Published in Neuropharmacology on April 11, 2013
A search for functional histamine H4 receptors in the human, guinea pig and mouse brain. Naunyn Schmiedebergs Arch Pharmacol (2014) 1.40
Histamine H4 receptor agonist-induced relief from painful peripheral neuropathy is mediated by inhibition of spinal neuroinflammation and oxidative stress. Br J Pharmacol (2016) 0.80
Central neuronal functions of histamine H4 receptors. Oncotarget (2017) 0.75
Evidence for a Role of Orexin/Hypocretin System in Vestibular Lesion-Induced Locomotor Abnormalities in Rats. Front Neurosci (2016) 0.75
Histamine H4-receptor expression in the brain? Naunyn Schmiedebergs Arch Pharmacol (2014) 0.75
Aryl-1,3,5-triazine ligands of histamine H4 receptor attenuate inflammatory and nociceptive response to carrageen, zymosan and lipopolysaccharide. Inflamm Res (2016) 0.75
Menthol: a natural analgesic compound. Neurosci Lett (2002) 1.32
Morphologic features and glial activation in rat oxaliplatin-dependent neuropathic pain. J Pain (2013) 1.05
Oxaliplatin-induced neuropathy: oxidative stress as pathological mechanism. Protective effect of silibinin. J Pain (2012) 1.02
Signaling pathway of morphine induced acute thermal hyperalgesia in mice. Pain (2006) 1.01
[(3-Chlorophenyl)piperazinylpropyl]pyridazinones and analogues as potent antinociceptive agents. J Med Chem (2003) 0.97
A TRPA1 antagonist reverts oxaliplatin-induced neuropathic pain. Sci Rep (2013) 0.95
Effects of dietary extra-virgin olive oil on behaviour and brain biochemical parameters in ageing rats. Br J Nutr (2010) 0.93
Different involvement of type 1, 2, and 3 ryanodine receptors in memory processes. Learn Mem (2008) 0.93
Protective effect of alpha7 nAChR: behavioural and morphological features on neuropathy. Pain (2010) 0.92
Novel potent 5-HT(3) receptor ligands based on the pyrrolidone structure: synthesis, biological evaluation, and computational rationalization of the ligand-receptor interaction modalities. Bioorg Med Chem (2002) 0.91
Neuroprotective effects of acetyl-L-carnitine on neuropathic pain and apoptosis: a role for the nicotinic receptor. J Neurosci Res (2009) 0.91
Arylpiperazinylalkylpyridazinones and analogues as potent and orally active antinociceptive agents: synthesis and studies on mechanism of action. J Med Chem (2006) 0.91
Development, characterization and in vivo evaluation of benzocaine-loaded liposomes. Eur J Pharm Biopharm (2007) 0.91
Effect of preparation technique on the properties and in vivo efficacy of benzocaine-loaded ethosomes. J Liposome Res (2009) 0.90
Ethyl 8-fluoro-6-(3-nitrophenyl)-4H-imidazo[1,5-a][1,4]benzodiazepine-3-carboxylate as novel, highly potent, and safe antianxiety agent. J Med Chem (2008) 0.89
Alpha-2 agonist-induced memory impairment is mediated by the alpha-2A-adrenoceptor subtype. Behav Brain Res (2004) 0.89
4-amino-5-substituted-3(2H)-pyridazinones as orally active antinociceptive agents: synthesis and studies on the mechanism of action. J Med Chem (2007) 0.89
New 1,8-naphthyridine and quinoline derivatives as CB2 selective agonists. Bioorg Med Chem Lett (2007) 0.88
Low dose native type II collagen prevents pain in a rat osteoarthritis model. BMC Musculoskelet Disord (2013) 0.88
A smart platform for hyperthermia application in cancer treatment: cobalt-doped ferrite nanoparticles mineralized in human ferritin cages. ACS Nano (2014) 0.88
Alpha2-agonists as analgesic agents. Med Res Rev (2009) 0.87
