Published in Drug Metab Dispos on May 30, 1991
A highly efficient ligand-regulated Cre recombinase mouse line shows that LoxP recombination is position dependent. EMBO Rep (2001) 3.67
Islet 1 is expressed in distinct cardiovascular lineages, including pacemaker and coronary vascular cells. Dev Biol (2006) 2.81
Spinal cord injury reveals multilineage differentiation of ependymal cells. PLoS Biol (2008) 2.80
Smooth muscle cell plasticity: fact or fiction? Circ Res (2012) 2.18
Molecular neuroanatomy's "Three Gs": a primer. Neuron (2007) 1.91
Cells of origin in the embryonic nerve roots for NF1-associated plexiform neurofibroma. Cancer Cell (2014) 1.57
The effects of norethisterone on endometrial abnormalities identified by transvaginal ultrasound screening of healthy post-menopausal women on tamoxifen or placebo. Br J Cancer (1998) 1.44
Permanent genetic access to transiently active neurons via TRAP: targeted recombination in active populations. Neuron (2013) 1.33
Temporal-spatial changes in Sonic Hedgehog expression and signaling reveal different potentials of ventral mesencephalic progenitors to populate distinct ventral midbrain nuclei. Neural Dev (2011) 1.32
Comparative analysis of conditional reporter alleles in the developing embryo and embryonic nervous system. Gene Expr Patterns (2009) 1.29
Fourteenth Gaddum Memorial Lecture. A current view of tamoxifen for the treatment and prevention of breast cancer. Br J Pharmacol (1993) 1.27
EphB signaling controls lineage plasticity of adult neural stem cell niche cells. Cell Stem Cell (2010) 1.17
Antifungal activity of tamoxifen: in vitro and in vivo activities and mechanistic characterization. Antimicrob Agents Chemother (2009) 1.12
Fgf8 expression in the Tbx1 domain causes skeletal abnormalities and modifies the aortic arch but not the outflow tract phenotype of Tbx1 mutants. Dev Biol (2006) 1.10
Estrogen receptor antagonists are anti-cryptococcal agents that directly bind EF hand proteins and synergize with fluconazole in vivo. MBio (2014) 1.07
Sonic hedgehog lineage in the mouse hypothalamus: from progenitor domains to hypothalamic regions. Neural Dev (2012) 1.05
The duration of Fgf8 isthmic organizer expression is key to patterning different tectal-isthmo-cerebellum structures. Development (2009) 1.05
17β-estradiol and tamoxifen prevent gastric cancer by modulating leukocyte recruitment and oncogenic pathways in Helicobacter pylori-infected INS-GAS male mice. Cancer Prev Res (Phila) (2011) 1.01
Stimulation of endogenous cardioblasts by exogenous cell therapy after myocardial infarction. EMBO Mol Med (2014) 1.00
Differential modulation of doxorubicin toxicity to multidrug and intrinsically drug resistant cell lines by anti-oestrogens and their major metabolites. Br J Cancer (1993) 0.98
Sox9-haploinsufficiency causes glucose intolerance in mice. PLoS One (2011) 0.97
The influence of tamoxifen on normal mouse mammary gland homeostasis. Breast Cancer Res (2014) 0.95
Timing of Sonic hedgehog and Gli1 expression segregates midbrain dopamine neurons. J Comp Neurol (2011) 0.95
Tamoxifen is effective in the treatment of Leishmania amazonensis infections in mice. PLoS Negl Trop Dis (2008) 0.95
Comparative temporal and dose-dependent morphological and transcriptional uterine effects elicited by tamoxifen and ethynylestradiol in immature, ovariectomized mice. BMC Genomics (2007) 0.95
Cardiac Bmi1(+) cells contribute to myocardial renewal in the murine adult heart. Stem Cell Res Ther (2015) 0.93
Myf5 expression during fetal myogenesis defines the developmental progenitors of adult satellite cells. Dev Biol (2013) 0.93
Mouse Label-Retaining Cells Are Molecularly and Functionally Distinct From Reserve Intestinal Stem Cells. Gastroenterology (2016) 0.92
Evidence for NG2-glia derived, adult-born functional neurons in the hypothalamus. PLoS One (2013) 0.90
Combination therapy with tamoxifen and amphotericin B in experimental cutaneous leishmaniasis. Antimicrob Agents Chemother (2014) 0.88
