Published in Pharmacol Res on September 01, 2001
Location, location, location...site-specific GPCR phosphorylation offers a mechanism for cell-type-specific signalling. Trends Pharmacol Sci (2008) 2.03
Muscarinic receptors: their distribution and function in body systems, and the implications for treating overactive bladder. Br J Pharmacol (2006) 1.94
Muscarinic receptors and ligands in cancer. Am J Physiol Cell Physiol (2008) 1.42
Bile acid-induced arrhythmia is mediated by muscarinic M2 receptors in neonatal rat cardiomyocytes. PLoS One (2010) 1.15
Dysautonomia due to reduced cholinergic neurotransmission causes cardiac remodeling and heart failure. Mol Cell Biol (2010) 1.12
Muscarinic regulation of cardiac ion channels. Br J Pharmacol (2003) 1.12
Myths and realities of the cardiac vagus. J Physiol (2013) 1.09
Caveolae create local signalling domains through their distinct protein content, lipid profile and morphology. J Mol Cell Cardiol (2011) 1.05
Nerves Regulate Cardiomyocyte Proliferation and Heart Regeneration. Dev Cell (2015) 1.04
Functional M3 muscarinic acetylcholine receptors in mammalian hearts. Br J Pharmacol (2004) 1.01
The safety and tolerability of donepezil in patients with Alzheimer's disease. Br J Clin Pharmacol (2004) 0.97
Non-neuronal cholinergic machinery present in cardiomyocytes offsets hypertrophic signals. J Mol Cell Cardiol (2012) 0.95
Mechanisms underlying the autonomic modulation of ventricular fibrillation initiation--tentative prophylactic properties of vagus nerve stimulation on malignant arrhythmias in heart failure. Heart Fail Rev (2013) 0.88
Abundance, distribution, mobility and oligomeric state of M₂ muscarinic acetylcholine receptors in live cardiac muscle. J Mol Cell Cardiol (2013) 0.88
Cardiac effects of muscarinic receptor antagonists used for voiding dysfunction. Br J Clin Pharmacol (2011) 0.87
Existence of functional M3-muscarinic receptors in the human heart. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.87
Demonstration of functional M3-muscarinic receptors in ventricular cardiomyocytes of adult rats. Br J Pharmacol (2003) 0.87
The role of G protein coupled receptor kinases in neurocardiovascular pathophysiology. Arch Med Sci (2012) 0.87
In vivo and in vitro pharmacological characterization of SVT-40776, a novel M3 muscarinic receptor antagonist, for the treatment of overactive bladder. Br J Pharmacol (2009) 0.87
Functional M3 cholinoreceptors are present in pacemaker and working myocardium of murine heart. Pflugers Arch (2012) 0.86
Opposing cardiac effects of autoantibody activation of β-adrenergic and M2 muscarinic receptors in cardiac-related diseases. Int J Cardiol (2010) 0.85
Organophosphorus pesticides decrease M2 muscarinic receptor function in guinea pig airway nerves via indirect mechanisms. PLoS One (2010) 0.85
In Vitro and In Vivo Assessments of Cardiovascular Effects with Omadacycline. Antimicrob Agents Chemother (2016) 0.84
Genetic disruption of G proteins, G(i2)alpha or G(o)alpha, does not abolish inotropic and chronotropic effects of stimulating muscarinic cholinoceptors in atrium. Br J Pharmacol (2009) 0.84
Age-associated abnormalities of intrinsic automaticity of sinoatrial nodal cells are linked to deficient cAMP-PKA-Ca(2+) signaling. Am J Physiol Heart Circ Physiol (2014) 0.83
Effects of acetylcholinesterase inhibitor paraoxon denote the possibility of non-quantal acetylcholine release in myocardium of different vertebrates. J Comp Physiol B (2011) 0.83
The cholinomimetic agent bethanechol activates IK(ACh) in feline atrial myocytes. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.79
