Published in J Biol Chem on May 07, 1999
PTEN-mediated apical segregation of phosphoinositides controls epithelial morphogenesis through Cdc42. Cell (2007) 5.84
Transforming growth factor-beta1 mediates epithelial to mesenchymal transdifferentiation through a RhoA-dependent mechanism. Mol Biol Cell (2001) 5.84
A PtdInsP(3)- and Rho GTPase-mediated positive feedback loop regulates neutrophil polarity. Nat Cell Biol (2002) 5.58
Edg-1, the G protein-coupled receptor for sphingosine-1-phosphate, is essential for vascular maturation. J Clin Invest (2000) 5.48
Rac and Cdc42 play distinct roles in regulating PI(3,4,5)P3 and polarity during neutrophil chemotaxis. J Cell Biol (2003) 4.02
p120 catenin regulates the actin cytoskeleton via Rho family GTPases. J Cell Biol (2000) 3.60
Activation of ARF6 by ARNO stimulates epithelial cell migration through downstream activation of both Rac1 and phospholipase D. J Cell Biol (2001) 3.49
Coactivation of Rac and Rho by Wnt/Frizzled signaling is required for vertebrate gastrulation. Genes Dev (2003) 3.46
Hem-1 complexes are essential for Rac activation, actin polymerization, and myosin regulation during neutrophil chemotaxis. PLoS Biol (2006) 3.01
Innate immune sensing of bacterial modifications of Rho GTPases by the Pyrin inflammasome. Nature (2014) 2.82
Nonpolarized signaling reveals two distinct modes of 3D cell migration. J Cell Biol (2012) 2.76
The fic domain: regulation of cell signaling by adenylylation. Mol Cell (2009) 2.73
Regulation of cell polarity during eukaryotic chemotaxis: the chemotactic compass. Curr Opin Cell Biol (2002) 2.68
Leukocytes navigate by compass: roles of PI3Kgamma and its lipid products. Trends Cell Biol (2000) 2.59
Increased LIS1 expression affects human and mouse brain development. Nat Genet (2009) 2.45
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
Defective lymphocyte chemotaxis in beta-arrestin2- and GRK6-deficient mice. Proc Natl Acad Sci U S A (2002) 2.26
PAK and other Rho-associated kinases--effectors with surprisingly diverse mechanisms of regulation. Biochem J (2005) 2.19
Rac1 is essential for platelet lamellipodia formation and aggregate stability under flow. J Biol Chem (2005) 2.07
Signaling and cytoskeletal requirements in erythroblast enucleation. Blood (2012) 2.05
Inactivation of AtRac1 by abscisic acid is essential for stomatal closure. Genes Dev (2001) 2.02
Activation of cdc42, rac, PAK, and rho-kinase in response to hepatocyte growth factor differentially regulates epithelial cell colony spreading and dissociation. Mol Biol Cell (2000) 2.00
Identification of a tight junction-associated guanine nucleotide exchange factor that activates Rho and regulates paracellular permeability. J Cell Biol (2003) 2.00
Endogenous, hyperactive Rac3 controls proliferation of breast cancer cells by a p21-activated kinase-dependent pathway. Proc Natl Acad Sci U S A (2000) 1.97
Big roles for small GTPases in the control of directed cell movement. Biochem J (2007) 1.89
Integrins engage mitochondrial function for signal transduction by a mechanism dependent on Rho GTPases. J Cell Biol (2002) 1.88
Vav2 activates Rac1, Cdc42, and RhoA downstream from growth factor receptors but not beta1 integrins. Mol Cell Biol (2000) 1.83
Rac and Cdc42 GTPases control hematopoietic stem cell shape, adhesion, migration, and mobilization. Proc Natl Acad Sci U S A (2001) 1.80
Beta1 integrin activates Rac1 in Schwann cells to generate radial lamellae during axonal sorting and myelination. J Cell Biol (2007) 1.77
Modulation of Rac localization and function by dynamin. Mol Biol Cell (2003) 1.75
Activation of LIMK1 by binding to the BMP receptor, BMPRII, regulates BMP-dependent dendritogenesis. EMBO J (2004) 1.70
PIP3, PIP2, and cell movement--similar messages, different meanings? Dev Cell (2001) 1.70
p120 catenin regulates lamellipodial dynamics and cell adhesion in cooperation with cortactin. Proc Natl Acad Sci U S A (2007) 1.59
Wnts induce migration and invasion of myeloma plasma cells. Blood (2005) 1.58
Rac regulation of chemotaxis and morphogenesis in Dictyostelium. EMBO J (2004) 1.56
The signaling mechanisms underlying cell polarity and chemotaxis. Cold Spring Harb Perspect Biol (2009) 1.53