Effects of repeated administration of chemotherapeutic agents tamoxifen, methotrexate, and 5-fluorouracil on the acquisition and retention of a learned response in mice. Psychopharmacology (Berl) (2011) 0.88
Estimating xenobiotic half-lives in humans from rat data: influence of log P. Environ Health Perspect (1997) 0.87
The lineage contribution and role of Gbx2 in spinal cord development. PLoS One (2011) 0.86
Fgf signaling controls the telencephalic distribution of Fgf-expressing progenitors generated in the rostral patterning center. Neural Dev (2015) 0.82
Reversible control of oestradiol-stimulated growth of MCF-7 tumours by tamoxifen in the athymic mouse. Br J Cancer (1991) 0.82
Simulation with cells in vitro of tamoxifen treatment in premenopausal breast cancer patients with different CYP2D6 genotypes. Br J Pharmacol (2014) 0.82
In vitro and in vivo effects of tamoxifen against larval stage Echinococcus granulosus. Antimicrob Agents Chemother (2014) 0.81
Improved specificity of hippocampal memory trace labeling. Hippocampus (2016) 0.81
Tamoxifen Administration Immediately or 24 Hours after Spinal Cord Injury Improves Locomotor Recovery and Reduces Secondary Damage in Female Rats. J Neurotrauma (2016) 0.80
Oxidative stress contributes to the tamoxifen-induced killing of breast cancer cells: implications for tamoxifen therapy and resistance. Sci Rep (2016) 0.79
Characterization of the Frizzled10-CreER transgenic mouse: an inducible Cre line for the study of Cajal-Retzius cell development. Genesis (2009) 0.79
Investigating the origins of somatic cell populations in the perinatal mouse ovaries using genetic lineage tracing and immunohistochemistry. Methods Mol Biol (2012) 0.79
Boronic prodrug of 4-hydroxytamoxifen is more efficacious than tamoxifen with enhanced bioavailability independent of CYP2D6 status. BMC Cancer (2015) 0.79
The kinetics of ER fusion protein activation in vivo. Oncogene (2014) 0.78
Uridine prevents tamoxifen-induced liver lipid droplet accumulation. BMC Pharmacol Toxicol (2014) 0.78
Tamoxifen-elicited uterotrophy: cross-species and cross-ligand analysis of the gene expression program. BMC Med Genomics (2009) 0.78
Development of a novel molecular sensor for imaging estrogen receptor-coactivator protein-protein interactions. PLoS One (2012) 0.78
Pros and cons of the tuberculosis drugome approach--an empirical analysis. PLoS One (2014) 0.77
Comparative uterotrophic effects of endoxifen and tamoxifen in ovariectomized Sprague-Dawley rats. Toxicol Pathol (2014) 0.77
Heterogeneity in readouts of canonical wnt pathway activity within intestinal crypts. Dev Dyn (2016) 0.76
No effect on pharmacokinetics of tamoxifen and 4-hydroxytamoxifen by multiple doses of red clover capsule in rats. Sci Rep (2015) 0.75
Endothelium in the pharyngeal arches 3, 4 and 6 is derived from the second heart field. Dev Biol (2016) 0.75
Interaction of tamoxifen and noise-induced damage to the cochlea. Hear Res (2011) 0.75
Differences in the timing and magnitude of Pkd1 gene deletion determine the severity of polycystic kidney disease in an orthologous mouse model of ADPKD. Physiol Rep (2016) 0.75
Conditional genetic deletion of Ano1 in interstitial cells of Cajal impairs Ca2+ transients and slow-waves in adult mouse small intestine. Am J Physiol Gastrointest Liver Physiol (2016) 0.75
The effects of a novel hormonal breast cancer therapy, endoxifen, on the mouse skeleton. PLoS One (2014) 0.75
Multipotent Myoepithelial Progenitor Cells Are Born Early During Airway Submucosal Gland Development. Am J Respir Cell Mol Biol (2017) 0.75
Continuous tamoxifen delivery improves locomotor recovery 6h after spinal cord injury by neuronal and glial mechanisms in male rats. Exp Neurol (2017) 0.75
Sonic Hedgehog from both nerves and epithelium is a key trophic factor for taste bud maintenance. Development (2017) 0.75
P-selectin glycoprotein ligand-1 mediates rolling of human neutrophils on P-selectin. J Cell Biol (1995) 4.31