M3 muscarinic receptors mediate positive inotropic responses in mouse atria: a study with muscarinic receptor knockout mice. J Pharmacol Exp Ther (2009) 0.78
Muscarinic 2 receptors modulate cardiac proteasome function in a protein kinase G-dependent manner. J Mol Cell Cardiol (2014) 0.78
Activation of muscarinic receptors elicits inotropic responses in ventricular muscle from rats with heart failure through myosin light chain phosphorylation. Br J Pharmacol (2009) 0.77
Role of hyperglycaemia in the pathogenesis of hypotension observed in type-1 diabetic rats. Int J Exp Pathol (2008) 0.77
In vivo antimuscarinic actions of the third generation antihistaminergic agent, desloratadine. BMC Pharmacol (2005) 0.77
In vitro sensitivity of cholinesterases and [3H]oxotremorine-M binding in heart and brain of adult and aging rats to organophosphorus anticholinesterases. Biochem Pharmacol (2008) 0.77
The detection of the non-M2 muscarinic receptor subtype in the rat heart atria and ventricles. Naunyn Schmiedebergs Arch Pharmacol (2008) 0.77
Acute desensitization of acetylcholine and endothelin-1 activated inward rectifier K+ current in myocytes from the cardiac atrioventricular node. Biochem Biophys Res Commun (2012) 0.77
Gi proteins regulate adenylyl cyclase activity independent of receptor activation. PLoS One (2014) 0.76
Priming the proteasome by protein kinase G: a novel cardioprotective mechanism of sildenafil. Future Cardiol (2015) 0.75
Muscarinic Stimulation Facilitates Sarcoplasmic Reticulum Ca Release by Modulating Ryanodine Receptor 2 Phosphorylation Through Protein Kinase G and Ca/Calmodulin-Dependent Protein Kinase II. Hypertension (2016) 0.75
Cyclic AMP-dependent inotropic effects are differentially regulated by muscarinic G(i)-dependent constitutive inhibition of adenylyl cyclase in failing rat ventricle. Br J Pharmacol (2011) 0.75
Right Cervical Vagotomy Aggravates Viral Myocarditis in Mice Via the Cholinergic Anti-inflammatory Pathway. Front Pharmacol (2017) 0.75
Zebrafish heart as a model to study the integrative autonomic control of pacemaker function. Am J Physiol Heart Circ Physiol (2016) 0.75
Influence of age on inducibility and cholinergic modulation of arrhythmia in isolated rat right atria. Age (Dordr) (2008) 0.75
An inotropic action caused by muscarinic receptor subtype 3 in canine cardiac purkinje fibers. ISRN Pharmacol (2013) 0.75
Decrease in the Sensitivity of Myocardium to M3 Muscarinic Receptor Stimulation during Postnatal Ontogenisis. Acta Naturae (2016) 0.75
Nicotine effects on human endothelial intercellular communication via α4β2 and α3β2 nicotinic acetylcholine receptor subtypes. Naunyn Schmiedebergs Arch Pharmacol (2012) 0.75
Effects of atropine on human cardiac beta 1- and/or beta 2-adrenoceptor stimulation. Naunyn Schmiedebergs Arch Pharmacol (2003) 0.75
Endo- and exocytosis of vesicles in the intramural nerve fibers of the rat right atrium. Dokl Biol Sci (2009) 0.75
Seasonal changes of cholinergic response in the atrium of Arctic navaga cod (Eleginus navaga). J Comp Physiol B (2016) 0.75
Acetylcholine-induced suppression of electric activity of working myocardium of the cod atrium. Dokl Biol Sci (2008) 0.75
Effect of acetylcholine on the action potential in the bat atrium and ventricle. Dokl Biol Sci (2006) 0.75
Positive inotropic effects of the beta 2-adrenoceptor agonist terbutaline in the human heart: effects of long-term beta 1-adrenoceptor antagonist treatment. J Am Coll Cardiol (1994) 1.64
Sphingosine kinase-mediated Ca2+ signalling by G-protein-coupled receptors. EMBO J (1998) 1.41
Development of short-term myocardial hibernation. Its limitation by the severity of ischemia and inotropic stimulation. Circulation (1993) 1.41
