Published in Nature on June 05, 2006
Genome evolution and adaptation in a long-term experiment with Escherichia coli. Nature (2009) 11.36
Molecular characterization of clonal interference during adaptive evolution in asexual populations of Saccharomyces cerevisiae. Nat Genet (2008) 2.98
Mutation and selection in bacterial populations: alternatives to the hypothesis of directed mutation. Proc Natl Acad Sci U S A (1989) 2.95
Homeostatic adjustment and metabolic remodeling in glucose-limited yeast cultures. Mol Biol Cell (2005) 2.30
Genome dynamics during experimental evolution. Nat Rev Genet (2013) 2.07
Probing nucleosome function: a highly versatile library of synthetic histone H3 and H4 mutants. Cell (2008) 1.99
Evidence for multiple adaptive peaks from populations of bacteria evolving in a structured habitat. Proc Natl Acad Sci U S A (1994) 1.76
Long-term experimental evolution in Escherichia coli. XI. Rejection of non-transitive interactions as cause of declining rate of adaptation. BMC Evol Biol (2002) 1.71
Sex and the evolution of intrahost competition in RNA virus phi6. Genetics (1998) 1.65
Divergence in fitness and evolution of drug resistance in experimental populations of Candida albicans. J Bacteriol (2001) 1.63
Adaptive molecular evolution for 13,000 phage generations: a possible arms race. Genetics (2005) 1.59
Escherichia coli rpoB mutants have increased evolvability in proportion to their fitness defects. Mol Biol Evol (2010) 1.41
Adaptive laboratory evolution -- principles and applications for biotechnology. Microb Cell Fact (2013) 1.29
Hunger artists: yeast adapted to carbon limitation show trade-offs under carbon sufficiency. PLoS Genet (2011) 1.28
Structure of evolving populations of Saccharomyces cerevisiae: adaptive changes are frequently associated with sequence alterations involving mobile elements belonging to the Ty family. Proc Natl Acad Sci U S A (1986) 1.26
How does adaptation sweep through the genome? Insights from long-term selection experiments. Proc Biol Sci (2012) 1.25
Cancer in light of experimental evolution. Curr Biol (2012) 1.17
Sex enhances adaptation by unlinking beneficial from detrimental mutations in experimental yeast populations. BMC Evol Biol (2012) 1.11
Evolution of restraint in a structured rock-paper-scissors community. Proc Natl Acad Sci U S A (2011) 1.10
Loss of dispensable genes is not adaptive in yeast. Proc Natl Acad Sci U S A (2005) 1.07
Improving industrial yeast strains: exploiting natural and artificial diversity. FEMS Microbiol Rev (2014) 1.05
Long-term experimental evolution in Escherichia coli. VI. Environmental constraints on adaptation and divergence. Genetics (1997) 1.01
Molecular specificity, convergence and constraint shape adaptive evolution in nutrient-poor environments. PLoS Genet (2014) 0.99
Cryptic fitness advantage: diploids invade haploid populations despite lacking any apparent advantage as measured by standard fitness assays. PLoS One (2011) 0.97
Mutator dynamics in sexual and asexual experimental populations of yeast. BMC Evol Biol (2011) 0.94
The fitness consequences of aneuploidy are driven by condition-dependent gene effects. PLoS Biol (2015) 0.93
The functional basis of adaptive evolution in chemostats. FEMS Microbiol Rev (2014) 0.92
The evolution of restraint in bacterial biofilms under nontransitive competition. Evolution (2007) 0.88
Cryptic evolution: does environmental deterioration have a genetic basis? Genetics (2011) 0.88
Persistence in fluctuating environments for interacting structured populations. J Math Biol (2013) 0.86
Different selective pressures lead to different genomic outcomes as newly-formed hybrid yeasts evolve. BMC Evol Biol (2012) 0.86
The yield of experimental yeast populations declines during selection. Proc Biol Sci (2012) 0.85
Cyclic competition of mobile species on continuous space: pattern formation and coexistence. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.84
Complex genetic changes in strains of Saccharomyces cerevisiae derived by selection in the laboratory. Genetics (2007) 0.83
Pattern formation, synchronization, and outbreak of biodiversity in cyclically competing games. Phys Rev E Stat Nonlin Soft Matter Phys (2011) 0.83
Hybrid apomicts trapped in the ecological niches of their sexual ancestors. Proc Natl Acad Sci U S A (2015) 0.82