Colorectal cancer prevention 2000: screening recommendations of the American College of Gastroenterology. American College of Gastroenterology. Am J Gastroenterol (2000) 4.17
Lipopolysaccharide (LPS)-binding protein accelerates the binding of LPS to CD14. J Exp Med (1994) 3.61
Barrett's esophagus. A prevalent, occult complication of gastroesophageal reflux disease. Gastroenterology (1987) 3.56
Effects of tamoxifen on bone mineral density in postmenopausal women with breast cancer. N Engl J Med (1992) 3.54
Effect of fixation on the amplification of nucleic acids from paraffin-embedded material by the polymerase chain reaction. J Histochem Cytochem (1991) 3.51
Changes in annual tuberculosis notification rates between 1978/79 and 1983 for the population of Indian subcontinent ethnic origin resident in England. J Epidemiol Community Health (1986) 3.48
Treatment of depression in general practice. Br Med J (1973) 3.44
Risk factors associated with failure to receive vaccinations. Pediatrics (1979) 3.44
A monohydroxylated metabolite of tamoxifen with potent antioestrogenic activity. J Endocrinol (1977) 3.03
The pharmacology and clinical uses of tamoxifen. Pharmacol Ther (1984) 3.02
Effects of the antiestrogens tamoxifen, toremifene, and ICI 182,780 on endometrial cancer growth. J Natl Cancer Inst (1998) 2.88
Genetic structure of natural populations of the nitrogen-fixing bacterium Rhizobium meliloti. Appl Environ Microbiol (1990) 2.84
Size matters: the relationship between MMP-9 expression and aortic diameter. Circulation (1997) 2.72
A laboratory model to explain the survival advantage observed in patients taking adjuvant tamoxifen therapy. Recent Results Cancer Res (1993) 2.65
A study of the use of antidepressant medication in general practice. Br J Psychiatry (1974) 2.63
Complexes formed by (pyrimidine)n . (purine)n DNAs on lowering the pH are three-stranded. Nucleic Acids Res (1979) 2.62
The possible significance of the ferrous oxidase activity of ceruloplasmin in normal human serum. J Biol Chem (1966) 2.58
Basic guide to the mechanisms of antiestrogen action. Pharmacol Rev (1998) 2.50
Depression: treatment compliance in general practice. Acta Psychiatr Scand Suppl (1981) 2.27
Continued breast cancer risk reduction in postmenopausal women treated with raloxifene: 4-year results from the MORE trial. Multiple outcomes of raloxifene evaluation. Breast Cancer Res Treat (2001) 2.26
Growth regulation of estrogen receptor-negative breast cancer cells transfected with complementary DNAs for estrogen receptor. J Natl Cancer Inst (1992) 2.19
Effectiveness of a mailed reminder on the immunization levels of infants at high risk of failure to complete immunizations. Am J Public Health (1980) 2.16
MCF-7: the first hormone-responsive breast cancer cell line. Cancer Res (1997) 2.12
Effects of tamoxifen therapy on lipid and lipoprotein levels in postmenopausal patients with node-negative breast cancer. J Natl Cancer Inst (1990) 1.97
Respiratory symptoms, lung function, and sensitisation to flour in a British bakery. Br J Ind Med (1989) 1.85
Development of tamoxifen-stimulated growth of MCF-7 tumors in athymic mice after long-term antiestrogen administration. Cancer Res (1988) 1.80
Models of estrogen receptor regulation by estrogens and antiestrogens in breast cancer cell lines. Cancer Res (1996) 1.79
Development of antiestrogens and their use in breast cancer: eighth Cain memorial award lecture. Cancer Res (1990) 1.78
The mobilization of iron from the perfused mammalian liver by a serum copper enzyme, ferroxidase I. J Biol Chem (1971) 1.75
Long-term visual results and complications in children with aphakia. A function of cataract type. Ophthalmology (1993) 1.74
Biochemical pharmacology of antiestrogen action. Pharmacol Rev (1984) 1.74
Antitumor action of physiological estradiol on tamoxifen-stimulated breast tumors grown in athymic mice. Clin Cancer Res (2000) 1.73
Radioimmunoassay of prostaglandin F-2-alpha in peripheral venous plasma from men and women. Prostaglandins (1974) 1.71
