Published in Appl Environ Microbiol on June 01, 2006
Impaired insulin/IGF1 signaling extends life span by promoting mitochondrial L-proline catabolism to induce a transient ROS signal. Cell Metab (2012) 2.43
Progress in metabolic engineering of Saccharomyces cerevisiae. Microbiol Mol Biol Rev (2008) 2.27
Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic Biol Med (2007) 1.54
Plant L10 ribosomal proteins have different roles during development and translation under ultraviolet-B stress. Plant Physiol (2010) 1.16
Regulation and function of proline oxidase under nutrient stress. J Cell Biochem (2009) 1.06
Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free Radic Biol Med (2012) 1.02
Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress. Infect Immun (2008) 0.98
Multiple abiotic stress responsive rice cyclophilin: (OsCYP-25) mediates a wide range of cellular responses. Commun Integr Biol (2013) 0.92
Actions of a proline analogue, L-thiazolidine-4-carboxylic acid (T4C), on Trypanosoma cruzi. PLoS One (2009) 0.89
Proline dehydrogenase regulates redox state and respiratory metabolism in Trypanosoma cruzi. PLoS One (2013) 0.87
Up-regulation of antioxidant and glyoxalase systems by exogenous glycinebetaine and proline in mung bean confer tolerance to cadmium stress. Physiol Mol Biol Plants (2010) 0.87
Proline biosynthesis is required for endoplasmic reticulum stress tolerance in Saccharomyces cerevisiae. J Biol Chem (2014) 0.85
Reactive oxygen species homeostasis and virulence of the fungal pathogen Cryptococcus neoformans requires an intact proline catabolism pathway. Genetics (2013) 0.84
Role of proline and pyrroline-5-carboxylate metabolism in plant defense against invading pathogens. Front Plant Sci (2015) 0.80
The Involvement of Glutamate Metabolism in the Resistance to Thermal, Nutritional, and Oxidative Stress in Trypanosoma cruzi. Enzyme Res (2011) 0.77
Connecting proline metabolism and signaling pathways in plant senescence. Front Plant Sci (2015) 0.76
Identification and expression analysis of QM-like gene from Spodoptera litura after challenge by the entomopathogenic fungus Nomuraea rileyi. J Insect Sci (2014) 0.75
Δ(1)-pyrroline-5-carboxylate/glutamate biogenesis is required for fungal virulence and sporulation. PLoS One (2013) 0.75
Reactive oxygen species: metabolism, oxidative stress, and signal transduction. Annu Rev Plant Biol (2004) 18.76
Living with water stress: evolution of osmolyte systems. Science (1982) 17.27
Oxygen stress: a regulator of apoptosis in yeast. J Cell Biol (1999) 4.76
Proline over-production results in enhanced osmotolerance in Salmonella typhimurium. Mol Gen Genet (1981) 3.85
Role of oxygen radicals in DNA damage and cancer incidence. Mol Cell Biochem (2004) 3.54
Interactions among members of the Bcl-2 protein family analyzed with a yeast two-hybrid system. Proc Natl Acad Sci U S A (1994) 3.26
Inhibition of proline oxidation by water stress. Plant Physiol (1977) 3.17
Bax inhibitor-1, a mammalian apoptosis suppressor identified by functional screening in yeast. Mol Cell (1998) 3.09
Proapoptotic protein Bax heterodimerizes with Bcl-2 and homodimerizes with Bax via a novel domain (BH3) distinct from BH1 and BH2. J Biol Chem (1996) 2.79
Structure-function analysis of Bcl-2 protein. Identification of conserved domains important for homodimerization with Bcl-2 and heterodimerization with Bax. J Biol Chem (1995) 2.35
Antisense suppression of proline degradation improves tolerance to freezing and salinity in Arabidopsis thaliana. FEBS Lett (1999) 2.24
Oxidative stress is involved in heat-induced cell death in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1996) 2.20
Proline oxidase, encoded by p53-induced gene-6, catalyzes the generation of proline-dependent reactive oxygen species. Cancer Res (2001) 2.05
Osmoregulation in Klebsiella pneumoniae: enhancement of anaerobic growth and nitrogen fixation under stress by proline betaine, gamma-butyrobetaine, and other related compounds. Can J Microbiol (1984) 1.93
Proline utilization in Saccharomyces cerevisiae: sequence, regulation, and mitochondrial localization of the PUT1 gene product. Mol Cell Biol (1987) 1.89
Salt tolerance in plants and microorganisms: toxicity targets and defense responses. Int Rev Cytol (1996) 1.77
Removal of feedback inhibition of delta(1)-pyrroline-5-carboxylate synthetase results in increased proline accumulation and protection of plants from osmotic stress. Plant Physiol (2000) 1.77