On the presence and distribution of alpha-adrenoceptors in the heart of various mammalian species. Naunyn Schmiedebergs Arch Pharmacol (1978) 1.40
Terbutaline-induced desensitization of human lymphocyte beta 2-adrenoceptors. Accelerated restoration of beta-adrenoceptor responsiveness by prednisone and ketotifen. J Clin Invest (1985) 1.39
Coexistence of beta 1- and beta 2-adrenoceptors in human right atrium. Direct identification by (+/-)-[125I]iodocyanopindolol binding. Circ Res (1983) 1.32
Molecular diversity of sphingolipid signalling. FEBS Lett (1997) 1.31
Regulation of muscarinic acetylcholine receptor sequestration and function by beta-arrestin. J Biol Chem (1999) 1.29
[3H]idazoxan and some other alpha 2-adrenergic drugs also bind with high affinity to a nonadrenergic site. Mol Pharmacol (1989) 1.22
Activation of muscarinic K+ current in guinea-pig atrial myocytes by sphingosine-1-phosphate. J Physiol (1995) 1.22
In-vivo studies do not support a major functional role for the Gly389Arg beta 1-adrenoceptor polymorphism in humans. Pharmacogenetics (2001) 1.21
Selective regulation of beta 1- and beta 2-adrenoceptors in the human heart by chronic beta-adrenoceptor antagonist treatment. Br J Pharmacol (1988) 1.20
Regional distribution of beta-adrenoceptors in the human heart: coexistence of functional beta 1- and beta 2-adrenoceptors in both atria and ventricles in severe congestive cardiomyopathy. J Cardiovasc Pharmacol (1987) 1.14
Peripheral adrenergic receptors in hypertension. Hypertension (1990) 1.13
H1 - and H2-receptor mediated responses to histamine on contractility and cyclic AMP of atrial and papillary muscles from guinea-pig hearts. Agents Actions (1977) 1.11
The time course of the effects of beta- and alpha-adrenoceptor stimulation by isoprenaline and methoxamine on the contractile force and cAMP level of the isolated rabbit papillary muscle. Naunyn Schmiedebergs Arch Pharmacol (1975) 1.10
The beta-adrenergic receptor in human lymphocytes: subclassification by the use of a new radio-ligand, (+/-)-125 Iodocyanopindolol. Life Sci (1981) 1.09
Spare receptors for beta-adrenoceptor-mediated positive inotropic effects of catecholamines in the human heart. J Cardiovasc Pharmacol (1992) 1.08
Comparison of the positive inotropic effects of serotonin, histamine, angiotensin II, endothelin and isoprenaline in the isolated human right atrium. Naunyn Schmiedebergs Arch Pharmacol (1993) 1.05
Beta-adrenoceptor changes in human lymphocytes, induced by dynamic exercise. Naunyn Schmiedebergs Arch Pharmacol (1984) 1.05
Receptor subtype-specific regulation of muscarinic acetylcholine receptor sequestration by dynamin. Distinct sequestration of m2 receptors. J Biol Chem (1998) 1.04
Human beta-adrenoceptors: relation of myocardial and lymphocyte beta-adrenoceptor density. Science (1986) 1.03
Human myocardial beta-adrenoceptors: demonstration of both beta 1- and beta 2-adrenoceptors mediating contractile responses to beta-agonists on the isolated right atrium. Naunyn Schmiedebergs Arch Pharmacol (1986) 1.02
Expression, activity and functional significance of inducible nitric oxide synthase in the failing human heart. J Am Coll Cardiol (1998) 1.02
Muscarinic cholinoceptors in the human heart: demonstration, subclassification, and distribution. Naunyn Schmiedebergs Arch Pharmacol (1990) 1.00
Catecholamines increase lymphocyte beta 2-adrenergic receptors via a beta 2-adrenergic, spleen-dependent process. Am J Physiol (1990) 0.99
