Specific activation of microRNA-127 with downregulation of the proto-oncogene BCL6 by chromatin-modifying drugs in human cancer cells.

PubWeight™: 8.46‹?› | Rank: Top 0.1%

🔗 View Article (PMID 16766263)

Published in Cancer Cell on June 01, 2006

Authors

Yoshimasa Saito1, Gangning Liang, Gerda Egger, Jeffrey M Friedman, Jody C Chuang, Gerhard A Coetzee, Peter A Jones

Author Affiliations

1: Department of Urology, Biochemistry, and Molecular Biology, Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, California 90089, USA.

Articles citing this

(truncated to the top 100)

The epigenomics of cancer. Cell (2007) 30.91

Causes and consequences of microRNA dysregulation in cancer. Nat Rev Genet (2009) 16.58

Many roads to maturity: microRNA biogenesis pathways and their regulation. Nat Cell Biol (2009) 11.50

Non-coding RNAs in human disease. Nat Rev Genet (2011) 11.40

A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33

miRecords: an integrated resource for microRNA-target interactions. Nucleic Acids Res (2008) 8.97

Epigenetics in cancer. Carcinogenesis (2009) 7.49

Epigenetic modifications and human disease. Nat Biotechnol (2010) 7.29

A microRNA DNA methylation signature for human cancer metastasis. Proc Natl Acad Sci U S A (2008) 7.14

Targeting microRNAs in cancer: rationale, strategies and challenges. Nat Rev Drug Discov (2010) 6.07

miRNAs in human cancer. J Pathol (2010) 6.02

MicroRNAs in cancer: small molecules with a huge impact. J Clin Oncol (2009) 5.92

miR-124 and miR-137 inhibit proliferation of glioblastoma multiforme cells and induce differentiation of brain tumor stem cells. BMC Med (2008) 5.91

MicroRNA-29b induces global DNA hypomethylation and tumor suppressor gene reexpression in acute myeloid leukemia by targeting directly DNMT3A and 3B and indirectly DNMT1. Blood (2009) 5.87

MicroRNA dysregulation in cancer: diagnostics, monitoring and therapeutics. A comprehensive review. EMBO Mol Med (2012) 5.46

Chromatin structure analyses identify miRNA promoters. Genes Dev (2008) 5.40

Genomic analysis of human microRNA transcripts. Proc Natl Acad Sci U S A (2007) 5.20

Genomic profiling of microRNA and messenger RNA reveals deregulated microRNA expression in prostate cancer. Cancer Res (2008) 5.16

Genomic and epigenetic alterations deregulate microRNA expression in human epithelial ovarian cancer. Proc Natl Acad Sci U S A (2008) 4.79

The microcosmos of cancer. Nature (2012) 4.50

MicroRNAs in cancer. Annu Rev Pathol (2009) 4.47

Retracted A TARBP2 mutation in human cancer impairs microRNA processing and DICER1 function. Nat Genet (2009) 3.88

Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65

MicroRNAs in cancer. Annu Rev Pathol (2013) 3.50

MicroRNAs in human cancer. Adv Exp Med Biol (2013) 3.19

MicroRNA: implications for cancer. Virchows Arch (2007) 3.17

Epigenetic modifications as therapeutic targets. Nat Biotechnol (2010) 3.16

Methylation mediated silencing of MicroRNA-1 gene and its role in hepatocellular carcinogenesis. Cancer Res (2008) 3.16

Distinct microRNA expression profiles in acute myeloid leukemia with common translocations. Proc Natl Acad Sci U S A (2008) 3.13

microRNA-29 can regulate expression of the long non-coding RNA gene MEG3 in hepatocellular cancer. Oncogene (2011) 3.02

MicroRNA expression signatures accurately discriminate acute lymphoblastic leukemia from acute myeloid leukemia. Proc Natl Acad Sci U S A (2007) 3.00

microRNA involvement in human cancer. Carcinogenesis (2012) 2.98

MicroRNA-antagonism regulates breast cancer stemness and metastasis via TET-family-dependent chromatin remodeling. Cell (2013) 2.92

IL-21 and IL-6 are critical for different aspects of B cell immunity and redundantly induce optimal follicular helper CD4 T cell (Tfh) differentiation. PLoS One (2011) 2.92

A functional screen identifies miR-34a as a candidate neuroblastoma tumor suppressor gene. Mol Cancer Res (2008) 2.77