Salvianolic acid B and its liposomal formulations: anti-hyperalgesic activity in the treatment of neuropathic pain. Eur J Pharm Sci (2011) 0.86
Regionally selective activation and differential regulation of ERK, JNK and p38 MAP kinase signalling pathway by protein kinase C in mood modulation. Int J Neuropsychopharmacol (2011) 0.86
Histamine H4 receptor activation alleviates neuropathic pain through differential regulation of ERK, JNK, and P38 MAPK phosphorylation. Pain (2015) 0.86
Supraspinal Gbetagamma-dependent stimulation of PLCbeta originating from G inhibitory protein-mu opioid receptor-coupling is necessary for morphine induced acute hyperalgesia. J Neurochem (2009) 0.86
Blockade of intracellular calcium release induces an antidepressant-like effect in the mouse forced swimming test. Neuropharmacology (2005) 0.85
Acetyl-L-carnitine requires phospholipase C-IP3 pathway activation to induce antinociception. Neuropharmacology (2004) 0.85
Analgesic and antineuropathic drugs acting through central cholinergic mechanisms. Recent Pat CNS Drug Discov (2011) 0.85
Structural investigation of the 7-chloro-3-hydroxy-1H-quinazoline-2,4-dione scaffold to obtain AMPA and kainate receptor selective antagonists. Synthesis, pharmacological, and molecular modeling studies. J Med Chem (2006) 0.84
H1-receptor stimulation induces hyperalgesia through activation of the phospholipase C-PKC pathway. Neuropharmacology (2004) 0.83
Dopamine is necessary to endogenous morphine formation in mammalian brain in vivo. J Neurochem (2008) 0.83
A novel manganese complex effective as superoxide anion scavenger and therapeutic agent against cell and tissue oxidative injury. J Med Chem (2009) 0.82
Novel 3-iodo-8-ethoxypyrazolo[5,1-c][1,2,4]benzotriazine 5-oxide as promising lead for design of alpha5-inverse agonist useful tools for therapy of mnemonic damage. Bioorg Med Chem (2007) 0.82
Therapeutic effects of the superoxide dismutase mimetic compound MnIIMe2DO2A on experimental articular pain in rats. Mediators Inflamm (2013) 0.82
Activation of JNK pathway in spinal astrocytes contributes to acute ultra-low-dose morphine thermal hyperalgesia. Pain (2015) 0.81
Inhibition of the PKCγ-ε pathway relieves from meningeal nociception in an animal model: an innovative perspective for migraine therapy? Neurotherapeutics (2013) 0.81
Methylamine, but not ammonia, is hypophagic in mouse by interaction with brain Kv1.6 channel subtype. Br J Pharmacol (2004) 0.81
Design and study of piracetam-like nootropics, controversial members of the problematic class of cognition-enhancing drugs. Curr Pharm Des (2002) 0.81
Indomethacin, caffeine and prochlorperazine alone and combined revert hyperalgesia in in vivo models of migraine. Pharmacol Res (2002) 0.80
Role of intracellular calcium in acute thermal pain perception. Neuropharmacology (2004) 0.80
Methylamine: a new endogenous modulator of neuron firing? Med Sci Monit (2005) 0.80
Selective modulation of the PKCɛ/p38MAP kinase signalling pathway for the antidepressant-like activity of amitriptyline. Neuropharmacology (2011) 0.80
Liposomal formulations of prilocaine: effect of complexation with hydroxypropyl-ß-cyclodextrin on drug anesthetic efficacy. J Liposome Res (2010) 0.80
Novel analgesic/anti-inflammatory agents: diarylpyrrole acetic esters endowed with nitric oxide releasing properties. J Med Chem (2011) 0.79
Antidepressant-like effect of artemin in mice: a mechanism for acetyl-L-carnitine activity on depression. Psychopharmacology (Berl) (2011) 0.79
