Published in Biophys J on March 03, 2010
Phytochemicals perturb membranes and promiscuously alter protein function. ACS Chem Biol (2014) 1.39
Functional reconstitution of a voltage-gated potassium channel in giant unilamellar vesicles. PLoS One (2011) 1.13
Alcohol's effects on lipid bilayer properties. Biophys J (2011) 0.99
Changes in single K(+) channel behavior induced by a lipid phase transition. Biophys J (2010) 0.95
Short-chain phosphoinositide partitioning into plasma membrane models. Biophys J (2013) 0.94
Cholesterol tuning of BK ethanol response is enantioselective, and is a function of accompanying lipids. PLoS One (2011) 0.94
Voltage-gated channel mechanosensitivity: fact or friction? Front Physiol (2011) 0.93
Coupled left-shift of Nav channels: modeling the Na⁺-loading and dysfunctional excitability of damaged axons. J Comput Neurosci (2012) 0.92
Left-shifted nav channels in injured bilayer: primary targets for neuroprotective nav antagonists? Front Pharmacol (2012) 0.87
Molecular mapping of general anesthetic sites in a voltage-gated ion channel. Biophys J (2011) 0.86
Distinct sensitivity of slo1 channel proteins to ethanol. Mol Pharmacol (2012) 0.86
Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps. PLoS Comput Biol (2012) 0.85
A synthetic S6 segment derived from KvAP channel self-assembles, permeabilizes lipid vesicles, and exhibits ion channel activity in bilayer lipid membrane. J Biol Chem (2011) 0.80
Reconstitution of a transmembrane protein, the voltage-gated ion channel, KvAP, into giant unilamellar vesicles for microscopy and patch clamp studies. J Vis Exp (2015) 0.79
Volatile anesthetics inhibit sodium channels without altering bulk lipid bilayer properties. J Gen Physiol (2014) 0.78
Fluorescence anisotropy of diphenylhexatriene and its cationic Trimethylamino derivative in liquid dipalmitoylphosphatidylcholine liposomes: opposing responses to isoflurane. BMC Biophys (2012) 0.77
Mechanosensitive gating of Kv channels. PLoS One (2015) 0.76
Open-state stabilization in Kv channels: voltage-sensor relaxation and pore propping by a bound ion. J Gen Physiol (2012) 0.76
High-Throughput Simulations Reveal Membrane-Mediated Effects of Alcohols on MscL Gating. J Am Chem Soc (2017) 0.75
bSUM: A bead-supported unilamellar membrane system facilitating unidirectional insertion of membrane proteins into giant vesicles. J Gen Physiol (2016) 0.75
Control of ion selectivity in potassium channels by electrostatic and dynamic properties of carbonyl ligands. Nature (2004) 4.37
Phospholipids and the origin of cationic gating charges in voltage sensors. Nature (2006) 3.99
Bilayer thickness and membrane protein function: an energetic perspective. Annu Rev Biophys Biomol Struct (2007) 3.52
Energetics of pore opening in a voltage-gated K(+) channel. Cell (2002) 3.36
Structure of the KvAP voltage-dependent K+ channel and its dependence on the lipid membrane. Proc Natl Acad Sci U S A (2005) 3.25
S4-based voltage sensors have three major conformations. Proc Natl Acad Sci U S A (2008) 3.21
Lipid composition and the lateral pressure profile in bilayers. Biophys J (1999) 3.04
Emerging molecular mechanisms of general anesthetic action. Trends Pharmacol Sci (2005) 2.91
Molecular driving forces determining potassium channel slow inactivation. Nat Struct Mol Biol (2007) 2.56
Lipid bilayer pressure profiles and mechanosensitive channel gating. Biophys J (2004) 2.30
Dynamics of the Kv1.2 voltage-gated K+ channel in a membrane environment. Biophys J (2007) 2.10
Voltage-dependent K+ channel gating and voltage sensor toxin sensitivity depend on the mechanical state of the lipid membrane. Proc Natl Acad Sci U S A (2008) 2.07