MicroRNA-377 is up-regulated and can lead to increased fibronectin production in diabetic nephropathy. FASEB J (2008) 2.75

Distinct microRNA alterations characterize high- and low-grade bladder cancer. Cancer Res (2009) 2.58

Targeting DNA methylation. Clin Cancer Res (2009) 2.45

MicroRNA and cancer--focus on apoptosis. J Cell Mol Med (2009) 2.44

Dynamic epigenetic regulation of the microRNA-200 family mediates epithelial and mesenchymal transitions in human tumorigenesis. Oncogene (2011) 2.42

Epigenetic regulation of SOX9 by the NF-κB signaling pathway in pancreatic cancer stem cells. Stem Cells (2013) 2.40

Pancreatic cancers epigenetically silence SIP1 and hypomethylate and overexpress miR-200a/200b in association with elevated circulating miR-200a and miR-200b levels. Cancer Res (2010) 2.39

Regulation of MicroRNA Biogenesis: A miRiad of mechanisms. Cell Commun Signal (2009) 2.27

Distinctive patterns of microRNA expression associated with karyotype in acute myeloid leukaemia. PLoS One (2008) 2.27

MicroRNA targets in immune genes and the Dicer/Argonaute and ARE machinery components. Mol Immunol (2007) 2.24

Epigenetic repression of microRNA-129-2 leads to overexpression of SOX4 oncogene in endometrial cancer. Cancer Res (2009) 2.23

Small molecule enoxacin is a cancer-specific growth inhibitor that acts by enhancing TAR RNA-binding protein 2-mediated microRNA processing. Proc Natl Acad Sci U S A (2011) 2.21

RDX induces aberrant expression of microRNAs in mouse brain and liver. Environ Health Perspect (2008) 1.95

Altered microRNA expression profile with miR-146a upregulation in CD4+ T cells from patients with rheumatoid arthritis. Arthritis Res Ther (2010) 1.94

A simple array platform for microRNA analysis and its application in mouse tissues. RNA (2007) 1.91

Roles of small RNAs in tumor formation. Trends Mol Med (2010) 1.89

Cancer epigenetics: linking basic biology to clinical medicine. Cell Res (2011) 1.88

MiR-17-92 cluster is associated with 13q gain and c-myc expression during colorectal adenoma to adenocarcinoma progression. Br J Cancer (2009) 1.87

The dynamic DNA methylomes of double-stranded DNA viruses associated with human cancer. Genome Res (2009) 1.87

The role of miR-18b in MDM2-p53 pathway signaling and melanoma progression. J Natl Cancer Inst (2013) 1.76

DNA methylation-associated silencing of tumor-suppressor microRNAs in cancer. Oncogene (2011) 1.76

Epigenetic silencing of MicroRNA miR-107 regulates cyclin-dependent kinase 6 expression in pancreatic cancer. Pancreatology (2009) 1.76

microRNA 184 regulates expression of NFAT1 in umbilical cord blood CD4+ T cells. Blood (2009) 1.75

Epigenetically silenced miR-34b/c as a novel faecal-based screening marker for colorectal cancer. Br J Cancer (2011) 1.73

Chromosomal rearrangements and microRNAs: a new cancer link with clinical implications. J Clin Invest (2007) 1.72

MicroRNAs as Novel Biomarkers for Breast Cancer. J Oncol (2009) 1.72

Aberrant regulation and function of microRNAs in cancer. Curr Biol (2014) 1.72

miRNA expression in colon polyps provides evidence for a multihit model of colon cancer. PLoS One (2011) 1.72

The future of epigenetic therapy in solid tumours--lessons from the past. Nat Rev Clin Oncol (2013) 1.70

Methylation-mediated silencing and tumour suppressive function of hsa-miR-124 in cervical cancer. Mol Cancer (2010) 1.69

MicroRNA-127 modulates fetal lung development. Physiol Genomics (2009) 1.68

CpG island hypermethylation-associated silencing of non-coding RNAs transcribed from ultraconserved regions in human cancer. Oncogene (2010) 1.65

MicroRNAs: New Biomarkers for Diagnosis, Prognosis, Therapy Prediction and Therapeutic Tools for Breast Cancer. Theranostics (2015) 1.62

Targeting DNA methylation for epigenetic therapy. Trends Pharmacol Sci (2010) 1.61

At least ten genes define the imprinted Dlk1-Dio3 cluster on mouse chromosome 12qF1. PLoS One (2009) 1.60