Alpha 1-adrenoceptor subtype affinities of drugs for the treatment of prostatic hypertrophy. Evidence for heterogeneity of chloroethylclonidine-resistant rat renal alpha 1-adrenoceptor. Naunyn Schmiedebergs Arch Pharmacol (1993) 0.99
Calcium signalling by G protein-coupled sphingolipid receptors in bovine aortic endothelial cells. Naunyn Schmiedebergs Arch Pharmacol (1996) 0.99
Formyl peptide receptor signaling in HL-60 cells through sphingosine kinase. J Biol Chem (1999) 0.98
Age-dependent changes in cardiac muscarinic receptor function in healthy volunteers. J Am Coll Cardiol (1997) 0.97
Essential role of dynamin in internalization of M2 muscarinic acetylcholine and angiotensin AT1A receptors. J Biol Chem (2000) 0.95
Chronic beta 1-adrenoceptor antagonist treatment sensitizes beta 2-adrenoceptors, but desensitizes M2-muscarinic receptors in the human right atrium. Br J Pharmacol (1990) 0.93
Beta-2 adrenoceptor-mediated relaxation of the isolated human saphenous vein. J Pharmacol Exp Ther (1987) 0.93
Arterial hypotension in chronic hemodialyzed patients. Kidney Int (1987) 0.93
Coexistence of beta 1- and beta 2-adrenoceptors in the rabbit heart: quantitative analysis of the regional distribution by (-)-3H-dihydroalprenolol binding. J Cardiovasc Pharmacol (1982) 0.92
Beta-adrenoceptor stimulation attenuates the hypertrophic effect of alpha-adrenoceptor stimulation in adult rat ventricular cardiomyocytes. J Am Coll Cardiol (2001) 0.91
The role of lactic acid in retinal neovascularization. Albrecht Von Graefes Arch Klin Exp Ophthalmol (1976) 0.91
In vitro and in vivo down-regulation of human platelet alpha 2-adrenoceptors by clonidine. Eur J Clin Pharmacol (1982) 0.90
Increased beta 2-adrenoreceptor density in heart, kidney and lung of spontaneously hypertensive rats. J Auton Pharmacol (1987) 0.90
The contribution of reactive oxygen species and p38 mitogen-activated protein kinase to myofilament oxidation and progression of heart failure in rabbits. Br J Pharmacol (2010) 0.90
Age-dependent decrease of alpha 2-adrenergic receptor number in human platelets. Eur J Pharmacol (1982) 0.89
Endothelin receptors in the failing and nonfailing human heart. Circulation (1998) 0.89
Human cardiac beta-adrenoceptors: both beta 1- and beta 2-adrenoceptors are functionally coupled to the adenylate cyclase in right atrium. J Cardiovasc Pharmacol (1985) 0.88
Distinct internalization of M2 muscarinic acetylcholine receptors confers selective and long-lasting desensitization of signaling to phospholipase C. J Neurochem (2000) 0.88
Vascular dopamine receptors: Demonstration and characterization by in vitro studies. Life Sci (1982) 0.88
Influence of adrenoceptor and muscarinic receptor blockade on the cardiovascular effects of exogenous noradrenaline and of endogenous noradrenaline released by infused tyramine. Naunyn Schmiedebergs Arch Pharmacol (1997) 0.88
Effects of beta-adrenoceptor antagonist administration on beta 2-adrenoceptor density in human lymphocytes. The role of the "intrinsic sympathomimetic activity". Naunyn Schmiedebergs Arch Pharmacol (1985) 0.87
Properties of alpha- and beta-adrenoceptors in circulating blood cells of patients with essential hypertension. J Cardiovasc Pharmacol (1985) 0.87
FP-receptor mediated trophic effects of prostanoids in rat ventricular cardiomyocytes. Br J Pharmacol (2000) 0.87
The role of cyclic AMP in the positive inotropic effect mediated by beta 1- and beta 2-adrenoceptors in isolated human right atrium. Naunyn Schmiedebergs Arch Pharmacol (1987) 0.87
Effects of thyroid hormone deficiency on pre- and postsynaptic noradrenergic mechanisms in the rat cerebral cortex. Arch Int Pharmacodyn Ther (1980) 0.87
