Published in J Mol Cell Cardiol on June 30, 2006
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation (2010) 2.95
Methods in cardiomyocyte isolation, culture, and gene transfer. J Mol Cell Cardiol (2011) 2.12
A cardiac myosin light chain kinase regulates sarcomere assembly in the vertebrate heart. J Clin Invest (2007) 1.61
Cardiac myosin light chain kinase is necessary for myosin regulatory light chain phosphorylation and cardiac performance in vivo. J Biol Chem (2010) 1.37
Signaling to myosin regulatory light chain in sarcomeres. J Biol Chem (2011) 1.33
Myosin regulatory light chain phosphorylation attenuates cardiac hypertrophy. J Biol Chem (2008) 1.23
Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. J Physiol (2007) 1.18
A new state of cardiac myosin with very slow ATP turnover: a potential cardioprotective mechanism in the heart. Biophys J (2011) 1.11
Myosin light chain phosphorylation enhances contraction of heart muscle via structural changes in both thick and thin filaments. Proc Natl Acad Sci U S A (2016) 1.04
Desensitization of myofilaments to Ca2+ as a therapeutic target for hypertrophic cardiomyopathy with mutations in thin filament proteins. Circ Cardiovasc Genet (2014) 0.98
Cardiac myosin is a substrate for zipper-interacting protein kinase (ZIPK). J Biol Chem (2009) 0.97
Neonatal gene transfer of Serca2a delays onset of hypertrophic remodeling and improves function in familial hypertrophic cardiomyopathy. J Mol Cell Cardiol (2010) 0.97
Getting the skinny on thick filament regulation in cardiac muscle biology and disease. Trends Cardiovasc Med (2013) 0.93
Transmural heterogeneity of myofilament function and sarcomeric protein phosphorylation in remodeled myocardium of pigs with a recent myocardial infarction. Front Physiol (2011) 0.90
Constitutive phosphorylation of cardiac myosin regulatory light chain in vivo. J Biol Chem (2015) 0.90
Phosphorylation of myosin regulatory light chain controls myosin head conformation in cardiac muscle. J Mol Cell Cardiol (2015) 0.90
Functional effects of a tropomyosin mutation linked to FHC contribute to maladaptation during acidosis. J Mol Cell Cardiol (2010) 0.86
Ablation of iNOS delays cardiac contractile dysfunction in chronic hypertension. Front Biosci (Elite Ed) (2010) 0.82
Human RFamide-related peptide-1 diminishes cellular and integrated cardiac contractile performance. Peptides (2010) 0.82
Fibronectin increases the force production of mouse papillary muscles via α5β1 integrin. J Mol Cell Cardiol (2010) 0.80
Influence of a constitutive increase in myofilament Ca(2+)-sensitivity on Ca(2+)-fluxes and contraction of mouse heart ventricular myocytes. Arch Biochem Biophys (2014) 0.79
Effects of nicotine administration in a mouse model of familial hypertrophic cardiomyopathy, α-tropomyosin D175N. Am J Physiol Heart Circ Physiol (2011) 0.78
Phosphorylation of myosin regulatory light chain has minimal effect on kinetics and distribution of orientations of cross bridges of rabbit skeletal muscle. Am J Physiol Regul Integr Comp Physiol (2013) 0.76
Phosphorylation of the regulatory light chain of myosin in striated muscle: methodological perspectives. Eur Biophys J (2016) 0.75
CaMKII-dependent myofilament Ca(2+) desensitization contributes to the frequency-dependent acceleration of relaxation. Cell Calcium (2015) 0.75
Role of myosin light chain phosphatase in cardiac physiology and pathophysiology. J Mol Cell Cardiol (2016) 0.75
Guidelines for the use and interpretation of assays for monitoring autophagy. Autophagy (2012) 20.08
Loss of cyclophilin D reveals a critical role for mitochondrial permeability transition in cell death. Nature (2005) 11.22
Evidence from a genetic fate-mapping study that stem cells refresh adult mammalian cardiomyocytes after injury. Nat Med (2007) 8.06
