Published in Cancer Cell on October 30, 2014
A RASopathy gene commonly mutated in cancer: the neurofibromatosis type 1 tumour suppressor. Nat Rev Cancer (2015) 1.40
Surgical management of giant neurofibroma in soft tissue: a single-center retrospective analysis. Int J Clin Exp Med (2015) 0.95
A novel genomic alteration of LSAMP associates with aggressive prostate cancer in African American men. EBioMedicine (2015) 0.91
RASopathies: unraveling mechanisms with animal models. Dis Model Mech (2015) 0.84
Identification of hair shaft progenitors that create a niche for hair pigmentation. Genes Dev (2017) 0.82
Insertional Mutagenesis Identifies a STAT3/Arid1b/β-catenin Pathway Driving Neurofibroma Initiation. Cell Rep (2016) 0.80
NOTCH1 and SOX10 are Essential for Proliferation and Radiation Resistance of Cancer Stem-Like Cells in Adenoid Cystic Carcinoma. Clin Cancer Res (2016) 0.77
NF GEMMs already! The power and promise of mouse tumor models. Cancer Cell (2014) 0.75
The role of nerve microenvironment for neurofibroma development. Oncotarget (2016) 0.75
EGFR-Stat3 signalling in nerve glial cells modifies neurofibroma initiation. Oncogene (2016) 0.75
Spatially- and temporally-controlled postnatal p53 knockdown cooperates with embryonic Schwann cell precursor Nf1 gene loss to promote malignant peripheral nerve sheath tumor formation. Oncotarget (2016) 0.75
Human stem cell modeling in neurofibromatosis type 1 (NF1). Exp Neurol (2017) 0.75
Stem cells, cancer, and cancer stem cells. Nature (2001) 50.27
Human acute myeloid leukemia is organized as a hierarchy that originates from a primitive hematopoietic cell. Nat Med (1997) 32.63
Crypt stem cells as the cells-of-origin of intestinal cancer. Nature (2008) 11.66
A restricted cell population propagates glioblastoma growth after chemotherapy. Nature (2012) 8.88
Identification of a cell of origin for human prostate cancer. Science (2010) 6.33
The origin and development of glial cells in peripheral nerves. Nat Rev Neurosci (2005) 5.59
The neurofibromatosis type 1 gene encodes a protein related to GAP. Cell (1990) 5.24
Neurofibromas in NF1: Schwann cell origin and role of tumor environment. Science (2002) 5.08
Malignant peripheral nerve sheath tumours in neurofibromatosis 1. J Med Genet (2002) 5.06
Malignant astrocytomas originate from neural stem/progenitor cells in a somatic tumor suppressor mouse model. Cancer Cell (2009) 4.82
Ablation of NF1 function in neurons induces abnormal development of cerebral cortex and reactive gliosis in the brain. Genes Dev (2001) 4.68
The NF1 locus encodes a protein functionally related to mammalian GAP and yeast IRA proteins. Cell (1990) 4.12
NF1 tumor suppressor gene function: narrowing the GAP. Cell (2001) 4.11
Krox-20 controls myelination in the peripheral nervous system. Nature (1994) 4.04
Mouse models of tumor development in neurofibromatosis type 1. Science (1999) 3.40
Mouse tumor model for neurofibromatosis type 1. Science (1999) 2.89
Nf1-dependent tumors require a microenvironment containing Nf1+/-- and c-kit-dependent bone marrow. Cell (2008) 2.84
Loss of the normal NF1 allele from the bone marrow of children with type 1 neurofibromatosis and malignant myeloid disorders. N Engl J Med (1994) 2.81
Clinical and genetic aspects of neurofibromatosis 1. Genet Med (2010) 2.77
Schwann cell-derived Desert hedgehog controls the development of peripheral nerve sheaths. Neuron (1999) 2.50
CT imaging in adults with neurofibromatosis-1: frequent asymptomatic plexiform lesions. Neurology (1998) 2.32