Beta-adrenoceptor antagonists (non-selective as well as beta 1-selective) with partial agonistic activity decrease beta 2-adrenoceptor density in human lymphocytes. Evidence for a beta 2-agonistic component of the partial agonistic activity. Naunyn Schmiedebergs Arch Pharmacol (1986) 0.87
On the physiologic role of beta-2 adrenoceptors in the human heart: in vitro and in vivo studies. Am Heart J (1990) 0.86
Endogenous and exogenous regulation of human alpha- and beta-adrenergic receptors. J Recept Res (1983) 0.86
Endothelin ETA-receptors couple to inositol phosphate formation and inhibition of adenylate cyclase in human right atrium. J Cardiovasc Pharmacol (1994) 0.86
Guanine nucleotide-sensitive inhibition of L-type Ca2+ current by lysosphingolipids in RINm5F insulinoma cells. Mol Pharmacol (1998) 0.86
The beta-adrenoceptor subtype(s) mediating adrenaline- and dobutamine-induced blood pressure and heart rate changes in healthy volunteers. Int J Clin Pharmacol Ther (1995) 0.86
Bisoprolol (EMD 33512), a highly selective beta 1-adrenoceptor antagonist: in vitro and in vivo studies. J Cardiovasc Pharmacol (1986) 0.85
Renal alpha-adrenergic receptor alterations: a cause of essential hypertension? FASEB J (1989) 0.85
Frequency dependence of cyclic AMP in mammalian myocardium. Nature (1976) 0.85
Alpha- and beta-adrenoceptors in hypertension. II. Platelet alpha 2- and lymphocyte beta 2-adrenoceptors in children of parents with essential hypertension. A model for the pathogenesis of the genetically determined hypertension. J Cardiovasc Pharmacol (1989) 0.85
Tocolytic therapy with fenoterol induces selective down-regulation of beta-adrenergic receptors in human myometrium. J Clin Endocrinol Metab (1997) 0.85
Trophic effect of angiotensin II in neonatal rat cardiomyocytes: role of endothelin-1 and non-myocyte cells. Br J Pharmacol (1997) 0.85
The cardiac beta-adrenoceptor-G-protein(s)-adenylyl cyclase system in monocrotaline-treated rats. J Mol Cell Cardiol (2000) 0.84
Nitric oxide inhibits isoprenaline-induced positive inotropic effects in normal, but not in hypertrophied rat heart. Naunyn Schmiedebergs Arch Pharmacol (1998) 0.84
Stimulation of sphingosine-1-phosphate formation by the P2Y(2) receptor in HL-60 cells: Ca(2+) requirement and implication in receptor-mediated Ca(2+) mobilization, but not MAP kinase activation. Mol Pharmacol (2000) 0.84
Noradrenaline-induced increase in protein synthesis in adult rat cardiomyocytes: involvement of only alpha1A-adrenoceptors. Naunyn Schmiedebergs Arch Pharmacol (2001) 0.84
Chronic treatment with carbachol sensitizes the myocardium to cAMP-induced arrhythmia. Circulation (1996) 0.84
Cardiac beta-adrenoceptors in chronic uremia: studies in humans and rats. J Am Coll Cardiol (2000) 0.83
Myocardial and pulmonary uptake of S-1'-[18F]fluorocarazolol in intact rats reflects radioligand binding to beta-adrenoceptors. Eur J Pharmacol (1995) 0.83
Gq/11-coupled receptors and protein synthesis in rat cardiomyocytes: role of Gi-proteins and protein kinase C-isozymes. Naunyn Schmiedebergs Arch Pharmacol (1999) 0.83
Decreased responsiveness of the adenylate cyclase system on left atria from hypothyroid rats. Mol Pharmacol (1980) 0.83
Alpha and beta-adrenoceptors in hypertension. I. Cardiac and renal alpha 1-, beta 1-, and beta 2-adrenoceptors in rat models of acquired hypertension. J Cardiovasc Pharmacol (1989) 0.83
Alpha-adrenoceptor antagonistic action of amiloride. Biochem Pharmacol (1987) 0.83
Disease states can modify both receptor number and signal transduction pathways. Trends Pharmacol Sci (1989) 0.83
Lack of correlation between the positive inotropic effect evoked by alpha-adrenoceptor stimulation and the levels of cyclic AMP and/or cyclic GMP in the isolated ventricle strip of the rabbit. J Mol Cell Cardiol (1978) 0.83
