Published in J Gen Physiol on June 01, 2006
Structure and hydration of membranes embedded with voltage-sensing domains. Nature (2009) 2.15
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07
Stretch-activated ion channels: what are they? Physiology (Bethesda) (2010) 1.85
Mechanosensitivity of Nav1.5, a voltage-sensitive sodium channel. J Physiol (2010) 1.58
Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophys J (2007) 1.44
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Effects of GsMTx4 on bacterial mechanosensitive channels in inside-out patches from giant spheroplasts. Biophys J (2010) 1.06
Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents. Biophys J (2010) 1.04
Mechanosensitivity of ion channels based on protein-lipid interactions. J R Soc Interface (2010) 1.02
Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation. Biophys J (2006) 1.02
The contribution of individual subunits to the coupling of the voltage sensor to pore opening in Shaker K channels: effect of ILT mutations in heterotetramers. J Gen Physiol (2010) 0.99
Voltage-gated channel mechanosensitivity: fact or friction? Front Physiol (2011) 0.93
Targeting ion channels for the treatment of gastrointestinal motility disorders. Therap Adv Gastroenterol (2012) 0.92
Role of the Fourth Transmembrane α Helix in the Allosteric Modulation of Pentameric Ligand-Gated Ion Channels. Structure (2015) 0.82
Mechanosensitive gating of Kv channels. PLoS One (2015) 0.76
The Hv1 proton channel responds to mechanical stimuli. J Gen Physiol (2016) 0.76
The role of stretch-activated ion channels in acute respiratory distress syndrome: finally a new target? Am J Physiol Lung Cell Mol Physiol (2016) 0.75
Molecular Mechanoneurobiology: An Emerging Angle to Explore Neural Synaptic Functions. Biomed Res Int (2015) 0.75
Crystal structure of a mammalian voltage-dependent Shaker family K+ channel. Science (2005) 17.70
Voltage sensor of Kv1.2: structural basis of electromechanical coupling. Science (2005) 7.82
Shaker potassium channel gating. II: Transitions in the activation pathway. J Gen Physiol (1994) 4.98
TRPC1 forms the stretch-activated cation channel in vertebrate cells. Nat Cell Biol (2005) 3.92
Shaker potassium channel gating. I: Transitions near the open state. J Gen Physiol (1994) 3.48
Mutations in the S4 region isolate the final voltage-dependent cooperative step in potassium channel activation. J Gen Physiol (1999) 3.42
Energetics of pore opening in a voltage-gated K(+) channel. Cell (2002) 3.36
Gating of Shaker K+ channels: I. Ionic and gating currents. Biophys J (1994) 3.28
Gating charge displacement in voltage-gated ion channels involves limited transmembrane movement. Nature (2005) 2.98
Calibrated measurement of gating-charge arginine displacement in the KvAP voltage-dependent K+ channel. Cell (2005) 2.97
Uncharged S4 residues and cooperativity in voltage-dependent potassium channel activation. J Gen Physiol (1998) 2.59
Mechanosensitive ion channels: molecules of mechanotransduction. J Cell Sci (2004) 2.58
Activation of shaker potassium channels. I. Characterization of voltage-dependent transitions. J Gen Physiol (1998) 2.49
Intracellular gate opening in Shaker K+ channels defined by high-affinity metal bridges. Nature (2004) 2.42
Role of the S4 in cooperativity of voltage-dependent potassium channel activation. J Gen Physiol (1998) 2.31
Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys J (2004) 2.30
The cooperative voltage sensor motion that gates a potassium channel. J Gen Physiol (2005) 1.89
Regulation of sodium channel function by bilayer elasticity: the importance of hydrophobic coupling. Effects of Micelle-forming amphiphiles and cholesterol. J Gen Physiol (2004) 1.83
Membrane-protein interactions in mechanosensitive channels. Biophys J (2004) 1.78
The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers. Biophys J (2004) 1.69
Mechanosensitive ion channels in nonspecialized cells. Rev Physiol Biochem Pharmacol (1998) 1.61
Calcium channel currents recorded from isolated myocytes of rat basilar artery are stretch sensitive. J Physiol (1993) 1.48
Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers. Mol Pharmacol (2003) 1.42
