Substrate channeling in proline metabolism.

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Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16

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Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition. Protein Sci (2006) 1.08

The PutA protein of Salmonella typhimurium catalyzes the two steps of proline degradation via a leaky channel. Arch Biochem Biophys (1998) 1.07

The PUA domain - a structural and functional overview. FEBS J (2007) 1.05

The small subunit of carbamoyl phosphate synthetase: snapshots along the reaction pathway. Biochemistry (1999) 1.04

Control of expression of divergent Pseudomonas putida put promoters for proline catabolism. Appl Environ Microbiol (2000) 1.02

Inborn errors of proline metabolism. J Nutr (2008) 1.01

Dual role for the glutamine phosphoribosylpyrophosphate amidotransferase ammonia channel. Interdomain signaling and intermediate channeling. J Biol Chem (2000) 1.01

The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction. Biochemistry (2010) 1.00

Aquifex aeolicus aspartate transcarbamoylase, an enzyme specialized for the efficient utilization of unstable carbamoyl phosphate at elevated temperature. J Biol Chem (2003) 0.97

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A compelling genetic hypothesis for a complex disease: PRODH2/DGCR6 variation leads to schizophrenia susceptibility. Proc Natl Acad Sci U S A (2002) 0.93

Inhibition of Escherichia coli CTP synthase by glutamate gamma-semialdehyde and the role of the allosteric effector GTP in glutamine hydrolysis. Biochem J (2001) 0.93

Pyridoxal phosphate de-activation by pyrroline-5-carboxylic acid. Increased risk of vitamin B6 deficiency and seizures in hyperprolinemia type II. J Biol Chem (2000) 0.91

A novel, definitive test for substrate channeling illustrated with the aspartate aminotransferase/malate dehydrogenase system. Biochemistry (1999) 0.88

Pyrroline-5-carboxylate synthase and proline biosynthesis: from osmotolerance to rare metabolic disease. Protein Sci (2010) 0.88

Dissection of Escherichia coli glutamate 5-kinase: functional impact of the deletion of the PUA domain. FEBS Lett (2005) 0.87

Crystal structure of gamma-glutamyl phosphate reductase (TM0293) from Thermotoga maritima at 2.0 A resolution. Proteins (2004) 0.87

Mapping active site residues in glutamate-5-kinase. The substrate glutamate and the feed-back inhibitor proline bind at overlapping sites. FEBS Lett (2006) 0.85

Solution structure of the Pseudomonas putida protein PpPutA45 and its DNA complex. Proteins (2009) 0.84

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Directed evolution of an artificial bifunctional enzyme, gamma-glutamyl kinase/gamma-glutamyl phosphate reductase, for improved osmotic tolerance of Escherichia coli transformants. FEMS Microbiol Lett (2006) 0.79

Substrate channelling in an engineered bifunctional aldolase/kinase enzyme confers catalytic advantage for C-C bond formation. Chem Commun (Camb) (2009) 0.79

Kinetic evidence for channeling of dopamine between monoamine transporter and membranous dopamine-beta-monooxygenase in chromaffin granule ghosts. J Biol Chem (2004) 0.78

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Structure of the proline dehydrogenase domain of the multifunctional PutA flavoprotein. Nat Struct Biol (2003) 1.76

Proline modulates the intracellular redox environment and protects mammalian cells against oxidative stress. Free Radic Biol Med (2007) 1.54

Structure and kinetics of monofunctional proline dehydrogenase from Thermus thermophilus. J Biol Chem (2007) 1.44

Structures of the Escherichia coli PutA proline dehydrogenase domain in complex with competitive inhibitors. Biochemistry (2004) 1.41

Flavin redox state triggers conformational changes in the PutA protein from Escherichia coli. Biochemistry (2003) 1.28

Identification and characterization of the DNA-binding domain of the multifunctional PutA flavoenzyme. J Biol Chem (2004) 1.25

Structural basis of the transcriptional regulation of the proline utilization regulon by multifunctional PutA. J Mol Biol (2008) 1.22

Redox-induced changes in flavin structure and roles of flavin N(5) and the ribityl 2'-OH group in regulating PutA--membrane binding. Biochemistry (2007) 1.21

Effects of proline analog binding on the spectroscopic and redox properties of PutA. Arch Biochem Biophys (2002) 1.20

Regulation of PutA-membrane associations by flavin adenine dinucleotide reduction. Biochemistry (2004) 1.17

Crystal structure of the bifunctional proline utilization A flavoenzyme from Bradyrhizobium japonicum. Proc Natl Acad Sci U S A (2010) 1.16

Electrochemical and functional characterization of the proline dehydrogenase domain of the PutA flavoprotein from Escherichia coli. Biochemistry (2002) 1.13