Differential changes in lymphocyte beta 2-adrenoceptor density by beta-blocker administration: role of intrinsic sympathomimetic activity. J Cardiovasc Pharmacol (1986) 0.83
Cyclic AMP counteracts mitogen-induced inositol phosphate generation and increases in intracellular Ca2+ concentrations in human lymphocytes. Br J Pharmacol (1991) 0.83
Decreased myometrial beta-adrenoceptors in women receiving beta 2-adrenergic tocolytic therapy: correlation with lymphocyte beta-adrenoceptors. Clin Pharmacol Ther (1989) 0.82
Characterization of the muscarinic receptor in human tracheal smooth muscle. Naunyn Schmiedebergs Arch Pharmacol (1985) 0.82
No evidence for temperature-dependent changes in the pharmacological specificity of beta 1- and beta 2-adrenoceptors in rabbit lung membranes. Naunyn Schmiedebergs Arch Pharmacol (1983) 0.82
Demonstration of vascular dopamine receptors in membranes from rabbit renal artery using 3H-spiroperidol binding. Experientia (1981) 0.82
Identification of a homogeneous class of beta 2-adrenoceptors in human platelets by (-)-125I-iodopindolol binding. J Cyclic Nucleotide Protein Phosphor Res (1985) 0.81
Muscarinic receptors in the failing human heart. Eur J Pharmacol (1999) 0.81
GTP regulates binding of agonists to alpha 2-adrenergic receptors in human platelets. Arch Int Pharmacodyn Ther (1982) 0.81
Rapid and persistent desensitization of m3 muscarinic acetylcholine receptor-stimulated phospholipase D. Concomitant sensitization of phospholipase C. J Biol Chem (1995) 0.81
Influence of acetylcholine on the positive inotropic effect evoked by alpha- or beta-adrenoceptor stimulation in the rabbit heart. Naunyn Schmiedebergs Arch Pharmacol (1982) 0.80
Lymphocyte beta 2-adrenoceptors mirror precisely beta 2-adrenoceptor, but poorly beta 1-adrenoceptor changes in the human heart. J Hypertens Suppl (1986) 0.80
Changes in platelet alpha 2-adrenoceptors in human phaeochromocytoma. Eur J Clin Pharmacol (1984) 0.80
Dynamic exercise-induced increase in lymphocyte beta-2-adrenoceptors: abnormality in essential hypertension and its correction by antihypertensives. Clin Pharmacol Ther (1987) 0.80
Relationship between the level of cAMP and the contractile force under stimulation of alpha- and beta-adrenoceptors by phenylephrine in the isolated rabbit papillary muscle. Naunyn Schmiedebergs Arch Pharmacol (1976) 0.80
Terbutaline-induced desensitization of human cardiac beta 2-adrenoceptor-mediated positive inotropic effects: attenuation by ketotifen. Cardiovasc Res (1998) 0.80
Impaired regulation of beta-adrenoceptors in patients on maintenance haemodialysis. Proc Eur Dial Transplant Assoc Eur Ren Assoc (1985) 0.80
Alpha- and beta-adrenoceptor changes in patients on maintenance hemodialysis. Contrib Nephrol (1984) 0.80
Ontogenesis of sympathetic responsiveness in spontaneously hypertensive rats. I. Renal alpha 1-, alpha 2-, and beta-adrenergic receptors and their signaling. Hypertension (1993) 0.80
Regulation of expression and function of muscarinic receptors. Life Sci (1993) 0.79
Effect of propranolol, alprenolol, pindolol, and bopindolol on beta 2-adrenoceptor density in human lymphocytes. J Cardiovasc Pharmacol (1986) 0.79
Beta-adrenoceptors in human tracheal smooth muscle: characteristics of binding and relaxation. Life Sci (1987) 0.79
Hypersensitivity of adrenergic receptors and blood-pressure response to oral yohimbine in orthostatic hypotension. N Engl J Med (1983) 0.79
Lymphocyte adenylate cyclase activity in immunosuppressed patients. Eur J Clin Pharmacol (1989) 0.79