Lateral pressure profile, spontaneous curvature frustration, and the incorporation and conformation of proteins in membranes. Biophys J (2007) 1.90
The organization of n-alkanes in lipid bilayers. Biochim Biophys Acta (1980) 1.86
Membrane-protein interactions in mechanosensitive channels. Biophys J (2004) 1.78
A putative cation channel and its novel regulator: cross-species conservation of effects on general anesthesia. Curr Biol (2007) 1.70
The influence of short-chain alcohols on interfacial tension, mechanical properties, area/molecule, and permeability of fluid lipid bilayers. Biophys J (2004) 1.69
Tarantula toxins interact with voltage sensors within lipid membranes. J Gen Physiol (2007) 1.58
The essence of being extremophilic: the role of the unique archaeal membrane lipids. Extremophiles (1998) 1.50
Involvement of lipid rafts and caveolae in cardiac ion channel function. Cardiovasc Res (2006) 1.48
Nuclear Overhauser enhancement spectroscopy cross-relaxation rates and ethanol distribution across membranes. Biophys J (2002) 1.43
Effects of membrane lipids on ion channel structure and function. Cell Biochem Biophys (2003) 1.43
Cholesterol antagonizes ethanol potentiation of human brain BKCa channels reconstituted into phospholipid bilayers. Mol Pharmacol (2003) 1.42
Localization of the voltage-sensor toxin receptor on KvAP. Biochemistry (2004) 1.42
The thickness, composition and structure of some lipid bilayers and natural membranes. J Membr Biol (1971) 1.32
A gating model for the archeal voltage-dependent K(+) channel KvAP in DPhPC and POPE:POPG decane lipid bilayers. J Mol Biol (2009) 1.32
Physico-chemical correlates of alcohol intoxication. Neuropharmacology (1978) 1.29
Large-scale molecular dynamics simulations of general anesthetic effects on the ion channel in the fully hydrated membrane: the implication of molecular mechanisms of general anesthesia. Proc Natl Acad Sci U S A (2002) 1.29
The interaction of n-octanol with black lipid bilayer membranes. Biochim Biophys Acta (1979) 1.26
CaM kinase II phosphorylation of slo Thr107 regulates activity and ethanol responses of BK channels. Nat Neurosci (2005) 1.25
Regulation of the gating of BKCa channel by lipid bilayer thickness. J Biol Chem (2007) 1.20
The role of multiple hydrogen-bonding groups in specific alcohol binding sites in proteins: insights from structural studies of LUSH. J Mol Biol (2008) 1.15
Optical and electrical properties of thin monoolein lipid bilayers. J Membr Biol (1985) 1.15
Cholesterol modifies the gating of Kv1.3 in human T lymphocytes. Pflugers Arch (2003) 1.09
Propofol block of I(h) contributes to the suppression of neuronal excitability and rhythmic burst firing in thalamocortical neurons. Eur J Neurosci (2006) 1.06
Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys J (2002) 1.05
Effect of n-alcohols on the structure and stability of the Drosophila odorant binding protein LUSH. Biochemistry (2006) 1.04
Acute alcohol tolerance is intrinsic to the BKCa protein, but is modulated by the lipid environment. J Biol Chem (2007) 1.04
Membrane stretch slows the concerted step prior to opening in a Kv channel. J Gen Physiol (2006) 1.04
Partitioning of anesthetics into a lipid bilayer and their interaction with membrane-bound peptide bundles. Biophys J (2006) 1.03
Allosteric modulation of a neuronal K+ channel by 1-alkanols is linked to a key residue in the activation gate. Am J Physiol Cell Physiol (2003) 1.03
The concerted contribution of the S4-S5 linker and the S6 segment to the modulation of a Kv channel by 1-alkanols. Mol Pharmacol (2006) 1.01