Imaging cellular signals in the heart in vivo: Cardiac expression of the high-signal Ca2+ indicator GCaMP2. Proc Natl Acad Sci U S A (2006) 4.71
Genetic manipulation of periostin expression reveals a role in cardiac hypertrophy and ventricular remodeling. Circ Res (2007) 4.53
PKC-alpha regulates cardiac contractility and propensity toward heart failure. Nat Med (2004) 4.50
Reengineering inducible cardiac-specific transgenesis with an attenuated myosin heavy chain promoter. Circ Res (2003) 3.16
Ca2+- and mitochondrial-dependent cardiomyocyte necrosis as a primary mediator of heart failure. J Clin Invest (2007) 3.13
Adora2b-elicited Per2 stabilization promotes a HIF-dependent metabolic switch crucial for myocardial adaptation to ischemia. Nat Med (2012) 3.03
Uncoupled cardiac nitric oxide synthase mediates diastolic dysfunction. Circulation (2010) 2.95
Cardiac myosin-binding protein-C phosphorylation and cardiac function. Circ Res (2005) 2.67
Circadian rhythms govern cardiac repolarization and arrhythmogenesis. Nature (2012) 2.59
Neural crest cells retain multipotential characteristics in the developing valves and label the cardiac conduction system. Circ Res (2006) 2.59
Genetic and pharmacologic inhibition of mitochondrial-dependent necrosis attenuates muscular dystrophy. Nat Med (2008) 2.49
Macrophage autophagy plays a protective role in advanced atherosclerosis. Cell Metab (2012) 2.48
Cardiac myosin binding protein C phosphorylation is cardioprotective. Proc Natl Acad Sci U S A (2006) 2.46
Phenotyping hypertrophy: eschew obfuscation. Circ Res (2003) 2.32
Desmin-related cardiomyopathy in transgenic mice: a cardiac amyloidosis. Proc Natl Acad Sci U S A (2004) 2.32
Inhibition of ischemic cardiomyocyte apoptosis through targeted ablation of Bnip3 restrains postinfarction remodeling in mice. J Clin Invest (2007) 2.23
Myofilament calcium sensitivity does not affect cross-bridge activation-relaxation kinetics. Am J Physiol Regul Integr Comp Physiol (2006) 2.21
Impact of beta-myosin heavy chain expression on cardiac function during stress. J Am Coll Cardiol (2004) 2.17
Genetic variability in forced and voluntary endurance exercise performance in seven inbred mouse strains. J Appl Physiol (1985) (2002) 2.15
Heart failure and protein quality control. Circ Res (2006) 2.15
Cardiomyocyte GATA4 functions as a stress-responsive regulator of angiogenesis in the murine heart. J Clin Invest (2007) 2.12
Methods in cardiomyocyte isolation, culture, and gene transfer. J Mol Cell Cardiol (2011) 2.12
Partial replacement of cardiac troponin I with a non-phosphorylatable mutant at serines 43/45 attenuates the contractile dysfunction associated with PKCepsilon phosphorylation. J Mol Cell Cardiol (2006) 2.06
Characterization and functionality of cardiac progenitor cells in congenital heart patients. Circulation (2011) 1.99
Cardiac transgenic and gene transfer strategies converge to support an important role for troponin I in regulating relaxation in cardiac myocytes. Circ Res (2007) 1.95
Genetic inhibition of cardiac ERK1/2 promotes stress-induced apoptosis and heart failure but has no effect on hypertrophy in vivo. Proc Natl Acad Sci U S A (2007) 1.93
Troponin I in the murine myocardium: influence on length-dependent activation and interfilament spacing. J Physiol (2003) 1.85
Rescue of tropomyosin-induced familial hypertrophic cardiomyopathy mice by transgenesis. Am J Physiol Heart Circ Physiol (2007) 1.84
Ablation of ventricular myosin regulatory light chain phosphorylation in mice causes cardiac dysfunction in situ and affects neighboring myofilament protein phosphorylation. J Biol Chem (2008) 1.75
The troponin C G159D mutation blunts myofilament desensitization induced by troponin I Ser23/24 phosphorylation. Circ Res (2007) 1.74