Optimality models in the age of experimental evolution and genomics. J Evol Biol (2010) 0.82
Effect of epidemic spreading on species coexistence in spatial rock-paper-scissors games. Phys Rev E Stat Nonlin Soft Matter Phys (2010) 0.79
Comparative evolution: latent potentials for anagenetic advance. Proc Natl Acad Sci U S A (1988) 0.77
Microbiology: Taking the bad with the good. Nature (2015) 0.76
What is adaptation by natural selection? Perspectives of an experimental microbiologist. PLoS Genet (2017) 0.75
Experimental evolution and the dynamics of adaptation and genome evolution in microbial populations. ISME J (2017) 0.75
Comprehensive geriatric assessment: a meta-analysis of controlled trials. Lancet (1993) 8.39
The proteasome inhibitor PS-341 inhibits growth, induces apoptosis, and overcomes drug resistance in human multiple myeloma cells. Cancer Res (2001) 6.93
Inhibition of HIV-1 replication by a nonnucleoside reverse transcriptase inhibitor. Science (1990) 5.49
Benefit of cervical screening at different ages: evidence from the UK audit of screening histories. Br J Cancer (2003) 4.14
Estimation of the number of sex alleles and queen matings from diploid male frequencies in a population of Apis mellifera. Genetics (1977) 3.98
The learning curve for laparoscopic colorectal surgery. Preliminary results from a prospective analysis of 1194 laparoscopic-assisted colectomies. Arch Surg (1997) 3.57
Effect of screening on cervical cancer mortality in England and Wales: analysis of trends with an age period cohort model. BMJ (1999) 3.50
A phase 2 study of two doses of bortezomib in relapsed or refractory myeloma. Br J Haematol (2004) 3.49
Evolution of Escherichia coli during growth in a constant environment. Genetics (1987) 3.44
NG-methyl-L-arginine inhibits tumor necrosis factor-induced hypotension: implications for the involvement of nitric oxide. Proc Natl Acad Sci U S A (1990) 3.28
Eya1-deficient mice lack ears and kidneys and show abnormal apoptosis of organ primordia. Nat Genet (1999) 3.24
Microbial evolution in a simple unstructured environment: genetic differentiation in Escherichia coli. Genetics (1994) 3.19
Prevalence of polycystic ovaries in women with anovulation and idiopathic hirsutism. Br Med J (Clin Res Ed) (1986) 3.14
Coronary vasospasm induced by subcutaneous sumatriptan. BMJ (1992) 3.13
RNA recognition by a Staufen double-stranded RNA-binding domain. EMBO J (2000) 3.12
Frequency of fixation of adaptive mutations is higher in evolving diploid than haploid yeast populations. Nature (1983) 3.03
Reversal of endotoxin-mediated shock by NG-methyl-L-arginine, an inhibitor of nitric oxide synthesis. Biochem Biophys Res Commun (1990) 2.77
Repeated evolution of an acetate-crossfeeding polymorphism in long-term populations of Escherichia coli. Mol Biol Evol (1998) 2.69
Novel proteasome inhibitor PS-341 inhibits activation of nuclear factor-kappa B, cell survival, tumor growth, and angiogenesis in squamous cell carcinoma. Clin Cancer Res (2001) 2.65
Polycystic ovaries--a common finding in normal women. Lancet (1988) 2.58
A novel dipyridodiazepinone inhibitor of HIV-1 reverse transcriptase acts through a nonsubstrate binding site. Biochemistry (1991) 2.57
Pattern of malformations in the children of women treated with carbamazepine during pregnancy. N Engl J Med (1989) 2.56
Evidence for high-energy extraterrestrial neutrinos at the IceCube detector. Science (2013) 2.56
Determinants of patient satisfaction and willingness to return with emergency care. Ann Emerg Med (2000) 2.49
Admixture studies and the detection of selection. Science (1973) 2.41
Arm edema in breast cancer patients. J Natl Cancer Inst (2001) 2.35
A systematic review of the role of human papillomavirus testing within a cervical screening programme. Health Technol Assess (1999) 2.32
Influence of serum luteinising hormone concentrations on ovulation, conception, and early pregnancy loss in polycystic ovary syndrome. BMJ (1988) 2.29
Intermittent versus continuous renal replacement therapy for acute renal failure in adults. Cochrane Database Syst Rev (2007) 2.26
Enhanced chemosensitivity to CPT-11 with proteasome inhibitor PS-341: implications for systemic nuclear factor-kappaB inhibition. Cancer Res (2001) 2.18