Determinants of the anesthetic sensitivity of two-pore domain acid-sensitive potassium channels: molecular cloning of an anesthetic-activated potassium channel from Lymnaea stagnalis. J Biol Chem (2007) 0.95
Lateral pressure profiles in cholesterol-DPPC bilayers. Eur Biophys J (2005) 0.93
Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel. J Gen Physiol (2004) 0.93
Lipid stress at play: mechanosensitivity of voltage-gated channels. Curr Top Membr (2007) 0.91
Gating kinetics of Shaker K+ channels are differentially modified by general anesthetics. Am J Physiol (1998) 0.91
Alcohols reduce lateral membrane pressures: predictions from molecular theory. Biophys J (2006) 0.83
Molecular dynamics simulations of C2F6 effects on gramicidin A: implications of the mechanisms of general anesthesia. Biophys J (2005) 0.83
The influence of 1-alkanols and external pressure on the lateral pressure profiles of lipid bilayers. Biophys J (2008) 0.83
Modulation of two cloned potassium channels by 1-alkanols demonstrates different cutoffs. Alcohol Clin Exp Res (1997) 0.82
Packing properties of 1-alkanols and alkanes in a phospholipid membrane. Biophys Chem (2005) 0.82
The effect of benzyl alcohol and cholesterol on the acyl chain order and alkane solubility of bimolecular phosphatidylcholine membranes. Biochim Biophys Acta (1986) 0.82
Greasing the gears of potassium channels. Nat Chem Biol (2006) 0.81
The influence of n-alkanols on the capacity per unit area of planar lipid bilayers. Biochim Biophys Acta (1984) 0.79
Inorganic polyphosphate modulates TRPM8 channels. PLoS One (2009) 1.64
High sensitivity, quantitative measurements of polyphosphate using a new DAPI-based approach. J Fluoresc (2008) 1.49
Structure/function characterization of micro-conotoxin KIIIA, an analgesic, nearly irreversible blocker of mammalian neuronal sodium channels. J Biol Chem (2007) 1.48
Nav channel mechanosensitivity: activation and inactivation accelerate reversibly with stretch. Biophys J (2007) 1.44
Targeted polyphosphatase expression alters mitochondrial metabolism and inhibits calcium-dependent cell death. Proc Natl Acad Sci U S A (2007) 1.38
A large, voltage-dependent channel, isolated from mitochondria by water-free chloroform extraction. Biophys J (2005) 1.38
Electrostatic and steric contributions to block of the skeletal muscle sodium channel by mu-conotoxin. J Gen Physiol (2002) 1.33
Gating transitions in the selectivity filter region of a sodium channel are coupled to the domain IV voltage sensor. Proc Natl Acad Sci U S A (2012) 1.28
The pore, not cytoplasmic domains, underlies inactivation in a prokaryotic sodium channel. Biophys J (2005) 1.25
Mechanosensitivity of N-type calcium channel currents. Biophys J (2002) 1.24
Osmotic adjustment in chickpea (Cicer arietinum L.) results in no yield benefit under terminal drought. J Exp Bot (2006) 1.13
Membrane trauma and Na+ leak from Nav1.6 channels. Am J Physiol Cell Physiol (2009) 1.12
Synergistic and antagonistic interactions between tetrodotoxin and mu-conotoxin in blocking voltage-gated sodium channels. Channels (Austin) (2009) 1.11
Docking of mu-conotoxin GIIIA in the sodium channel outer vestibule. Channels (Austin) (2007) 1.07
Membrane stretch accelerates activation and slow inactivation in Shaker channels with S3-S4 linker deletions. Biophys J (2002) 1.05
Membrane stretch slows the concerted step prior to opening in a Kv channel. J Gen Physiol (2006) 1.04
Dual stretch responses of mHCN2 pacemaker channels: accelerated activation, accelerated deactivation. Biophys J (2006) 1.02
Enhanced neuronal damage after ischemic insults in mice lacking Kir6.2-containing ATP-sensitive K+ channels. J Neurophysiol (2005) 1.00
Impaired stretch modulation in potentially lethal cardiac sodium channel mutants. Channels (Austin) (2010) 0.98