A class of pyrrole derivatives endowed with analgesic/anti-inflammatory activity. Bioorg Med Chem (2013) 0.79
The phospholipase C-IP3 pathway is involved in muscarinic antinociception. Neuropsychopharmacology (2002) 0.79
Role of Gi proteins in the antidepressant-like effect of amitriptyline and clomipramine. Neuropsychopharmacology (2002) 0.79
Activity and expression of semicarbazide-sensitive benzylamine oxidase in a rodent model of diabetes: interactive effects with methylamine and alpha-aminoguanidine. Eur J Pharmacol (2005) 0.79
Aminopyrrolic synthetic receptors for monosaccharides: a class of carbohydrate-binding agents endowed with antibiotic activity versus pathogenic yeasts. Chemistry (2012) 0.79
Reversal of NO-induced nociceptive hypersensitivity by St. John's wort and hypericin: NF-κB, CREB and STAT1 as molecular targets. Psychopharmacology (Berl) (2012) 0.79
Effects of endogenous morphine deprivation on memory retention of passive avoidance learning in mice. Int J Neuropsychopharmacol (2004) 0.79
Novel 3-aroylpyrazolo[5,1-c][1,2,4]benzotriazine 5-oxides 8-substituted, ligands at GABAA/benzodiazepine receptor complex: synthesis, pharmacological and molecular modeling studies. Bioorg Med Chem (2008) 0.79
Synthesis, biological evaluation, and receptor docking simulations of 2-[(acylamino)ethyl]-1,4-benzodiazepines as kappa-opioid receptor agonists endowed with antinociceptive and antiamnesic activity. J Med Chem (2003) 0.78
A gene-specific cerebral types 1, 2, and 3 RyR protein knockdown induces an antidepressant-like effect in mice. J Neurochem (2008) 0.78
Synthesis and biological evaluation of chiral alpha-aminoanilides with central antinociceptive activity. J Med Chem (2007) 0.78
Novel ester and acid derivatives of the 1,5-diarylpyrrole scaffold as anti-inflammatory and analgesic agents. Synthesis and in vitro and in vivo biological evaluation. J Med Chem (2010) 0.78
Novel analgesic/anti-inflammatory agents: 1,5-diarylpyrrole nitrooxyalkyl ethers and related compounds as cyclooxygenase-2 inhibiting nitric oxide donors. J Med Chem (2013) 0.78
Cyclooxygenase-2 inhibitors. 1,5-diarylpyrrol-3-acetic esters with enhanced inhibitory activity toward cyclooxygenase-2 and improved cyclooxygenase-2/cyclooxygenase-1 selectivity. J Med Chem (2007) 0.78
Synthesis and toxicopharmacological evaluation of m-hydroxymexiletine, the first metabolite of mexiletine more potent than the parent compound on voltage-gated sodium channels. J Med Chem (2012) 0.78
St. John's Wort reduces neuropathic pain through a hypericin-mediated inhibition of the protein kinase Cgamma and epsilon activity. Biochem Pharmacol (2010) 0.78
Lipoic-based TRPA1/TRPV1 antagonist to treat orofacial pain. ACS Chem Neurosci (2015) 0.77
Neurotransmitter role of endogenous morphine in CNS. Med Sci Monit (2005) 0.77
Antidepressant phenotype by inhibiting the phospholipase Cβ(1)--protein kinase Cγ pathway in the forced swim test. Neuropharmacology (2011) 0.77
Antihyperalgesic activity of verbascoside in two models of neuropathic pain. J Pharm Pharmacol (2011) 0.77
Nicotine is a pain reliever in trauma- and chemotherapy-induced neuropathy models. Eur J Pharmacol (2013) 0.77
Synthesis and biological evaluation of 3,7-diazabicyclo[4.3.0]nonan-8-ones as potential nootropic and analgesic drugs. J Med Chem (2011) 0.77
Design, synthesis and preliminary pharmacological evaluation of new piperidine and piperazine derivatives as cognition-enhancers. Bioorg Med Chem (2007) 0.77