Osmoprotective compounds in the Plumbaginaceae: a natural experiment in metabolic engineering of stress tolerance. Proc Natl Acad Sci U S A (1994) 1.73
Differential gene expression in p53-mediated apoptosis-resistant vs. apoptosis-sensitive tumor cell lines. Proc Natl Acad Sci U S A (2000) 1.72
Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii. Proc Natl Acad Sci U S A (2005) 1.70
Role of mitochondria and C-terminal membrane anchor of Bcl-2 in Bax induced growth arrest and mortality in Saccharomyces cerevisiae. FEBS Lett (1996) 1.59
The p53-induced gene-6 (proline oxidase) mediates apoptosis through a calcineurin-dependent pathway. J Biol Chem (2005) 1.58
Redox properties of the PutA protein from Escherichia coli and the influence of the flavin redox state on PutA-DNA interactions. Biochemistry (2001) 1.48
Proline utilization in Saccharomyces cerevisiae: analysis of the cloned PUT1 gene. Mol Cell Biol (1986) 1.48
Proline accumulates in plants exposed to UV radiation and protects them against UV induced peroxidation. Biochem Biophys Res Commun (1995) 1.44
Ageing, oxidative stress, and mitochondrial uncoupling. Acta Physiol Scand (2004) 1.42
Molecular mechanisms of proline-mediated tolerance to toxic heavy metals in transgenic microalgae. Plant Cell (2002) 1.40
Proline: an essential intermediate in arginine degradation in Saccharomyces cerevisiae. J Bacteriol (1980) 1.40
MnSOD inhibits proline oxidase-induced apoptosis in colorectal cancer cells. Carcinogenesis (2005) 1.39
Metabolic engineering of osmoprotectant accumulation in plants. Metab Eng (2002) 1.34
Subcellular compartmentation in control of converging pathways for proline and arginine metabolism in Saccharomyces cerevisiae. J Bacteriol (1981) 1.33
Role of the yeast acetyltransferase Mpr1 in oxidative stress: regulation of oxygen reactive species caused by a toxic proline catabolism intermediate. Proc Natl Acad Sci U S A (2004) 1.33
Catalytic transfer of hydride ions from NADPH to oxygen by the interconversions of proline and delta 1-pyrroline-5-carboxylate. Arch Biochem Biophys (1986) 1.32
Proline accumulation and AtP5CS2 gene activation are induced by plant-pathogen incompatible interactions in Arabidopsis. Mol Plant Microbe Interact (2004) 1.29
Evolutionally conserved plant homologue of the Bax inhibitor-1 (BI-1) gene capable of suppressing Bax-induced cell death in yeast(1). FEBS Lett (1999) 1.23
Drosophila pro-apoptotic Bcl-2/Bax homologue reveals evolutionary conservation of cell death mechanisms. J Biol Chem (2000) 1.15
Proline accumulation by mutation or disruption of the proline oxidase gene improves resistance to freezing and desiccation stresses in Saccharomyces cerevisiae. FEMS Microbiol Lett (2000) 1.12
Suppression of tumorigenicity in Wilms tumor by the p15.5-p14 region of chromosome 11. Science (1991) 1.09
A Jun-binding protein related to a putative tumor suppressor. Proc Natl Acad Sci U S A (1993) 1.09
L-proline accumulation and freeze tolerance of Saccharomyces cerevisiae are caused by a mutation in the PRO1 gene encoding gamma-glutamyl kinase. Appl Environ Microbiol (2003) 1.07
Tomato phospholipid hydroperoxide glutathione peroxidase inhibits cell death induced by Bax and oxidative stresses in yeast and plants. Plant Physiol (2004) 1.04
Gene dosage effect of L-proline biosynthetic enzymes on L-proline accumulation and freeze tolerance in Saccharomyces cerevisiae. Appl Environ Microbiol (2003) 0.99
Growth-related gene expression in Nicotiana tabacum mesophyll protoplasts. Plant J (1993) 0.98
Mammalian prion protein suppresses Bax-induced cell death in yeast. J Biol Chem (2005) 0.97
Extreme evolutionary conservation of QM, a novel c-Jun associated transcription factor. Hum Mol Genet (1994) 0.93
Ribosomal protein L9 is the product of GRC5, a homolog of the putative tumor suppressor QM in S. cerevisiae. Yeast (1997) 0.88
Suppression in mitochondrial electron transport is the prime cause behind stress induced proline accumulation. Biochem Biophys Res Commun (1993) 0.88
QM, a putative tumor suppressor, regulates proto-oncogene c-yes. J Biol Chem (2002) 0.87
A novel mouse gene highly conserved throughout evolution: regulation in adipocyte differentiation and in tumorigenic cell lines. Biochem Biophys Res Commun (1993) 0.83
Lifestyle transitions in plant pathogenic Colletotrichum fungi deciphered by genome and transcriptome analyses. Nat Genet (2012) 2.92