Negative regulation of lncRNA GAS5 by miR-21. Cell Death Differ (2013) 1.60

Regulation of ABCG2 expression at the 3' untranslated region of its mRNA through modulation of transcript stability and protein translation by a putative microRNA in the S1 colon cancer cell line. Mol Cell Biol (2008) 1.58

A brief review on the mechanisms of miRNA regulation. Genomics Proteomics Bioinformatics (2009) 1.56

Genome-wide profiling of histone h3 lysine 4 and lysine 27 trimethylation reveals an epigenetic signature in prostate carcinogenesis. PLoS One (2009) 1.54

Causes and consequences of microRNA dysregulation. Cancer J (2012) 1.51

Transcriptional mechanism for the paired miR-433 and miR-127 genes by nuclear receptors SHP and ERRgamma. Nucleic Acids Res (2008) 1.50

Got target? Computational methods for microRNA target prediction and their extension. Exp Mol Med (2010) 1.49

Expression of microRNA and their gene targets are dysregulated in preinvasive breast cancer. Breast Cancer Res (2011) 1.49

Mechanisms of control of microRNA biogenesis. J Biochem (2010) 1.48

miR-23b represses proto-oncogene Src kinase and functions as methylation-silenced tumor suppressor with diagnostic and prognostic significance in prostate cancer. Cancer Res (2012) 1.46

Molecular signatures of pancreatic cancer. Arch Pathol Lab Med (2011) 1.46

MicroRNA-34a inhibits the proliferation and metastasis of osteosarcoma cells both in vitro and in vivo. PLoS One (2012) 1.45

MicroRNAs: critical mediators of differentiation, development and disease. Swiss Med Wkly (2009) 1.43

Regulation of cellular miRNA expression by human papillomaviruses. Biochim Biophys Acta (2011) 1.40

DNA methylation prevents CTCF-mediated silencing of the oncogene BCL6 in B cell lymphomas. J Exp Med (2010) 1.39

Retracted Integrated gene network analysis and text mining revealing PIK3R1 regulated by miR-127 in human bladder cancer. Eur J Med Res (2013) 1.39

miRNA regulation of cytokine genes. Cytokine (2009) 1.39

DNA methylation of cancer genome. Birth Defects Res C Embryo Today (2009) 1.39

MicroRNA expression after ionizing radiation in human endothelial cells. Radiat Oncol (2010) 1.38

miR-30d, miR-181a and miR-199a-5p cooperatively suppress the endoplasmic reticulum chaperone and signaling regulator GRP78 in cancer. Oncogene (2012) 1.34

The role of microRNAs in human liver cancers. Semin Oncol (2011) 1.34

MicroRNAs and prostate cancer. J Cell Mol Med (2008) 1.33

DNA-demethylating and anti-tumor activity of synthetic miR-29b mimics in multiple myeloma. Oncotarget (2012) 1.33

MicroRNAs: molecular features and role in cancer. Front Biosci (Landmark Ed) (2012) 1.32

microRNA and cancer. AAPS J (2010) 1.32

Myc-mediated repression of microRNA-34a promotes high-grade transformation of B-cell lymphoma by dysregulation of FoxP1. Blood (2011) 1.32

Aberrant MicroRNA-155 expression is an early event in the multistep progression of pancreatic adenocarcinoma. Pancreatology (2010) 1.31

Induction of hepatocellular carcinoma by in vivo gene targeting. Proc Natl Acad Sci U S A (2012) 1.31

Advances in microRNAs: implications for immunity and inflammatory diseases. J Cell Mol Med (2009) 1.29

Diagnostic, prognostic and therapeutic implications of microRNAs in urologic tumors. Nat Rev Urol (2010) 1.28

Articles by these authors

Comprehensive analysis of CpG islands in human chromosomes 21 and 22. Proc Natl Acad Sci U S A (2002) 12.33

Epigenetics in human disease and prospects for epigenetic therapy. Nature (2004) 11.46

A decade of exploring the cancer epigenome - biological and translational implications. Nat Rev Cancer (2011) 11.33

Epigenetics in cancer. Carcinogenesis (2009) 7.49

The 8q24 cancer risk variant rs6983267 shows long-range interaction with MYC in colorectal cancer. Nat Genet (2009) 6.99

Identification of white adipocyte progenitor cells in vivo. Cell (2008) 6.58

Epigenetic therapy of cancer: past, present and future. Nat Rev Drug Discov (2006) 6.39

