Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder.

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Published in Br J Pharmacol on June 05, 2006

Authors

Paul Abrams1, Karl-Erik Andersson, Jerry J Buccafusco, Christopher Chapple, William Chet de Groat, Alison D Fryer, Gary Kay, Alan Laties, Neil M Nathanson, Pankaj Jay Pasricha, Alan J Wein

Author Affiliations

1: Bristol Urological Institute, Southmead Hospital, Westbury-on-Trym, Bristol BS10 5NB. paul_abrams@bui.ac.uk

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Protective effect of a β3-adrenoceptor agonist on bladder function in a rat model of chronic bladder ischemia. Eur Urol (2013) 1.39

Association between utility and treatment among patients with prostate cancer. Qual Life Res (2010) 1.39

Images in clinical medicine. Eosinophilic esophagitis. N Engl J Med (2007) 1.38

Multi-functional drugs for various CNS targets in the treatment of neurodegenerative disorders. Trends Pharmacol Sci (2005) 1.35

Diabetes induces sex-dependent changes in neuronal nitric oxide synthase dimerization and function in the rat gastric antrum. Am J Physiol Gastrointest Liver Physiol (2007) 1.35

Neural stem cell transplantation in the stomach rescues gastric function in neuronal nitric oxide synthase-deficient mice. Gastroenterology (2005) 1.29

Obstruction-induced changes in urinary bladder smooth muscle contractility: a role for Rho kinase. Am J Physiol Renal Physiol (2003) 1.27

Simultaneous registration of intraabdominal and intravesical pressures during cystometry in conscious rats--effects of bladder outlet obstruction and intravesical PGE2. Neurourol Urodyn (2008) 1.26

Bladder afferent signaling: recent findings. J Urol (2010) 1.25

Quantitative analysis of muscarinic acetylcholine receptor homo- and heterodimerization in live cells: regulation of receptor down-regulation by heterodimerization. J Biol Chem (2005) 1.24

Enhanced excitability and suppression of A-type K+ current of pancreas-specific afferent neurons in a rat model of chronic pancreatitis. Am J Physiol Gastrointest Liver Physiol (2006) 1.23

Contemporary management of lower urinary tract disease with botulinum toxin A: a systematic review of botox (onabotulinumtoxinA) and dysport (abobotulinumtoxinA). Eur Urol (2011) 1.23

Human bladder as a novel target for vitamin D receptor ligands. J Clin Endocrinol Metab (2004) 1.22

Autoimmunity in Alzheimer's disease: increased levels of circulating IgGs binding Abeta and RAGE peptides. Neurobiol Aging (2004) 1.22

Characterization of urine-derived stem cells obtained from upper urinary tract for use in cell-based urological tissue engineering. Tissue Eng Part A (2011) 1.21

CYP3A4, CYP3A5, and CYP3A43 genotypes and haplotypes in the etiology and severity of prostate cancer. Cancer Res (2004) 1.21

Detrusor overactivity is associated with downregulation of large-conductance calcium- and voltage-activated potassium channel protein. Am J Physiol Renal Physiol (2010) 1.21

A mutation in the inner mitochondrial membrane peptidase 2-like gene (Immp2l) affects mitochondrial function and impairs fertility in mice. Biol Reprod (2007) 1.20

Pharmacological treatment of overactive bladder: report from the International Consultation on Incontinence. Curr Opin Urol (2009) 1.19

Increased connexin43-mediated intercellular communication in a rat model of bladder overactivity in vivo. Am J Physiol Regul Integr Comp Physiol (2003) 1.19

Cisplatin-induced hair cell death requires STAT1 and is attenuated by epigallocatechin gallate. J Neurosci (2009) 1.18

Characteristics of patients presenting with LUTS/BPH in six European countries. Eur Urol (2006) 1.17

Chronic, intermittent exposure to chlorpyrifos in rats: protracted effects on axonal transport, neurotrophin receptors, cholinergic markers, and information processing. J Pharmacol Exp Ther (2007) 1.17

A systematic review of the efficacy of domperidone for the treatment of diabetic gastroparesis. Clin Gastroenterol Hepatol (2008) 1.16

Intravesical adenosine triphosphate stimulates the micturition reflex in awake, freely moving rats. J Urol (2002) 1.15

Antimuscarinic drugs in detrusor overactivity and the overactive bladder syndrome: motor or sensory actions? BJU Int (2006) 1.15

Pharmacological characterization of a novel investigational antimuscarinic drug, fesoterodine, in vitro and in vivo. BJU Int (2008) 1.15

Origins and patterns of spontaneous and drug-induced canine gastric myoelectrical dysrhythmia. Dig Dis Sci (2003) 1.13

Increased basal phosphorylation of detrusor smooth muscle myosin in alloxan-induced diabetic rabbit is mediated by upregulation of Rho-kinase beta and CPI-17. Am J Physiol Renal Physiol (2005) 1.12

Diabetes induced decrease in detrusor smooth muscle force is associated with oxidative stress and overactivity of aldose reductase. J Urol (2005) 1.12

Endorectal T2-weighted MRI does not differentiate between favorable and adverse pathologic features in men with prostate cancer who would qualify for active surveillance. Urol Oncol (2012) 1.12

Patient-reported outcomes in overactive bladder: importance for determining clinical effectiveness of treatment. Urology (2006) 1.12

The role of the rhabdosphincter in female rat voiding. BJU Int (2004) 1.11

Management of lower urinary tract symptoms in men: summary of NICE guidance. BMJ (2010) 1.09

Detrusor responses to prostaglandin E2 and bladder outlet obstruction in wild-type and Ep1 receptor knockout mice. J Urol (2004) 1.09

Nerve growth factor modulates TRPV1 expression and function and mediates pain in chronic pancreatitis. Gastroenterology (2011) 1.08

Benign prostatic hyperplasia in primary care: what you need to know. J Urol (2006) 1.08

Chlorpyrifos, chlorpyrifos-oxon, and diisopropylfluorophosphate inhibit kinesin-dependent microtubule motility. Toxicol Appl Pharmacol (2006) 1.07

Experimental colitis triggers the release of substance P and calcitonin gene-related peptide in the urinary bladder via TRPV1 signaling pathways. Exp Neurol (2010) 1.07

Diagnosis and reconstruction of the dorsal or circumferential urethral diverticulum. J Urol (2003) 1.07

A review of adherence to drug therapy in patients with overactive bladder. BJU Int (2008) 1.06