Published in J Orthop Res on August 01, 2006
The role of growth factors in cartilage repair. Clin Orthop Relat Res (2011) 2.20
Age-related changes in the musculoskeletal system and the development of osteoarthritis. Clin Geriatr Med (2010) 1.72
Effects of aging on articular cartilage homeostasis. Bone (2012) 1.40
Age-dependent alteration of TGF-β signalling in osteoarthritis. Cell Tissue Res (2011) 1.10
Signaling pathways in cartilage repair. Int J Mol Sci (2014) 0.86
Wnt and Rho GTPase signaling in osteoarthritis development and intervention: implications for diagnosis and therapy. Arthritis Res Ther (2013) 0.75
Rho GTPases in cell biology. Nature (2002) 22.81
Senescent cells, tumor suppression, and organismal aging: good citizens, bad neighbors. Cell (2005) 12.73
Characterization of rac and cdc42 activation in chemoattractant-stimulated human neutrophils using a novel assay for active GTPases. J Biol Chem (1999) 5.80
DNA repair, genome stability, and aging. Cell (2005) 5.52
Rho GTPase-activating proteins in cell regulation. Trends Cell Biol (2003) 3.44
GAPs galore! A survey of putative Ras superfamily GTPase activating proteins in man and Drosophila. Biochim Biophys Acta (2003) 2.71
Cell cycle-dependent activation of Ras. Curr Biol (1996) 2.26
Cellular senescence and apoptosis: how cellular responses might influence aging phenotypes. Exp Gerontol (2003) 2.03
Potential involvement of oxidative stress in cartilage senescence and development of osteoarthritis: oxidative stress induces chondrocyte telomere instability and downregulation of chondrocyte function. Arthritis Res Ther (2005) 1.79
The role of chondrocyte senescence in the pathogenesis of osteoarthritis and in limiting cartilage repair. J Bone Joint Surg Am (2003) 1.73
Chondrocyte-mediated depletion of articular cartilage proteoglycans in vitro. Biochem J (1985) 1.63
Reduction in the chondrocyte response to insulin-like growth factor 1 in aging and osteoarthritis: studies in a non-human primate model of naturally occurring disease. Arthritis Rheum (2000) 1.54
Age-related decline in chondrocyte response to insulin-like growth factor-I: the role of growth factor binding proteins. J Orthop Res (1997) 1.54
Stimulation of proteoglycan biosynthesis by serum and insulin-like growth factor-I in cultured bovine articular cartilage. Biochem J (1986) 1.51
Rho signalling at a glance. J Cell Sci (2004) 1.43
Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels. Arthritis Rheum (2003) 1.41
GTPase-activating proteins for Cdc42. Eukaryot Cell (2002) 1.35
Aging bone and cartilage: cross-cutting issues. Biochem Biophys Res Commun (2005) 1.18
Fluorimetric DNA assay for cell growth estimation. Anal Biochem (1992) 1.17
Human osteoarthritic chondrocytes possess an increased number of insulin-like growth factor 1 binding sites but are unresponsive to its stimulation. Possible role of IGF-1-binding proteins. Arthritis Rheum (1994) 1.13
The future of aging therapies. Cell (2005) 1.13
Cellular senescence requires CDK5 repression of Rac1 activity. Mol Cell Biol (2004) 1.10
Effects of oxidative damage and telomerase activity on human articular cartilage chondrocyte senescence. J Gerontol A Biol Sci Med Sci (2004) 1.09
Biomechanical regulation of matrix metalloproteinase-9 in cultured chondrocytes. J Orthop Res (2000) 1.08
Chondrocytes from osteoarthritic cartilage have increased expression of insulin-like growth factor I (IGF-I) and IGF-binding protein-3 (IGFBP-3) and -5, but not IGF-II or IGFBP-4. J Clin Endocrinol Metab (1996) 1.01
Cellular patterns of insulin-like growth factor system gene expression in murine chondrogenesis and osteogenesis. Endocrinology (1995) 1.00
Growth promoting peptides in osteoarthritis and diffuse idiopathic skeletal hyperostosis--insulin, insulin-like growth factor-I, growth hormone. J Rheumatol (1994) 0.99
Chondrocyte number and proteoglycan synthesis in the aging and osteoarthritic human articular cartilage. Ann Rheum Dis (2004) 0.95