Pseudomonas type III effector AvrPtoB induces plant disease susceptibility by inhibition of host programmed cell death. EMBO J (2003) 2.48
Identification of Pseudomonas syringae type III effectors that can suppress programmed cell death in plants and yeast. Plant J (2004) 1.86
Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein. Nat Struct Biol (2003) 1.76
Proline suppresses apoptosis in the fungal pathogen Colletotrichum trifolii. Proc Natl Acad Sci U S A (2005) 1.70
Tipping the balance: Sclerotinia sclerotiorum secreted oxalic acid suppresses host defenses by manipulating the host redox environment. PLoS Pathog (2011) 1.55
Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic Biol Med (2007) 1.54
Oxalic acid is an elicitor of plant programmed cell death during Sclerotinia sclerotiorum disease development. Mol Plant Microbe Interact (2008) 1.53
Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus. J Biol Chem (2007) 1.44
Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors. Biochemistry (2004) 1.41
Identification and functional characterization of the BAG protein family in Arabidopsis thaliana. J Biol Chem (2006) 1.34
Flavin redox state triggers conformational changes in the PutA protein from Escherichia coli. Biochemistry (2003) 1.28
Identification and characterization of the DNA-binding domain of the multifunctional PutA flavoenzyme. J Biol Chem (2004) 1.25
Dominant active Rac and dominant negative Rac revert the dominant active Ras phenotype in Colletotrichum trifolii by distinct signalling pathways. Mol Microbiol (2004) 1.23
Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA. J Mol Biol (2008) 1.22
Redox-induced changes in flavin structure and roles of flavin N(5) and the ribityl 2'-OH group in regulating PutA--membrane binding. Biochemistry (2007) 1.21
Cell death control: the interplay of apoptosis and autophagy in the pathogenicity of Sclerotinia sclerotiorum. PLoS Pathog (2013) 1.20
Effects of proline analog binding on the spectroscopic and redox properties of PutA. Arch Biochem Biophys (2002) 1.20
Regulation of PutA-membrane associations by flavin adenine dinucleotide reduction. Biochemistry (2004) 1.17
Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16
The unfolded protein response is triggered by a plant viral movement protein. Plant Physiol (2011) 1.14
Electrochemical and functional characterization of the proline dehydrogenase domain of the PutA flavoprotein from Escherichia coli. Biochemistry (2002) 1.13
The dawn of fungal pathogen genomics. Annu Rev Phytopathol (2006) 1.12
Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli. Arch Biochem Biophys (2011) 1.10
Bcl-2 family members localize to tobacco chloroplasts and inhibit programmed cell death induced by chloroplast-targeted herbicides. J Exp Bot (2004) 1.09
Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition. Protein Sci (2006) 1.08
Programmed cell death occurs asymmetrically during abscission in tomato. Plant Cell (2011) 1.07
Proline mechanisms of stress survival. Antioxid Redox Signal (2013) 1.06
Oxygen reactivity of PutA from Helicobacter species and proline-linked oxidative stress. J Bacteriol (2006) 1.06
Characterization of a bifunctional PutA homologue from Bradyrhizobium japonicum and identification of an active site residue that modulates proline reduction of the flavin adenine dinucleotide cofactor. Biochemistry (2005) 1.06
Apoptosis-related genes confer resistance to Fusarium wilt in transgenic 'Lady Finger' bananas. Plant Biotechnol J (2011) 1.06
Tomato phospholipid hydroperoxide glutathione peroxidase inhibits cell death induced by Bax and oxidative stresses in yeast and plants. Plant Physiol (2004) 1.04
Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress. Cell Health Cytoskelet (2012) 1.04
Probing a hydrogen bond pair and the FAD redox properties in the proline dehydrogenase domain of Escherichia coli PutA. Biochim Biophys Acta (2004) 1.03
Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free Radic Biol Med (2012) 1.02
AtBAG7, an Arabidopsis Bcl-2-associated athanogene, resides in the endoplasmic reticulum and is involved in the unfolded protein response. Proc Natl Acad Sci U S A (2010) 1.01
A secretory protein of necrotrophic fungus Sclerotinia sclerotiorum that suppresses host resistance. PLoS One (2013) 1.01
