses (2015) 0.83
Restoration of the activated Rig-I pathway in hepatitis C virus (HCV) replicon cells by HCV protease, polymerase, and NS5A inhibitors in vitro at clinically relevant concentrations. Antimicrob Agents Chemother (2013) 0.83
MiR-942 mediates hepatitis C virus-induced apoptosis via regulation of ISG12a. PLoS One (2014) 0.80
Outrunning the Red Queen: bystander activation as a means of outpacing innate immune subversion by intracellular pathogens. Cell Mol Immunol (2016) 0.80
Identification of Cholesterol 25-Hydroxylase as a Novel Host Restriction Factor and a Part of the Primary Innate Immune Responses against Hepatitis C Virus Infection. J Virol (2015) 0.79
Activation of Type I and III Interferon Response by Mitochondrial and Peroxisomal MAVS and Inhibition by Hepatitis C Virus. PLoS Pathog (2015) 0.79
Understanding the interaction of hepatitis C virus with host DEAD-box RNA helicases. World J Gastroenterol (2014) 0.78
Efficient virus assembly, but not infectivity, determines the magnitude of hepatitis C virus-induced interferon alpha responses of plasmacytoid dendritic cells. J Virol (2014) 0.77
Immunopathogenesis of Hepatitis C Virus Infection. Gastroenterol Clin North Am (2015) 0.77
Elimination of hepatitis C virus from hepatocytes by a selective activation of therapeutic molecules. PLoS One (2011) 0.76
Interferon (IFN) and Cellular Immune Response Evoked in RNA-Pattern Sensing During Infection with Hepatitis C Virus (HCV). Sensors (Basel) (2015) 0.76
A point mutation in the N-terminal amphiphathic helix α0 in NS3 promotes HCV assembly by altering core localization to ER and facilitating virus budding. J Virol (2017) 0.75
STAT1 is essential for the inhibition of hepatitis C virus replication by interferon-λ but not by interferon-α. Sci Rep (2016) 0.75
Intrinsic Viral Factors Are the Dominant Determinants of the Hepatitis C Virus Response to Interferon Alpha Treatment in Chimeric Mice. PLoS One (2016) 0.75
The RNA helicase RIG-I has an essential function in double-stranded RNA-induced innate antiviral responses. Nat Immunol (2004) 26.12
Production of infectious hepatitis C virus in tissue culture from a cloned viral genome. Nat Med (2005) 21.56
Identification and characterization of MAVS, a mitochondrial antiviral signaling protein that activates NF-kappaB and IRF 3. Cell (2005) 20.30
Complete replication of hepatitis C virus in cell culture. Science (2005) 18.59
IPS-1, an adaptor triggering RIG-I- and Mda5-mediated type I interferon induction. Nat Immunol (2005) 18.32
Cardif is an adaptor protein in the RIG-I antiviral pathway and is targeted by hepatitis C virus. Nature (2005) 17.47
IKKepsilon and TBK1 are essential components of the IRF3 signaling pathway. Nat Immunol (2003) 15.67
Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2005) 14.78
VISA is an adapter protein required for virus-triggered IFN-beta signaling. Mol Cell (2005) 14.20
Triggering the interferon antiviral response through an IKK-related pathway. Science (2003) 11.62
The nature of the principal type 1 interferon-producing cells in human blood. Science (1999) 10.90
IRF family of transcription factors as regulators of host defense. Annu Rev Immunol (2001) 8.18
Regulation of interferon regulatory factor-3 by the hepatitis C virus serine protease. Science (2003) 7.91
The V proteins of paramyxoviruses bind the IFN-inducible RNA helicase, mda-5, and inhibit its activation of the IFN-beta promoter. Proc Natl Acad Sci U S A (2004) 7.51
Virus-dependent phosphorylation of the IRF-3 transcription factor regulates nuclear translocation, transactivation potential, and proteasome-mediated degradation. Mol Cell Biol (1998) 7.43
Decoding the patterns of self and nonself by the innate immune system. Science (2002) 7.19
Cutting edge: a novel Toll/IL-1 receptor domain-containing adapter that preferentially activates the IFN-beta promoter in the Toll-like receptor signaling. J Immunol (2002) 7.07
Course and outcome of hepatitis C. Hepatology (2002) 6.51
Activation of interferon regulatory factor 3 is inhibited by the influenza A virus NS1 protein. J Virol (2000) 6.22
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Control of antiviral defenses through hepatitis C virus disruption of retinoic acid-inducible gene-I signaling. Proc Natl Acad Sci U S A (2005) 5.64