Stromal cell-derived factor 1alpha activates LIM kinase 1 and induces cofilin phosphorylation for T-cell chemotaxis. Mol Cell Biol (2002) 1.49
Rac1 links leading edge and uropod events through Rho and myosin activation during chemotaxis. Blood (2006) 1.49
TrkB binds and tyrosine-phosphorylates Tiam1, leading to activation of Rac1 and induction of changes in cellular morphology. Proc Natl Acad Sci U S A (2006) 1.48
Plant Rac-like GTPases are activated by auxin and mediate auxin-responsive gene expression. Plant Cell (2002) 1.47
Two pathways through Cdc42 couple the N-formyl receptor to actin nucleation in permeabilized human neutrophils. J Cell Biol (2000) 1.44
uPAR promotes formation of the p130Cas-Crk complex to activate Rac through DOCK180. J Cell Biol (2008) 1.43
Pom1 DYRK regulates localization of the Rga4 GAP to ensure bipolar activation of Cdc42 in fission yeast. Curr Biol (2008) 1.43
FAK potentiates Rac1 activation and localization to matrix adhesion sites: a role for betaPIX. Mol Biol Cell (2006) 1.42
Yeast translation elongation factor-1A binds vacuole-localized Rho1p to facilitate membrane integrity through F-actin remodeling. J Biol Chem (2015) 1.41
miR-10b targets Tiam1: implications for Rac activation and carcinoma migration. J Biol Chem (2010) 1.41
Rac GTPases regulate the morphology and deformability of the erythrocyte cytoskeleton. Blood (2006) 1.41
The role of phosphoinositide 3-kinases in neutrophil migration in 3D collagen gels. PLoS One (2015) 1.38
Granulocyte CEACAM3 is a phagocytic receptor of the innate immune system that mediates recognition and elimination of human-specific pathogens. J Exp Med (2004) 1.37
The distinct roles of Ras and Rac in PI 3-kinase-dependent protrusion during EGF-stimulated cell migration. J Cell Sci (2007) 1.34
Small GTPase RhoG is a key regulator for neurite outgrowth in PC12 cells. Mol Cell Biol (2000) 1.34
Singularity in budding: a role for the evolutionarily conserved small GTPase Cdc42p. Proc Natl Acad Sci U S A (2002) 1.33
Insight into the mode of action of the LRRK2 Y1699C pathogenic mutant. J Neurochem (2011) 1.33
A mathematical model for neutrophil gradient sensing and polarization. PLoS Comput Biol (2007) 1.32
ADP-ribosylation factor 6 and a functional PIX/p95-APP1 complex are required for Rac1B-mediated neurite outgrowth. Mol Biol Cell (2003) 1.31
Rac1 and Rac3 isoform activation is involved in the invasive and metastatic phenotype of human breast cancer cells. Breast Cancer Res (2005) 1.30
ISG15 modification of filamin B negatively regulates the type I interferon-induced JNK signalling pathway. EMBO Rep (2009) 1.30
Regulation of the Rac1-specific exchange factor Tiam1 involves both phosphoinositide 3-kinase-dependent and -independent components. Biochem J (2000) 1.26
CARD9 facilitates microbe-elicited production of reactive oxygen species by regulating the LyGDI-Rac1 complex. Nat Immunol (2009) 1.26
Parallel phosphatidylinositol 3-kinase (PI3K)-dependent and Src-dependent pathways lead to CXCL8-mediated Rac2 activation and chemotaxis. J Biol Chem (2008) 1.25
Positive feedback between Cdc42 activity and H+ efflux by the Na-H exchanger NHE1 for polarity of migrating cells. J Cell Biol (2007) 1.25
Ephexin4 and EphA2 mediate cell migration through a RhoG-dependent mechanism. J Cell Biol (2010) 1.24
Nucleotide exchange factor ECT2 interacts with the polarity protein complex Par6/Par3/protein kinase Czeta (PKCzeta) and regulates PKCzeta activity. Mol Cell Biol (2004) 1.24
GM130-dependent control of Cdc42 activity at the Golgi regulates centrosome organization. Mol Biol Cell (2008) 1.23
Rho family GTPases are required for activation of Jak/STAT signaling by G protein-coupled receptors. Mol Cell Biol (2003) 1.22
Phospholipase cbeta is critical for T cell chemotaxis. J Immunol (2007) 1.22
WGEF activates Rho in the Wnt-PCP pathway and controls convergent extension in Xenopus gastrulation. EMBO J (2008) 1.22
Association of PI-3 kinase with PAK1 leads to actin phosphorylation and cytoskeletal reorganization. Mol Biol Cell (2002) 1.21
Tenascin-C suppresses Rho activation. J Cell Biol (2000) 1.20
The hematopoiesis-specific GTP-binding protein RhoH is GTPase deficient and modulates activities of other Rho GTPases by an inhibitory function. Mol Cell Biol (2002) 1.20