Studying the mechanosensitivity of voltage-gated channels using oocyte patches. Methods Mol Biol (2006) 0.93
State-dependent inhibition of cystic fibrosis transmembrane conductance regulator chloride channels by a novel peptide toxin. J Biol Chem (2007) 0.93
Membrane tension accelerates rate-limiting voltage-dependent activation and slow inactivation steps in a Shaker channel. J Gen Physiol (2004) 0.93
Novel interactions identified between micro -Conotoxin and the Na+ channel domain I P-loop: implications for toxin-pore binding geometry. Biophys J (2003) 0.92
Coupled left-shift of Nav channels: modeling the Na⁺-loading and dysfunctional excitability of damaged axons. J Comput Neurosci (2012) 0.92
Sodium channel selectivity and conduction: prokaryotes have devised their own molecular strategy. J Gen Physiol (2014) 0.91
Multiple, distributed interactions of μ-conotoxin PIIIA associated with broad targeting among voltage-gated sodium channels. Biochemistry (2010) 0.89
A high-conductance mode of a poly-3-hydroxybutyrate/calcium/polyphosphate channel isolated from competent Escherichia coli cells. FEBS Lett (2005) 0.88
Conotoxins as sensors of local pH and electrostatic potential in the outer vestibule of the sodium channel. J Gen Physiol (2003) 0.87
Conotoxins targeting neuronal voltage-gated sodium channel subtypes: potential analgesics? Toxins (Basel) (2012) 0.87
Isolation and characterization of a high affinity peptide inhibitor of ClC-2 chloride channels. J Biol Chem (2009) 0.86
Mechanosensitive closed-closed transitions in large membrane proteins: osmoprotection and tension damping. Biophys J (2009) 0.85
Spontaneous excitation patterns computed for axons with injury-like impairments of sodium channels and Na/K pumps. PLoS Comput Biol (2012) 0.85
Involvement of hippocampal CA3 K(ATP) channels in contextual memory. Neuropharmacology (2008) 0.84
Force spectroscopy measurements show that cortical neurons exposed to excitotoxic agonists stiffen before showing evidence of bleb damage. PLoS One (2013) 0.83
Dicarba α-conotoxin Vc1.1 analogues with differential selectivity for nicotinic acetylcholine and GABAB receptors. ACS Chem Biol (2013) 0.82
Stimulation-induced ectopicity and propagation windows in model damaged axons. J Comput Neurosci (2014) 0.82
Differential Cav2.1 and Cav2.3 channel inhibition by baclofen and α-conotoxin Vc1.1 via GABAB receptor activation. J Gen Physiol (2014) 0.81
Cardioselectivity of the sulphonylurea HMR 1098: studies on native and recombinant cardiac and pancreatic K(ATP) channels. Br J Pharmacol (2002) 0.80
Inhibition of a cardiac sarcoplasmic reticulum chloride channel by tamoxifen. Pflugers Arch (2008) 0.79
Trans-channel interactions in batrachotoxin-modified rat skeletal muscle sodium channels: kinetic analysis of mutual inhibition between mu-conotoxin GIIIA derivatives and amine blockers. Biophys J (2008) 0.78
Perturbed voltage-gated channel activity in perturbed bilayers: implications for ectopic arrhythmias arising from damaged membrane. Prog Biophys Mol Biol (2012) 0.78
ω-Conotoxin GVIA mimetics that bind and inhibit neuronal Ca(v)2.2 ion channels. Mar Drugs (2012) 0.78
A method for identifying viable and damaged neurons in adult mouse brain slices. Acta Histochem (2009) 0.78
Block of Kv1.7 potassium currents increases glucose-stimulated insulin secretion. EMBO Mol Med (2012) 0.78
Open-state stabilization in Kv channels: voltage-sensor relaxation and pore propping by a bound ion. J Gen Physiol (2012) 0.76
Dissemination of a Child Passenger Safety Program Through Trauma Center-Community Partnerships. J Trauma Nurs (2017) 0.75