Hepatitis C virus protease NS3/4A cleaves mitochondrial antiviral signaling protein off the mitochondria to evade innate immunity. Proc Natl Acad Sci U S A (2005) 5.31
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
Viral and therapeutic control of IFN-beta promoter stimulator 1 during hepatitis C virus infection. Proc Natl Acad Sci U S A (2006) 4.84
Intrahepatic gene expression during chronic hepatitis C virus infection in chimpanzees. J Virol (2004) 3.43
The beta-interferon promoter responds to priming through multiple independent regulatory elements. J Biol Chem (1994) 2.36
Sensitivity of NS3 serine proteases from hepatitis C virus genotypes 2 and 3 to the inhibitor BILN 2061. J Virol (2004) 1.32
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Robust hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2005) 14.78
Interferon modulation of cellular microRNAs as an antiviral mechanism. Nature (2007) 7.04
Broadly neutralizing antibodies protect against hepatitis C virus quasispecies challenge. Nat Med (2007) 6.05
Viral and immunological determinants of hepatitis C virus clearance, persistence, and disease. Proc Natl Acad Sci U S A (2002) 5.81
Lambda interferon inhibits hepatitis B and C virus replication. J Virol (2005) 5.47
Genomic analysis of the host response to hepatitis C virus infection. Proc Natl Acad Sci U S A (2002) 5.28
CD8(+) T cells mediate viral clearance and disease pathogenesis during acute hepatitis B virus infection. J Virol (2003) 4.42
Immunobiology and pathogenesis of viral hepatitis. Annu Rev Pathol (2006) 3.84
Hepatitis C virus RNA replication is regulated by host geranylgeranylation and fatty acids. Proc Natl Acad Sci U S A (2005) 3.83
Cellular determinants of hepatitis C virus assembly, maturation, degradation, and secretion. J Virol (2007) 3.57
Antiplatelet therapy prevents hepatocellular carcinoma and improves survival in a mouse model of chronic hepatitis B. Proc Natl Acad Sci U S A (2012) 3.50
Genomic analysis of the host response to hepatitis B virus infection. Proc Natl Acad Sci U S A (2004) 3.16
Human liver chimeric mice provide a model for hepatitis B and C virus infection and treatment. J Clin Invest (2010) 3.10
Automated generation and evaluation of specific MHC binding predictive tools: ARB matrix applications. Immunogenetics (2005) 2.99
Stealth and cunning: hepatitis B and hepatitis C viruses. J Virol (2005) 2.94
The autophagy machinery is required to initiate hepatitis C virus replication. Proc Natl Acad Sci U S A (2009) 2.91
Persistent hepatitis C virus infection in vitro: coevolution of virus and host. J Virol (2006) 2.77
Hydrodynamic injection of viral DNA: a mouse model of acute hepatitis B virus infection. Proc Natl Acad Sci U S A (2002) 2.71
Differential biophysical properties of infectious intracellular and secreted hepatitis C virus particles. J Virol (2006) 2.68
Initiation of hepatitis C virus infection is dependent on cholesterol and cooperativity between CD81 and scavenger receptor B type I. J Virol (2006) 2.65
Interference of hepatitis C virus RNA replication by short interfering RNAs. Proc Natl Acad Sci U S A (2003) 2.64
Plasmacytoid dendritic cells sense hepatitis C virus-infected cells, produce interferon, and inhibit infection. Proc Natl Acad Sci U S A (2010) 2.46
Hepatitis C virus blocks interferon effector function by inducing protein kinase R phosphorylation. Cell Host Microbe (2009) 2.33
Double-stranded DNA and double-stranded RNA induce a common antiviral signaling pathway in human cells. Proc Natl Acad Sci U S A (2007) 2.33
Short-range exosomal transfer of viral RNA from infected cells to plasmacytoid dendritic cells triggers innate immunity. Cell Host Microbe (2012) 2.25
Platelets mediate cytotoxic T lymphocyte-induced liver damage. Nat Med (2005) 2.19
Toll-like receptor signaling inhibits hepatitis B virus replication in vivo. J Virol (2005) 2.13
PD-1:PD-L1 interactions contribute to the functional suppression of virus-specific CD8+ T lymphocytes in the liver. J Immunol (2007) 2.08
Cytokine-sensitive replication of hepatitis B virus in immortalized mouse hepatocyte cultures. J Virol (2002) 2.05