The distribution and mechanism of action of ghrelin in the CNS demonstrates a novel hypothalamic circuit regulating energy homeostasis. Neuron (2003) 6.05

Loss of stearoyl-CoA desaturase-1 function protects mice against adiposity. Proc Natl Acad Sci U S A (2002) 6.00

Rapid rewiring of arcuate nucleus feeding circuits by leptin. Science (2004) 5.98

Role for stearoyl-CoA desaturase-1 in leptin-mediated weight loss. Science (2002) 5.89

Whole population, genome-wide mapping of hidden relatedness. Genome Res (2008) 4.72

Cancer epigenetics: modifications, screening, and therapy. Annu Rev Med (2008) 4.41

Distinct localization of histone H3 acetylation and H3-K4 methylation to the transcription start sites in the human genome. Proc Natl Acad Sci U S A (2004) 4.39

Frequent switching of Polycomb repressive marks and DNA hypermethylation in the PC3 prostate cancer cell line. Proc Natl Acad Sci U S A (2008) 4.20

Rethinking how DNA methylation patterns are maintained. Nat Rev Genet (2009) 4.03

Demethylation of a hypermethylated P15/INK4B gene in patients with myelodysplastic syndrome by 5-Aza-2'-deoxycytidine (decitabine) treatment. Blood (2002) 3.89

Abnormal osmotic regulation in trpv4-/- mice. Proc Natl Acad Sci U S A (2003) 3.87

Genome-wide association studies identify four ER negative-specific breast cancer risk loci. Nat Genet (2013) 3.81

Principles for the post-GWAS functional characterization of cancer risk loci. Nat Genet (2011) 3.73

Cancer genetics and epigenetics: two sides of the same coin? Cancer Cell (2012) 3.65

Cooperativity between DNA methyltransferases in the maintenance methylation of repetitive elements. Mol Cell Biol (2002) 3.61

Functional enhancers at the gene-poor 8q24 cancer-linked locus. PLoS Genet (2009) 3.59

DZNep is a global histone methylation inhibitor that reactivates developmental genes not silenced by DNA methylation. Mol Cancer Ther (2009) 3.56

The CpG island searcher: a new WWW resource. In Silico Biol (2003) 3.42

8q24 prostate, breast, and colon cancer risk loci show tissue-specific long-range interaction with MYC. Proc Natl Acad Sci U S A (2010) 3.37

Foxa2 regulates lipid metabolism and ketogenesis in the liver during fasting and in diabetes. Nature (2004) 3.29

Association of breast cancer DNA methylation profiles with hormone receptor status and response to tamoxifen. Cancer Res (2004) 3.23

Epigenetic modifications as therapeutic targets. Nat Biotechnol (2010) 3.16

Role of nucleosomal occupancy in the epigenetic silencing of the MLH1 CpG island. Cancer Cell (2007) 3.15

Rapid regulation of depression-related behaviours by control of midbrain dopamine neurons. Nature (2012) 3.15

Transgenic mice expressing green fluorescent protein under the control of the melanocortin-4 receptor promoter. J Neurosci (2003) 3.08

DNA methylation and breast carcinogenesis. Oncogene (2002) 3.03

Histone H3-lysine 9 methylation is associated with aberrant gene silencing in cancer cells and is rapidly reversed by 5-aza-2'-deoxycytidine. Cancer Res (2002) 3.02

DNA methylation: the nuts and bolts of repression. J Cell Physiol (2007) 3.00

Interaction of nuclear receptors with the Wnt/beta-catenin/Tcf signaling axis: Wnt you like to know? Endocr Rev (2005) 2.87

The putative tumor suppressor microRNA-101 modulates the cancer epigenome by repressing the polycomb group protein EZH2. Cancer Res (2009) 2.83

Leptin targets in the mouse brain. J Comp Neurol (2009) 2.80

Identification of Genetic Susceptibility Loci for Colorectal Tumors in a Genome-Wide Meta-analysis. Gastroenterology (2012) 2.57

Epigenetics and microRNAs. Pediatr Res (2007) 2.52

Mammalian TRPV4 (VR-OAC) directs behavioral responses to osmotic and mechanical stimuli in Caenorhabditis elegans. Proc Natl Acad Sci U S A (2003) 2.50

Stearoyl-CoA desaturase 1 deficiency increases fatty acid oxidation by activating AMP-activated protein kinase in liver. Proc Natl Acad Sci U S A (2004) 2.48