Isolation, propagation, and cryopreservation of equine articular chondrocytes. Am J Vet Res (1992) 0.95
Effects of age on the histochemical characterization of costal cartilage. Am J Physiol (1954) 0.93
The effect of aging on articular cartilage. Bull N Y Acad Med (1968) 0.93
IGF and IGF-binding protein system in the synovial fluid of osteoarthritic and rheumatoid arthritic patients. Osteoarthritis Cartilage (1996) 0.90
Age-related changes in serum insulin-like growth factor-I, insulin-like growth factor-I binding protein-3 and articular cartilage structure in Thoroughbred horses. Equine Vet J (2005) 0.90
Effects of basic fibroblast growth factor, transforming growth factor-beta 1, insulin-like growth factor-1, and insulin on human osteoarthritic articular cartilage explants. J Orthop Res (1995) 0.89
Effect of age on polysaccharide composition of cartilage. Proc Soc Exp Biol Med (1955) 0.88
Insulin-like growth factor (IGF) receptor, IGF-I, interleukin-1 beta (IL-1 beta), and IL-6 mRNA expression in osteoarthritic and normal human cartilage. J Histochem Cytochem (1996) 0.87
Production of binding proteins and role of the insulin-like growth factor I binding protein 3 in human articular cartilage explants. Br J Rheumatol (1996) 0.85
Articular cartilage destruction in experimental inflammatory arthritis: insulin-like growth factor-1 regulation of proteoglycan metabolism in chondrocytes. Histochem J (1996) 0.83
Change in response with age of human articular cartilage to plasma somatomedin activity. Calcif Tissue Int (1979) 0.81
Hypoxia-induced nitric oxide protects chondrocytes from damage by hydrogen peroxide. Inflamm Res (2004) 0.79
Insulin-like growth factor-I diminishes the activation status and expression of the small GTPase Cdc42 in articular chondrocytes. J Orthop Res (2004) 0.79
Retarded intracellular lipid transport associated with reduced expression of Cdc42, a member of Rho-GTPases, in human aged skin fibroblasts: a possible function of Cdc42 in mediating intracellular lipid transport. Arterioscler Thromb Vasc Biol (2002) 0.79
Protein kinase B, P34cdc2 kinase, and p21 ras GTP-binding in kidneys of aging rats. Exp Biol Med (Maywood) (2004) 0.78
Psychiatric comorbidities and schizophrenia. Schizophr Bull (2008) 2.69
Naturally occurring rhodopsin mutation in the dog causes retinal dysfunction and degeneration mimicking human dominant retinitis pigmentosa. Proc Natl Acad Sci U S A (2002) 1.67
Platelet rich plasma (PRP) enhances anabolic gene expression patterns in flexor digitorum superficialis tendons. J Orthop Res (2007) 1.54
Prospective study of outcomes after reduction mammaplasty: long-term follow-up. Plast Reconstr Surg (2006) 1.53
A study of large-bowel volvulus in urban Australia. Can J Surg (2006) 1.38
Meta-analysis of oxidative stress in schizophrenia. Biol Psychiatry (2013) 1.27
Is abnormal glucose tolerance in antipsychotic-naive patients with nonaffective psychosis confounded by poor health habits? Schizophr Bull (2010) 1.11
Abnormal glucose tolerance, white blood cell count, and telomere length in newly diagnosed, antidepressant-naïve patients with depression. Brain Behav Immun (2012) 1.07
Inflammation and schizophrenia. Schizophr Bull (2013) 1.02
Antibiotic-associated psychosis during treatment of urinary tract infections: a systematic review. J Clin Psychopharmacol (2014) 0.86
Urinary tract infections in acute psychosis. J Clin Psychiatry (2014) 0.79
Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes. Am J Vet Res (2006) 0.78
Hospital admission for schizophrenia and bipolar disorder. BMJ (2011) 0.78
Beyond Urinary Tract Infections (UTIs) and Delirium: A Systematic Review of UTIs and Neuropsychiatric Disorders. J Psychiatr Pract (2015) 0.77
Differential white blood cell counts may predict urinary tract infection in acute non-affective psychosis. Schizophr Res (2013) 0.75