Multifollicular ovaries: clinical and endocrine features and response to pulsatile gonadotropin releasing hormone. Lancet (1986) 2.14
Case-mix adjustment of the National CAHPS benchmarking data 1.0: a violation of model assumptions? Health Serv Res (2001) 2.10
Screening for vertebral osteoporosis using individual risk factors. The Multicentre Vertebral Fracture Study Group. Osteoporos Int (1991) 2.07
Fas ligand, Bcl-2, granulocyte colony-stimulating factor, and p38 mitogen-activated protein kinase: Regulators of distinct cell death and survival pathways in granulocytes. J Exp Med (2000) 2.07
Frequency-Dependent Selection for Plasmid-Containing Cells of ESCHERICHIA COLI. Genetics (1979) 2.07
Changing rates of adenocarcinoma and adenosquamous carcinoma of the cervix in England. Lancet (2001) 2.05
Proteasome inhibition measurements: clinical application. Clin Chem (2000) 2.04
Ovulatory disorders in women with polycystic ovary syndrome. Clin Obstet Gynaecol (1985) 2.00
First observation of PeV-energy neutrinos with IceCube. Phys Rev Lett (2013) 2.00
Estimation of phylogenetic relationships from DNA restriction patterns and selection of endonuclease cleavage sites. Proc Natl Acad Sci U S A (1982) 1.98
Genetic evidence that Neisseria gonorrhoeae produces specific receptors for transferrin and lactoferrin. J Bacteriol (1990) 1.94
The proteasome inhibitor PS-341 in cancer therapy. Clin Cancer Res (1999) 1.94
Characterization of the binding site for nevirapine (BI-RG-587), a nonnucleoside inhibitor of human immunodeficiency virus type-1 reverse transcriptase. J Biol Chem (1991) 1.90
Distinct roles of two conserved Staufen domains in oskar mRNA localization and translation. EMBO J (2000) 1.87
The maintenance of Plasmid-containing organisms in populations of Escherichia coli. J Gen Microbiol (1981) 1.85
Laparoscopic complications in markedly obese urologic patients (a multi-institutional review) Urology (1996) 1.75
Role of the proteasome and NF-kappaB in streptococcal cell wall-induced polyarthritis. Proc Natl Acad Sci U S A (1998) 1.69
Enhancement of radiosensitivity by proteasome inhibition: implications for a role of NF-kappaB. Int J Radiat Oncol Biol Phys (2001) 1.67
Continuous ambulatory peritoneal dialysis versus automated peritoneal dialysis for end-stage renal disease. Cochrane Database Syst Rev (2007) 1.67
Fibromyalgia: a risk factor for osteoporosis. J Rheumatol (1999) 1.63
Nonoperative management of posterior tibial tendon dysfunction. Foot Ankle Int (1996) 1.61
Evaluation of outpatient geriatric assessment: a randomized multi-site trial. J Am Geriatr Soc (1995) 1.58
Molecular and imaging correlates of the fragile X-associated tremor/ataxia syndrome. Neurology (2006) 1.55
Cysteine usage increases the need for acetate in neonates who receive total parenteral nutrition. Am J Clin Nutr (1991) 1.53
Proteasome inhibition with bortezomib (PS-341): a phase I study with pharmacodynamic end points using a day 1 and day 4 schedule in a 14-day cycle. J Clin Oncol (2005) 1.50
Pharmacological effects of SB 220025, a selective inhibitor of P38 mitogen-activated protein kinase, in angiogenesis and chronic inflammatory disease models. J Pharmacol Exp Ther (1998) 1.46
A community-level HIV prevention intervention for inner-city women: results of the women and infants demonstration projects. Am J Public Health (2000) 1.46
Ultrasound demonstration of increased frequency of functional ovarian cysts in women using progestogen-only oral contraception. Br J Obstet Gynaecol (1985) 1.44
Characterizing discrete subsets of polycystic ovary syndrome as defined by the Rotterdam criteria: the impact of weight on phenotype and metabolic features. J Clin Endocrinol Metab (2006) 1.41
Juvenile spring eruption of the ears: a probable variant of polymorphic light eruption. Br J Dermatol (1991) 1.40
Wnt pathway regulation in chronic renal allograft damage. Am J Transplant (2009) 1.39
The Wake-up Call. West J Med (1993) 1.39
ATP-induced killing of virulent Mycobacterium tuberculosis within human macrophages requires phospholipase D. J Immunol (2000) 1.38
Orientation of histopathology specimens. Br J Oral Maxillofac Surg (2004) 1.38
Defining constant versus variable phenotypic features of women with polycystic ovary syndrome using different ethnic groups and populations. J Clin Endocrinol Metab (2006) 1.38