Steady-state kinetic mechanism of the proline:ubiquinone oxidoreductase activity of proline utilization A (PutA) from Escherichia coli. Arch Biochem Biophys (2011) 1.10

Crystal structures of the DNA-binding domain of Escherichia coli proline utilization A flavoprotein and analysis of the role of Lys9 in DNA recognition. Protein Sci (2006) 1.08

Proline mechanisms of stress survival. Antioxid Redox Signal (2013) 1.06

Oxygen reactivity of PutA from Helicobacter species and proline-linked oxidative stress. J Bacteriol (2006) 1.06

Characterization of a bifunctional PutA homologue from Bradyrhizobium japonicum and identification of an active site residue that modulates proline reduction of the flavin adenine dinucleotide cofactor. Biochemistry (2005) 1.06

Role of apoptosis-inducing factor, proline dehydrogenase, and NADPH oxidase in apoptosis and oxidative stress. Cell Health Cytoskelet (2012) 1.04

Probing a hydrogen bond pair and the FAD redox properties in the proline dehydrogenase domain of Escherichia coli PutA. Biochim Biophys Acta (2004) 1.03

Tomato QM-like protein protects Saccharomyces cerevisiae cells against oxidative stress by regulating intracellular proline levels. Appl Environ Microbiol (2006) 1.02

Proline dehydrogenase is essential for proline protection against hydrogen peroxide-induced cell death. Free Radic Biol Med (2012) 1.02

The structure of the proline utilization a proline dehydrogenase domain inactivated by N-propargylglycine provides insight into conformational changes induced by substrate binding and flavin reduction. Biochemistry (2010) 1.00

Direct linking of metabolism and gene expression in the proline utilization A protein from Escherichia coli. Amino Acids (2008) 0.98

Characterization of a Helicobacter hepaticus putA mutant strain in host colonization and oxidative stress. Infect Immun (2008) 0.98

The three-dimensional structural basis of type II hyperprolinemia. J Mol Biol (2012) 0.96

Rapid reaction kinetics of proline dehydrogenase in the multifunctional proline utilization A protein. Biochemistry (2011) 0.95

Exploring the proline-dependent conformational change in the multifunctional PutA flavoprotein by tryptophan fluorescence spectroscopy. Biochemistry (2005) 0.95

Purification and characterization of Put1p from Saccharomyces cerevisiae. Arch Biochem Biophys (2010) 0.95

Structures of the PutA peripheral membrane flavoenzyme reveal a dynamic substrate-channeling tunnel and the quinone-binding site. Proc Natl Acad Sci U S A (2014) 0.92

Identification and characterization of oxalate oxidoreductase, a novel thiamine pyrophosphate-dependent 2-oxoacid oxidoreductase that enables anaerobic growth on oxalate. J Biol Chem (2010) 0.90

Pseudomonas syringae Catalases Are Collectively Required for Plant Pathogenesis. J Bacteriol (2012) 0.88

Crystal structures and kinetics of monofunctional proline dehydrogenase provide insight into substrate recognition and conformational changes associated with flavin reduction and product release. Biochemistry (2012) 0.87

Structural studies of yeast Δ(1)-pyrroline-5-carboxylate dehydrogenase (ALDH4A1): active site flexibility and oligomeric state. Biochemistry (2014) 0.85

Evidence for hysteretic substrate channeling in the proline dehydrogenase and Δ1-pyrroline-5-carboxylate dehydrogenase coupled reaction of proline utilization A (PutA). J Biol Chem (2013) 0.84

Solution structure of the Pseudomonas putida protein PpPutA45 and its DNA complex. Proteins (2009) 0.84

Involvement of the β3-α3 loop of the proline dehydrogenase domain in allosteric regulation of membrane association of proline utilization A. Biochemistry (2013) 0.83

Kinetic and thermodynamic analysis of Bradyrhizobium japonicum PutA-membrane associations. Arch Biochem Biophys (2005) 0.82

Small-angle X-ray scattering studies of the oligomeric state and quaternary structure of the trifunctional proline utilization A (PutA) flavoprotein from Escherichia coli. J Biol Chem (2011) 0.82

Evidence that the C-terminal domain of a type B PutA protein contributes to aldehyde dehydrogenase activity and substrate channeling. Biochemistry (2014) 0.79

Kinetic and structural characterization of tunnel-perturbing mutants in Bradyrhizobium japonicum proline utilization A. Biochemistry (2014) 0.78

Discovery of the Membrane Binding Domain in Trifunctional Proline Utilization A. Biochemistry (2017) 0.75

Cautionary tale of using tris(alkyl)phosphine reducing agents with NAD-dependent enzymes. Biochemistry (2020) 0.75