With great power comes great responsibility: using mouse genetics to study cardiac hypertrophy and failure. J Mol Cell Cardiol (2008) 1.74
Mitochondrial dysfunction and apoptosis underlie the pathogenic process in alpha-B-crystallin desmin-related cardiomyopathy. Circulation (2005) 1.72
PKC-betaII sensitizes cardiac myofilaments to Ca2+ by phosphorylating troponin I on threonine-144. J Mol Cell Cardiol (2006) 1.71
Incomplete recovery of myocyte contractile function despite improvement of myocardial architecture with left ventricular assist device support. Circ Heart Fail (2011) 1.64
A critical function for Ser-282 in cardiac Myosin binding protein-C phosphorylation and cardiac function. Circ Res (2011) 1.61
Analysis of myosin heavy chain functionality in the heart. J Biol Chem (2003) 1.57
Rheb is a critical regulator of autophagy during myocardial ischemia: pathophysiological implications in obesity and metabolic syndrome. Circulation (2012) 1.56
Control of in vivo left ventricular [correction] contraction/relaxation kinetics by myosin binding protein C: protein kinase A phosphorylation dependent and independent regulation. Circulation (2007) 1.55
Atg7 induces basal autophagy and rescues autophagic deficiency in CryABR120G cardiomyocytes. Circ Res (2011) 1.53
Cardiac myosin binding protein-C phosphorylation in a {beta}-myosin heavy chain background. Circulation (2009) 1.52
Inducible expression of active protein phosphatase-1 inhibitor-1 enhances basal cardiac function and protects against ischemia/reperfusion injury. Circ Res (2009) 1.52
alpha1G-dependent T-type Ca2+ current antagonizes cardiac hypertrophy through a NOS3-dependent mechanism in mice. J Clin Invest (2009) 1.51
Cardiomyocyte expression of a polyglutamine preamyloid oligomer causes heart failure. Circulation (2008) 1.49
Reversal of amyloid-induced heart disease in desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2005) 1.49
Enhancement of proteasomal function protects against cardiac proteinopathy and ischemia/reperfusion injury in mice. J Clin Invest (2011) 1.48
Mediating ERK 1/2 signaling rescues congenital heart defects in a mouse model of Noonan syndrome. J Clin Invest (2007) 1.48
A non-equilibrium isoelectric focusing method to determine states of phosphorylation of cardiac troponin I: identification of Ser-23 and Ser-24 as significant sites of phosphorylation by protein kinase C. J Mol Cell Cardiol (2004) 1.48
Distinct sarcomeric substrates are responsible for protein kinase D-mediated regulation of cardiac myofilament Ca2+ sensitivity and cross-bridge cycling. J Biol Chem (2009) 1.47
A thrombospondin-dependent pathway for a protective ER stress response. Cell (2012) 1.45
In vivo and in vitro analysis of cardiac troponin I phosphorylation. J Biol Chem (2004) 1.43
Enhanced autophagy ameliorates cardiac proteinopathy. J Clin Invest (2013) 1.41
Unique single molecule binding of cardiac myosin binding protein-C to actin and phosphorylation-dependent inhibition of actomyosin motility requires 17 amino acids of the motif domain. J Mol Cell Cardiol (2011) 1.40
Selective class I histone deacetylase inhibition suppresses hypoxia-induced cardiopulmonary remodeling through an antiproliferative mechanism. Circ Res (2012) 1.37
Electron microscopy and 3D reconstruction of F-actin decorated with cardiac myosin-binding protein C (cMyBP-C). J Mol Biol (2011) 1.37
Anti-clumping factor A immunoglobulin reduces the duration of methicillin-resistant Staphylococcus aureus bacteremia in an experimental model of infective endocarditis. Antimicrob Agents Chemother (2003) 1.35
Physiological growth synergizes with pathological genes in experimental cardiomyopathy. Circ Res (2004) 1.34
Protein kinase Cepsilon overexpression alters myofilament properties and composition during the progression of heart failure. Circ Res (2004) 1.32
