Published in Med Chem on September 01, 2005
Central nicotinic receptors: structure, function, ligands, and therapeutic potential. ChemMedChem (2007) 1.36
Menthol: a natural analgesic compound. Neurosci Lett (2002) 1.32
Heptad repeat 2 in herpes simplex virus 1 gH interacts with heptad repeat 1 and is critical for virus entry and fusion. J Virol (2006) 1.29
Drug binding to human serum albumin: abridged review of results obtained with high-performance liquid chromatography and circular dichroism. Chirality (2006) 1.16
beta-Amyloid aggregation induced by human acetylcholinesterase: inhibition studies. Biochem Pharmacol (2003) 1.16
Enantioselective separation and online affinity chromatographic characterization of R,R- and S,S-fenoterol. Chirality (2006) 1.14
Paclitaxel directly binds to Bcl-2 and functionally mimics activity of Nur77. Cancer Res (2009) 1.13
Insight into the kinetic of amyloid beta (1-42) peptide self-aggregation: elucidation of inhibitors' mechanism of action. Chembiochem (2007) 1.10
Cholinergic nicotinic receptors: competitive ligands, allosteric modulators, and their potential applications. Med Res Rev (2003) 1.07
Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain. J Pain (2013) 1.05
Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. J Pain (2012) 1.02
Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain (2006) 1.01
Substitution in the murine nectin1 receptor of a single conserved amino acid at a position distal from the herpes simplex virus gD binding site confers high-affinity binding to gD. J Virol (2002) 0.98
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. J Med Chem (2003) 0.97
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. Sci Rep (2013) 0.95
Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats. Br J Nutr (2010) 0.93
Investigation on the photochemical stability of lercanidipine and its determination in tablets by HPLC-UV and LC-ESI-MS/MS. J Pharm Biomed Anal (2005) 0.93
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. Learn Mem (2008) 0.93
Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain (2010) 0.92
Chiral triazole fungicide difenoconazole: absolute stereochemistry, stereoselective bioactivity, aquatic toxicity, and environmental behavior in vegetables and soil. Environ Sci Technol (2013) 0.92
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor. J Neurosci Res (2009) 0.91
Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities. Bioorg Med Chem (2002) 0.91
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. J Med Chem (2006) 0.91
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur J Pharm Biopharm (2007) 0.91
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes. J Liposome Res (2009) 0.90
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent. J Med Chem (2008) 0.89
4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. J Med Chem (2007) 0.89
Enantioselective nonsteroidal aromatase inhibitors identified through a multidisciplinary medicinal chemistry approach. J Med Chem (2005) 0.89
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype. Behav Brain Res (2004) 0.89
Reliable HPLC method for therapeutic drug monitoring of frequently prescribed tricyclic and nontricyclic antidepressants. J Pharm Biomed Anal (2007) 0.89
Posttranscriptional changes of serum albumin: clinical and prognostic significance in hospitalized patients with cirrhosis. Hepatology (2014) 0.88
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett (2007) 0.88
Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord (2013) 0.88
A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. ACS Nano (2014) 0.88
Pleiotropic effect of histamine H4 receptor modulation in the central nervous system. Neuropharmacology (2013) 0.88
Alpha2-agonists as analgesic agents. Med Res Rev (2009) 0.87
Exploratory chemistry toward the identification of a new class of multidrug resistance reverters inspired by pervilleine and verapamil models. J Med Chem (2005) 0.86
Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. Pain (2015) 0.86
Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation. Int J Neuropsychopharmacol (2011) 0.86
Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain. Eur J Pharm Sci (2011) 0.86
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. J Neurochem (2009) 0.86
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test. Neuropharmacology (2005) 0.85
Effectiveness of the histone deacetylase inhibitor (S)-2 against LNCaP and PC3 human prostate cancer cells. PLoS One (2013) 0.85
Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology (2004) 0.85
Analgesic and antineuropathic drugs acting through central cholinergic mechanisms. Recent Pat CNS Drug Discov (2011) 0.85
Synthesis, affinity profile, and functional activity of muscarinic antagonists with a 1-methyl-2-(2,2-alkylaryl-1,3-oxathiolan-5-yl)pyrrolidine structure. J Med Chem (2007) 0.84
N-aryl-2,6-dimethylbenzamides, a new generation of tocainide analogues as blockers of skeletal muscle voltage-gated sodium channels. J Med Chem (2014) 0.84
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. J Med Chem (2006) 0.84
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway. Neuropharmacology (2004) 0.83
Rifampicin determination in plasma by stir bar-sorptive extraction and liquid chromatography. J Pharm Biomed Anal (2009) 0.83
Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo. J Neurochem (2008) 0.83
Species-dependent stereoselective drug binding to albumin: a circular dichroism study. Chirality (2008) 0.82
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury. J Med Chem (2009) 0.82
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage. Bioorg Med Chem (2007) 0.82
Mycoleptones A-C and polyketides from the endophyte Mycoleptodiscus indicus. J Nat Prod (2014) 0.82
Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats. Mediators Inflamm (2013) 0.82
N,N-bis(cyclohexanol)amine aryl esters: a new class of highly potent transporter-dependent multidrug resistance inhibitors. J Med Chem (2009) 0.82
Synthesis and biological evaluation of 2'-methyl taxoids derived from baccatin III and 14beta-OH-baccatin III 1,14-carbonate. J Med Chem (2003) 0.81
Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia. Pain (2015) 0.81
Kinetic disposition of lorazepam with focus on the glucuronidation capacity, transplacental transfer in parturients and racemization in biological samples. J Pharm Biomed Anal (2005) 0.81
Multidrug reverting activity toward leukemia cells in a group of new verapamil analogues with low cardiovascular activity. Leuk Res (2005) 0.81
Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype. Br J Pharmacol (2004) 0.81
Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy? Neurotherapeutics (2013) 0.81
The rapid and direct determination of ATPase activity by ion exchange chromatography and the application to the activity of heat shock protein-90. J Pharm Biomed Anal (2012) 0.81
HDAC-inhibitor (S)-8 disrupts HDAC6-PP1 complex prompting A375 melanoma cell growth arrest and apoptosis. J Cell Mol Med (2014) 0.81
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. Curr Pharm Des (2002) 0.81
Methylamine: a new endogenous modulator of neuron firing? Med Sci Monit (2005) 0.80
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline. Neuropharmacology (2011) 0.80
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. Pharmacol Res (2002) 0.80
Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy. J Liposome Res (2010) 0.80
Role of intracellular calcium in acute thermal pain perception. Neuropharmacology (2004) 0.80
New structure-activity relationship studies in a series of N,N-bis(cyclohexanol)amine aryl esters as potent reversers of P-glycoprotein-mediated multidrug resistance (MDR). Bioorg Med Chem (2012) 0.80
Aminopyrrolic synthetic receptors for monosaccharides: a class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. Chemistry (2012) 0.79
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression. Psychopharmacology (Berl) (2011) 0.79
Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine. Neuropsychopharmacology (2002) 0.79
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies. Bioorg Med Chem (2008) 0.79
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. Psychopharmacology (Berl) (2012) 0.79