Expansion and contraction of the hepatitis B virus transcriptional template in infected chimpanzees. Proc Natl Acad Sci U S A (2004) 1.96
Replication of a hepatitis C virus replicon clone in mouse cells. Virol J (2006) 1.90
Simultaneous detection of hepatitis C virus and interferon stimulated gene expression in infected human liver. Hepatology (2014) 1.89
Oscillating CD8(+) T cell effector functions after antigen recognition in the liver. Immunity (2005) 1.83
Immune effectors required for hepatitis B virus clearance. Proc Natl Acad Sci U S A (2009) 1.76
The size of the viral inoculum contributes to the outcome of hepatitis B virus infection. J Virol (2009) 1.71
Viruses and the autophagy machinery. Cell Cycle (2010) 1.68
Interferon-regulated pathways that control hepatitis B virus replication in transgenic mice. J Virol (2002) 1.66
MMPs are required for recruitment of antigen-nonspecific mononuclear cells into the liver by CTLs. J Clin Invest (2004) 1.65
CD40 activation rescues antiviral CD8⁺ T cells from PD-1-mediated exhaustion. PLoS Pathog (2013) 1.65
Ultrastructural and biophysical characterization of hepatitis C virus particles produced in cell culture. J Virol (2010) 1.64
Immune tolerance split between hepatitis B virus precore and core proteins. J Virol (2005) 1.63
A function of the hepatitis B virus precore protein is to regulate the immune response to the core antigen. Proc Natl Acad Sci U S A (2004) 1.61
Interleukin-18 inhibits hepatitis B virus replication in the livers of transgenic mice. J Virol (2002) 1.61
Inhibition of hepatitis B virus replication by interferon requires proteasome activity. J Virol (2002) 1.58
Immunogenicity and tolerogenicity of hepatitis B virus structural and nonstructural proteins: implications for immunotherapy of persistent viral infections. J Virol (2002) 1.56
Gene expression during the priming phase of liver regeneration after partial hepatectomy in mice. Proc Natl Acad Sci U S A (2002) 1.51
Platelets prevent IFN-alpha/beta-induced lethal hemorrhage promoting CTL-dependent clearance of lymphocytic choriomeningitis virus. Proc Natl Acad Sci U S A (2008) 1.48
A virocidal amphipathic {alpha}-helical peptide that inhibits hepatitis C virus infection in vitro. Proc Natl Acad Sci U S A (2008) 1.48
Identification of a residue in hepatitis C virus E2 glycoprotein that determines scavenger receptor BI and CD81 receptor dependency and sensitivity to neutralizing antibodies. J Virol (2008) 1.48
Production of infectious hepatitis C virus by well-differentiated, growth-arrested human hepatoma-derived cells. J Virol (2006) 1.47
Interferon prevents formation of replication-competent hepatitis B virus RNA-containing nucleocapsids. Proc Natl Acad Sci U S A (2005) 1.47
Native hepatitis B virions and capsids visualized by electron cryomicroscopy. Mol Cell (2006) 1.44
Self-assembling peptide nanotubes with antiviral activity against hepatitis C virus. Chem Biol (2011) 1.41
Recruitment of host functions suggests a repair pathway for late steps in group II intron retrohoming. Genes Dev (2005) 1.41
Searching for interferon-induced genes that inhibit hepatitis B virus replication in transgenic mouse hepatocytes. J Virol (2003) 1.39
Transcriptional and posttranscriptional control of hepatitis B virus gene expression. Proc Natl Acad Sci U S A (2003) 1.35
Kupffer cells hasten resolution of liver immunopathology in mouse models of viral hepatitis. PLoS Pathog (2011) 1.34
Activated intrahepatic antigen-presenting cells inhibit hepatitis B virus replication in the liver of transgenic mice. J Immunol (2002) 1.34
Previously infected chimpanzees are not consistently protected against reinfection or persistent infection after reexposure to the identical hepatitis C virus strain. J Virol (2008) 1.33
Complete genome sequence of Lactococcus lactis subsp. lactis CV56, a probiotic strain isolated from the vaginas of healthy women. J Bacteriol (2011) 1.31
Clearance of hepatitis B virus from the liver of transgenic mice by short hairpin RNAs. Proc Natl Acad Sci U S A (2005) 1.30
Depletion of neutrophils blocks the recruitment of antigen-nonspecific cells into the liver without affecting the antiviral activity of hepatitis B virus-specific cytotoxic T lymphocytes. Proc Natl Acad Sci U S A (2002) 1.29