AlphaB-crystallin modulates protein aggregation of abnormal desmin. Circ Res (2003) 1.31
Functional effects of the hypertrophic cardiomyopathy R403Q mutation are different in an alpha- or beta-myosin heavy chain backbone. J Biol Chem (2008) 1.31
Impact of osmotic compression on sarcomere structure and myofilament calcium sensitivity of isolated rat myocardium. Am J Physiol Heart Circ Physiol (2006) 1.30
Regulated overexpression of the A1-adenosine receptor in mice results in adverse but reversible changes in cardiac morphology and function. Circulation (2006) 1.30
Dilated cardiomyopathy mutant tropomyosin mice develop cardiac dysfunction with significantly decreased fractional shortening and myofilament calcium sensitivity. Circ Res (2007) 1.29
FTY720 prevents ischemia/reperfusion injury-associated arrhythmias in an ex vivo rat heart model via activation of Pak1/Akt signaling. J Mol Cell Cardiol (2009) 1.29
Molecular and functional characterization of a novel cardiac-specific human tropomyosin isoform. Circulation (2010) 1.29
Bax and Bak function as the outer membrane component of the mitochondrial permeability pore in regulating necrotic cell death in mice. Elife (2013) 1.28
Regulation of cardiac contractility by Rab4-modulated beta2-adrenergic receptor recycling. Proc Natl Acad Sci U S A (2004) 1.28
Left ventricular myofilament dysfunction in rat experimental hypertrophy and congestive heart failure. Am J Physiol Heart Circ Physiol (2006) 1.25
Desmin-related cardiomyopathy: an unfolding story. Am J Physiol Heart Circ Physiol (2011) 1.24
Cardiomyocyte degeneration with calpain deficiency reveals a critical role in protein homeostasis. Circ Res (2007) 1.23
Role of ERK1/2 signaling in congenital valve malformations in Noonan syndrome. Proc Natl Acad Sci U S A (2008) 1.21
Dock6, a Dock-C subfamily guanine nucleotide exchanger, has the dual specificity for Rac1 and Cdc42 and regulates neurite outgrowth. Exp Cell Res (2006) 1.19
Pak1 as a novel therapeutic target for antihypertrophic treatment in the heart. Circulation (2011) 1.18
Frequency-dependent myofilament Ca2+ desensitization in failing rat myocardium. J Physiol (2007) 1.18
Signaling and myosin-binding protein C. J Biol Chem (2011) 1.18
Molecular mechanics of mouse cardiac myosin isoforms. Am J Physiol Heart Circ Physiol (2002) 1.17
Plasma membrane Ca2+-ATPase isoform 4 antagonizes cardiac hypertrophy in association with calcineurin inhibition in rodents. J Clin Invest (2009) 1.17
Expression of active p21-activated kinase-1 induces Ca2+ flux modification with altered regulatory protein phosphorylation in cardiac myocytes. Am J Physiol Cell Physiol (2008) 1.16
Effects of cardiac myosin isoform variation on myofilament function and crossbridge kinetics in transgenic rabbits. Circ Heart Fail (2009) 1.16
Inducible and myocyte-specific inhibition of PKCalpha enhances cardiac contractility and protects against infarction-induced heart failure. Am J Physiol Heart Circ Physiol (2007) 1.16
Ca2+ influx through T- and L-type Ca2+ channels have different effects on myocyte contractility and induce unique cardiac phenotypes. Circ Res (2008) 1.16
Diminished autophagy limits cardiac injury in mouse models of type 1 diabetes. J Biol Chem (2013) 1.15
Forced expression of alpha-myosin heavy chain in the rabbit ventricle results in cardioprotection under cardiomyopathic conditions. Circulation (2005) 1.15
Stage-specific changes in myofilament protein phosphorylation following myocardial infarction in mice. J Mol Cell Cardiol (2009) 1.15
Distribution and structure-function relationship of myosin heavy chain isoforms in the adult mouse heart. J Biol Chem (2007) 1.15
Exercise reverses preamyloid oligomer and prolongs survival in alphaB-crystallin-based desmin-related cardiomyopathy. Proc Natl Acad Sci U S A (2007) 1.12