The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction. Biochemistry (2010) 1.00
Direct linking of metabolism and gene expression in the proline utilization A protein from Escherichia coli. Amino Acids (2008) 0.98
Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress. Infect Immun (2008) 0.98
The three-dimensional structural basis of type II hyperprolinemia. J Mol Biol (2012) 0.96
Exploring the proline-dependent conformational change in the multifunctional PutA flavoprotein by tryptophan fluorescence spectroscopy. Biochemistry (2005) 0.95
Purification and characterization of Put1p from Saccharomyces cerevisiae. Arch Biochem Biophys (2010) 0.95
Identification and characterization of Sclerotinia sclerotiorum NADPH oxidases. Appl Environ Microbiol (2011) 0.95
Rapid reaction kinetics of proline dehydrogenase in the multifunctional proline utilization A protein. Biochemistry (2011) 0.95
Substrate channeling in proline metabolism. Front Biosci (Landmark Ed) (2012) 0.94
MAPK regulation of sclerotial development in Sclerotinia sclerotiorum is linked with pH and cAMP sensing. Mol Plant Microbe Interact (2004) 0.93
Bcl-2 family members inhibit oxidative stress-induced programmed cell death in Saccharomyces cerevisiae. Free Radic Biol Med (2003) 0.93
Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc Natl Acad Sci U S A (2014) 0.92
Proline reverses the abnormal phenotypes of Colletotrichum trifolii associated with expression of endogenous constitutively active Ras. Appl Environ Microbiol (2002) 0.91
A CDC42 homologue in Claviceps purpurea is involved in vegetative differentiation and is essential for pathogenicity. Eukaryot Cell (2005) 0.91
Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate. J Biol Chem (2010) 0.90
Pseudomonas syringae Catalases Are Collectively Required for Plant Pathogenesis. J Bacteriol (2012) 0.88
Functional analysis of Ras in Colletotrichum trifolii. FEMS Microbiol Lett (2003) 0.88
Cdc42 is required for proper growth and development in the fungal pathogen Colletotrichum trifolii. Eukaryot Cell (2006) 0.87
Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release. Biochemistry (2012) 0.87
cAMP blocks MAPK activation and sclerotial development via Rap-1 in a PKA-independent manner in Sclerotinia sclerotiorum. Mol Microbiol (2005) 0.86
Colletotrichum trifolii TB3 kinase, a COT1 homolog, is light inducible and becomes localized in the nucleus during hyphal elongation. Eukaryot Cell (2002) 0.86
Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state. Biochemistry (2014) 0.85
Solution structure of the Pseudomonas putida protein PpPutA45 and its DNA complex. Proteins (2009) 0.84
Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA). J Biol Chem (2013) 0.84
Abiotic stress induces apoptotic-like features in tobacco that is inhibited by expression of human Bcl-2. Biotechnol Lett (2004) 0.83
Involvement of the β3-α3 loop of the proline dehydrogenase domain in allosteric regulation of membrane association of proline utilization A. Biochemistry (2013) 0.83
Small-angle X-ray scattering studies of the oligomeric state and quaternary structure of the trifunctional proline utilization A (PutA) flavoprotein from Escherichia coli. J Biol Chem (2011) 0.82
Kinetic and thermodynamic analysis of Bradyrhizobium japonicum PutA-membrane associations. Arch Biochem Biophys (2005) 0.82
TGBp3 triggers the unfolded protein response and SKP1-dependent programmed cell death. Mol Plant Pathol (2013) 0.81
Tripping on acid: trans-kingdom perspectives on biological acids in immunity and pathogenesis. PLoS Pathog (2013) 0.80
Inhibition of Agrobacterium-induced cell death by antiapoptotic gene expression leads to very high transformation efficiency of banana. Mol Plant Microbe Interact (2007) 0.79
SGT1 is induced by the potato virus X TGBp3 and enhances virus accumulation in Nicotiana benthamiana. Mol Plant (2012) 0.79
Evidence that the C-terminal domain of a type B PutA protein contributes to aldehyde dehydrogenase activity and substrate channeling. Biochemistry (2014) 0.79
Kinetic and structural characterization of tunnel-perturbing mutants in Bradyrhizobium japonicum proline utilization A. Biochemistry (2014) 0.78
Synthesis of (R)- and (S)-10,16-dihydroxyhexadecanoic acid: cutin stereochemistry and fungal activation. Phytochemistry (2003) 0.76
Cautionary tale of using tris(alkyl)phosphine reducing agents with NAD-dependent enzymes. Biochemistry (2020) 0.75