Cell of origin and microenvironment contribution for NF1-associated dermal neurofibromas. Cell Stem Cell (2009) 2.12
Metabolites, pharmacodynamics, and pharmacokinetics of tamoxifen in rats and mice compared to the breast cancer patient. Drug Metab Dispos (1991) 2.04
Tumor microenvironment and neurofibromatosis type I: connecting the GAPs. Oncogene (2007) 1.97
Plexiform and dermal neurofibromas and pigmentation are caused by Nf1 loss in desert hedgehog-expressing cells. Cancer Cell (2008) 1.86
Tamoxifen-inducible glia-specific Cre mice for somatic mutagenesis in oligodendrocytes and Schwann cells. Mol Cell Neurosci (2003) 1.84
MEK inhibition exhibits efficacy in human and mouse neurofibromatosis tumors. J Clin Invest (2012) 1.83
The loss of Nf1 transiently promotes self-renewal but not tumorigenesis by neural crest stem cells. Cancer Cell (2008) 1.54
Sustained MEK inhibition abrogates myeloproliferative disease in Nf1 mutant mice. J Clin Invest (2012) 1.52
Induction of abnormal proliferation by nonmyelinating schwann cells triggers neurofibroma formation. Cancer Cell (2008) 1.46
Development of the Schwann cell lineage: from the neural crest to the myelinated nerve. Glia (2008) 1.42
Neurofibromatosis 1: from lab bench to clinic. Pediatr Neurol (2005) 1.40
Neurofibromatosis 1. Eur J Hum Genet (2006) 1.40
Neurofibromatosis type 1 - a model for nervous system tumour formation? Nat Rev Cancer (2005) 1.33
Inducible site-specific recombination in neural stem/progenitor cells. Genesis (2009) 1.31
ERK inhibition rescues defects in fate specification of Nf1-deficient neural progenitors and brain abnormalities. Cell (2012) 1.18
The boundary cap: a source of neural crest stem cells that generate multiple sensory neuron subtypes. Development (2005) 1.17
Nf1 mutation expands an EGFR-dependent peripheral nerve progenitor that confers neurofibroma tumorigenic potential. Cell Stem Cell (2008) 1.15
Tumor-initiating and -propagating cells: cells that we would like to identify and control. Neoplasia (2010) 1.11
Normal hematopoiesis and neurofibromin-deficient myeloproliferative disease require Erk. J Clin Invest (2012) 1.10
Susceptible stages in Schwann cells for NF1-associated plexiform neurofibroma development. Cancer Res (2011) 1.05
Neurofibromin is required for barrel formation in the mouse somatosensory cortex. J Neurosci (2008) 1.03
BET bromodomain inhibition triggers apoptosis of NF1-associated malignant peripheral nerve sheath tumors through Bim induction. Cell Rep (2013) 1.01
NF-κB forms a complex with the chromatin remodeler BRG1 to regulate Schwann cell differentiation. J Neurosci (2013) 0.98
Perinatal or adult Nf1 inactivation using tamoxifen-inducible PlpCre each cause neurofibroma formation. Cancer Res (2011) 0.98
Novel features of boundary cap cells revealed by the analysis of newly identified molecular markers. Glia (2009) 0.95
Neurofibromin modulates adult hippocampal neurogenesis and behavioral effects of antidepressants. J Neurosci (2012) 0.92
Skin-derived precursors as a source of progenitors for cutaneous nerve regeneration. Stem Cells (2012) 0.91
Schwann cell preparation from single mouse embryos: analyses of neurofibromin function in Schwann cells. Methods Enzymol (2006) 0.90
Rodent sensory neuron culture and analysis. Curr Protoc Neurosci (2006) 0.88
Preclinical therapeutic efficacy of a novel pharmacologic inducer of apoptosis in malignant peripheral nerve sheath tumors. Cancer Res (2013) 0.81
Neuroscience. Following the same nerve track toward different cell fates. Science (2014) 0.77