Event-related potentials in schizophrenia: their biological and clinical correlates and a new model of schizophrenic pathophysiology. Schizophr Res (1991) 1.38
The use of traditional, complementary and alternative medicine in Sri Lankan cancer care: results from a survey of 500 cancer patients. Public Health (2010) 1.36
Identification of vertebral fractures: an update. Osteoporos Int (2005) 1.34
Fitness effects of Ty transposition in Saccharomyces cerevisiae. Genetics (1992) 1.33
Estimation of expected number of rare alleles of a locus and calculation of mutation rate. Proc Natl Acad Sci U S A (1978) 1.32
Too much of a good thing: retinoic acid as an endogenous regulator of neural differentiation and exogenous teratogen. Eur J Neurosci (2003) 1.32
The relationship between enzyme activity, cell geometry, and fitness in Saccharomyces cerevisiae. Proc Natl Acad Sci U S A (1975) 1.31
Detection of Epstein-Barr virus genomes in Hodgkin's disease: relation to age. J Clin Pathol (1991) 1.29
Population studies in microorganisms. I. Evolution of diploidy in Saccharomyces cerevisiae. Genetics (1974) 1.28
Physiological characterization of adaptive clones in evolving populations of the yeast, Saccharomyces cerevisiae. Genetics (1985) 1.28
Association between amputation, arthritis and osteopenia in British male war veterans with major lower limb amputations. Clin Rehabil (1998) 1.28
Induction of ovulation with pulsatile luteinising hormone releasing hormone. Br Med J (Clin Res Ed) (1984) 1.26
Inhibition of human immunodeficiency virus type 1 (HIV-1) replication by the dipyridodiazepinone BI-RG-587. J Infect Dis (1991) 1.26
Structure of evolving populations of Saccharomyces cerevisiae: adaptive changes are frequently associated with sequence alterations involving mobile elements belonging to the Ty family. Proc Natl Acad Sci U S A (1986) 1.26
Tetracycline-resistant gonococci in UK. Lancet (1988) 1.26
The response of general practitioners to the threat of violence in their practices: results from a qualitative study. Fam Pract (2006) 1.25
Mechanisms of immune lysis of the red cells in hereditary erythroblastic multinuclearity with a positive acidified serum test and paroxysmal nocturnal hemoglobinuria. J Clin Invest (1974) 1.24
Lack of multicellular drug resistance observed in human ovarian and prostate carcinoma treated with the proteasome inhibitor PS-341. Clin Cancer Res (2000) 1.24
New insights into proteasome function: from archaebacteria to drug development. Chem Biol (1995) 1.23
26S proteasome inhibition induces apoptosis and limits growth of human pancreatic cancer. J Cell Biochem (2001) 1.23
The population biology and evolutionary significance of Ty elements in Saccharomyces cerevisiae. Genetica (1992) 1.23
Role of nitric oxide in lysis of tumor cells by cytokine-activated endothelial cells. Cancer Res (1991) 1.22
Bone marrow lesions predict increase in knee cartilage defects and loss of cartilage volume in middle-aged women without knee pain over 2 years. Ann Rheum Dis (2008) 1.22
1,25-Dihydroxyvitamin D inhibits lipopolysaccharide-induced immune activation in human endothelial cells. Clin Exp Immunol (2006) 1.22
Standardized lifetime risk. Am J Epidemiol (1999) 1.21
Predicting patient visits to an urgent care clinic using calendar variables. Acad Emerg Med (2001) 1.21
Mice overexpressing genes from the 22q11 region deleted in velo-cardio-facial syndrome/DiGeorge syndrome have middle and inner ear defects. Hum Mol Genet (2001) 1.19
Bicycle helmets. Risk taking is influenced by people's perception of safety and danger. BMJ (2001) 1.18
A reassessment of cardiac toxicity associated with Taxol. J Natl Cancer Inst Monogr (1993) 1.17
Chronic low back pain in traumatic lower limb amputees. Clin Rehabil (2005) 1.16
After hours care--a qualitative study of GPs' perceptions of risk of violence and effect on service provision. Aust Fam Physician (2005) 1.16
Laparoscopic bladder augmentation using stomach. Urology (1995) 1.16
Right atrial angiographic evaluation of the posterior isthmus: relevance for ablation of typical atrial flutter. Circulation (2000) 1.14
Sleep apnea in patients with myasthenia gravis. Neurology (2006) 1.14
Major trauma enhances store-operated calcium influx in human neutrophils. J Trauma (2000) 1.13