WAVE regulatory complex activation by cooperating GTPases Arf and Rac1. Proc Natl Acad Sci U S A (2011) 1.20
Role of LPA4/p2y9/GPR23 in negative regulation of cell motility. Mol Biol Cell (2008) 1.20
LRRK2 kinase activity is dependent on LRRK2 GTP binding capacity but independent of LRRK2 GTP binding. PLoS One (2011) 1.19
Delta-catenin-induced dendritic morphogenesis. An essential role of p190RhoGEF interaction through Akt1-mediated phosphorylation. J Biol Chem (2007) 1.18
Characterization of the Rac-GAP (Rac-GTPase-activating protein) activity of beta2-chimaerin, a 'non-protein kinase C' phorbol ester receptor. Biochem J (2003) 1.18
Loss of Dact1 disrupts planar cell polarity signaling by altering dishevelled activity and leads to posterior malformation in mice. J Biol Chem (2010) 1.17
Novel mechanism for gonadotropin-releasing hormone neuronal migration involving Gas6/Ark signaling to p38 mitogen-activated protein kinase. Mol Cell Biol (2002) 1.17
Novel regulatory mechanisms for the Dbl family guanine nucleotide exchange factor Cool-2/alpha-Pix. EMBO J (2004) 1.17
Osteopontin regulates actin cytoskeleton and contributes to cell proliferation in primary erythroblasts. J Biol Chem (2008) 1.16
TNFα-exposed bone marrow-derived mesenchymal stem cells promote locomotion of MDA-MB-231 breast cancer cells through transcriptional activation of CXCR3 ligand chemokines. J Biol Chem (2010) 1.16
Porphyromonas gingivalis outer membrane vesicles enter human epithelial cells via an endocytic pathway and are sorted to lysosomal compartments. Infect Immun (2009) 1.15
Tyrosine 221 in Crk regulates adhesion-dependent membrane localization of Crk and Rac and activation of Rac signaling. EMBO J (2002) 1.15
Epithelial cell polarity alters Rho-GTPase responses to Pseudomonas aeruginosa. Mol Biol Cell (2003) 1.14
The Src family kinases Hck and Fgr regulate neutrophil responses to N-formyl-methionyl-leucyl-phenylalanine. J Immunol (2007) 1.14
Myosin II directly binds and inhibits Dbl family guanine nucleotide exchange factors: a possible link to Rho family GTPases. J Cell Biol (2010) 1.13
Cross-talk between RhoH and Rac1 in regulation of actin cytoskeleton and chemotaxis of hematopoietic progenitor cells. Blood (2007) 1.13
The Rac effector p67phox regulates phagocyte NADPH oxidase by stimulating Vav1 guanine nucleotide exchange activity. Mol Cell Biol (2006) 1.13
Biochemical suppression of small-molecule inhibitors: a strategy to identify inhibitor targets and signaling pathway components. Chem Biol (2006) 1.12
Phosphorylation of p130Cas initiates Rac activation and membrane ruffling. BMC Cell Biol (2008) 1.12
The TC10-interacting protein CIP4/2 is required for insulin-stimulated Glut4 translocation in 3T3L1 adipocytes. Proc Natl Acad Sci U S A (2002) 1.12
Regulation of glioma cell migration by serine-phosphorylated P311. Neoplasia (2005) 1.11
Impaired hair follicle morphogenesis and polarized keratinocyte movement upon conditional inactivation of integrin-linked kinase in the epidermis. Mol Biol Cell (2008) 1.11
Skeletal muscle differentiation and fusion are regulated by the BAR-containing Rho-GTPase-activating protein (Rho-GAP), GRAF1. J Biol Chem (2011) 1.11
Human neutrophils coordinate chemotaxis by differential activation of Rac1 and Rac2. J Immunol (2009) 1.10
Enhanced transformation by a plasma membrane-associated met oncoprotein: activation of a phosphoinositide 3'-kinase-dependent autocrine loop involving hyaluronic acid and CD44. Mol Cell Biol (2000) 1.10
Vav activation and function as a rac guanine nucleotide exchange factor in macrophage colony-stimulating factor-induced macrophage chemotaxis. Mol Cell Biol (2005) 1.10
Axon guidance: asymmetric signaling orients polarized outgrowth. Trends Cell Biol (2008) 1.09
Primary granule exocytosis in human neutrophils is regulated by Rac-dependent actin remodeling. Am J Physiol Cell Physiol (2008) 1.08
Identification of a conserved Rac-binding site on NADPH oxidases supports a direct GTPase regulatory mechanism. J Biol Chem (2008) 1.08
The RAC1 P29S hotspot mutation in melanoma confers resistance to pharmacological inhibition of RAF. Cancer Res (2014) 1.08
Localized Rac activation dynamics visualized in living cells. Science (2000) 7.00