Dynamics of hepatitis B virus clearance in chimpanzees. Proc Natl Acad Sci U S A (2005) 1.29
Hepatitis C virus NS5A anchor peptide disrupts human immunodeficiency virus. Proc Natl Acad Sci U S A (2008) 1.26
Hepatitis B small surface antigen particles are octahedral. Proc Natl Acad Sci U S A (2005) 1.25
IL28B genetic variation is associated with spontaneous clearance of hepatitis C virus, treatment response, serum IL-28B levels in Chinese population. PLoS One (2012) 1.25
Novel mechanism for nisin resistance via proteolytic degradation of nisin by the nisin resistance protein NSR. Antimicrob Agents Chemother (2009) 1.17
Activation of sterol regulatory element-binding protein 1c and fatty acid synthase transcription by hepatitis C virus non-structural protein 2. J Gen Virol (2008) 1.15
Unbiased probing of the entire hepatitis C virus life cycle identifies clinical compounds that target multiple aspects of the infection. Proc Natl Acad Sci U S A (2009) 1.11
Signal transduction pathways that inhibit hepatitis B virus replication. Proc Natl Acad Sci U S A (2004) 1.08
Hepatitis C virus (HCV) induces formation of stress granules whose proteins regulate HCV RNA replication and virus assembly and egress. J Virol (2012) 1.08
Pluripotent stem cells identified in multiple murine tissues. Ann N Y Acad Sci (2003) 1.08
Hepatitis C virus NS4B blocks the interaction of STING and TBK1 to evade host innate immunity. J Hepatol (2013) 1.06
Identification of ligand specificity determinants in lantibiotic bovicin HJ50 and the receptor BovK, a multitransmembrane histidine kinase. J Biol Chem (2014) 1.04
Detailed characterization of the peptide binding specificity of five common Patr class I MHC molecules. Immunogenetics (2006) 1.03
Autophagy proteins promote hepatitis C virus replication. Autophagy (2009) 1.02
Dissection of the bridging pattern of bovicin HJ50, a lantibiotic containing a characteristic disulfide bridge. Microbiol Res (2010) 1.00
Role of immunoproteasome catalytic subunits in the immune response to hepatitis B virus. J Virol (2006) 0.98
Characterization of the peptide-binding specificity of the chimpanzee class I alleles A 0301 and A 0401 using a combinatorial peptide library. Immunogenetics (2007) 0.97
A single point mutation in E2 enhances hepatitis C virus infectivity and alters lipoprotein association of viral particles. Virology (2009) 0.96
Sphingomyelin activates hepatitis C virus RNA polymerase in a genotype-specific manner. J Virol (2010) 0.95
Impact of the autophagy machinery on hepatitis C virus infection. Viruses (2011) 0.95
Cerecidins, novel lantibiotics from Bacillus cereus with potent antimicrobial activity. Appl Environ Microbiol (2014) 0.95
Gene targeting using randomly inserted group II introns (targetrons) recovered from an Escherichia coli gene disruption library. Nucleic Acids Res (2005) 0.94
Pathogenic role of B cells in anti-CD40-induced necroinflammatory liver disease. Am J Pathol (2006) 0.94
Hepatitis C virus NS3/4A protease blocks IL-28 production. Eur J Immunol (2012) 0.90
Restoration of bioactive lantibiotic suicin from a remnant lan locus of pathogenic Streptococcus suis serotype 2. Appl Environ Microbiol (2013) 0.90
Characteristics of the bovicin HJ50 gene cluster in Streptococcus bovis HJ50. Microbiology (2009) 0.90
Bortezomib inhibits hepatitis B virus replication in transgenic mice. Antimicrob Agents Chemother (2009) 0.89
Mutations in the Lactococcus lactis Ll.LtrB group II intron that retain mobility in vivo. BMC Mol Biol (2002) 0.87
Antiviral stilbene 1,2-diamines prevent initiation of hepatitis C virus RNA replication at the outset of infection. J Virol (2011) 0.86
High content of resveratrol in lettuce transformed with a stilbene synthase gene of Parthenocissus henryana. J Agric Food Chem (2006) 0.86
Negative regulation of interferon-induced transmembrane protein 3 by SET7-mediated lysine monomethylation. J Biol Chem (2013) 0.84
A nonribosomal peptide synthase containing a stand-alone condensation domain is essential for phytotoxin zeamine biosynthesis. Mol Plant Microbe Interact (2013) 0.83
Purification and characterization of two novel antimicrobial peptides Subpeptin JM4-A and Subpeptin JM4-B produced by Bacillus subtilis JM4. Curr Microbiol (2005) 0.83