Fast gating in the Shaker K+ channel and the energy landscape of activation. Proc Natl Acad Sci U S A (2003) 1.39
Modulation of the Shaker K(+) channel gating kinetics by the S3-S4 linker. J Gen Physiol (2000) 1.37
Stretch-activation and stretch-inactivation of Shaker-IR, a voltage-gated K+ channel. Biophys J (2001) 1.33
Mechanosensitivity of N-type calcium channel currents. Biophys J (2002) 1.24
Status of the intracellular gate in the activated-not-open state of shaker K+ channels. J Gen Physiol (2005) 1.23
Voltage-gated ion channels. IEEE Trans Nanobioscience (2005) 1.22
Lysophosphatidic acid-operated K+ channels. J Biol Chem (2004) 1.19
Size distribution of barrel-stave aggregates of membrane peptides: influence of the bilayer lateral pressure profile. Biophys J (2002) 1.17
Mechanosensitive channels: what can we learn from 'simple' model systems? Trends Neurosci (2004) 1.14
Molecular features of an alcohol binding site in a neuronal potassium channel. Biochemistry (2003) 1.07
Cholesterol inhibits spontaneous action potentials and calcium currents in guinea pig gallbladder smooth muscle. Am J Physiol (1999) 1.07
Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys J (2002) 1.05
Channels in microbes: so many holes to fill. Mol Microbiol (2004) 1.05
Anesthetic potency of two novel synthetic polyhydric alkanols longer than the n-alkanol cutoff: evidence for a bilayer-mediated mechanism of anesthesia? J Med Chem (2005) 1.04
Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate. Am J Physiol Cell Physiol (2003) 1.03
FMRFamide and membrane stretch as activators of the Aplysia S-channel. Biophys J (1994) 1.02
Hydrophobic mutations alter the movement of Mg2+ in the pore of voltage-gated potassium channels. Biophys J (1996) 0.94
Heterologously expressed fungal transient receptor potential channels retain mechanosensitivity in vitro and osmotic response in vivo. Eur Biophys J (2005) 0.94
Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel. J Gen Physiol (2004) 0.93
Structure and anticipatory movements of the S6 gate in Kv channels. J Gen Physiol (2005) 0.91
Activity regulation of the betaine transporter BetP of Corynebacterium glutamicum in response to osmotic compensation. Biochim Biophys Acta (2004) 0.86
Folding and stability of a primitive protein. J Mol Biol (2005) 0.81
How ion channels sense membrane potential. Proc Natl Acad Sci U S A (2005) 0.79
Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophys J (2007) 1.44
Mechanosensitivity of N-type calcium channel currents. Biophys J (2002) 1.24
Membrane trauma and Na+ leak from Nav1.6 channels. Am J Physiol Cell Physiol (2009) 1.12
Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys J (2002) 1.05
Modulation of KvAP unitary conductance and gating by 1-alkanols and other surface active agents. Biophys J (2010) 1.04
Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation. Biophys J (2006) 1.02
Impaired stretch modulation in potentially lethal cardiac sodium channel mutants. Channels (Austin) (2010) 0.98
Studying the mechanosensitivity of voltage-gated channels using oocyte patches. Methods Mol Biol (2006) 0.93
Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel. J Gen Physiol (2004) 0.93
Coupled left-shift of Nav channels: modeling the Na⁺-loading and dysfunctional excitability of damaged axons. J Comput Neurosci (2012) 0.92
Mechanosensitive closed-closed transitions in large membrane proteins: osmoprotection and tension damping. Biophys J (2009) 0.85
Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps. PLoS Comput Biol (2012) 0.85
Force spectroscopy measurements show that cortical neurons exposed to excitotoxic agonists stiffen before showing evidence of bleb damage. PLoS One (2013) 0.83
Stimulation-induced ectopicity and propagation windows in model damaged axons. J Comput Neurosci (2014) 0.82
Perturbed voltage-gated channel activity in perturbed bilayers: implications for ectopic arrhythmias arising from damaged membrane. Prog Biophys Mol Biol (2012) 0.78
Dissemination of a Child Passenger Safety Program Through Trauma Center-Community Partnerships. J Trauma Nurs (2017) 0.75