Development and characterization of niosomal formulations of doxorubicin aimed at brain targeting. J Pharm Pharm Sci (2012) 0.77
Chiral aryloxyalkylamines: Selective 5-HT(1B/1D) activation and analgesic activity. ChemMedChem (2010) 0.77
Contribution of G inhibitory protein alpha subunits in paradoxical hyperalgesia elicited by exceedingly low doses of morphine in mice. Life Sci (2011) 0.77
A prolonged protein kinase C-mediated, opioid-related antinociceptive effect of st John's Wort in mice. J Pain (2009) 0.76
Synthesis of novel cognition enhancers with pyrazolo[5,1-c][1,2,4]benzotriazine core acting at γ-aminobutyric acid type A (GABA(A)) receptor. Bioorg Med Chem (2013) 0.76
Acetyl-L-carnitine in the management of pain during methadone withdrawal syndrome. Clin Neuropharmacol (2009) 0.76
α2 Adrenoceptor: a Target for Neuropathic Pain Treatment. Mini Rev Med Chem (2017) 0.75
3-Hydroxy-1H-quinazoline-2,4-dione derivatives as new antagonists at ionotropic glutamate receptors: molecular modeling and pharmacological studies. Eur J Med Chem (2012) 0.75
Dual effect of morphine in long-term social memory in rat. Br J Pharmacol (2013) 0.75
BDNF and Artemin are increased in drug-naïve non-depressed GAD patients: preliminary data. Int J Psychiatry Clin Pract (2014) 0.75
4-methyl benzylamine stimulates food consumption and counteracts the hypophagic effects of amphetamine acting on brain Shaker-like Kv1.1 channels. Br J Pharmacol (2006) 0.75
Gi/o proteins: expression for direct activation enquiry. Protein Expr Purif (2005) 0.75
Synthesis and biological evaluation of novel dimiracetam derivatives useful for the treatment of neuropathic pain. Bioorg Med Chem (2007) 0.75
Receptor-independent modulation of reconstituted Galpha(i) protein mediated by liposomes. Mol Biosyst (2009) 0.75
Improving the solubility of a new class of antiinflammatory pharmacodynamic hybrids, that release nitric oxide and inhibit cycloxygenase-2 isoenzyme. Eur J Med Chem (2012) 0.75
Design, synthesis, and preliminary pharmacological evaluation of 4-aminopiperidine derivatives as N-type calcium channel blockers active on pain and neuropathic pain. J Med Chem (2004) 0.75
2-Arylpyrazolo[4,3-d]pyrimidin-7-amino derivatives as new potent and selective human A3 adenosine receptor antagonists. Molecular modeling studies and pharmacological evaluation. J Med Chem (2013) 0.75
Structure-activity relationship studies on unifiram (DM232) and sunifiram (DM235), two novel and potent cognition enhancing drugs. Bioorg Med Chem (2004) 0.75
Structure-activity relationships of methoctramine-related polyamines as muscarinic antagonist: effect of replacing the inner polymethylene chain with cyclic moieties. Bioorg Med Chem (2007) 0.75
Ryanodine receptors are involved in muscarinic antinociception in mice. Behav Brain Res (2005) 0.75
Enantioselective synthesis and preliminary pharmacological evaluation of the enantiomers of unifiram (DM232), a potent cognition-enhancing agent. Med Chem (2005) 0.75
Design, synthesis, and preliminary pharmacological evaluation of new quinoline derivatives as nicotinic ligands. J Med Chem (2007) 0.75
PKC-mediated potentiation of morphine analgesia by St. John's Wort in rodents and humans. J Pharmacol Sci (2014) 0.75
Identification of a new pyrazolo[1,5-a]quinazoline ligand highly affine to γ-aminobutyric type A (GABAA) receptor subtype with anxiolytic-like and antihyperalgesic activity. J Med Chem (2017) 0.75
Differentiation state affects morphine induced cell regulation in neuroblastoma cultured cells. Neurosci Lett (2013) 0.75