A central thermogenic-like mechanism in feeding regulation: an interplay between arcuate nucleus T3 and UCP2. Cell Metab (2007) 2.48

DNA methylation screening identifies driver epigenetic events of cancer cell survival. Cancer Cell (2012) 2.45

A meta-analysis of genome-wide association studies of breast cancer identifies two novel susceptibility loci at 6q14 and 20q11. Hum Mol Genet (2012) 2.45

Preferential response of cancer cells to zebularine. Cancer Cell (2004) 2.39

Selective anchoring of DNA methyltransferases 3A and 3B to nucleosomes containing methylated DNA. Mol Cell Biol (2009) 2.34

Impairment of hepatic growth hormone and glucocorticoid receptor signaling causes steatosis and hepatocellular carcinoma in mice. Hepatology (2011) 2.33

Krox20 stimulates adipogenesis via C/EBPbeta-dependent and -independent mechanisms. Cell Metab (2005) 2.29

Topographic mapping of VMH --> arcuate nucleus microcircuits and their reorganization by fasting. Nat Neurosci (2005) 2.29

Negative and positive regulation of gene expression by mouse histone deacetylase 1. Mol Cell Biol (2006) 2.28

The proteasome inhibitor PS-341 markedly enhances sensitivity of multiple myeloma tumor cells to chemotherapeutic agents. Clin Cancer Res (2003) 2.27

Hypomethylation of a LINE-1 promoter activates an alternate transcript of the MET oncogene in bladders with cancer. PLoS Genet (2010) 2.27

Identification of DNMT1 (DNA methyltransferase 1) hypomorphs in somatic knockouts suggests an essential role for DNMT1 in cell survival. Proc Natl Acad Sci U S A (2006) 2.25

Inhibition of DNA methylation and reactivation of silenced genes by zebularine. J Natl Cancer Inst (2003) 2.22

Molecular profiling of activated neurons by phosphorylated ribosome capture. Cell (2012) 2.22

Genomic androgen receptor-occupied regions with different functions, defined by histone acetylation, coregulators and transcriptional capacity. PLoS One (2008) 2.18

Serotonin reciprocally regulates melanocortin neurons to modulate food intake. Neuron (2006) 2.16

Radio-wave heating of iron oxide nanoparticles can regulate plasma glucose in mice. Science (2012) 2.14

Polycomb-repressed genes have permissive enhancers that initiate reprogramming. Cell (2011) 2.14

p53 gene and protein status: the role of p53 alterations in predicting outcome in patients with bladder cancer. J Clin Oncol (2007) 2.14

High STAT5 levels mediate imatinib resistance and indicate disease progression in chronic myeloid leukemia. Blood (2011) 2.08

Evaluating potential for whole-genome studies in Kosrae, an isolated population in Micronesia. Nat Genet (2006) 2.07

Long-term epigenetic therapy with oral zebularine has minimal side effects and prevents intestinal tumors in mice. Cancer Prev Res (Phila) (2008) 2.04

Genome-wide association studies in an isolated founder population from the Pacific Island of Kosrae. PLoS Genet (2009) 2.02

Androgen receptor inhibits estrogen receptor-alpha activity and is prognostic in breast cancer. Cancer Res (2009) 1.98

Epigenetic activation of tumor suppressor microRNAs in human cancer cells. Cell Cycle (2006) 1.98

Epigenetic changes in cancer. APMIS (2007) 1.96

Genome-wide mapping of nucleosome positioning and DNA methylation within individual DNA molecules. Genome Res (2012) 1.95

Footprinting of mammalian promoters: use of a CpG DNA methyltransferase revealing nucleosome positions at a single molecule level. Nucleic Acids Res (2005) 1.94

Genome-wide association study of electrocardiographic conduction measures in an isolated founder population: Kosrae. Heart Rhythm (2009) 1.91

H2A.Z maintenance during mitosis reveals nucleosome shifting on mitotically silenced genes. Mol Cell (2010) 1.85

Comparison of biological effects of non-nucleoside DNA methylation inhibitors versus 5-aza-2'-deoxycytidine. Mol Cancer Ther (2005) 1.85

Antidiabetic effects of IGFBP2, a leptin-regulated gene. Cell Metab (2010) 1.85

DNA methylation directly silences genes with non-CpG island promoters and establishes a nucleosome occupied promoter. Hum Mol Genet (2011) 1.83

A meta-analysis identifies new loci associated with body mass index in individuals of African ancestry. Nat Genet (2013) 1.82