Activation of LIM-kinase by Pak1 couples Rac/Cdc42 GTPase signalling to actin cytoskeletal dynamics. Nat Cell Biol (1999) 6.18
Inhibition of myosin light chain kinase by p21-activated kinase. Science (1999) 5.41
Activation of Rac and Cdc42 by integrins mediates cell spreading. Mol Biol Cell (1998) 5.00
Human p21-activated kinase (Pak1) regulates actin organization in mammalian cells. Curr Biol (1997) 4.91
The small GTP-binding protein Rho regulates a phosphatidylinositol 4-phosphate 5-kinase in mammalian cells. Cell (1994) 4.80
Thrombin receptor ligation and activated Rac uncap actin filament barbed ends through phosphoinositide synthesis in permeabilized human platelets. Cell (1995) 4.39
Rho family GTPases regulate p38 mitogen-activated protein kinase through the downstream mediator Pak1. J Biol Chem (1995) 4.36
Regulation of phagocyte oxygen radical production by the GTP-binding protein Rac 2. Science (1991) 3.87
Requirements for both Rac1 and Cdc42 in membrane ruffling and phagocytosis in leukocytes. J Exp Med (1997) 3.32
rac, a novel ras-related family of proteins that are botulinum toxin substrates. J Biol Chem (1989) 3.21
Identification of the predominant substrate for ADP-ribosylation by islet activating protein. J Biol Chem (1983) 3.11
Membrane and morphological changes in apoptotic cells regulated by caspase-mediated activation of PAK2. Science (1997) 3.07
Inhibition of receptor-mediated release of arachidonic acid by pertussis toxin. Cell (1984) 2.96
Regulation of human leukocyte p21-activated kinases through G protein--coupled receptors. Science (1995) 2.87
Regulation of receptor-mediated endocytosis by Rho and Rac. Nature (1996) 2.84
Purification and properties of the inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. J Biol Chem (1984) 2.56
Molecular basis for Rac2 regulation of phagocyte NADPH oxidase. Nat Immunol (2001) 2.45
p21-activated kinase 1 phosphorylates the death agonist bad and protects cells from apoptosis. Mol Cell Biol (2000) 2.42
Localization of p21-activated kinase 1 (PAK1) to pinocytic vesicles and cortical actin structures in stimulated cells. J Cell Biol (1997) 2.37
Identification of a central phosphorylation site in p21-activated kinase regulating autoinhibition and kinase activity. J Biol Chem (1999) 2.36
A role for p21-activated kinase in endothelial cell migration. J Cell Biol (1999) 2.35
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Regulation of macropinocytosis by p21-activated kinase-1. Mol Biol Cell (2000) 2.16
Guanine nucleotide exchange regulates membrane translocation of Rac/Rho GTP-binding proteins. J Biol Chem (1994) 2.15
Regulation of actin polymerization in cell-free systems by GTPgammaS and Cdc42. J Cell Biol (1997) 2.14
Translocation of Rac correlates with NADPH oxidase activation. Evidence for equimolar translocation of oxidase components. J Biol Chem (1993) 2.13
Rho family proteins modulate rapid apoptosis induced by cytotoxic T lymphocytes and Fas. J Biol Chem (2000) 2.12
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Adenovirus endocytosis requires actin cytoskeleton reorganization mediated by Rho family GTPases. J Virol (1998) 1.99
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Rac translocates independently of the neutrophil NADPH oxidase components p47phox and p67phox. Evidence for its interaction with flavocytochrome b558. J Biol Chem (1994) 1.74
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The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and guanine nucleotide-dependent hormonal inhibition. J Biol Chem (1984) 1.69
Physical association of the small GTPase Rho with a 68-kDa phosphatidylinositol 4-phosphate 5-kinase in Swiss 3T3 cells. Mol Biol Cell (1996) 1.66
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The inhibitory guanine nucleotide-binding regulatory component of adenylate cyclase. Subunit dissociation and the inhibition of adenylate cyclase in S49 lymphoma cyc- and wild type membranes. J Biol Chem (1984) 1.62
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Multiple GTP-binding proteins regulate vesicular transport from the ER to Golgi membranes. J Cell Biol (1992) 1.52
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