Antiestrogenic and antitumor properties of tamoxifen in laboratory animals. Cancer Treat Rep (1976) 1.63
The spectrum of spontaneous and iatrogenic esophageal injury: perforations, Mallory-Weiss tears, and hematomas. J Clin Gastroenterol (1999) 1.57
Effects of tamoxifen on cardiovascular risk factors in postmenopausal women. Ann Intern Med (1991) 1.55
The severity of depression in patients treated in general practice. J R Coll Gen Pract (1977) 1.53
Effect of cadmium on estrogen receptor levels and estrogen-induced responses in human breast cancer cells. J Biol Chem (1994) 1.53
Antitumor actions of keoxifene and tamoxifen in the N-nitrosomethylurea-induced rat mammary carcinoma model. Cancer Res (1987) 1.52
The Glu residue in the conserved Asn-Glu-Pro sequence of two highly divergent endo-beta-1,4-glucanases is essential for enzymatic activity. Biochem Biophys Res Commun (1990) 1.52
Effect of tamoxifen (ICI 46,474) on initiation and growth of DMBA-induced rat mammary carcinomata. Eur J Cancer (1976) 1.50
Esomeprazole improves healing and symptom resolution as compared with omeprazole in reflux oesophagitis patients: a randomized controlled trial. The Esomeprazole Study Investigators. Aliment Pharmacol Ther (2000) 1.49
Metabolites of tamoxifen in animals and man: identification, pharmacology, and significance. Breast Cancer Res Treat (1982) 1.48
Elastinolytic activity of human cathepsin L. Biochem J (1986) 1.48
Improving cognitive function after brain injury: the use of exercise and virtual reality. Arch Phys Med Rehabil (1999) 1.47
Anesthetic implications of the child with homocystinuria. J Clin Anesth (1994) 1.45
Transverse distance between the membrane and the agonist binding sites on the Torpedo acetylcholine receptor: a fluorescence study. Biophys J (1994) 1.45
Contrasting actions of tamoxifen on endometrial and breast tumor growth in the athymic mouse. Cancer Res (1988) 1.44
Propionibacterium acnes as a cause of visually significant corneal ulcers. Cornea (2000) 1.42
Tamoxifen and contralateral breast cancer. J Am Coll Surg (1999) 1.41
A further study of psychiatric out-patient services in Manchester. An operational study of general practitioner and patient expectation. Br J Psychiatry (1973) 1.39
An estrogen receptor positive MCF-7 clone that is resistant to antiestrogens and estradiol. Mol Cell Endocrinol (1992) 1.39
Adaptation of estrogen-dependent MCF-7 cells to low estrogen (phenol red-free) culture. Eur J Cancer Clin Oncol (1987) 1.38
Race affects healing of erosive oesophagitis in patients treated with proton pump inhibitors. Aliment Pharmacol Ther (2011) 1.38
Pharmacology of tamoxifen in laboratory animals. Cancer Treat Rep (1981) 1.37
A risk-benefit assessment of tamoxifen therapy. Drug Saf (1993) 1.34
Human lung tryptase. Purification and characterization. J Biol Chem (1984) 1.33
Spontaneous and induced leukemias of myeloid origin in recombinant inbred BXH mice. J Virol (1984) 1.33
Fine-needle aspiration cytology of the thyroid. A 12-year experience with 11,000 biopsies. Clin Lab Med (1993) 1.33
Antibody directed to determinants of a Moloney virus derived MCF GP70 recognizes a thymic differentiation antigen. J Exp Med (1983) 1.32
Estrogen-induced apoptosis in a breast cancer model resistant to long-term estrogen withdrawal. J Steroid Biochem Mol Biol (2005) 1.31
Bone mineral density in women with breast cancer treated with adjuvant tamoxifen for at least two years. Breast Cancer Res Treat (1988) 1.29
Afamin is a new member of the albumin, alpha-fetoprotein, and vitamin D-binding protein gene family. J Biol Chem (1994) 1.28
Interaction of noncompetitive inhibitors with the acetylcholine receptor. The site specificity and spectroscopic properties of ethidium binding. J Biol Chem (1987) 1.28
Tamoxifen as an anti-tumour agent: effect on oestrogen binding. J Endocrinol (1976) 1.27
Evaluation of intracutaneous testing for investigation of allergy to local anesthetic agents. Anesth Analg (1970) 1.27
Fine needle aspiration cytology of the thyroid, 1980 to 1986. Acta Cytol (1987) 1.27
Evaluation of the antitumour activity of the non-steroidal antioestrogen monohydroxytamoxifen in the DMBA-induced rat mammary carcinoma model. Eur J Cancer (1980) 1.27
Studies of depressive symptoms in schizophrenia. Br J Psychiatry (1981) 1.26
Fast-Growing Rhizobium japonicum That Effectively Nodulates Several Commercial Glycine max L. Merrill Cultivars. Appl Environ Microbiol (1984) 1.26
Mimicking the alloantigenicity of proteins with chemically synthesized peptides differing in single amino acids. Nature (1984) 1.26
Use of nonfat dry milk to block nonspecific nuclear and membrane staining by avidin conjugates. J Histochem Cytochem (1985) 1.25
Human bronchial leucocyte proteinase inhibitor. Rapid isolation and kinetic analysis with human leucocyte proteinases. Biochem J (1985) 1.25
Role of bacterial products in periodontitis: immune response in gnotobiotic rats monoinfected with Eikenella corrodens. Infect Immun (1978) 1.24
Inactivation of human bronchial mucosal proteinase inhibitor by Pseudomonas aeruginosa elastase. Am Rev Respir Dis (1982) 1.23
An estrogen-independent MCF-7 breast cancer cell line which contains a novel 80-kilodalton estrogen receptor-related protein. Cancer Res (1995) 1.23
High-dose ketoconazole in advanced hormone-refractory prostate cancer: endocrinologic and clinical effects. J Clin Oncol (1989) 1.21
Construction and characterization of multicopy plasmids containing the entire F transfer region. Plasmid (1980) 1.21
Endocrine status of premenopausal node-positive breast cancer patients following adjuvant chemotherapy and long-term tamoxifen. Cancer Res (1988) 1.19
Estradiol-stimulated growth of MCF-7 tumors implanted in athymic mice: a model to study the tumoristatic action of tamoxifen. J Steroid Biochem (1988) 1.19
Human mast cell tryptase activates single-chain urinary-type plasminogen activator (pro-urokinase). J Biol Chem (1994) 1.19
Studies on the mechanism of action of the nonsteroidal antioestrogen tamoxifen (I.C.I. 46,474) in the rat. Mol Cell Endocrinol (1977) 1.18
Mobilization of the A-kinase N-myristate through an isoform-specific intermolecular switch. Proc Natl Acad Sci U S A (1999) 1.18
Inhibition of tamoxifen-stimulated growth of an MCF-7 tumor variant in athymic mice by novel steroidal antiestrogens. Cancer Res (1989) 1.17
Esophageal acid sensitivity in Barrett's esophagus. J Clin Gastroenterol (1987) 1.17
Mammalian tissue trypsin-like enzymes. Comparative reactivities of human skin tryptase, human lung tryptase, and bovine trypsin with peptide 4-nitroanilide and thioester substrates. J Biol Chem (1983) 1.16
Evidence for the metabolic activation of non-steroidal antioestrogens: a study of structure-activity relationships. Br J Pharmacol (1980) 1.16
Increasing the number of tandem estrogen response elements increases the estrogenic activity of a tamoxifen analogue. Cancer Lett (1995) 1.16
Structure-activity relationships of estrogens. Environ Health Perspect (1985) 1.15
Long-acting tranquillizers. Practitioner (1972) 1.14
Stimulation of breast cancer cells in vitro by the environmental estrogen enterolactone and the phytoestrogen equol. Breast Cancer Res Treat (1987) 1.13
Post-natal reduction of neural unit size in the rabbit ciliary ganglion. J Physiol (1981) 1.13
Human pituitary tryptase: molecular forms, NH2-terminal sequence, immunocytochemical localization, and specificity with prohormone and fluorogenic substrates. J Biol Chem (1987) 1.13
Synthesis of F-pilin polypeptide in the absence of F traJ product. Plasmid (1984) 1.12
The preparation and structure of hetacillin. J Org Chem (1966) 1.12
Tamoxifen as an anti-tumour agent: oestrogen binding as a predictive test for tumour response. J Endocrinol (1976) 1.12
Molecular cloning, expression, and characterization of endo-beta-1,4-glucanase genes from Bacillus polymyxa and Bacillus circulans. J Bacteriol (1990) 1.12